메뉴 건너뛰기




Volumn 28, Issue 6, 2015, Pages 647-658

Prognostic role of tumour-infiltrating inflammatory cells in brain tumours: Literature review

Author keywords

Brain tumours; Immune infiltrates; Prognosis; Tumour associated macrophages; Tumour infiltrating lymphocytes

Indexed keywords

BRAIN METASTASIS; BRAIN TUMOR; CENTRAL NERVOUS SYSTEM TUMOR; DISEASE COURSE; GLIOMA; INFLAMMATORY INFILTRATE; INFORMATION RETRIEVAL; LYMPHOCYTE SUBPOPULATION; MACROPHAGE; MENINGIOMA; MICROGLIA; NATURAL KILLER CELL; PRIMARY CENTRAL NERVOUS SYSTEM LYMPHOMA; PROGNOSIS; REVIEW; T LYMPHOCYTE; TUMOR ASSOCIATED LEUKOCYTE; BRAIN NEOPLASMS; HUMAN; IMMUNOLOGY;

EID: 84947493002     PISSN: 13507540     EISSN: 14736551     Source Type: Journal    
DOI: 10.1097/WCO.0000000000000251     Document Type: Review
Times cited : (35)

References (111)
  • 1
    • 84931083080 scopus 로고    scopus 로고
    • Nivolumab versus chemotherapy in patients with advanced melanoma who progressed after anti-CTLA-4 treatment (CheckMate 037): A randomized, controlled, open-label, phase 3 trial
    • Weber JS, D'Angelo SP, Minor D, et al. Nivolumab versus chemotherapy in patients with advanced melanoma who progressed after anti-CTLA-4 treatment (CheckMate 037): a randomized, controlled, open-label, phase 3 trial. Lancet Oncol 2015; 16:375-384.
    • (2015) Lancet Oncol , vol.16 , pp. 375-384
    • Weber, J.S.1    D'Angelo, S.P.2    Minor, D.3
  • 2
    • 84924901863 scopus 로고    scopus 로고
    • Activity and safety of nivolumab, an anti-PD-1 immune checkpoint inhibitor, for patients with advanced, refractory squamous nonsmall-cell lung cancer (CheckMate 063): A phase 2, single-arm trial
    • Rizvi NA, Mazieres J, Planchard D, et al. Activity and safety of nivolumab, an anti-PD-1 immune checkpoint inhibitor, for patients with advanced, refractory squamous nonsmall-cell lung cancer (CheckMate 063): a phase 2, single-arm trial. Lancet Oncol 2015; 16:257-265.
    • (2015) Lancet Oncol , vol.16 , pp. 257-265
    • Rizvi, N.A.1    Mazieres, J.2    Planchard, D.3
  • 3
    • 84925221855 scopus 로고    scopus 로고
    • PD-1 blockade with nivolumab in relapsed or refractory Hodgkin's lymphoma
    • Ansell SM, Lesokhin AM, Borrello I, et al. PD-1 blockade with nivolumab in relapsed or refractory Hodgkin's lymphoma. New Engl J Med 2015; 372:311-319.
    • (2015) New Engl J Med , vol.372 , pp. 311-319
    • Ansell, S.M.1    Lesokhin, A.M.2    Borrello, I.3
  • 4
    • 0035901090 scopus 로고    scopus 로고
    • Inflammation and cancer: Back to Virchow?
    • Balkwill F, Mantovani A. Inflammation and cancer: back to Virchow? Lancet 2001; 357:539-545.
    • (2001) Lancet , vol.357 , pp. 539-545
    • Balkwill, F.1    Mantovani, A.2
  • 5
    • 84866852663 scopus 로고    scopus 로고
    • Cancer classification using the Immunoscore: A worldwide task force
    • Galon J, Pages F, Marincola FM, et al. Cancer classification using the Immunoscore: a worldwide task force. J Transl Med 2012; 10:205.
    • (2012) J Transl Med , vol.10 , pp. 205
    • Galon, J.1    Pages, F.2    Marincola, F.M.3
  • 6
    • 84890280907 scopus 로고    scopus 로고
    • Towards the introduction of the "immunoscore" in the classification of malignant tumours
    • Galon J, Mlecnik B, Bindea G, et al. Towards the introduction of the "Immunoscore" in the classification of malignant tumours. J Pathol 2014; 232:199-209.
    • (2014) J Pathol , vol.232 , pp. 199-209
    • Galon, J.1    Mlecnik, B.2    Bindea, G.3
  • 7
    • 31544441610 scopus 로고    scopus 로고
    • Distinct role of macrophages in different tumor microenvironments
    • Lewis CE, Pollard JW. Distinct role of macrophages in different tumor microenvironments. Cancer Res 2006; 66:605-612.
    • (2006) Cancer Res , vol.66 , pp. 605-612
    • Lewis, C.E.1    Pollard, J.W.2
  • 8
    • 84877076923 scopus 로고    scopus 로고
    • From the immune contexture to the Immunoscore: The role of prognostic and predictive immune markers in cancer
    • Angell H, Galon J. From the immune contexture to the Immunoscore: the role of prognostic and predictive immune markers in cancer. Curr Opin Immunol 2013; 25:261-267.
    • (2013) Curr Opin Immunol , vol.25 , pp. 261-267
    • Angell, H.1    Galon, J.2
  • 9
    • 33749319703 scopus 로고    scopus 로고
    • Type, density, and location of immune cells within human colorectal tumors predict clinical outcome
    • Galon J, Costes A, Sanchez-Cabo F, et al. Type, density, and location of immune cells within human colorectal tumors predict clinical outcome. Science 2006; 313:1960-1964.
    • (2006) Science , vol.313 , pp. 1960-1964
    • Galon, J.1    Costes, A.2    Sanchez-Cabo, F.3
  • 10
    • 79959745851 scopus 로고    scopus 로고
    • The prognostic influence of tumour-infiltrating lymphocytes in cancer: A systematic review with metaanalysis
    • Gooden MJM, de Bock GH, Leffers N, et al. The prognostic influence of tumour-infiltrating lymphocytes in cancer: a systematic review with metaanalysis. Br J Cancer 2011; 105:93-103.
    • (2011) Br J Cancer , vol.105 , pp. 93-103
    • Mjm, G.1    De Bock, G.H.2    Leffers, N.3
  • 11
    • 4644237613 scopus 로고    scopus 로고
    • Specific recruitment of regulatory T cells in ovarian carcinoma fosters immune privilege and predicts reduced survival
    • Curiel TJ, Coukos G, Zou L, et al. Specific recruitment of regulatory T cells in ovarian carcinoma fosters immune privilege and predicts reduced survival. Nature Med 2004; 10:942-949.
    • (2004) Nature Med , vol.10 , pp. 942-949
    • Curiel, T.J.1    Coukos, G.2    Zou, L.3
  • 12
    • 33244472107 scopus 로고    scopus 로고
    • Tumor-infiltrating T lymphocytes: Friends or foes?
