HLA-DRB1 alleles encoding an aspartic acid at position 70 protect against development of rheumatoid arthritis

Journal of Rheumatology

Volumn 28, Issue 2, 2001, Pages 232-239

  Mattey, D L ^a   Dawes, P T ^a   Gonzalez Gay, M A ^a   Garcia Porrua, C ^a   Thomson, W ^a   Hajeer, A H ^a   Ollier, W E R ^a  

^a Staffordshire Rheumatology Centre   (United Kingdom)

Author keywords

Aspartic acid; HLA; Rheumatoid arthritis; Shared epitope; Susceptibility

Indexed keywords

ASPARTIC ACID; EPITOPE; HLA DR ANTIGEN;

ADULT; AGED; AMINO ACID SEQUENCE; ARTICLE; CONTROLLED STUDY; FEMALE; GENE FREQUENCY; GENETIC RISK; GENETIC SUSCEPTIBILITY; HLA TYPING; HUMAN; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; RHEUMATOID ARTHRITIS; RISK FACTOR;

ALLELES; AMINO ACID SEQUENCE; ARTHRITIS, RHEUMATOID; ASPARTIC ACID; EPITOPE MAPPING; EPITOPES; FEMALE; GENETIC PREDISPOSITION TO DISEASE; GENOTYPE; GREAT BRITAIN; HLA-DR ANTIGENS; HUMANS; MALE; SPAIN;

EID: 0035112851     PISSN: 0315162X     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (40)

1. The shared epitope hypothesis: An approach to understanding the molecular genetics of susceptibility to rheumatoid arthritis
2. Three dimensional structure of the human class II histocompatibility antigen HLA-DR1
3. Population genetics of rheumatoid arthritis
4. Association of HLA-DR4/Dw4 and DR2/Dw2 with radiologic change in a prospective study of patients with rheumatoid arthritis: Preferential relationship with HLA-Dw rather than HLA-DR specificities
5. Protective HLA-DR phenotypes in rheumatoid arthritis
6. The association of HLA-DRB genes and the shared epitope with rheumatoid arthritis in Pakistan
7. The relationship between HLA-DRB1 alleles and disease subsets of rheumatoid arthritis in Japanese
8. Relevant residues of DRB1 third hypervariable region contributing to the expression and severity of rheumatoid arthritis in Mexicans
9. HLA-DRB1 alleles associated with susceptibility or resistance to rheumatoid arthritis, articular deformities, and disability in Mexican Americans
10. HLA class II region nucleotide sequences, 1995
11. Use of T cell receptor/HLA-DRB 1*04 molecular modeling to predict site-specific interactions for the DR shared epitope associated with rheumatoid arthritis
12. A hypothetical model of the foreign antigen binding site of class II histocompatibility molecules
13. Peptide binding specificity of HLA-DR4 molecules: Correlation with rheumatoid arthritis association
14. Negatively charged residues interacting with the p4 pocket confer binding specificity to DRB1*0401
15. Naturally processed peptides from two disease-resistance-associated HLA-DR13 alleles show related sequence motifs and the effects of the dimorphism at position 86 of the HLA-DRβ chain
16. Relevant residues of DRβ1 third hypervariable region contributing to the expression and to severity of rheumatoid arthritis in Mexicans
17. HLA-DR alleles with naturally occurring amino acid substitutions and risk for development of rheumatoid arthritis
18. Polymorphism of HLA-DRB, -DQA1, and DQB1 in rheumatoid arthritis in Asian Indians: Association with DRB1*0405 and DRB1*1001
19. HLA heterozygosity contributes to susceptibility to rheumatoid arthritis
20. HLA-DRB1*0401/0404 genotype and rheumatoid arthritis: Increased association in men, young age at onset and disease severity
21. Does the HLA-DRB1 shared epitope really contribute that much to the development or severity of rheumatoid arthritis?
22. Could HLA-DRB1 be the protective locus in rheumatoid arthritis?
23. Critical residues on HLA-DRB1*0402 HV3 peptide for HLA-DQ8-restricted immunogenicity. Implications for rheumatoid arthritis predisposition
24. HLA-DQ-associated predisposition to and dominant HLA-DR associated protection against rheumatoid arthritis
25. The influence of HLA-DRB1 alleles encoding the DERAA amino acid motif on radiological outcome in rheumatoid arthritis
26. The relationship between serial measures of disease activity and outcome in rheumatoid arthritis
27. Measurement and prediction of radiological progression in early rheumatoid arthritis
28. The American Rheumatism Association 1987 revised criteria for the classification of rheumatoid arthritis
29. Different gene loci within the HLA-DR and TNF regions are independently associated with susceptibility and severity in Spanish rheumatoid arthritis patients
30. Radiographic evaluation of rheumatoid arthritis and related conditions by standard reference films
31. A simple sequentially rejective multiple test procedure
32. Adjusting for multiple testing when reporting research results: The Bonferroni vs Holm methods
33. No support for HLA-DQ encoded susceptibility in rheumatoid arthritis
34. X-ray crystal structure of HLA-DR4 (DRA*0101, DRB1*0401) complexed with peptide from human collagen II
35. HLA-DR/DQ/DP interactions in rheumatoid arthritis
36. Role of polymorphic residues of human leucocyte antigen-DR molecules on the binding of human immunodeficiency virus peptides
37. Residue 67 in the Drβz.ast;0101 and Drβ*0103 chains strongly influences antigen presentation and DR-peptide molecular complex conformation
38. Structural basis of specificity and degeneracy of T cell recognition: Pluriallelic restriction of T cell responses to a peptide antigen involves both specific and promiscuous interactions between the T cell receptor, peptide, and HLA-DR
39. Naturally processed peptides from rheumatoid arthritis associated and non-associated HLA-DR alleles