Serenoa Repens Induces Growth Arrest, Apoptosis and Inactivation of STAT3 Signaling in Human Glioma Cells

Technology in Cancer Research and Treatment

Volumn 14, Issue 6, 2015, Pages 729-736

  Zhou, Tiezhu ^a   Yang, Yang ^a   Zhang, Hongyan ^a   Che, Yuqin ^a   Wang, Wei ^a   Lv, Hui ^a   Li, Jie ^a   Wang, Yuanyuan ^a   Hou, Shuai ^a  

^a CHINA MEDICAL UNIVERSITY   (China)

Author keywords

Apoptosis; Glioma; Serenoa repens; STAT 3

Indexed keywords

CASPASE 3; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE 1; PROTEIN P27; PROTEIN TYROSINE KINASE; SABAL EXTRACT; STAT3 PROTEIN; ANTINEOPLASTIC AGENT; PLANT EXTRACT; STAT3 PROTEIN, HUMAN;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CANCER INHIBITION; CELL PROLIFERATION; CONTROLLED STUDY; FLOW CYTOMETRY; GLIOMA; HUMAN; HUMAN CELL; MTT ASSAY; PROTEIN EXPRESSION; SABAL; SIGNAL TRANSDUCTION; WESTERN BLOTTING; CELL CYCLE CHECKPOINT; DRUG EFFECTS; METABOLISM; PATHOLOGY; TUMOR CELL LINE;

ANTINEOPLASTIC AGENTS; APOPTOSIS; BLOTTING, WESTERN; CELL CYCLE CHECKPOINTS; CELL LINE, TUMOR; CELL PROLIFERATION; FLOW CYTOMETRY; GLIOMA; HUMANS; PLANT EXTRACTS; SERENOA; SIGNAL TRANSDUCTION; STAT3 TRANSCRIPTION FACTOR;

EID: 84947782897     PISSN: 15330346     EISSN: 15330338     Source Type: Journal    
DOI: 10.7785/tcrt.2012.500417     Document Type: Article

References (40)

