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Volumn 31, Issue 3, 2007, Pages 593-600

Saw Palmetto induces growth arrest and apoptosis of androgen-dependent prostate cancer LNCaP cells via inactivation of STAT 3 and androgen receptor signaling

Author keywords

Androgen receptor; Prostate cancer; PSA; Saw Palometto; STAT 3

Indexed keywords

ANDROGEN RECEPTOR; ANTIANDROGEN; INTERLEUKIN 6; PLANT EXTRACT; PROSTATE SPECIFIC ANTIGEN; SABAL EXTRACT; STAT3 PROTEIN; STAT3 PROTEIN, HUMAN; UNCLASSIFIED DRUG;

EID: 38449120751     PISSN: 10196439     EISSN: 17912423     Source Type: Journal    
DOI: 10.3892/ijo.31.3.593     Document Type: Article
Times cited : (28)

References (36)
  • 2
    • 0036645414 scopus 로고    scopus 로고
    • Molecular biology of the androgen receptor
    • Gelmann EP: Molecular biology of the androgen receptor. J Clin Oncol 20: 3001-3015, 2002.
    • (2002) J Clin Oncol , vol.20 , pp. 3001-3015
    • Gelmann, E.P.1
  • 3
    • 0032855594 scopus 로고    scopus 로고
    • Prostate specific antigen: A decade of discovery - What we have learned and where we are going
    • Polascik TJ, Oesterling JE and Partin AW: Prostate specific antigen: a decade of discovery - what we have learned and where we are going. J Urol 162: 293-306, 1999.
    • (1999) J Urol , vol.162 , pp. 293-306
    • Polascik, T.J.1    Oesterling, J.E.2    Partin, A.W.3
  • 4
    • 0031059178 scopus 로고    scopus 로고
    • Identification of a positive regulatory element responsible for tissue-specific expression of prostate-specific antigen
    • Pang S, Dannull J, Kaboo R, Xie Y, Tso CL, Michel K, deKernion JB and Belldegrun AS: Identification of a positive regulatory element responsible for tissue-specific expression of prostate-specific antigen. Cancer Res 57: 495-499, 1997.
    • (1997) Cancer Res , vol.57 , pp. 495-499
    • Pang, S.1    Dannull, J.2    Kaboo, R.3    Xie, Y.4    Tso, C.L.5    Michel, K.6    DeKernion, J.B.7    Belldegrun, A.S.8
  • 5
    • 0033520426 scopus 로고    scopus 로고
    • Cooperative assembly of androgen receptor into a nucleoprotein complex that regulates the prostate-specific antigen enhancer
    • DOI 10.1074/jbc.274.36.25756
    • Huang W, Shostak Y, Tarr P, Sawyers C and Carey M: Cooperative assembly of androgen receptor into a nucleoprotein complex that regulates the prostate-specific antigen enhancer. J Biol Chem 274: 25756-25768, 1999. (Pubitemid 29418607)
    • (1999) Journal of Biological Chemistry , vol.274 , Issue.36 , pp. 25756-25768
    • Huang, W.1    Shostak, Y.2    Tarr, P.3    Sawyers, C.4    Carey, M.5
  • 7
    • 0030088077 scopus 로고    scopus 로고
    • STATs and MAPKs: Obligate or opportunistic partners in signaling
    • Ihle JN: STATs and MAPKs: obligate or opportunistic partners in signaling. BioEssays 18: 95-98, 1996. (Pubitemid 126599924)
    • (1996) BioEssays , vol.18 , Issue.2 , pp. 95-98
    • Ihle, J.N.1
  • 8
    • 0030840464 scopus 로고    scopus 로고
    • STATs and gene regulation
    • Darnell JE Jr: STATs and gene regulation. Science 277: 1630-1635, 1997.
    • (1997) Science , vol.277 , pp. 1630-1635
    • Darnell Jr., J.E.1
  • 9
    • 0013689209 scopus 로고    scopus 로고
    • Requirement of Stat3 but not Stat1 activation for epidermal growth factor receptor-mediated cell growth in vitro
