Ethosuximide induces hippocampal neurogenesis and reverses cognitive deficits in an amyloid-β toxin-induced Alzheimer rat model via the phosphatidylinositol 3-kinase (PI3K)/Akt/Wnt/β-catenin pathway

Journal of Biological Chemistry

Volumn 290, Issue 47, 2015, Pages 28540-28558

  Tiwari, Shashi Kant ^a,b   Seth, Brashket ^a,b   Agarwal, Swati ^a,b   Yadav, Anuradha ^a,b   Karmakar, Madhumita ^a   Gupta, Shailendra Kumar ^a   Choubey, Vinay ^c   Sharma, Abhay ^d   Chaturvedi, Rajnish Kumar ^a,b  

^a CSIR INDIAN INSTITUTE OF TOXICOLOGY RESEARCH   (India)

^b ACADEMY OF SCIENTIFIC AND INNOVATIVE RESEARCH ACSIR   (India)

^c Faculty of Medicine   (Estonia)

^d CSIR INSTITUTE OF GENOMICS AND INTEGRATIVE BIOLOGY   (India)

Author keywords

[No Author keywords available]

Indexed keywords

BRAIN; GENE EXPRESSION; GLYCOPROTEINS; NEURODEGENERATIVE DISEASES; RATS; STEM CELLS; TOXIC MATERIALS;

COGNITIVE FUNCTIONS; HIPPOCAMPAL NEUROGENESIS; MOLECULAR MECHANISM; NEURODEGENERATIVE DISORDERS; NEURONAL CIRCUITRIES; NEURONAL DIFFERENTIATION; PHOSPHATIDYLINOSITOL 3-KINASE; TRANSDUCTION PATHWAYS;

NEURONS;

AMYLOID BETA PROTEIN; AXIN 1; BETA CATENIN; BETA TUBULIN; CYCLIN D1; DICKKOPF 1 PROTEIN; DISHEVELLED PROTEIN; DOUBLECORTIN; ETHOSUXIMIDE; FRIZZLED PROTEIN; GLIAL FIBRILLARY ACIDIC PROTEIN; GLYCOGEN SYNTHASE KINASE 3BETA; HISTONE H3; LOW DENSITY LIPOPROTEIN RECEPTOR RELATED PROTEIN 6; LYMPHOID ENHANCER FACTOR 1; MESSENGER RNA; NESTIN; NEUROGENIC DIFFERENTIATION FACTOR; NEUROGENIN; NEUROLIGIN; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; SODIUM CHLORIDE; STAT3 PROTEIN; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR PAX6; UNCLASSIFIED DRUG; WNT PROTEIN; WNT1 PROTEIN; WNT3 PROTEIN;

ALZHEIMER DISEASE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL COUNT; CELL FATE; CELL PROLIFERATION; COGNITIVE DEFECT; COMPUTER MODEL; CONTROLLED STUDY; DISEASE MODEL; ENZYME ACTIVATION; ENZYME INHIBITION; GENE EXPRESSION; HIPPOCAMPUS; HISTONE PHOSPHORYLATION; IN VITRO STUDY; INHIBITION KINETICS; LONG TERM SURVIVAL; MALE; MITOGENESIS; MOLECULAR DOCKING; MULTIPOTENT STEM CELL; NERVE CELL DIFFERENTIATION; NERVE DEGENERATION; NEURAL STEM CELL; NONHUMAN; PHENOTYPE; PREDICTION; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN INTERACTION; PROTEIN TARGETING; RAT; SIGNAL TRANSDUCTION; SINGLE DRUG DOSE; WNT SIGNALING PATHWAY; ANIMAL; CELL DIFFERENTIATION; CHEMICALLY INDUCED; DRUG EFFECTS; ENZYMOLOGY; METABOLISM; NERVOUS SYSTEM DEVELOPMENT; PATHOLOGY;

ALZHEIMER DISEASE; AMYLOID BETA-PEPTIDES; ANIMALS; BETA CATENIN; CELL DIFFERENTIATION; CELL PROLIFERATION; COGNITION DISORDERS; DISEASE MODELS, ANIMAL; ETHOSUXIMIDE; HIPPOCAMPUS; NEUROGENESIS; PHOSPHATIDYLINOSITOL 3-KINASES; PROTO-ONCOGENE PROTEINS C-AKT; RATS; WNT PROTEINS;

EID: 84947723793     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M115.652586     Document Type: Article

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