    • Yu P, Fu Y-X. Tumor-infiltrating T lymphocytes: friends or foes? Lab Invest 2006; 86:231-245.
    • (2006) Lab Invest , vol.86 , pp. 231-245
    • Yu, P.1    Fu, Y.-X.2
  • 13
    • 31544441610 scopus 로고    scopus 로고
    • Distinct role of macrophages in different tumor microenvironments
    • Lewis CE, Pollard JW. Distinct role of macrophages in different tumor microenvironments. Cancer Res 2006; 66:605-612.
    • (2006) Cancer Res , vol.66 , pp. 605-612
    • Lewis, C.E.1    Pollard, J.W.2
  • 14
    • 84906312886 scopus 로고    scopus 로고
    • CNS macrophages and peripheral myeloid cells in brain tumours
    • Glass R, Synowitz M. CNS macrophages and peripheral myeloid cells in brain tumours. Acta Neuropathol 2014; 128:347-362.
    • (2014) Acta Neuropathol , vol.128 , pp. 347-362
    • Glass, R.1    Synowitz, M.2
  • 15
    • 84916936048 scopus 로고    scopus 로고
    • Immunotherapy for primary brain tumors: No longer a matter of privilege
    • Fecci PE, Heimberger AB, Sampson JH. Immunotherapy for primary brain tumors: no longer a matter of privilege. Clin Cancer Res 2014; 20:5620-5629.
    • (2014) Clin Cancer Res , vol.20 , pp. 5620-5629
    • Fecci, P.E.1    Heimberger, A.B.2    Sampson, J.H.3
  • 16
    • 34347207046 scopus 로고    scopus 로고
    • World Health Organization classification of tumours of the central nervous system
    • Lyon 164-172, 188-192, 247-252
    • Louis D, Ohgaki H, Wiestler O, Cavenee W. World Health Organization classification of tumours of the central nervous system. IARC, Lyon 2007; pp. 25-68, 164-172, 188-192, 247-252.
    • (2007) IARC , pp. 25-68
    • Louis, D.1    Ohgaki, H.2    Wiestler, O.3    Cavenee, W.4
  • 17
    • 77955817286 scopus 로고    scopus 로고
    • Guidelines on management of low-grade gliomas: Report of an EFNS-EANO∗ Task Force
    • Soffietti R, Baumert B, Bello L, et al. Guidelines on management of low-grade gliomas: report of an EFNS-EANO∗ Task Force. Eur J Neurol 2010; 17:1124-1133.
    • (2010) Eur J Neurol , vol.17 , pp. 1124-1133
    • Soffietti, R.1    Baumert, B.2    Bello, L.3
  • 18
    • 20044366163 scopus 로고    scopus 로고
    • Radiotherapy plus concomitant and adjuvant temozolomide for glioblastoma
    • Stupp R, Mason WP, Van Den Bent MJ, et al. Radiotherapy plus concomitant and adjuvant temozolomide for glioblastoma. New Engl J Med 2005; 352:987-996.
    • (2005) New Engl J Med , vol.352 , pp. 987-996
    • Stupp, R.1    Mason, W.P.2    Van Den Bent, M.J.3
  • 19
    • 0023239736 scopus 로고
    • Immunohistological study of mononuclear cell infiltrate in malignant gliomas
    • Rossi ML, Hughes JT, Esiri MM, et al. Immunohistological study of mononuclear cell infiltrate in malignant gliomas. Acta Neuropathol 1987; 74:269-277.
    • (1987) Acta Neuropathol , vol.74 , pp. 269-277
    • Rossi, M.L.1    Hughes, J.T.2    Esiri, M.M.3
  • 20
    • 0023855359 scopus 로고
    • Inflammatory infiltrates and natural killer cell presence in human brain tumors
    • Stevens A, Kloter I, Roggendorf W. Inflammatory infiltrates and natural killer cell presence in human brain tumors. Cancer 1988; 61:738-743.
    • (1988) Cancer , vol.61 , pp. 738-743
    • Stevens, A.1    Kloter, I.2    Roggendorf, W.3
  • 21
    • 0023873098 scopus 로고
    • Immunohistological evaluation of macrophage infiltrates in brain tumors. Correlation with peritumoral edema
    • Shinonaga M, Chang CC, Suzuki N, et al. Immunohistological evaluation of macrophage infiltrates in brain tumors. Correlation with peritumoral edema. J Neurosurg 1988; 68:259-265.
    • (1988) J Neurosurg , vol.68 , pp. 259-265
    • Shinonaga, M.1    Chang, C.C.2    Suzuki, N.3
  • 22
    • 0023841572 scopus 로고
    • Mononuclear cell infiltration in central portions of human astrocytomas
    • Hitchcock ER, Morris CS. Mononuclear cell infiltration in central portions of human astrocytomas. J Neurosurg 1988; 68:432-437.
    • (1988) J Neurosurg , vol.68 , pp. 432-437
    • Hitchcock, E.R.1    Morris, C.S.2
  • 23
    • 0024212342 scopus 로고
    • Immunohistological and functional analyses of lymphoid infiltrates in human glioblastomas
    • Kuppner MC, Hamou MF, de Tribolet N. Immunohistological and functional analyses of lymphoid infiltrates in human glioblastomas. Cancer Res 1988; 48:6926-6932.
    • (1988) Cancer Res , vol.48 , pp. 6926-6932
    • Kuppner, M.C.1    Hamou, M.F.2    De Tribolet, N.3
  • 24
    • 0024338056 scopus 로고
    • The mononuclear cell infiltrate compared with survival in high-grade astrocytomas
    • Rossi ML, Jones NR, Candy E, et al. The mononuclear cell infiltrate compared with survival in high-grade astrocytomas. Acta Neuropathol 1989; 78:189-193.
    • (1989) Acta Neuropathol , vol.78 , pp. 189-193
    • Rossi, M.L.1    Jones, N.R.2    Candy, E.3
  • 25
    • 0024598486 scopus 로고
    • Presence and significance of NK cells in glioblastomas
    • Vaquero J, Coca S, Oya S, et al. Presence and significance of NK cells in glioblastomas. J Neurosurg 1989; 70:728-731.
    • (1989) J Neurosurg , vol.70 , pp. 728-731
    • Vaquero, J.1    Coca, S.2    Oya, S.3
  • 26
    • 0025334502 scopus 로고
    • Monocyte subpopulations in human gliomas: Expression of Fc and complement receptors and correlation with tumor proliferation
    • Morimura T, Neuchrist C, Kitz K, et al. Monocyte subpopulations in human gliomas: expression of Fc and complement receptors and correlation with tumor proliferation. Acta Neuropathol 1990; 80:287-294.