    • Grandis JR, Drenning SD, Chakraborty A, Zhou MY, Zeng Q, Pitt AS and Tweardy DJ: Requirement of Stat3 but not Stat1 activation for epidermal growth factor receptor-mediated cell growth in vitro. J Clin Invest 102: 1385-1392, 1998.
    • (1998) J Clin Invest , vol.102 , pp. 1385-1392
    • Grandis, J.R.1    Drenning, S.D.2    Chakraborty, A.3    Zhou, M.Y.4    Zeng, Q.5    Pitt, A.S.6    Tweardy, D.J.7
  • 11
    • 0036554816 scopus 로고    scopus 로고
    • Activated STAT signaling in human tumors provides novel molecular targets for therapeutic intervention
    • Buettner R, Mora LB and Jove R: Activated STAT signaling in human tumors provides novel molecular targets for therapeutic intervention. Clin Cancer Res 8: 945-954, 2002.
    • (2002) Clin Cancer Res , vol.8 , pp. 945-954
    • Buettner, R.1    Mora, L.B.2    Jove, R.3
  • 13
    • 3042515162 scopus 로고    scopus 로고
    • IL-6 signaling by STAT3 participates in the change from hyperplasia to neoplasia in NRP-152 and NRP-154 rat prostatic epithelial cells
    • DOI 10.1186/1471-2407-1-19
    • Barton BE, Murphy TF, Adem P, Watson RA, Irwin RJ and Huang HS: IL-6 signaling by STAT3 participates in the change from hyperplasia to neoplasia in NRP-152 and NRP-154 rat prostatic epithelial cells. BMC Cancer 1: 19, 2001. (Pubitemid 38846500)
    • (2001) BMC Cancer , vol.1 , pp. 19
    • Barton, B.E.1    Murphy, T.F.2    Adem, P.3    Watson, R.A.4    Irwin, R.J.5    Huang, H.F.6
  • 14
    • 0031962229 scopus 로고    scopus 로고
    • Cancer patient use of nonproven therapy: 5-year follow-up study
    • Risberg T, Lund E, Wist E, Kaasa S and Wilsgaard T: Cancer patient use of nonproven therapy: 5-year follow-up study. J Clin Oncol 16: 6-12, 1998.
    • (1998) J Clin Oncol , vol.16 , pp. 6-12
    • Risberg, T.1    Lund, E.2    Wist, E.3    Kaasa, S.4    Wilsgaard, T.5
  • 16
    • 0032508952 scopus 로고    scopus 로고
    • Trends in alternative medicine use in the United States, 1990-1997: Results of a follow-up national survey
    • Eisenberg DM, Davis RB, Ettner SL, Appel S, Wilkey S, Van Rompay M and Kessler RC: Trends in alternative medicine use in the United States, 1990-1997: results of a follow-up national survey. JAMA 280: 1569-1575, 1998.
    • (1998) JAMA , vol.280 , pp. 1569-1575
    • Eisenberg, D.M.1    Davis, R.B.2    Ettner, S.L.3    Appel, S.4    Wilkey, S.5    Van Rompay, M.6    Kessler, R.C.7
  • 17
    • 0034903294 scopus 로고    scopus 로고
    • In vitro mechanism of PC-SPEC
    • Chen S: In vitro mechanism of PC-SPEC. Urology 58 (suppl 2A): 28-35, 2001.
    • (2001) Urology , vol.58 , Issue.SUPPL. 2A , pp. 28-35
    • Chen, S.1
  • 18
    • 0034295280 scopus 로고    scopus 로고
    • Chinese herbal mixture PC-SPES in treatment of prostate cancer
    • Darzykiewicz Z, Traganos F, Wu JM and Chen S: Chinese herbal mixture PC-SPES in treatment of prostate cancer. Int J Oncol 17: 729-736, 2001.
    • (2001) Int J Oncol , vol.17 , pp. 729-736
    • Darzykiewicz, Z.1    Traganos, F.2    Wu, J.M.3    Chen, S.4
  • 20
    • 0032725428 scopus 로고    scopus 로고
    • Effects of a phytotherapeutic agent, PC-SPES, on prostate cancer: A preliminary investigation on human cell lines and patients
    • DOI 10.1046/j.1464-410x.1999.00285.x
    • Taille A, Hayek OR, Buttyan R, Bagiella E, Burchardt M and Katz AE: Effects of a phytotherapeutic agent, PC-SPES, on prostate cancer: a preliminary investigation on human cell lines and patients. BJU Int 84: 845-850, 1999. (Pubitemid 29500054)
