A Small Molecule that Induces Intrinsic Pathway Apoptosis with Unparalleled Speed

Cell Reports

Volumn 13, Issue 9, 2015, Pages 2027-2036

  Palchaudhuri, Rahul ^a   Lambrecht, Michael J ^a   Botham, Rachel C ^a   Partlow, Kathryn C ^a   van Ham, Tjakko J ^b,c,e   Putt, Karson S ^d   Nguyen, Laurie T ^d   Kim, Seok Ho ^a   Peterson, Randall T ^b,c   Fan, Timothy M ^a   Hergenrother, Paul J ^a  

^a UNIVERSITY OF ILLINOIS AT URBANA CHAMPAIGN   (United States)

^b MASSACHUSETTS GENERAL HOSPITAL   (United States)

^c BROAD INSTITUTE OF MIT AND HARVARD   (United States)

^d UNIVERSITY OF ILLINOIS AT URBANA CHAMPAIGN   (United States)

^e ERASMUS MEDICAL CENTER   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

ANTINEOPLASTIC AGENT; APOPTOSIS INDUCING FACTOR; CASPASE 3; CASPASE 7; CASPASE 8; CYTOCHROME C; MITOCHONDRIAL COMPLEX IV; MITOCHONDRIAL PROTEIN; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE 1; PHOSPHATIDYLSERINE; PROCASPASE 3; RAPTINAL; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE DEHYDROGENASE (UBIQUINONE); SMALL INTERFERING RNA; UBIQUINOL CYTOCHROME C REDUCTASE; UNCLASSIFIED DRUG; COMPLEMENT COMPONENT C8; CYCLOPENTANE DERIVATIVE; FADD PROTEIN, HUMAN; FAS ASSOCIATED DEATH DOMAIN PROTEIN; FLUORENE DERIVATIVE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; BREAST CANCER; CANCER INHIBITION; CELL VIABILITY; CELLULAR DISTRIBUTION; CONCENTRATION RESPONSE; CONTROLLED STUDY; COUPLED RESPIRATION; DRUG BLOOD LEVEL; DRUG CYTOTOXICITY; DRUG HALF LIFE; DRUG MECHANISM; DRUG SCREENING; DRUG STRUCTURE; DRUG TOLERABILITY; EMBRYO; ENZYME ACTIVATION; GENE DELETION; HL 60 CELL LINE; HUMAN; HUMAN CELL; IC50; IN VITRO STUDY; IN VIVO STUDY; INTRACELLULAR SIGNALING; MELANOMA; MITOCHONDRIAL DYNAMICS; MITOCHONDRIAL MEDIATED INTRINSIC PATHWAY; MITOCHONDRIAL MEMBRANE POTENTIAL; MITOCHONDRIAL RESPIRATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN CLEAVAGE; PROTEIN FUNCTION; PROTEIN SECRETION; SIGNAL TRANSDUCTION; SINGLE DRUG DOSE; TIME SERIES ANALYSIS; TRANSGENIC ANIMAL; TUMOR VOLUME; ZEBRA FISH; ANIMAL; C57BL MOUSE; CHEMISTRY; DEFICIENCY; DRUG EFFECTS; GENETICS; HALF LIFE TIME; JURKAT CELL LINE; METABOLISM; MITOCHONDRION; NONMAMMALIAN EMBRYO; RNA INTERFERENCE; TUMOR CELL LINE;

ANIMALS; APOPTOSIS; CASPASE 3; CELL LINE, TUMOR; COMPLEMENT C8; CYCLOPENTANES; EMBRYO, NONMAMMALIAN; FAS-ASSOCIATED DEATH DOMAIN PROTEIN; FLUORENES; HALF-LIFE; HUMANS; JURKAT CELLS; MEMBRANE POTENTIAL, MITOCHONDRIAL; MICE; MICE, INBRED C57BL; MITOCHONDRIA; RNA INTERFERENCE; RNA, SMALL INTERFERING; ZEBRAFISH;

EID: 84947583848     PISSN: None     EISSN: 22111247     Source Type: Journal    
DOI: 10.1016/j.celrep.2015.10.042     Document Type: Article

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