    • (1990) Acta Neuropathol , vol.80 , pp. 287-294
    • Morimura, T.1    Neuchrist, C.2    Kitz, K.3
  • 27
    • 0025852630 scopus 로고
    • Monocyte/macrophage infiltrate in 41 oligodendrogliomas. Paraffin-wax study
    • Rossi ML, Buller J, Heath SA, Coakham HB. Monocyte/macrophage infiltrate in 41 oligodendrogliomas. Paraffin-wax study. Pathol Res Pract 1991; 187:166-169.
    • (1991) Pathol Res Pract , vol.187 , pp. 166-169
    • Rossi, M.L.1    Buller, J.2    Heath, S.A.3    Coakham, H.B.4
  • 28
    • 0025770177 scopus 로고
    • Characterization of the mononuclear cell infiltrate and HLA-Dr expression in 19 oligodendrogliomas
    • Rossi ML, Esiri MM, Jones NR, et al. Characterization of the mononuclear cell infiltrate and HLA-Dr expression in 19 oligodendrogliomas. Surg Neurol 1991; 36:119-125.
    • (1991) Surg Neurol , vol.36 , pp. 119-125
    • Rossi, M.L.1    Esiri, M.M.2    Jones, N.R.3
  • 29
    • 0027230411 scopus 로고
    • Tumor-infiltrating lymphocytes expressing IOT-10 marker. An immunohistochemical study of a series of 185 brain tumors
    • Zurita M, Vaquero J, Coca S, et al. Tumor-infiltrating lymphocytes expressing IOT-10 marker. An immunohistochemical study of a series of 185 brain tumors. Histol Histopathol 1993; 8:345-350.
    • (1993) Histol Histopathol , vol.8 , pp. 345-350
    • Zurita, M.1    Vaquero, J.2    Coca, S.3
  • 30
    • 0028000525 scopus 로고
    • Immunohistochemical analysis of tumor-infiltrating lymphocytes and adhesion molecules (ICAM-1, NCAM) in human gliomas
    • Yamanaka R, Tanaka R, Saito T. Immunohistochemical analysis of tumor-infiltrating lymphocytes and adhesion molecules (ICAM-1, NCAM) in human gliomas. Neurol Med Chir (Tokyo) 1994; 34:583-587.
    • (1994) Neurol Med Chir (Tokyo) , vol.34 , pp. 583-587
    • Yamanaka, R.1    Tanaka, R.2    Saito, T.3
  • 31
    • 1442301664 scopus 로고    scopus 로고
    • Immune cell infiltration of intrinsic and metastatic intracranial tumours
    • Strik HM, Stoll M, Meyermann R. Immune cell infiltration of intrinsic and metastatic intracranial tumours. Anticancer Res 2004; 24:37-42.
    • (2004) Anticancer Res , vol.24 , pp. 37-42
    • Strik, H.M.1    Stoll, M.2    Meyermann, R.3
  • 32
    • 0029781336 scopus 로고    scopus 로고
    • Distribution and characterization of microglia/macrophages in human brain tumors
    • Roggendorf W, Strupp S, Paulus W. Distribution and characterization of microglia/macrophages in human brain tumors. Acta Neuropathol 1996; 92:288-293.
    • (1996) Acta Neuropathol , vol.92 , pp. 288-293
    • Roggendorf, W.1    Strupp, S.2    Paulus, W.3
  • 34
    • 0030951515 scopus 로고    scopus 로고
    • Monocyte chemoattractant protein-1 expression and macrophage infiltration in gliomas
    • Leung SY, Wong MP, Chung LP, et al. Monocyte chemoattractant protein-1 expression and macrophage infiltration in gliomas. Acta Neuropathol 1997; 93:518-527.
    • (1997) Acta Neuropathol , vol.93 , pp. 518-527
    • Leung, S.Y.1    Wong, M.P.2    Chung, L.P.3
  • 35
    • 0032926784 scopus 로고    scopus 로고
    • Macrophage infiltration and heme oxyge-nase-1 expression correlate with angiogenesis in human gliomas
    • Nishie A, Ono M, Shono T, et al. Macrophage infiltration and heme oxyge-nase-1 expression correlate with angiogenesis in human gliomas. Clin Cancer Res 1999; 5:1107-1113.
    • (1999) Clin Cancer Res , vol.5 , pp. 1107-1113
    • Nishie, A.1    Ono, M.2    Shono, T.3
  • 36
    • 0035709184 scopus 로고    scopus 로고
    • Macrophage/microglial cell subpopulations in glioblastoma multiforme relapses are differentially altered by radiochemotherapy
    • Deininger MH, Pater S, Strik H, Meyermann R. Macrophage/microglial cell subpopulations in glioblastoma multiforme relapses are differentially altered by radiochemotherapy. J Neurooncol 2001; 55:141-147.
    • (2001) J Neurooncol , vol.55 , pp. 141-147
    • Deininger, M.H.1    Pater, S.2    Strik, H.3    Meyermann, R.4
  • 37
    • 9444290731 scopus 로고    scopus 로고
    • Presence of D110 antigen expressing immunocompetent cells in glioblastoma associates with prolonged survival
    • Preusser M, Ströbel T, Birner P, et al. Presence of D110 antigen expressing immunocompetent cells in glioblastoma associates with prolonged survival. Neuropathol Appl Neurobiol 2004; 30:608-614.
    • (2004) Neuropathol Appl Neurobiol , vol.30 , pp. 608-614
    • Preusser, M.1    Ströbel, T.2    Birner, P.3
  • 38
    • 33748197403 scopus 로고    scopus 로고
    • Gemistocytic astrocytomas: Histo-morphology, proliferative potential and genetic alterations - A study of 32 cases
    • Avninder S, Sharma MC, Deb P, et al. Gemistocytic astrocytomas: histo-morphology, proliferative potential and genetic alterations-a study of 32 cases. J Neurooncol 2006; 78:123-127.
    • (2006) J Neurooncol , vol.78 , pp. 123-127
    • Avninder, S.1    Sharma, M.C.2    Deb, P.3
  • 39
    • 33845603580 scopus 로고    scopus 로고
    • Clinico-pathological significance of RCAS1 expression in gliomas: A potential mechanism of tumor immune escape
    • Nakabayashi H, Nakashima M, Hara M, et al. Clinico-pathological significance of RCAS1 expression in gliomas: a potential mechanism of tumor immune escape. Cancer Lett 2007; 246:182-189.
    • (2007) Cancer Lett , vol.246 , pp. 182-189
    • Nakabayashi, H.1    Nakashima, M.2    Hara, M.3
  • 40
    • 34548496304 scopus 로고    scopus 로고
    • Elevated HLA-E levels in human glioblastomas but not in grade i to III astrocytomas correlate with infiltrating CD8+ cells
    • Mittelbronn M, Simon P, Löffler C, et al. Elevated HLA-E levels in human glioblastomas but not in grade I to III astrocytomas correlate with infiltrating CD8+ cells. J Neuroimmunol 2007; 189:50-58.
