A vigorous virus-specific CD4+ T cell response may contribute to the association of HLA-DR13 with viral clearance in hepatitis B

Clinical and Experimental Immunology

Volumn 113, Issue 2, 1998, Pages 244-251

  Diepolder, H M ^a,b   Jung, M C ^a,b   Keller, E ^b   Schraut, W ^b   Gerlach, J T ^b   Gruner N ^b   Zachoval, R ^a   Hoffmann, R M ^a,b   Schirren, C A ^a   Scholz, S ^b   Pape, G R ^a,b  

^a LUDWIG MAXIMILIANS UNIVERSITY   (Germany)

^b UNIVERSITY OF MUNICH   (Germany)

Author keywords

CD4+ T lymphocytes; Hepatitis B virus; Immune response; Viral infection

Indexed keywords

CD4 ANTIGEN; CD8 ANTIGEN; HLA DR ANTIGEN;

ANTIGEN PRESENTATION; ANTIGEN SPECIFICITY; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; EPITOPE MAPPING; HEPATITIS B VIRUS; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOREGULATION; LYMPHOCYTE ACTIVATION; PRIORITY JOURNAL; VIRUS STRAIN;

ACUTE DISEASE; ALLELES; CD4-POSITIVE T-LYMPHOCYTES; CLONE CELLS; EPITOPES; HEPATITIS B; HEPATITIS B CORE ANTIGENS; HISTOCOMPATIBILITY TESTING; HLA-DR ANTIGENS; HUMANS; JAUNDICE; LEUKOCYTES, MONONUCLEAR; LYMPHOCYTE ACTIVATION;

EID: 15644366143     PISSN: 00099104     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2249.1998.00665.x     Document Type: Article

References (21)

1. Thursz MR, Kwiatkowski D, Allsopp CEM, Greenwood BM, Thomas HC, Hill AVS. Association between an MHC class II allele and clearance of hepatitis B virus in the Gambia. N Engl J Med 1995 332:1065-9.
2. Höhler T, Gerken G, Notghi A et al. HLA DRB1*1301 and *1302 protect against chronic hepatitis B. J Hepatol 1997 26:503-7.
3. Ferrari C, Penna A, Bertoletti A et al. Cellular immune response to hepatitis B virus encoded antigens in acute and chronic hepatitis B virus infection. J Immunol 1990 145:3442-9.
4. + T-cell population during seroconversion to anti-HBe and anti-HBs in hepatitis B virus infection. J Virol 1995 69:3358-68.
5. Kimura A, Sasazuki T. Eleventh International Hisocompalibility Workshop reference protocol for the HLA DNA typing technique. In: Tsuji K, Aizawa M, Sasazuki T, eds. HLA 1991. Oxford-Tokyo: Oxford University Press, 1992:397-419.
6. Bodmer JG, Marsh SGE, Albert ED et al. Nomenclature for factors of the HLA system. 1996. Eur J Immunogenet 1997 24:105-51.
7. Nevinny-Stickel C, Bettinotti MP, Andreas A, Hinzperer M, Mühlegger K, Schmitz G, Albert ED. Nonradioactive HLA class II typing using polymerase chain reaction and digoxigenin-1 1-2′-3′-dideoxy-uridinetriphosphate labeled oligonucleotide probes. Hum Immunol 1991 31:7-13.
8. Ferrari C, Bertoletti A, Penna A et al. Identification of immunodominant T cell epitopes of the hepatitis B virus nucleocapsid antigen. J Clin Invest 1991 88:214-22.
9. + T cells in vitro. J Virol 1996 70:7540-8.
10. + lymphocytes expressing CD45RO and CD45RA. J Immunol Methods 1993 163:173-9.
11. + T cell epitope within nonstructural protein 3 in acute hepatitis C virus infection. J Virol 1997 71:6011-9.
12. Marinos G, Torre F, Chokshi S et al. Induction of T-helper cell response to hepatitis B core antigen in chronic hepatitis B. A major factor in activation of the host immune response to the hepatitis B virus. Hepatology 1995 22:1040-9.
13. Chisari FV, Ferrari C. Hepatitis B virus immunopathogenesis. Annu Rev Immunol 1995 13:29-60.
14. Chisari FV. Hepatitis B virus transgenic mice: insights into the virus and the disease. Hepatology 1995 22:1316-25.
15. Sastre Garau X, Loste MN, Vincent Salomon A et al. Decreased frequency of HLA-DRB1(*)13 alleles in Frenchwomen with HPV-positive carcinoma of the cervix. Int J Cancer 1996 69:159-64.
16. Apple RJ, Erlich HA, Klitz W, Manos MM, Becker TM, Wheeler CM. HLA DR-DQ associations with cervical carcinoma show papillomavirus-type specificity. Nat Genet 1994 6:157-62.
17. Itescu S, Rose S, Dwyer E, Winchester R. Certain HLA-DR5 and -DR6 major histocompatibility complex class II alleles are associated with a CD8 lymphocytic host response to human immunodeficiency virus type 1 characterized by low lymphocyte viral strain heterogeneity and slow disease progression. Proc Natl Acad Sci USA 1994 91:11472-6.
18. Winchester R, Chen Y, Rose S, Selby J, Borkowsky W. Major histocompatibility complex class II DR alleles DRB1*1501 and those encoding HLA-DR13 are preferentially associated with a diminution in maternally transmitted human immunodeficiency virus 1 infection in different ethnic groups: determination by an automated sequence-based typing method. Proc Natl Acad Sci USA 1995 92:12374-8.
19. Kuzushita N, Hayashi N, Katayama K et al. Increased frequency of HLA DR13 in hepatitis C virus carriers with persistently normal ALT levels. J Med Virol 1996 48:1-7.
20. Cascino I, D'Alfonso S, Cappello N, Giordano M, Pugliese A, Awdeh Z, Alper CA, Richardi PM. Gametic association of HSP70-1 promoter region alleles and their inclusion in extended HLA haplotypes. Tissue Antigens 1993 42:62-66.
21. Ronningen KS, Undlien DE, Ploski R et al. Linkage disequilibrium between TAP2 variants and HLA class II alleles; no primary association between TAP2 variants and insulin-dependent diabetes mellitus. Eur J Immunol 1993 23:1050-6.