The protective role of HLA-DRB1 13 in autoimmune diseases

Journal of Immunology Research

Volumn 2015, Issue , 2015, Pages

  Bettencourt, Andreia ^a   Carvalho, Cláudia ^a   Leal, Bárbara ^a   Brás, Sandra ^a   Lopes, Dina ^a   Martins Da Silva, Ana ^a,b   Santos, Ernestina ^a,b   Torres, Tiago ^a,b   Almeida, Isabel ^a,b   Farinha, Fátima ^a,b   Barbosa, Paulo ^a   Marinho, António ^a,b   Selores, Manuela ^b   Correia, João ^a,b   Vasconcelos, Carlos ^a,b   Costa, Paulo P ^a,c   Da Silva, Berta Martins ^a  

^a UNIVERSITY OF PORTO   (Portugal)

^b HOSPITAL DE SANTO ANTÓNIO   (Portugal)

^c NATIONAL INSTITUTE OF HEALTH   (Portugal)

Author keywords

[No Author keywords available]

Indexed keywords

HLA DRB1 ANTIGEN; HLA-DRB1*13 ANTIGEN;

ALLELE; ARTICLE; AUTOIMMUNE DISEASE; CONTROLLED STUDY; DISEASE ASSOCIATION; GENE FREQUENCY; GENE LOCUS; GENOTYPE; HUMAN; MAJOR CLINICAL STUDY; MULTIPLE SCLEROSIS; MYASTHENIA GRAVIS; PSORIASIS; PSORIATIC ARTHRITIS; RHEUMATOID ARTHRITIS; SYSTEMIC LUPUS ERYTHEMATOSUS; SYSTEMIC SCLEROSIS; AUTOIMMUNE DISEASES; CASE CONTROL STUDY; FEMALE; GENETIC ASSOCIATION STUDY; GENETIC PREDISPOSITION; GENETICS; IMMUNOLOGY; MALE; ODDS RATIO;

ALLELES; AUTOIMMUNE DISEASES; CASE-CONTROL STUDIES; FEMALE; GENE FREQUENCY; GENETIC ASSOCIATION STUDIES; GENETIC PREDISPOSITION TO DISEASE; HLA-DRB1 CHAINS; HUMANS; MALE; ODDS RATIO;

EID: 84947773692     PISSN: 23148861     EISSN: 23147156     Source Type: Journal    
DOI: 10.1155/2015/948723     Document Type: Article

References (47)