    • (2007) J Neuroimmunol , vol.189 , pp. 50-58
    • Mittelbronn, M.1    Simon, P.2    Löffler, C.3
  • 41
    • 47249086803 scopus 로고    scopus 로고
    • Preferential in situ CD4+CD56+ T cell activation and expansion within human glioblastoma
    • Waziri A, Killory B, Ogden AT, et al. Preferential in situ CD4+CD56+ T cell activation and expansion within human glioblastoma. J Immunol 2008; 180:7673-7680.
    • (2008) J Immunol , vol.180 , pp. 7673-7680
    • Waziri, A.1    Killory, B.2    Ogden, A.T.3
  • 42
    • 52649169692 scopus 로고    scopus 로고
    • Incidence and prognostic impact of FoxP3+ regulatory T cells in human gliomas
    • Heimberger AB, Abou-Ghazal M, Reina-Ortiz C, et al. Incidence and prognostic impact of FoxP3+ regulatory T cells in human gliomas. Clin Cancer Res 2008; 14:5166-5172.
    • (2008) Clin Cancer Res , vol.14 , pp. 5166-5172
    • Heimberger, A.B.1    Abou-Ghazal, M.2    Reina-Ortiz, C.3
  • 43
    • 50249144131 scopus 로고    scopus 로고
    • Possible involvement of the M2 anti-inflammatory macrophage phenotype in growth of human gliomas
    • Komohara Y, Ohnishi K, Kuratsu J, Takeya M. Possible involvement of the M2 anti-inflammatory macrophage phenotype in growth of human gliomas. J Pathol 2008; 216:15-24.
    • (2008) J Pathol , vol.216 , pp. 15-24
    • Komohara, Y.1    Ohnishi, K.2    Kuratsu, J.3    Takeya, M.4
  • 44
    • 67649448823 scopus 로고    scopus 로고
    • Tumor-associated macrophage/microglia infiltration in human gliomas is correlated with MCP-3, but not MCP-1
    • Okada M, Saio M, Kito Y, et al. Tumor-associated macrophage/microglia infiltration in human gliomas is correlated with MCP-3, but not MCP-1. Int J Oncol 2009; 34:1621-1627.
    • (2009) Int J Oncol , vol.34 , pp. 1621-1627
    • Okada, M.1    Saio, M.2    Kito, Y.3
  • 45
    • 68549096083 scopus 로고    scopus 로고
    • Prognostic impact of CD68 and kallikrein 6 in human glioma
    • Strojnik T, Kavalar R, Zajc I, et al. Prognostic impact of CD68 and kallikrein 6 in human glioma. Anticancer Res 2009; 29:3269-3279.
    • (2009) Anticancer Res , vol.29 , pp. 3269-3279
    • Strojnik, T.1    Kavalar, R.2    Zajc, I.3
  • 46
    • 68449093354 scopus 로고    scopus 로고
    • Infiltrating CTLs in human glioblastoma establish immunological synapses with tumorigenic cells
    • Barcia C, Gómez A, Gallego-Sanchez JM, et al. Infiltrating CTLs in human glioblastoma establish immunological synapses with tumorigenic cells. Am J Pathol 2009; 175:786-798.
    • (2009) Am J Pathol , vol.175 , pp. 786-798
    • Barcia, C.1    Gómez, A.2    Gallego-Sanchez, J.M.3
  • 47
    • 68949085209 scopus 로고    scopus 로고
    • Regulatory T cells and the PD-L1/PD-1 pathway mediate immune suppression in malignant human brain tumors
    • Jacobs JFM, Idema AJ, Bol KF, et al. Regulatory T cells and the PD-L1/PD-1 pathway mediate immune suppression in malignant human brain tumors. Neuro Oncol 2009; 11:394-402.
    • (2009) Neuro Oncol , vol.11 , pp. 394-402
    • Jfm, J.1    Idema, A.J.2    Bol, K.F.3
  • 48
    • 77955658133 scopus 로고    scopus 로고
    • Prognostic significance and mechanism of Treg infiltration in human brain tumors
    • Jacobs JF, Idema AJ, Bol KF, et al. Prognostic significance and mechanism of Treg infiltration in human brain tumors. J Neuroimmunol 2010; 225:195-199.
    • (2010) J Neuroimmunol , vol.225 , pp. 195-199
    • Jacobs, J.F.1    Idema, A.J.2    Bol, K.F.3
  • 49
    • 77649182786 scopus 로고    scopus 로고
    • Production of immune-modulatory nonclassical molecules HLA-G and HLA-E by tumor infiltrating ameboid microglia/macrophages in glioblastomas: A role in innate immunity?
    • Kren L, Muckova K, Lzicarova E, et al. Production of immune-modulatory nonclassical molecules HLA-G and HLA-E by tumor infiltrating ameboid microglia/macrophages in glioblastomas: a role in innate immunity? J Neu-roimmunol 2010; 220:131-135.
    • (2010) J Neu-roimmunol , vol.220 , pp. 131-135
    • Kren, L.1    Muckova, K.2    Lzicarova, E.3
  • 50
    • 77957342573 scopus 로고    scopus 로고
    • CD8+ T-cell infiltrate in newly diagnosed glioblastoma is associated with long-term survival
    • Yang I, Tihan T, Han SJ, et al. CD8+ T-cell infiltrate in newly diagnosed glioblastoma is associated with long-term survival. J Clin Neurosci 2010; 17:1381-1385.
    • (2010) J Clin Neurosci , vol.17 , pp. 1381-1385
    • Yang, I.1    Tihan, T.2    Han, S.J.3
  • 51
    • 79960301311 scopus 로고    scopus 로고
    • Effector T-cell infiltration positively impacts survival of glioblastoma patients and is impaired by tumor-derived TGF-b
    • Lohr J, Ratliff T, Huppertz A, et al. Effector T-cell infiltration positively impacts survival of glioblastoma patients and is impaired by tumor-derived TGF-b. Clin Cancer Res 2011; 17:4296-4308.
    • (2011) Clin Cancer Res , vol.17 , pp. 4296-4308
    • Lohr, J.1    Ratliff, T.2    Huppertz, A.3
  • 52
    • 80052343970 scopus 로고    scopus 로고
    • Immune cell infiltrate differences in pilocytic astrocytoma and glioblastoma: Evidence of distinct immunological microenvironments that reflect tumor biology
    • Yang I, Han SJ, Sughrue ME, et al. Immune cell infiltrate differences in pilocytic astrocytoma and glioblastoma: evidence of distinct immunological microenvironments that reflect tumor biology. J Neurosurg 2011; 115:505-511.