    • (1999) BJU International , vol.84 , Issue.7 , pp. 845-850
    • De La Taille, A.1    Hayek, O.R.2    Buttyan, R.3    Bagiella, E.4    Burchardt, M.5    Katz, A.E.6
  • 21
    • 0032770547 scopus 로고    scopus 로고
    • Use of PC-SPES, a commercially available supplement for prostate cancer, in a patient with hormone-naive disease
    • Moyad MA, Pienta KJ and Montie JE: Use of PC-SPES, a commercially available supplement for prostate cancer, in a patient with hormone-naive disease. Urology 54: 319-323, 1999.
    • (1999) Urology , vol.54 , pp. 319-323
    • Moyad, M.A.1    Pienta, K.J.2    Montie, J.E.3
  • 22
    • 0031394924 scopus 로고    scopus 로고
    • Regulation of androgen receptor (AR) and prostate specific antigen (PSA) expression in the androgen-responsive human prostate LNCaP cells by ethanolic extracts of the Chinese herbal preparation, PC-SPES
    • Hsieh T, Chen SS, Wang X and Wu JM: Regulation of androgen receptor (AR) and prostate specific antigen (PSA) expression in the androgen-responsive human prostate LNCaP cells by ethanolic extracts of the Chinese herbal preparation, PC-SPES. Biochem Mol Biol Int 42: 535-544, 1997.
    • (1997) Biochem Mol Biol Int , vol.42 , pp. 535-544
    • Hsieh, T.1    Chen, S.S.2    Wang, X.3    Wu, J.M.4
  • 23
    • 0031773115 scopus 로고    scopus 로고
    • Induction of apoptosis and down-regulation of bcl-6 in mutu I cells treated with ethanolic extracts of the Chinese herbal supplement PC-SPES
    • Hsieh TC, Ng C, Chang CC, Chen SS, Mittleman A and Wu JM: Induction of apoptosis and down-regulation of bcl-6 in mutu I cells treated with ethanolic extracts of the Chinese herbal supplement PC-SPES. Int J Oncol 13: 1199-1202, 1998.
    • (1998) Int J Oncol , vol.13 , pp. 1199-1202
    • Hsieh, T.C.1    Ng, C.2    Chang, C.C.3    Chen, S.S.4    Mittleman, A.5    Wu, J.M.6
  • 28
    • 1642486367 scopus 로고    scopus 로고
    • Proteasome inhibitor PS-341 induces growth arrest and apoptosis of non-small cell lung cancer cells via the JNK/c-Jun/AP-1 signaling
    • DOI 10.1111/j.1349-7006.2004.tb03200.x
    • Yang Y, Ikezoe T, Saito T, Kobayashi M, Koeffler HP and Taguchi H: Proteasome inhibitor PS-341 induces growth arrest and apoptosis of non-small cell lung cancer cells via the JNK/ c-Jun/AP-1 signaling. Cancer Sci 95: 176-180, 2004. (Pubitemid 38404320)
    • (2004) Cancer Science , vol.95 , Issue.2 , pp. 176-180
    • Yang, Y.1    Ikezoe, T.2    Saito, T.3    Kobayashi, M.4    Koeffler, H.P.5    Taguchi, H.6
  • 29
    • 3142753017 scopus 로고    scopus 로고
    • PC-SPES: Molecular mechanism to induce apoptosis and down-regulate expression of PSA in LNCaP human prostate cancer cells
    • Ikezoe T, Chen SS, Yang Y, Heber D, Taguchi H and Koeffler HP: PC-SPES: Molecular mechanism to induce apoptosis and down-regulate expression of PSA in LNCaP human prostate cancer cells. Int J Oncol 23: 1461-1470, 2003.
    • (2003) Int J Oncol , vol.23 , pp. 1461-1470
    • Ikezoe, T.1    Chen, S.S.2    Yang, Y.3    Heber, D.4    Taguchi, H.5    Koeffler, H.P.6
  • 30
    • 33644996315 scopus 로고    scopus 로고
    • Ponicidin, an ent-kaurane diterpenoid derived from a constituent of the herbal supplement PC-SPES, Rabdosia rubescens, induces apoptosis by activation of caspase-3 and mitochondrial events in lung cancer cells in vitro