1. Surawicz, T. S., McCarthy, B. J., Kupelian, V., et al. Descriptive epi­demiology of primary brain and CNS tumors: results from the central brain tumor registry of the United States, 1990-1994. Neuro Oncol 1, 14-25 (1999). DOI: 10.1215/15228517-1-1-14
2. Wen, P. Y., Kesari, S. Malignant gliomas in adults. N Engl J Med 492-507 (2008). DOI: 10.1056/NEJMra0708126
3. Van Meir, E. G., Hadjipanayis, C. G., Norden, A. D., et al. Exciting new advances in neuro-oncology: the avenue to a cure for malignant glioma. CA Cancer J Clin 60, 166-193 (2010). DOI: 10.3322/caac.20069
4. Furnari, F. B., Fenton, T., Bachoo, R. M., et al. Malignant astrocytic glioma: genetics, biology, and paths to treatment. Genes Dev 21, 2683-2710 (2007). DOI: 10.1101/gad.1596707
5. Stupp, R., Hegi, M. E., van den Bent, M. J., et al. European organisa­tion for research and treatment of cancer brain tumor and radiother­apy groups; national cancer institute of canada clinical trials group: changing paradigms-an update on the multidisciplinary manage­ment of malignant glioma. Oncologist 11, 165-180 (2006). PMID: 16476837
6. Stieber, V. W., Mehta, M. P. Advances in radiation therapy for brain tumors. Neurol Clin 25, 1005-1033 (2007). DOI: 10.1016/ j.ncl.2007.07.005
7. Darnell, J. E. Jr, Kerr, I. M., Stark, G. R. Jak-STAT pathways and transcriptional activation in response to IFNs and other extracellular signaling proteins. Science 264, 1415-1421 (1994). DOI: 10.1126/ science.8197455
8. Darnell, J. E. Jr. STATs and Gene regulation. Science 277, 1630- 1635 (1997). DOI: 10.1126/science.277.5332.1630
9. Murray, P. J. The JAK-STAT signaling pathway: input and output integration. J Immunol 178, 2623-2629 (2007). PMID: 17312100
10. Ihle, J., Kerr, I. M. Jaks and Stats in signaling by the cytokine recep­tor superfamily. Trends Genet 11, 69-74 (1995). DOI: 10.1016/ S0168-9525(00)89000-9
11. Aggarwal, B. B., Kunnumakkara, A. B., Harikumar, K. B., et al. Signal transducer and activator of transcription-3, inflammation, and cancer: how intimate is the relationship? Ann N Y Acad Sci 1171, 59-76 (2009). DIO: 10.1111/j.1749-6632.2009.04911.x
12. Seethala, R. R., Gooding, W. E., Handler, P. N., et al. Immunohisto­chemical analysis of phosphotyrosine signal transducer and activa­tor of transcription 3 and epidermal growth factor receptor autocrine signaling pathways in head and neck cancers and metastatic lymph nodes. Clin Cancer Res 14, 1303-1309 (2008). DOI: 10.1158/1078- 0432.CCR-07-1543
13. Buettner, R., Mora, L. B., Jove, R. Activated STAT signaling in human tumors provides novel molecular targets for therapeutic inter­vention. Clin Cancer Res 8, 945-954 (2002). PMID: 11948098
14. Catlett-Falcone, R., Landowski, T. H., Oshiro, M. M., et al. Con­stitutive activation of Stat3 signaling confers resistance to apopto­sis in human U266 myeloma cells. Immunity 10, 105-115 (1999). DOI: 10.1016/S1074-7613(00)80011-4
15. Epling-Burnette, P. K., Liu, J. H., Catlett-Falcone, R., et al. Inhibi­tion of STAT3 signaling leads to apoptosis of leukemic large granu­lar lymphocytes and decreased Mcl-1 expression. J Clin Invest 107, 351-362 (2001). DOI: 10.1172/JCI9940
16. Barton, B. E., Murphy, T. F., Adem, P., et al. IL-6 signaling by STAT3 participates in the change from hyperplasia to neoplasia in NRP-152 and NRP-154 rat prostatic epithelial cells. BMC Cancer 1, 19 (2001). PMID: 11710966
17. Risberg, T., Lund, E., Wist, E., et al. Cancer patients use of non­proven therapy: a 5-year follow-up study. J Clin Oncol 16, 6-12 (1998). PMID: 9440716
18. Barnes, P. M., Powell-Griner, E., McFann, K., et al. Complementary and alternative medicine use among adults: United States, 2002. Adv Data 343, 1-19 (2004). DOI: 10.1016/j.sigm.2004.07.003
19. Eisenberg, D. M., Davis, R. B., Ettner, S. L., et al. Trends in alterna­tive medicine use in the united states, 1990-1997: results of a follow-up national survey. JAMA 280, 1569-1575 (1998) DOI: 10.1001/ jama.280.18.1569
20. Gerber, G. S., Fitzpatrick, J. M. The role of a lipido-sterolic extract of Serenoa repens in the management of lower urinary tract symptoms associated with benign prostatic hyperplasia. BJU Int 94, 338-344 (2004). DOI: 10.1111/j.1464-410X.2004.04962.x
21. Che, Y., Hou, S., Kang, Z., Lin, Q. Serenoa repens induces growth arrest and apoptosis of human multiple myeloma cells via inac­tivation of STAT 3 signaling. Oncol Rep 22, 377-383 (2009). DOI: 10.3892/or_00000448
