Structural Evidence of Amyloid Fibril Formation in the Putative Aggregation Domain of TDP-43

Journal of Physical Chemistry Letters

Volumn 6, Issue 13, 2015, Pages 2608-2615

  Mompeán, Miguel ^a   Hervás, Rubén ^b,c   Xu, Yunyao ^d   Tran, Timothy H ^d   Guarnaccia, Corrado ^e   Buratti, Emanuele ^e   Baralle, Francisco ^e   Tong, Liang ^d   Carrión Vázquez, Mariano ^b,c   McDermott, Ann E ^d   Laurents, Douglas V ^a  

^a INSTITUTO DE QUÍMICA FÍSICA ROCASOLANO   (Spain)

^b INSTITUTO CAJAL   (Spain)

^c INSTITUTO MADRILEÑO DE ESTUDIOS AVANZADOS EN NANOCIENCIA IMDEA NANOCIENCIA   (Spain)

^d Och Spine at New York Presbyterian Hospitals   (United States)

^e INTERNATIONAL CENTRE FOR GENETIC ENGINEERING AND BIOTECHNOLOGY   (Italy)

Author keywords

amyloid; amyotrophic lateral schlerosis; cross beta spine; molecular dynamics; X ray diffraction

Indexed keywords

AGGREGATES; ANTIBODIES; CHROMOPHORES; MOLECULAR DYNAMICS; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; OLIGOMERS; QUANTUM THEORY; X RAY DIFFRACTION;

AMYLOID; AMYLOID FIBRIL FORMATION; AMYLOID FORMATION; AMYOTROPHIC; CROSS-BETA SPINE; SEMI-EMPIRICAL QUANTUM MECHANICS; STRUCTURAL CONVERSION; STRUCTURAL EVIDENCE;

GLYCOPROTEINS;

AMYLOID; DNA BINDING PROTEIN; PEPTIDE FRAGMENT; PROTEIN TDP-43;

CHEMISTRY; MOLECULAR DYNAMICS;

AMYLOID; DNA-BINDING PROTEINS; MOLECULAR DYNAMICS SIMULATION; PEPTIDE FRAGMENTS;

EID: 84947610200     PISSN: None     EISSN: 19487185     Source Type: Journal    
DOI: 10.1021/acs.jpclett.5b00918     Document Type: Article

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