HLA-DQ-associated predisposition to and dominant HLA-DR-associated protection against rheumatoid arthritis

Human Immunology

Volumn 60, Issue 2, 1999, Pages 152-158

  Van Der Horst Bruinsma, Irene E ^a   Visser, Henk ^b   Hazes, J Mieke W ^a   Breedveld, Ferdinand C ^a   Verduyn, Willem ^a   Schreuder, Geziena M Th ^a   De Vries, René R P ^a   Zanelli, Eric ^a  

^a LEIDEN UNIVERSITY MEDICAL CENTER   (Netherlands)

^b NONE

Author keywords

HLA DQ; HLA DR; Protection; Rheumatoid arthritis; Self HLA peptides

Indexed keywords

HLA DQ ANTIGEN; HLA DR ANTIGEN;

ALLELE; ARTICLE; CONTROLLED STUDY; GENETIC PREDISPOSITION; HLA TYPING; HUMAN; IMMUNOPATHOGENESIS; MAJOR CLINICAL STUDY; PRIORITY JOURNAL; RHEUMATOID ARTHRITIS;

ALLELES; ARTHRITIS, RHEUMATOID; FOLLOW-UP STUDIES; GENETIC PREDISPOSITION TO DISEASE; HLA-DQ ANTIGENS; HLA-DR ANTIGENS; HUMANS;

EID: 0032963059     PISSN: 01988859     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0198-8859(98)00101-3     Document Type: Article

References (37)