    • (2011) J Neurosurg , vol.115 , pp. 505-511
    • Yang, I.1    Han, S.J.2    Sughrue, M.E.3
  • 53
    • 79952711945 scopus 로고    scopus 로고
    • Gene expression profile correlates with T-cell infiltration and relative survival in glioblastoma patients vaccinated with dendritic cell immunotherapy
    • Prins RM, Soto H, Konkankit V, et al. Gene expression profile correlates with T-cell infiltration and relative survival in glioblastoma patients vaccinated with dendritic cell immunotherapy. Clin Cancer Res 2011; 17:1603-1615.
    • (2011) Clin Cancer Res , vol.17 , pp. 1603-1615
    • Prins, R.M.1    Soto, H.2    Konkankit, V.3
  • 54
    • 84863032932 scopus 로고    scopus 로고
    • Tumour-infiltrating T-cell subpopulations in glioblastomas
    • Kim Y-H, Jung T-Y, Jung S, et al. Tumour-infiltrating T-cell subpopulations in glioblastomas. Br J Neurosurg 2012; 26:21-27.
    • (2012) Br J Neurosurg , vol.26 , pp. 21-27
    • Kim, Y.-H.1    Jung, T.-Y.2    Jung, S.3
  • 55
    • 84865199671 scopus 로고    scopus 로고
    • Increased microglia/macrophage gene expression in a subset of adult and pediatric astrocytomas
    • Engler JR, Robinson AE, Smirnov I, et al. Increased microglia/macrophage gene expression in a subset of adult and pediatric astrocytomas. PLoS One 2012; 7:e43339.
    • (2012) PLoS One , vol.7 , pp. e43339
    • Engler, J.R.1    Robinson, A.E.2    Smirnov, I.3
  • 56
    • 84864822223 scopus 로고    scopus 로고
    • Increased immune gene expression and immune cell infiltration in high-grade astrocytoma distinguish long-term from short-term survivors
    • Donson AM, Birks DK, Schittone SA, et al. Increased immune gene expression and immune cell infiltration in high-grade astrocytoma distinguish long-term from short-term survivors. J Immunol 2012; 189:1920-1927.
    • (2012) J Immunol , vol.189 , pp. 1920-1927
    • Donson, A.M.1    Birks, D.K.2    Schittone, S.A.3
  • 57
    • 84870657385 scopus 로고    scopus 로고
    • Importance of direct macrophage-tumor cell interaction on progression of human glioma
    • Komohara Y, Horlad H, Ohnishi K, et al. Importance of direct macrophage-tumor cell interaction on progression of human glioma. Cancer Sci 2012; 103:2165-2172.
    • (2012) Cancer Sci , vol.103 , pp. 2165-2172
    • Komohara, Y.1    Horlad, H.2    Ohnishi, K.3
  • 58
    • 84877091854 scopus 로고    scopus 로고
    • LOH in the HLA class i region at 6p21 is associated with shorter survival in newly diagnosed adult glioblas-toma
    • Yeung JT, Hamilton RL, Ohnishi K, et al. LOH in the HLA class I region at 6p21 is associated with shorter survival in newly diagnosed adult glioblas-toma. Clin Cancer Res 2013; 19:1816-1826.
    • (2013) Clin Cancer Res , vol.19 , pp. 1816-1826
    • Yeung, J.T.1    Hamilton, R.L.2    Ohnishi, K.3
  • 59
    • 84881151730 scopus 로고    scopus 로고
    • Glioma grade is associated with the accumulation and activity of cells bearing M2 monocyte markers
    • Prosniak M, Harshyne LA, Andrews DW, et al. Glioma grade is associated with the accumulation and activity of cells bearing M2 monocyte markers. Clin Cancer Res 2013; 19:3776-3786.
    • (2013) Clin Cancer Res , vol.19 , pp. 3776-3786
    • Prosniak, M.1    Harshyne, L.A.2    Andrews, D.W.3
  • 60
  • 61
    • 84880667542 scopus 로고    scopus 로고
    • Increase in tumor-associated macrophages after antiangiogenic therapy is associated with poor survival among patients with recurrent glioblastoma
    • Lu-Emerson C, Snuderl M, Kirkpatrick ND, et al. Increase in tumor-associated macrophages after antiangiogenic therapy is associated with poor survival among patients with recurrent glioblastoma. Neuro Oncol 2013; 15:1079-1087.
    • (2013) Neuro Oncol , vol.15 , pp. 1079-1087
    • Lu-Emerson, C.1    Snuderl, M.2    Kirkpatrick, N.D.3
  • 62
    • 84886774000 scopus 로고    scopus 로고
    • Elevated CD3+ and CD8+ tumor-infiltrating immune cells correlate with prolonged survival in glioblastoma patients despite integrated immunosuppressive mechanisms in the tumor microenvironment and at thesystemic level
    • Kmiecik J, Poli A, Brons NHC, et al. Elevated CD3+ and CD8+ tumor-infiltrating immune cells correlate with prolonged survival in glioblastoma patients despite integrated immunosuppressive mechanisms in the tumor microenvironment and at thesystemic level. J Neuroimmunol 2013; 264:71-83.
    • (2013) J Neuroimmunol , vol.264 , pp. 71-83
    • Kmiecik, J.1    Poli, A.2    Nhc, B.3
  • 63
    • 84893637671 scopus 로고    scopus 로고
    • The prognostic value of Foxp3+ tumor-infiltrating lymphocytes in patients with glioblastoma
    • Yue Q, Zhang X, Ye H, et al. The prognostic value of Foxp3+ tumor-infiltrating lymphocytes in patients with glioblastoma. J Neurooncol 2014; 116:251-259.
    • (2014) J Neurooncol , vol.116 , pp. 251-259
    • Yue, Q.1    Zhang, X.2    Ye, H.3
  • 64
    • 84900527836 scopus 로고    scopus 로고
    • Tumour-infiltrating CD4(+) and CD8(+) lymphocytes as predictors of clinical outcome in glioma
    • Han S, Zhang C, Li Q, et al. Tumour-infiltrating CD4(+) and CD8(+) lymphocytes as predictors of clinical outcome in glioma. Br J Cancer 2014; 110:2560-2568.
    • (2014) Br J Cancer , vol.110 , pp. 2560-2568
    • Han, S.1    Zhang, C.2    Li, Q.3
  • 65
    • 84931467206 scopus 로고    scopus 로고
    • MIF receptor CD74 is restricted to microglia/macrophages, associated with a M1-polarized immune milieu and prolonged patient survival in gliomas
    • Zeiner PS, Preusse C, Blank A-E, et al. MIF receptor CD74 is restricted to microglia/macrophages, associated with a M1-polarized immune milieu and prolonged patient survival in gliomas. Brain Pathol 2014; 25:491-504.
    • (2014) Brain Pathol , vol.25 , pp. 491-504
    • Zeiner, P.S.1    Preusse, C.2    Blank, A.-E.3
  • 66
    • 84919948277 scopus 로고    scopus 로고
    • Expression oftumor-associated macrophage in progression of human glioma
    • Ding P, Wang W, Wang J, et al. Expression oftumor-associated macrophage in progression of human glioma. Cell Biochem Biophys 2014; 70:1625-1631.