    • Liu JJ, Huang RW, Lin DJ, Peng J, Zhang M, Pan X, Hou M, Wu XY, Lin Q and Chen F: Ponicidin, an ent-kaurane diterpenoid derived from a constituent of the herbal supplement PC-SPES, Rabdosia rubescens, induces apoptosis by activation of caspase-3 and mitochondrial events in lung cancer cells in vitro. Cancer Invest 24: 136-148, 2006.
    • (2006) Cancer Invest , vol.24 , pp. 136-148
    • Liu, J.J.1    Huang, R.W.2    Lin, D.J.3    Peng, J.4    Zhang, M.5    Pan, X.6    Hou, M.7    Wu, X.Y.8    Lin, Q.9    Chen, F.10
  • 32
    • 1642540641 scopus 로고    scopus 로고
    • Oridonin induces growth inhibition and apoptosis of a variety of human cancer cells
    • Ikezoe T, Chen SS, Tong XJ, Heber D, Taguchi H and Koeffler HP: Oridonin induces growth inhibition and apoptosis of a variety of human cancer cells. Int J Oncol 23: 1187-1193, 2003.
    • (2003) Int J Oncol , vol.23 , pp. 1187-1193
    • Ikezoe, T.1    Chen, S.S.2    Tong, X.J.3    Heber, D.4    Taguchi, H.5    Koeffler, H.P.6
  • 33
    • 0035212167 scopus 로고    scopus 로고
    • Baicalin is a major component of PC-SPES which inhibits the proliferation of human cancer cells via apoptosis and cell cycle arrest
    • Ikezoe T, Chen SS, Heber D, Taguchi H and Koeffler HP: Baicalin is a major component of PC-SPES which inhibits the proliferation of human cancer cells via apoptosis and cell cycle arrest. Prostate 49: 285-292, 2001.
    • (2001) Prostate , vol.49 , pp. 285-292
    • Ikezoe, T.1    Chen, S.S.2    Heber, D.3    Taguchi, H.4    Koeffler, H.P.5
  • 34
    • 7444238184 scopus 로고    scopus 로고
    • Novel single-stranded oligonucleotides that inhibit signal transducer and activator of transcription 3 induce apoptosis in vitro and in vivo in prostate cancer cell lines
    • Barton BE, Murphy TF, Shu P, Huang HF, Meyenhofen M and Barton A: Novel single-stranded oligonucleotides that inhibit signal transducer and activator of transcription 3 induce apoptosis in vitro and in vivo in prostate cancer cell lines. Mol Cancer Ther 3: 1183-1191, 2004.
    • (2004) Mol Cancer Ther , vol.3 , pp. 1183-1191
    • Barton, B.E.1    Murphy, T.F.2    Shu, P.3    Huang, H.F.4    Meyenhofen, M.5    Barton, A.6
  • 35
    • 4243156987 scopus 로고    scopus 로고
    • Signal transducer and activator of transcription 3 (STAT3) activation in prostate cancer: Direct STAT3 inhibition induces apoptosis in prostate cancer lines
    • Barton BE, Karras JG, Murphy TF, Barton A and Huang HF: Signal transducer and activator of transcription 3 (STAT3) activation in prostate cancer: Direct STAT3 inhibition induces apoptosis in prostate cancer lines. Mol Cancer Ther 3: 11-20, 2004. (Pubitemid 39193674)
    • (2004) Molecular Cancer Therapeutics , vol.3 , Issue.1 , pp. 11-20
    • Barton, B.E.1    Karras, J.G.2    Murphy, T.F.3    Barton, A.4    Huang, H.F.-S.5
  • 36
    • 17144411462 scopus 로고    scopus 로고
    • C/EBPdelta is a downstream mediator of IL-6 induced growth inhibition of prostate cancer cells
    • Sanford DC and Dewille JW: C/EBPdelta is a downstream mediator of IL-6 induced growth inhibition of prostate cancer cells. Prostate 63: 143-154, 2005.
    • (2005) Prostate , vol.63 , pp. 143-154
    • Sanford, D.C.1    Dewille, J.W.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.