1. Y. Shoenfeld, B. Gilburd, M. Abu-Shakra, et al., "The mosaic of autoimmunity: genetic factors involved in autoimmune diseases-2008, " Israel Medical Association Journal, vol. 10, no. 1, pp. 3-7, 2008.
2. J.-M. Anaya, L. Gomez, and J. Castiblanco, "Is there a common genetic basis for autoimmune diseases?" Clinical and Developmental Immunology, vol. 13, no. 2-4, pp. 185-195, 2006.
3. P. Cruz-Tapias, O. M. P?erez-Fernandez, A. Rojas-Villarraga, A. Rodriguez-Rodriguez, M.-T. Arango, and J.-M. Anaya, "Shared HLA class II in six autoimmune diseases in Latin America: a meta-analysis, " Autoimmune Diseases, vol. 2012, Article ID 569728, 10 pages, 2012.
4. J. M. Anaya, "The autoimmune tautology, " Arthritis Research and Therapy, vol. 12, no. 6, article 147, 2010.
5. D. E. Smilek and E. W. St Clair, "Solving the puzzle of autoimmunity: critical questions, " F1000Prime Reports, vol. 7, article 17, 2015.
6. J. Sprent and H. Kishimoto, "The thymus and central tolerance, " Transplantation, vol. 72, no. 8, supplement, pp. S25-S28, 2001.
7. J. A. Bluestone, "Mechanisms of tolerance, " Immunological Reviews, vol. 241, no. 1, pp. 5-19, 2011.
8. S. Tsai and P. Santamaria, "MHC class II polymorphisms, autoreactive T-cells, and autoimmunity, " Frontiers in Immunology, vol. 4, article 321, Article IDArticle 321, 2013.
9. T. K. Starr, S. C. Jameson, and K. A. Hogquist, "Positive and negative selection of T cells, " Annual Review of Immunology, vol. 21, pp. 139-176, 2003.
10. E. Palmer, "Negative selection-clearing out the bad apples from the T-cell repertoire, " Nature Reviews Immunology, vol. 3, no. 5, pp. 383-391, 2003.
11. F. Luhder, J. Katz, C. Benoist, and D. Mathis, "Major histocompatibility complex class II molecules can protect from diabetes by positively selecting T cells with additional specificities, " Journal of Experimental Medicine, vol. 187, no. 3, pp. 379-387, 1998.
12. D. Schmidt, J. Verdaguer, N. Averill, and P. Santamaria, "A mechanism for the major histocompatibility complex-linked resistance to autoimmunity, " Journal of Experimental Medicine, vol. 186, no. 7, pp. 1059-1075, 1997.
13. D. Schmidt, A. Amrani, J. Verdaguer, S. Bou, and P. Santamaria, "Autoantigen-independent deletion of diabetogenic CD4+ thymocytes by protective MHC class II molecules, " Journal of Immunology, vol. 162, no. 8, pp. 4627-4636, 1999.
14. S. Tsai, P. Serra, X. Clemente-Casares, et al., "Antidiabetogenic MHC class II promotes the differentiation of MHCpromiscuous autoreactive T cells into FOXP3+ regulatory T cells, " Proceedings of the National Academy of Sciences of the United States of America, vol. 110, no. 9, pp. 3471-3476, 2013.
15. K.W.Wucherpfennig and D. Sethi, "T cell receptor recognition of self and foreign antigens in the induction of autoimmunity, " Seminars in Immunology, vol. 23, no. 2, pp. 84-91, 2011.
16. D. L. Morris, K.E.Taylor, M.M. A. Fernando, et al., "Unraveling multiple MHC gene associations with systemic lupus erythematosus: model choice indicates a role for HLA alleles and non-HLA genes in Europeans, "The American Journal ofHuman Genetics, vol. 91, no. 5, pp. 778-793, 2012.
17. C. Vasconcelos, C. Carvalho, B. Leal, et al., "HLA in Portuguese systemic lupus erythematosus patients and their relation to clinical features, " Annals of the New York Academy of Sciences, vol. 1173, pp. 575-580, 2009.
18. H. Furukawa, A. Kawasaki, S. Oka, et al., "Human leukocyte antigens and systemic lupus erythematosus: a protective role for the HLA-DR6 alleles DRB1∗13 : 02 and ∗14:03, " PLoS ONE, vol. 9, no. 2, Article ID e87792, 2014.
19. P. Y. P. C. Ho, A. Barton, J. Worthington, et al., "Investigating the role of the HLA-Cw∗06 and HLA-DRB1 genes in susceptibility to psoriatic arthritis: comparison with psoriasis and undifferentiated inflammatory arthritis, " Annals of the RheumaticDiseases, vol. 67, no. 5, pp. 677-682, 2008.
20. I. Shawkatova, J. Javor, Z. Parnicka, et al., "HLA-C, DRB1 and DQB1 alleles involved in genetic predisposition to psoriasis vulgaris in the Slovak population, " FoliaMicrobiologica, vol. 58, no. 4, pp. 319-324, 2013.
21. H. Furukawa, S.Oka, K. Shimada, A.Hashimoto, and S. Tohma, "Human leukocyte antigen polymorphisms and personalized medicine for rheumatoid arthritis, " Journal of Human Genetics, 2015.
22. S. T. Flam, R. Gunnarsson, T. Garen, B. A. Lie, and O.Molberg, "The HLA profiles of mixed connective tissue disease differ distinctly fromthe profiles of clinically related connective tissue diseases, " Rheumatology, vol. 54, no. 3, pp. 528-535, 2015.
23. D. D. Gladman, T. N. Kung, F. Siannis, F. Pellett, V. T. Farewell, and P. Lee, "HLA markers for susceptibility and expression in scleroderma, " Journal of Rheumatology, vol. 32, no. 8, pp. 1481-1487, 2005.
24. B. A. C. Cree, "Multiple sclerosis genetics, " Handbook of Clinical Neurology, vol. 122, pp. 193-209, 2014.
25. A. M. Silva, C. Pereira, A. Bettencourt, et al., "The role of HLADRB1 alleles on susceptibility and outcome of a Portuguese Multiple Sclerosis population, " Journal of the Neurological Sciences, vol. 258, no. 1-2, pp. 69-74, 2007.
26. N.Avidan, R. Le Panse, S. Berrih-Aknin, and A. Miller, "Genetic basis ofmyasthenia gravis-a comprehensive review, " Journal of Autoimmunity, vol. 52, pp. 146-153, 2014.