    • (2014) Cell Biochem Biophys , vol.70 , pp. 1625-1631
    • Ding, P.1    Wang, W.2    Wang, J.3
  • 67
    • 84943241524 scopus 로고    scopus 로고
    • Programmed death ligand 1 expression and tumor-infiltrating lymphocytes in glioblastoma
    • Berghoff AS, Kiesel B, Widhalm G, et al. Programmed death ligand 1 expression and tumor-infiltrating lymphocytes in glioblastoma. Neuro Oncol 2014; 17:1064-1075.
    • (2014) Neuro Oncol , vol.17 , pp. 1064-1075
    • Berghoff, A.S.1    Kiesel, B.2    Widhalm, G.3
  • 68
    • 84925522153 scopus 로고    scopus 로고
    • Increased proportion of FoxP3+ regulatory T cells in tumor infiltrating lymphocytes is associated with tumor recurrence and reduced survival in patients with glioblastoma
    • Sayour EJ, McLendon P, McLendon R, et al. Increased proportion of FoxP3+ regulatory T cells in tumor infiltrating lymphocytes is associated with tumor recurrence and reduced survival in patients with glioblastoma. Cancer Immunol Immunother 2015; 64:419-427.
    • (2015) Cancer Immunol Immunother , vol.64 , pp. 419-427
    • Sayour, E.J.1    McLendon, P.2    McLendon, R.3
  • 69
    • 84926372398 scopus 로고    scopus 로고
    • Tumor-associated macrophages in glioblastoma multiforme - A suitable target for somatostatin receptor-based imaging and therapy?
    • Lapa C, Linsenmann T, Lückerath K, et al. Tumor-associated macrophages in glioblastoma multiforme-a suitable target for somatostatin receptor-based imaging and therapy? PLoS One 2015; 10:e0122269.
    • (2015) PLoS One , vol.10 , pp. e0122269
    • Lapa, C.1    Linsenmann, T.2    Lückerath, K.3
  • 70
    • 84884543901 scopus 로고    scopus 로고
    • Tumor-infiltrating lymphocytes in glioblastoma are associated with specific genomic alterations and related to transcriptional class
    • Rutledge WC, Kong J, Gao J, et al. Tumor-infiltrating lymphocytes in glioblastoma are associated with specific genomic alterations and related to transcriptional class. Clin Cancer Res 2013; 19:4951-4960.
    • (2013) Clin Cancer Res , vol.19 , pp. 4951-4960
    • Rutledge, W.C.1    Kong, J.2    Gao, J.3
  • 71
    • 58149340584 scopus 로고    scopus 로고
    • The incidence, correlation with tumor-infiltrating inflammation, and prognosis of phosphorylated STAT3 expression in human gliomas
    • Abou-Ghazal M, Yang DS, Qiao W, et al. The incidence, correlation with tumor-infiltrating inflammation, and prognosis of phosphorylated STAT3 expression in human gliomas. Clin Cancer Res 2008; 14:8228-8235.
    • (2008) Clin Cancer Res , vol.14 , pp. 8228-8235
    • Abou-Ghazal, M.1    Yang, D.S.2    Qiao, W.3
  • 72
    • 84860247330 scopus 로고    scopus 로고
    • The tumor microenvironment strongly impacts master transcriptional regulators and gene expression class of glioblastoma
    • Cooper LAD, Gutman DA, Chisolm C, et al. The tumor microenvironment strongly impacts master transcriptional regulators and gene expression class of glioblastoma. Am J Pathol 2012; 180:2108-2119.
    • (2012) Am J Pathol , vol.180 , pp. 2108-2119
    • Lad, C.1    Gutman, D.A.2    Chisolm, C.3
  • 74
    • 21344448199 scopus 로고    scopus 로고
    • High numbers of tumour-infiltrating activated cytotoxic T lymphocytes, and frequent loss of HLA class i and II expression, are features of aggressive B cell lymphomas of the brain and testis
    • Riemersma SA, Oudejans JJ, Vonk MJ, et al. High numbers of tumour-infiltrating activated cytotoxic T lymphocytes, and frequent loss of HLA class I and II expression, are features of aggressive B cell lymphomas of the brain and testis. J Pathol 2005; 206:328-336.
    • (2005) J Pathol , vol.206 , pp. 328-336
    • Riemersma, S.A.1    Oudejans, J.J.2    Vonk, M.J.3
  • 75
    • 34447131570 scopus 로고    scopus 로고
    • Reactive perivascular T-cell infiltrate predicts survival in primary central nervous system B-cell lymphomas
    • Ponzoni M, Berger F, Chassagne-Clement C, et al. Reactive perivascular T-cell infiltrate predicts survival in primary central nervous system B-cell lymphomas. Br J Haematol 2007; 138:316-323.
    • (2007) Br J Haematol , vol.138 , pp. 316-323
    • Ponzoni, M.1    Berger, F.2    Chassagne-Clement, C.3
  • 76
    • 77249107839 scopus 로고    scopus 로고
    • Primary central nervous system lymphoma: Prognostication as per international extranodal lymphoma study group score and reactive CD3 collar
    • Kumari N, Krishnani N, Rawat A, et al. Primary central nervous system lymphoma: prognostication as per international extranodal lymphoma study group score and reactive CD3 collar. J Postgraduate Med 2009; 55:247.
    • (2009) J Postgraduate Med , vol.55 , pp. 247
    • Kumari, N.1    Krishnani, N.2    Rawat, A.3
  • 77
    • 77956932786 scopus 로고    scopus 로고
    • Primary central nervous system lymphoma: A clinicopathological study of 75 cases
    • Preusser M, Woehrer A, Koperek O, et al. Primary central nervous system lymphoma: a clinicopathological study of 75 cases. Pathology 2010; 42:547-552.
    • (2010) Pathology , vol.42 , pp. 547-552
    • Preusser, M.1    Woehrer, A.2    Koperek, O.3
  • 78
    • 78049502210 scopus 로고    scopus 로고
    • Perivascular expression of CXCL9 and CXCL12 in primary central nervous system lymphoma: T-cell infiltration and positioning of malignant B cells
    • Venetz D, Ponzoni M, Schiraldi M, et al. Perivascular expression of CXCL9 and CXCL12 in primary central nervous system lymphoma: T-cell infiltration and positioning of malignant B cells. Int J Cancer 2010; 127:2300-2312.
    • (2010) Int J Cancer , vol.127 , pp. 2300-2312
    • Venetz, D.1    Ponzoni, M.2    Schiraldi, M.3
  • 79
    • 84861747362 scopus 로고    scopus 로고
    • M2 macrophage/microglial cells induce activation of Stat3 in primary central nervous system lymphoma
    • Komohara Y, Horlad H, Ohnishi K, et al. M2 macrophage/microglial cells induce activation of Stat3 in primary central nervous system lymphoma. J Clin Exp Hematop 2011; 51:93-99.
