Effects of the lipidosterolic extract of Serenoa repens (Permixon®) on human prostatic cell lines

Prostate

Volumn 29, Issue 4, 1996, Pages 219-230

  Ravenna, L ^a   Di Silverio, F ^a   Russo, M A ^a   Salvatori, L ^c   Morgante, E ^a   Morrone, S ^a   Cardillo, M R ^a   Russo, A ^a   Frati, L ^a,b   Gulino, A ^b   Petrangeli, E ^c,d  

^a SAPIENZA UNIVERSITY OF ROME   (Italy)

^b UNIVERSITY OF L'AQUILA   (Italy)

^c CNR   (Italy)

^d Istituto di Tecnologie Biomediche   (Italy)

Author keywords

androgens; LNCaP; PC3; Permixon ; prostatic cells

Indexed keywords

ANDROGEN RECEPTOR;

ANDROGEN BLOOD LEVEL; ARTICLE; CELL PROLIFERATION; DATA ANALYSIS; ELECTRON MICROSCOPY; HORMONAL REGULATION; HUMAN; HUMAN CELL; HUMAN TISSUE; PLASMID; PRIORITY JOURNAL; PROSTATE CANCER; REPORTER GENE; SABAL; SKIN FIBROBLAST;

ANDROGEN ANTAGONISTS; ANDROGENS; CELL LINE; CELL SEPARATION; CELL SURVIVAL; FLOW CYTOMETRY; HUMANS; MALE; METHIONINE; MICROSCOPY, ELECTRON; PLANT EXTRACTS; PROSTATE; SERENOA; THYMIDINE; TRANSCRIPTION, GENETIC;

EID: 10344251011     PISSN: 02704137     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1097-0045(199610)29:4<219::AID-PROS3>3.0.CO;2-6     Document Type: Article

References (16)

1. Briley M, Carilla E, Fauran F: Permixon®, a new treatment for benign prostatic hyperplasia, acts directly at the cytosolic androgen receptor in rat prostate. Br J Pharmacol 79:327-336, 1983.
2. Carilla E, Briley M, Fauran F, Sultan C, Deviller C: Binding of Permixon®, a new treatment for benign prostatic hyperplasia, to the cytosolic androgen receptor in the rat prostate. J Steroid Biochem 20:521-523, 1984.
3. Briley M, Carilla E, Roger A: Inhibitory effect of Permixon® on testosterone 5α-reductase activity of the rat ventral prostate. Br J Pharmacol 83:401-410, 1984.
4. Sultan C, Terraza A, Devillier C, Carilla E, Briley M, Loire C, Descomps B: Inhibition of androgen metabolism and binding by a liposterolic extract of Serenoa repens B in human foreskin fibroblast. J Steroid Biochem 20:515-519, 1984.
5. Délos S, Iehlé C, Martin PM, Raynaud JP: Inhibition of the activity of "basic" 5α-reductase (type 1) detected in DU 145 cells and expressed in insect cells. J Steroid Biochem Mol Biol 48:347-352, 1994.
6. Iehlé C, Délos S, Guirou O, Tate R, Raynaud JP, PM: Human prostatic steroid 5α-reductase isoforms: A comparative study of selective inhibitors. J Steroid Biochem Mol Biol 54:273-279, 1995.
7. Di Silverio F, D'Eramo G, Lubrano C, Flammia GP, Sciarra A, Palma E, Caponera M, Sciarra F: Evidence that Serenoa repens extract displays an antiestrogenic activity in prostatic tissue of benign prostatic hypertrophy patient. Eur Urol 21:309-314, 1992.
8. Kaighn ME, Shankar Narayan K, Ohnuki Y, Lechner JF, Jones LW: Establishment and characterization of a human prostatic carcinoma cell line (PC3). Invest Urol 17:16-23, 1979.
9. Culig Z, Klocker H, Eberle J, Kaspar F, Hobisch A, Cronauer M, Bartsch G: DNA sequence of the androgen receptor in prostatic tumor cell lines and tissue specimens assessed by means of polymerase chain reaction. Prostate 22:11-22, 1993.
10. Horoszewicz J, Leong S, Kawinski E, Karr J, Rosenthal H, Ming Chu T, Mirand E, Murphy G: LNCaP model of human prostatic carcinoma. Cancer Res 43:1808-1818, 1983.
11. Veldscholte J, Voorhorst-Ogink M, Bolt de Vries J, van Rooij H, Trapman J, Mulder E: Unusual specificity of the androgen receptor in the human prostate tumor cell line LNCaP: High affinity for progestagenic and estrogenic steroids. Biochim Biophys Acta 1052:187-194, 1990.
12. Maroder M, Farina A, Vacca A, Felli MP, Meco D, Screpanti I, Frati L, Gulino A: Cell-specific bifunctional role of Jun oncogene family members on glucocorticoid receptor-dependent transcription. Mol Endocrinol 7:570-584, 1993.
13. Lucoq J: Unbiased 3-D quantitation of ultrastructure in cell biology. Trends Cell Biol 3:354-358, 1993.
14. Kingston RE: Transfection of DNA into eukaryotic cells. In Ausbel FM, Brent R, Kingston RE, Moore DD, Seidma GC, Smith GA, Struhl K (eds): Current Protocol in Molecular Biology. New York: Wiley and Sons, 9.1.1.-9.1.4., 1993.
15. Gorman CM, Moffat LF, Howard BH: Recombinant genomes which express chloramphenicol acetyl transferase in mammalian cells. Mol Cell Biol 2:1044-1051, 1982.
16. Ravenna L, Lubrano C, Di Silverio F, Vacca A, Felli MP, Maroder M, D'Eramo G, Sciarra F, Frati L, Gulino A, Petrangeli E: Androgenic and antiandrogenic control on epidermal growth factor, epidermal growth factor receptor and androgen receptor expression in human prostate cancer cell line LNCaP. Prostate 26:290-298, 1995.