27. S. A. Miller, D. D. Dykes, and H. F. Polesky, "A simple salting out procedure for extractingDNA fromhuman nucleated cells, " Nucleic Acids Research, vol. 16, no. 3, article 1215, 1988.
28. O. Olerup and H. Zetterquist, "HLA-DR typing by PCR amplification with sequence-specific primers (PCR-SSP) in 2 hours: an alternative to serologicalDR typing in clinical practice including donor-recipient matching in cadaveric transplantation, " Tissue Antigens, vol. 39, no. 5, pp. 225-235, 1992.
29. G. Candore, D. Lio, G. Colonna Romano, and C. Caruso, "Pathogenesis of autoimmune diseases associated with 8.1 ancestral haplotype: effect of multiple gene interactions, " Autoimmunity Reviews, vol. 1, no. 1-2, pp. 29-35, 2002.
30. J. A. Collado, C. Guitart, M. Teresa Ciudad, I. Alvarez, and D. Jaraquemada, "The repertoires of peptides presented by MHC-II in the thymus and in peripheral tissue: a clue for autoimmunity?" Frontiers in Immunology, vol. 4, article 442, 2013.
31. A. Bruno and H. A. Lima, "HLA-A, -C, -B, and -DRB1 allelic and haplotypic diversity in bonemarrow volunteer donors from northern Portugal, " Organs, Tissues and Cells, vol. 16, pp. 19-26, 2013.
32. K. R. Jun, S.-E. Choi, C.-H. Cha, et al., "Meta-analysis of the association between HLA-DRB1 allele and rheumatoid arthritis susceptibility in Asian populations, " Journal of Korean Medical Science, vol. 22, no. 6, pp. 973-980, 2007.
33. S. Oka, H. Furukawa, A. Kawasaki, et al., "Protective effect of the HLA-DRB1∗13:02 allele in Japanese rheumatoid arthritis patients, " PLoS ONE, vol. 9, no. 6, Article ID e99453, 2014.
34. F. Ucar, M. Karkucak, E. Alemdaroglu, et al., "HLA-DRB1 allele distribution and its relation to rheumatoid arthritis in eastern Black Sea Turkish population, " Rheumatology International, vol. 32, no. 4, pp. 1003-1007, 2012.
35. J. Tuokko, S. Nejentsev, R. Luukkainen, A. Toivanen, and J. Ilonen, "HLA haplotype analysis in Finnish patients with rheumatoid arthritis, " Arthritis and Rheumatism, vol. 44, no. 2, pp. 315-322, 2001.
36. D. van der Woude, B. A. Lie, E. Lundstrom, et al., "Protection against anti-citrullinated protein antibody-positive rheumatoid arthritis is predominantly associated with HLA-DRB1?1301: a meta-analysis ofHLA-DRB1 associationswith anti-citrullinated protein antibody-positive and anti-citrullinated protein antibody-negative rheumatoid arthritis in four European populations, " Arthritis and Rheumatism, vol. 62, no. 5, pp. 1236-1245, 2010.
37. A. H. M. van der Helm-van Mil, T. W. J. Huizinga, G. M. T. Schreuder, F. C. Breedveld, R. R. P. de Vries, and R. E. M. Toes, "An independent role of protective HLA class II alleles in rheumatoid arthritis severity and susceptibility, " Arthritis and Rheumatism, vol. 52, no. 9, pp. 2637-2644, 2005.
38. P. M. Stassen, J. W. Cohen-Tervaert, S. P. M. Lems, B. G. Hepkema, C. G. M. Kallenberg, and C. A. Stegeman, "HLA-DR4, DR13(6) and the ancestral haplotype A1B8DR3 are associated with ANCA-associated vasculitis and Wegeners granulomatosis, " Rheumatology, vol. 48, no. 6, pp. 622-625, 2009.
39. L. Michou, P. Croiseau, E. Petit-Teixeira, et al., "Validation of the reshaped shared epitope HLA-DRB1 classification in rheumatoid arthritis, " Arthritis Research and Therapy, vol. 8, no. 3, article R79, 2006.
40. I. E. van der Horst-Bruinsma, H. Visser, J. M. W. Hazes, et al., "HLA-DQ-associated predisposition to and dominant HLADR-associated protection against rheumatoid arthritis, " Human Immunology, vol. 60, no. 2, pp. 152-158, 1999.
41. D. L. Mattey, P. T. Dawes, M. A. Gonzalez-Gay, et al., "HLADRB1 alleles encoding an aspartic acid at position 70 protect against development of rheumatoid arthritis, " Journal of Rheumatology, vol. 28, no. 2, pp. 232-239, 2001.
42. J. vanHeemst, D.T. Jansen, S. Polydorides, et al., "Crossreactivity to vinculin and microbes provides a molecular basis for HLAbased protection against rheumatoid arthritis, " Nature Communications, vol. 6, article 6681, 2015.
43. H. M. Diepolder, M.-C. Jung, E. Keller, et al., "A vigorous virusspecific CD4+ T cell response may contribute to the association of HLA-DR13 with viral clearance in hepatitis B, " Clinical and Experimental Immunology, vol. 113, no. 2, pp. 244-251, 1998.
44. A. Ramezani, M. R. Hasanjani Roshan, E. Kalantar, et al., "Association of human leukocyte antigen polymorphism with outcomes of hepatitis B virus infection, " Journal of Gastroenterology and Hepatology, vol. 23, no. 11, pp. 1716-1721, 2008.
45. C. Fesel, M. Barreto, R. C. Ferreira, et al., "Compensatory T-cell regulation in unaffected relatives of SLE patients, and opposite IL-2/CD25-mediated effects suggested by coreferentialitymodeling, " PLoS ONE, vol. 7, no. 3, Article ID e33992, 2012.
46. A. L. Ferre, P.W.Hunt, D.H.McConnell, et al., "HIV controllers with HLA-DRB1∗13 and HLA-DQB1 06 alleles have strong, polyfunctional mucosal CD4+ T-cell responses, " Journal of Virology, vol. 84, no. 21, pp. 11020-11029, 2010.
47. U. Malhotra, S. Holte, S. Dutta, et al., "Role for HLA class II molecules in HIV-1 suppression and cellular immunity following antiretroviral treatment, " The Journal of Clinical Investigation, vol. 107, no. 4, pp. 505-517, 2001.