    • (2011) J Clin Exp Hematop , vol.51 , pp. 93-99
    • Komohara, Y.1    Horlad, H.2    Ohnishi, K.3
  • 80
    • 84891654921 scopus 로고    scopus 로고
    • PD1 (CD279) and PD-L1 (CD274, B7H1) expression in primary central nervous system lymphomas (PCNSL)
    • Berghoff AS, Ricken G, Widhalm G, et al. PD1 (CD279) and PD-L1 (CD274, B7H1) expression in primary central nervous system lymphomas (PCNSL). Clin Neuropathol 2014; 33:42-49.
    • (2014) Clin Neuropathol , vol.33 , pp. 42-49
    • Berghoff, A.S.1    Ricken, G.2    Widhalm, G.3
  • 81
    • 33749519200 scopus 로고    scopus 로고
    • Indications for surgery in patients with asymptomatic meningiomas based on an extensive experience
    • Yano S, Kuratsu J. Indications for surgery in patients with asymptomatic meningiomas based on an extensive experience. J Neurosurg 2006; 105:538-543.
    • (2006) J Neurosurg , vol.105 , pp. 538-543
    • Yano, S.1    Kuratsu, J.2
  • 82
    • 84868201655 scopus 로고    scopus 로고
    • New insights into meningioma: From genetics to trials
    • Vranic A, Peyre M, Kalamarides M. New insights into meningioma: from genetics to trials. Curr Opin Oncol 2012; 24:660-665.
    • (2012) Curr Opin Oncol , vol.24 , pp. 660-665
    • Vranic, A.1    Peyre, M.2    Kalamarides, M.3
  • 84
    • 84947487016 scopus 로고    scopus 로고
    • Biology and clinical management challenges in meningioma
    • Mawrin C, Chung C, Preusser M. Biology and clinical management challenges in meningioma. Am Soc Clin Oncol Educ Book 2015; 35:e106-e115.
    • (2015) Am Soc Clin Oncol Educ Book , vol.35 , pp. e106-e115
    • Mawrin, C.1    Chung, C.2    Preusser, M.3
  • 85
    • 0023905195 scopus 로고
    • Immunocytochemical study of the cellular immune response in meningiomas
    • Rossi ML, Cruz Sanchez F, Hughes JT, et al. Immunocytochemical study of the cellular immune response in meningiomas. J Clin Pathol 1988; 41:314-319.
    • (1988) J Clin Pathol , vol.41 , pp. 314-319
    • Rossi, M.L.1    Cruz Sanchez, F.2    Hughes, J.T.3
  • 86
    • 0024853804 scopus 로고
    • Immunohistological investigation of mononuclear cell infiltrates in meningiomas
    • Becker I, Roggendorf W. Immunohistological investigation of mononuclear cell infiltrates in meningiomas. Acta Neuropathol 1989; 79:211-216.
    • (1989) Acta Neuropathol , vol.79 , pp. 211-216
    • Becker, I.1    Roggendorf, W.2
  • 88
    • 0027082369 scopus 로고
    • An immunohistochemical study of mononuclear cells in meningiomas
    • Bø L, Mørk S, Nyland H. An immunohistochemical study of mononuclear cells in meningiomas. Neuropath Appl Neurobiol 1992; 18:548-558.
    • (1992) Neuropath Appl Neurobiol , vol.18 , pp. 548-558
    • Bø, L.1    Mørk, S.2    Nyland, H.3
  • 89
    • 0033402504 scopus 로고    scopus 로고
    • Expression of BCL-2 oncoprotein on tumor cells and tumor-infiltrating lymphocytes (TIL) in meningiomas
    • Roessler K, Dietrich W, Kitz K. Expression of BCL-2 oncoprotein on tumor cells and tumor-infiltrating lymphocytes (TIL) in meningiomas. Neurosurg Rev 1999; 22:205-209.
    • (1999) Neurosurg Rev , vol.22 , pp. 205-209
    • Roessler, K.1    Dietrich, W.2    Kitz, K.3
  • 90
    • 0033625012 scopus 로고    scopus 로고
    • Expression of beta2 integrins and macrophage-associated antigens in meningeal tumours
    • Mosnier JF, Perret AG, Scoazec JY, Brunon J. Expression of beta2 integrins and macrophage-associated antigens in meningeal tumours. Virchows Arch 2000; 436:131-137.
    • (2000) Virchows Arch , vol.436 , pp. 131-137
    • Mosnier, J.F.1    Perret, A.G.2    Scoazec, J.Y.3    Brunon, J.4
  • 91
    • 58849130186 scopus 로고    scopus 로고
    • The microglial/macrophagic response at the tumour-brain border of invasive meningiomas
    • Grund S, Schittenhelm J, Roser F, et al. The microglial/macrophagic response at the tumour-brain border of invasive meningiomas. Neuropathol Appl Neurobiol 2009; 35:82-88.
    • (2009) Neuropathol Appl Neurobiol , vol.35 , pp. 82-88
    • Grund, S.1    Schittenhelm, J.2    Roser, F.3
  • 92
    • 84868108575 scopus 로고    scopus 로고
    • Immunophenotypic identification and characterization of tumor cells and infiltrating cell populations in me-ningiomas
    • Domingues PH, Teodósio C, Ortiz J, et al. Immunophenotypic identification and characterization of tumor cells and infiltrating cell populations in me-ningiomas. Am J Pathol 2012; 181:1749-1761.
    • (2012) Am J Pathol , vol.181 , pp. 1749-1761
    • Domingues, P.H.1    Teodósio, C.2    Ortiz, J.3
  • 93
    • 84885047663 scopus 로고    scopus 로고
    • Association between inflammatory infiltrates and isolated monosomy 22/del(22q) in meningiomas
    • Domingues PH, Teodósio C, Otero A, et al. Association between inflammatory infiltrates and isolated monosomy 22/del(22q) in meningiomas. PLoS One 2013; 8:e74798.
    • (2013) PLoS One , vol.8 , pp. e74798
    • Domingues, P.H.1    Teodósio, C.2    Otero, A.3
  • 94
    • 84891847993 scopus 로고    scopus 로고
    • The immune cell infiltrate populating meningiomas is composed of mature, antigen-experienced T and B cells
    • Fang L, Lowther DE, Meizlish ML, et al. The immune cell infiltrate populating meningiomas is composed of mature, antigen-experienced T and B cells. Neuro Oncol 2013; 15:1479-1490.