22. Baron, A., Mancini, M., Caldwell, E., et al. Serenoa repens extract targets mitochondria and activates the intrinsic apoptotic pathway in human prostate cancer cells. BJU Int 103, 1275-1283 (2009). DOI: 10.1111/j.1464-410X.2008.08266.x
23. Yang, Y., Ikezoe, T., Zheng, Z., et al. Saw Palmetto induces growth arrest and apoptosis of androgen-dependent prostate cancer LNCaP cells via inactivation of STAT 3 and androgen receptor signaling. Int J Oncol 31, 593-600 (2007). PMID: 17671686
24. Iguchi, K., Okumura, N., Usui, S., et al. Myristoleic acid, a cytotoxic component in the extract from Serenoa repens, induces apoptosis and necrosis in human prostatic LNCaP cells. Prostate 47, 59-65 (2001). DOI: 10.1002/pros.1047.abs
25. Ravenna, L., Di Silverio, F., Russo, M. A., et al. Effects of the lipidosterolic extract of Serenoa repens (Permixon) on human prostatic cell lines. Prostate 29, 219-230 (1996). DOI: 10.1002/ (SICI)1097-0045(199610)29:4<219::AID-PROS3>3.3.CO;2-S
26. Petrangeli, E., Lenti, L., Buchetti, B., et al. Lipido-sterolic extract of Serenoa repens (LSESr, Permixon) treatment affects human prostate cancer cell membrane organization. J Cell Physiol 219, 69-76 (2009). DOI: 10.1002/jcp.21648
27. Yang, Y., Ikezoe, T., Nishioka, C., et al. ZD6474 induces growth arrest and apoptosis of GIST-T1 cells, which is enhanced by con­comitant use of sunitinib. Cancer Sci 97, 1404-1409 (2006). DOI: 10.1111/j.1349-7006.2006.00325.x
28. Yang, Y., Ikezoe, T., Saito, T., et al. Proteasome inhibitor PS-341 induces growth arrest and apoptosis of non-small cell lung cancer cells via the JNK/c-Jun/AP-1 signaling. Cancer Sci 95, 176-180 (2004). DOI: 10.1111/j.1349-7006.2004.tb03200.x
29. Komotar, R. J., Otten, M. L., Moise, G., et al. Radiotherapy plus concomitant and adjuvant temozolomide for glioblastoma-a critical review. Clin Med Oncol 2, 421-422 (2008). PMID: 21892310
30. Stupp, R., Mason, W. P., van den Bent, M. J., et al. European organisation for research and treatment of cancer brain tumor and radiotherapy groups; national cancer institute of canada clinical tri­als group: radiotherapy plus concomitant and adjuvant temozolo­mide for glioblastoma. N Engl J Med 352, 987-996 (2005). PMID: 15758009
31. Tsai, N. M., Lin, S. Z., Lee, C. C., et al. The antitumor effects of angelica sinensis on malignant brain tumors in vitro and in vivo. Clin Cancer Res 11, 3475-3484 (2005). DOI: 10.1158/1078-0432.CCR-04-1827
32. Yin, D., Wakimoto, N., Xing, H., et al. Cucurbitacin B markedly inhibits growth and rapidly affects the cytoskeleton in glioblastoma multiforme. Int J Cancer 123, 1364-1375 (2008). DOI: 10.1002/ ijc.23648
33. Parajuli, P., Joshee, N., Chinni, S. R., et al. Delayed growth of gli­oma by Scutellaria flavonoids involve inhibition of Akt, GSK-3 and NF-κB signaling. J Neurooncol 101, 15-24 (2011). DOI: 10.1007/ s11060-010-0221-x
34. Hostanska, K., Suter, A., Melzer, J., et al. Evaluation of cell death caused by an ethanolic extract of serenoae repentis fructus (Prostasan®) on human carcinoma cell lines. Anticancer Res 27, 873-881 (2007). PMID: 17465214
35. Abou-Ghazal, M., Yang, D. S., Qiao, W., et al. The incidence, cor­relation with tumor-infiltrating inflammation, and prognosis of phosphorylated STAT3 expression in human gliomas. Clin Cancer Res 14, 8228-8235 (2008). DOI: 10.1158/1078-0432.CCR- 08-1329
36. Doucette, T. A., Kong, L. Y., Yang, Y., et al. Signal transducer and activator of transcription 3 promotes angiogenesis and drives malig­nant progression in glioma. Neuro Oncol 14, 1136-1145 (2012). DOI: 10.1093/neuonc/nos139
37. Carro, M. S., Lim, W. K., Alvarez, M. J., et al. The transcriptional network for mesenchymal transformation of brain tumours. Nature 463, 318-325 (2010). DOI: 10.1038/nature08712
38. Brantley, E. C., Benveniste, E. N. Signal transducer and activator of transcription-3: a molecular hub for signaling pathways in glio­mas. Mol Cancer Res 6, 675-684 (2008). DOI: 10.1158/1541-7786. MCR-07-2180
39. Brennan, C., Momota, H., Hambardzumyan, D., et al. Glioblastoma subclasses can be defined by activity among signal transduction path­ways and associated genomic alterations. PLoS One 4, e7752 (2009). DOI: 10.1371/journal.pone.0007752
40. Rahaman, S. O., Harbor, P. C., Chernova, O., et al. Inhibition of con­stitutively active Stat3 suppresses proliferation and induces apoptosis in glioblastoma multiforme cells. Oncogene 21, 8404-8413 (2002). DOI: 10.1038/sj.onc.1206047