NLK phosphorylates Raptor to mediate stress-induced mTORC1 inhibition

Genes and Development

Volumn 29, Issue 22, 2015, Pages 2362-2376

  Yuan, Hai Xin ^a,c   Wang, Zhen ^a   Yu, Fa Xing ^b,c   Li, Fulong ^a   Russell, Ryan C ^c   Jewell, Jenna L ^c   Guan, Kun Liang ^c  

^a BEIJING UNIVERSITY OF POSTS AND TELECOMMUNICATIONS   (China)

^b FUDAN UNIVERSITY   (China)

^c UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Cancer; MTOR; NLK; Raptor; Stress response

Indexed keywords

INITIATION FACTOR 4E BINDING PROTEIN 1; LYSOSOME ASSOCIATED MEMBRANE PROTEIN 2; MAMMALIAN TARGET OF RAPAMYCIN COMPLEX 1; NEMO LIKE KINASE; REGULATOR PROTEIN; S6 KINASE; UNCLASSIFIED DRUG; MECHANISTIC TARGET OF RAPAMYCIN COMPLEX 1; MITOGEN ACTIVATED PROTEIN KINASE; MULTIPROTEIN COMPLEX; RPTOR PROTEIN, HUMAN; SIGNAL TRANSDUCING ADAPTOR PROTEIN; TARGET OF RAPAMYCIN KINASE;

ANIMAL CELL; ARTICLE; CELL FUNCTION; CELL GROWTH; CELL STRESS; CRISPR CAS SYSTEM; EMBRYO; GENE DELETION; HYPEROSMOTIC STRESS; IN VITRO STUDY; KWASHIORKOR; LYSOSOME; MOUSE; NONHUMAN; OSMOTIC STRESS; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN LOCALIZATION; PROTEIN MOTIF; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; SIGNAL TRANSDUCTION; TRANSLATION REGULATION; ENZYME ACTIVATION; GENE TARGETING; GENETICS; HEK293 CELL LINE; HUMAN; METABOLISM; OSMOTIC PRESSURE; PHOSPHORYLATION; PHYSIOLOGY;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; ENZYME ACTIVATION; GENE DELETION; GENE KNOCK-IN TECHNIQUES; HEK293 CELLS; HUMANS; MITOGEN-ACTIVATED PROTEIN KINASES; MULTIPROTEIN COMPLEXES; OSMOTIC PRESSURE; PHOSPHORYLATION; TOR SERINE-THREONINE KINASES;

EID: 84947976753     PISSN: 08909369     EISSN: 15495477     Source Type: Journal    
DOI: 10.1101/gad.265116.115     Document Type: Article

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