Antidiabetogenic MHC class II promotes the differentiation of MHC-promiscuous autoreactive T cells into FOXP3+ regulatory T cells

Proceedings of the National Academy of Sciences of the United States of America

Volumn 110, Issue 9, 2013, Pages 3471-3476

  Tsai, Sue ^a   Serra, Pau ^b   Clemente Casares, Xavier ^a   Yamanouchi, Jun ^a   Thiessen, Shari ^a   Slattery, Robyn M ^c   Elliott, John F ^d   Santamaria, Pere ^a,b  

^a UNIVERSITY OF CALGARY   (Canada)

^b INSTITUT D INVESTIGACIONS BIOMÈDIQUES AUGUST PI I SUNYER IDIBAPS   (Spain)

^c MONASH UNIVERSITY   (Australia)

^d UNIVERSITY OF ALBERTA   (Canada)

Author keywords

Autoimmune diabetes; FoxP3+ Treg cells; Genetic resistance; Major histocompatibility complex class II; T cell tolerance

Indexed keywords

MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2; T LYMPHOCYTE RECEPTOR; TRANSCRIPTION FACTOR FOXP3;

ALLELE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIDIABETIC ACTIVITY; ARTICLE; CD11C GENE; CD4+ T LYMPHOCYTE; CELL DIFFERENTIATION; CONTROLLED STUDY; DENDRITIC CELL; DIABETES MELLITUS; FEMALE; GENE DELETION; GENE EXPRESSION; GENETIC POLYMORPHISM; LYMPHOCYTE FUNCTION; LYMPHOCYTE PROLIFERATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; REGULATORY T LYMPHOCYTE; T CELL DEPLETION; THYMOCYTE; TRANSGENE;

ANIMALS; ANTIGENS, CD11C; CELL DIFFERENTIATION; CLONAL ANERGY; DENDRITIC CELLS; DIABETES MELLITUS, EXPERIMENTAL; DIABETES MELLITUS, TYPE 1; DOWN-REGULATION; FORKHEAD TRANSCRIPTION FACTORS; HISTOCOMPATIBILITY ANTIGENS CLASS II; IMMUNE TOLERANCE; KERATIN-14; MICE; MICE, INBRED NOD; MICE, TRANSGENIC; PROMOTER REGIONS, GENETIC; T-LYMPHOCYTES, REGULATORY; THYMOCYTES; TRANSGENES;

EID: 84874461970     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1211391110     Document Type: Article

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