1. Breedveld F.C. New perspectives on treating rheumatoid arthritis. N Engl J Med. 333:1995;183.
2. Arnett F.C., Edworthy S.M., Bloch D.A., McShane D.J., Fries J.F., Cooper N.S., Healey L.A., Kaplan S.R., Liang M.H., Luthra H.S., Medsger T.A. Jr, Mitchell D.M., Neustadt D.H., Pinals R.S., Schaller J.G., Sharp J.T., Wilder R.L., Hunder G.G. The American Rheumatism Association 1987 revised criteria for the classification of rheumatoid arthritis. Arthritis Rheum. 31:1988;315.
3. McDonagh J.E., Dunn A., Ollier W.E.R., Walker D.J. Compound heterozygosity for the shared epitope and the risk and severity of rheumatoid arthritis in extended pedigrees. Br J Rheumatol. 36:1997;322.
4. Arnett F.C. Histocompatibility typing in the rheumatic diseases Diagnostic and prognostic implications . Rheum Dis Clin North Am. 20:1994;371.
5. Wagner U., Kaltenhäuser S., Sauer H., Arnold S., Seidel W., Häntzschel H., Kalden J.R., Wassmuth R. HLA markers and prediction of clinical course and outcome in rheumatoid arthritis. Arthritis Rheum. 40:1997;341.
6. Seitz M., Perler M., Pichler W. Only weak association between disease severity and HLA-DRB1 genes in a Swiss population of rheumatoid arthritis patients. Rheumatol Int. 16:1996;9.
7. Stastny P. Association of the B cell alloantigen DRw4 with rheumatoid arthritis. N Engl J Med. 298:1978;869.
8. Winchester R., Dwyer E., Rose S. The genetic basis of rheumatoid arthritis The shared epitope hypothesis . Rheum Dis Clin North Am. 18:1992;761.
9. Nelson J.L., Mickelson E., Masewicz S., Barrington R., Dugowson C., Koepsell T., Hansen J.A. Dw14 (DRB1*0404) is a Dw4-dependent risk factor for rheumatoid arthritis Rethinking the "shared epitope" hypothesis . Tissue Antigens. 38:1991;145.
10. Gao X., Gazit E., Livneh A., Stastny P. Rheumatoid arthritis in Israeli Jews shared sequences in the third hypervariable region of DRB1 alleles are associated with susceptibility . J Rheumatol. 18:1991;801.
11. Gregersen P.K., Silver J., Winchester R.J. The shared epitope hypothesis An approach to understanding the molecular genetics of susceptibility to rheumatoid arthritis . Arthritis Rheum. 30:1987;1205.
12. Penzotti J.E., Doherty D., Lybrand T.P., Nepom G.T. A structural model for TCR recognition of the HLA class II shared epitope sequence implicated in susceptibility to rheumatoid arthritis. J Autoimmun. 9:1996;287.
13. Salvat S., Rochelle L., Begovich A., Sette A., Roudier J. Tolerance to a self-peptide from the third hypervariable region of HLA-DRB1*0401 in rheumatoid arthritis patients and controls. J Immunol. 153:1994;5321.
14. Benazet J.-F., Reviron D., Mercier P., Roux H., Roudier J. HLA-DRB1 alleles associated with rheumatoid arthritis in Southern France Absence of extraarticular disease despite expression of the shared epitope . J Rheumatol. 22:1995;607.
15. Agrawal S., Aggarwal A., Dabadghao S., Naik S., Misra R. Compound heterozigosity of HLA-DR4 and DR1 antigens in Asian Indians increases the risk of extra-articular features in rheumatoid arthritis. Br J Rheumatol. 34:1995;41.
16. Weyand C., Xie C., Goronzy J.J. Homozygosity for the HLA-DRB1 allele selects for extraarticular manifestations in rheumatoid arthritis. J Clin Invest. 89:1992;2033.
17. van Zeben D., Hazes J.M.W., Zwinderman A.H., Cats A., Schreuder G.M.Th., D'Amaro J., Breedveld F.C. Association of HLA-DR4 with a more progressive disease course in patients with rheumatoid arthritis. Arthritis Rheum. 34:1991;822.
18. McCusker C.T., Reid B., Green D., Gladman D.D., Buchanan W.W., Singal D.P. HLA-D region antigens in patients with rheumatoid arthritis. Arthritis Rheum. 34:1991;192.
19. Ploski R., Mellbye O.J., Rønningen K.S., Førre Ø., Thorsby E. Seronegative and weakly seropositive rheumatoid arthritis differ from clearly seropositive rheumatoid arthritis in HLA class II associations. J Rheumatol. 21:1994;1397.
20. Rigby A.S., Silman A.J., Voelm L., Gregory J.C., Ollier W.E.R., Khan M.A., Nepom G.T., Thomson G. Investigating the HLA component in rheumatoid arthritis an additive (dominant) mode of inheritance is rejected, a recessive mode is preferred . Genet Epidemiol. 8:1991;153.
21. Wordsworth P., Pile K.D., Buckely J.D., Lanchbury J.S.S., Ollier B., Lathrop M., Bell J.I. HLA heterozigosity contributes to susceptibility to rheumatoid arthritis. Am J Hum Genet. 51:1992;585.
22. Toda Y., Minamikawa Y., Akagi S., Sugano H., Mori Y., Nishimura H., Arita S., Sugino Y., Ogawa R. Rheumatoid-susceptible alleles of HLA-DRB1 are genetically recessive to non-susceptible alleles in the progression of bone destruction in the wrists and fingers of patients with RA. Ann Rheum Dis. 53:1994;587.
23. Eberhardt K., Fex E., Johnson U., Wollheim F.A. Associations of HLA-DRB and -DQB genes with two and five year outcome in rheumatoid arthritis. Ann Rheum Dis. 5:1996;34.
24. Zanelli E., Gonzalez-Gay M.A., David C.S. Could HLA-DRB1 be the protective locus in rheumatoid arthritis? Immunol Today. 16:1995;274.
25. Zanelli E., Krco C.J., Baisch J.M., Cheng S., David C.S. Immune response of HLA-DQ8 transgenic mice to peptides from the third hypervariable region of HLA-DRB1 correlates with predisposition to rheumatoid arthritis. Proc Natl Acad Sci USA. 93:1996;1814.
26. Zanelli E., Krco C.J., David C.S. Critical residues on HLA-DRB1*0402 HV3 peptide for HLA-DQ8-restricted immunogenicity Implications for rheumatoid arthritis predisposition . J Immunol. 158:1997;3545.
27. Speyer I., Hazes J.M.W., Breedveld F.C. Recruitment of patients with early rheumatoid arthritis The Netherlands experience . J Rheumatol. 23:(suppl 44):1996;84.
28. Biotinylated DRB sequence-specific oligonucleotides comparison to serologic HLA-DR typing of organ donors in Eurotransplant . Human Immunol. 37:1993;59.
29. Gao X., Serjeantson S.W. Diversity in HLA-DR4-related DR, DQ haplotypes in Australia, Oceania, and China. Human Immunol. 32:1991;269.
30. Olerup O., Zetterquiet H. HLA-DR typing by PCR amplification with sequence-specific primers (PCR-SSP) in 2 h An alternative to serological DR typing in clinical practice including donor-recipient matching in cadaveric transplantation . Tissue Antigens. 39:1992;225.
31. Fleiss JL: Sampling methods I: Naturalistic or cross-sectional studies. In Wiley (ed): Statistical methods for rates and proportions. Cambridge, 1981.
32. Woolf B. On estimating the relation between blood group and disease. Ann Hum Genet. 19:1955;251.
33. Morling N., Andersen V., Fugger L., Georgsen J., Halberg P., Oxholm P., Ødum N., Svejgaard A. Immunogenetics of rheumatoid arthritis and primary Sjögren's syndrome DNA polymorphism of HLA class II genes . Dis Markers. 9:1991;289.
34. Rønningen S., Spurkland A., Egeland T., Iwe T., Munthe E., Vartdal F., Thorsby E. Rheumatoid arthritis may be primarily associated with HLA-DR4 molecules sharing a particular sequence at residues 67-74. Tissue Antigens. 36:1990;235.
35. Taneja V., Megra N.K., Kailash S., Anand C., Malaviya A.N. Protective and risk DR phenotypes in Asian Indian patients with rheumatoid arthritis. Ind J Med Res. 96:1992;16.
36. Larsen B.A., Alderdice C.A., Hawkins D., Martin J.R., Mitchell D.M., Sheridan D.P. Protective HLA-DR phenotypes in rheumatoid arthritis. J Rheumatol. 16:1989;455.
37. de Vries R.R.P., Nijenhuis L.E., Khan M.A., Mehra N.K. Paradoxical inheritance of HLA-linked susceptibility to rheumatoid arthritis. Tissue Antigens. 26:1985;286.