    • (2013) Neuro Oncol , vol.15 , pp. 1479-1490
    • Fang, L.1    Lowther, D.E.2    Meizlish, M.L.3
  • 95
    • 84924973643 scopus 로고    scopus 로고
    • Increased expression of the immune modulatory molecule PD-L1 (CD274) in anaplastic meningioma
    • Du Z, Abedalthagafi M, Aizer AA, et al. Increased expression of the immune modulatory molecule PD-L1 (CD274) in anaplastic meningioma. Oncotarget 2015; 6:4704-4716.
    • (2015) Oncotarget , vol.6 , pp. 4704-4716
    • Du, Z.1    Abedalthagafi, M.2    Aizer, A.A.3
  • 96
    • 84912121685 scopus 로고    scopus 로고
    • Relationships between tumor microenvironment and clinicopathological parameters in meningioma
    • Ding Y, Qiu L, Xu Q, et al. Relationships between tumor microenvironment and clinicopathological parameters in meningioma. Int J Clin Exp Pathol 2014; 7:6973-6979.
    • (2014) Int J Clin Exp Pathol , vol.7 , pp. 6973-6979
    • Ding, Y.1    Qiu, L.2    Xu, Q.3
  • 97
    • 27644546807 scopus 로고    scopus 로고
    • Brain metastases: Epidemiology and pathophysiol-ogy
    • Gavrilovic IT, Posner JB. Brain metastases: epidemiology and pathophysiol-ogy. J Neurooncol 2005; 75:5-14.
    • (2005) J Neurooncol , vol.75 , pp. 5-14
    • Gavrilovic, I.T.1    Posner, J.B.2
  • 98
    • 38149075264 scopus 로고    scopus 로고
    • A new prognostic index and comparison to three other indices for patients with brain metastases: An analysis of 1, 960 patients in the RTOG database
    • Sperduto PW, Berkey B, Gaspar LE, et al. A new prognostic index and comparison to three other indices for patients with brain metastases: an analysis of 1, 960 patients in the RTOG database. Int J Radiat Oncol Biol Phys 2008; 70:510-514.
    • (2008) Int J Radiat Oncol Biol Phys , vol.70 , pp. 510-514
    • Sperduto, P.W.1    Berkey, B.2    Gaspar, L.E.3
  • 99
    • 75049084451 scopus 로고    scopus 로고
    • The role of whole brain radiation therapy in the management of newly diagnosed brain metastases: A systematic review and evidence-based clinical practice guideline
    • Gaspar LE, Mehta MP, Patchell RA, et al. The role of whole brain radiation therapy in the management of newly diagnosed brain metastases: a systematic review and evidence-based clinical practice guideline. J Neurooncol 2010; 96:17-32.
    • (2010) J Neurooncol , vol.96 , pp. 17-32
    • Gaspar, L.E.1    Mehta, M.P.2    Patchell, R.A.3
  • 100
    • 75049083726 scopus 로고    scopus 로고
    • The role of surgical resection in the management of newly diagnosed brain metastases: A systematic review and evidence-based clinical practice guideline
    • Kalkanis SN, Kondziolka D, Gaspar LE, et al. The role of surgical resection in the management of newly diagnosed brain metastases: a systematic review and evidence-based clinical practice guideline. J Neurooncol 2010; 96:33-43.
    • (2010) J Neurooncol , vol.96 , pp. 33-43
    • Kalkanis, S.N.1    Kondziolka, D.2    Gaspar, L.E.3
  • 101
    • 74949144656 scopus 로고    scopus 로고
    • The role of stereotactic radio-surgery in the management of patients with newly diagnosed brain metas-tases: A systematic review and evidence-based clinical practice guideline
    • Linskey ME, Andrews DW, Asher AL, et al. The role of stereotactic radio-surgery in the management of patients with newly diagnosed brain metas-tases: a systematic review and evidence-based clinical practice guideline. J Neurooncol 2010; 96:45-68.
    • (2010) J Neurooncol , vol.96 , pp. 45-68
    • Linskey, M.E.1    Andrews, D.W.2    Asher, A.L.3
  • 102
    • 75049084643 scopus 로고    scopus 로고
    • The role of chemotherapy in the management of newly diagnosed brain metastases: A systematic review and evidence-based clinical practice guideline
    • Mehta MP, Paleologos NA, Mikkelsen T, et al. The role of chemotherapy in the management of newly diagnosed brain metastases: a systematic review and evidence-based clinical practice guideline. J Neurooncol 2010; 96:71-83.
    • (2010) J Neurooncol , vol.96 , pp. 71-83
    • Mehta, M.P.1    Paleologos, N.A.2    Mikkelsen, T.3
  • 103
    • 84921937656 scopus 로고    scopus 로고
    • Predictive molecular markers in metastases to the central nervous system: Recent advances and future avenues
    • Berghoff AS, Bartsch R, Wöhrer A, et al. Predictive molecular markers in metastases to the central nervous system: recent advances and future avenues. Acta Neuropathol 2014; 128:879-891.
    • (2014) Acta Neuropathol , vol.128 , pp. 879-891
    • Berghoff, A.S.1    Bartsch, R.2    Wöhrer, A.3
  • 104
    • 84860446616 scopus 로고    scopus 로고
    • Ipilimumab in patients with melanoma and brain metastases: An open-label, phase 2 trial
    • Margolin K, Ernstoff MS, Hamid O, et al. Ipilimumab in patients with melanoma and brain metastases: an open-label, phase 2 trial. Lancet Oncol 2012; 13:459-465.
    • (2012) Lancet Oncol , vol.13 , pp. 459-465
    • Margolin, K.1    Ernstoff, M.S.2    Hamid, O.3
  • 105
    • 0025366002 scopus 로고
    • Immunohistochemical study of IOT-10 natural killer cells in brain metastases
    • Vaquero J, Coca S, Escandón J, et al. Immunohistochemical study of IOT-10 natural killer cells in brain metastases. Acta Neurochir (Wien) 1990; 104:17-20.
    • (1990) Acta Neurochir (Wien) , vol.104 , pp. 17-20
    • Vaquero, J.1    Coca, S.2    Escandón, J.3
  • 106
    • 33750480232 scopus 로고    scopus 로고
    • Differential reactions of microglia to brain metastasis of lung cancer
    • He BP, Wang JJ, Zhang X, et al. Differential reactions of microglia to brain metastasis of lung cancer. Mol Med 2006; 12:161-170.
    • (2006) Mol Med , vol.12 , pp. 161-170
    • He, B.P.1    Wang, J.J.2    Zhang, X.3
  • 107
    • 77956603258 scopus 로고    scopus 로고
    • Microglia promote colonization of brain tissue by breast cancer cells in a Wnt-dependent way
    • Pukrop T, Dehghani F, Chuang H-N, et al. Microglia promote colonization of brain tissue by breast cancer cells in a Wnt-dependent way. Glia 2010; 58:1477-1489.
    • (2010) Glia , vol.58 , pp. 1477-1489
    • Pukrop, T.1    Dehghani, F.2    Chuang, H.-N.3
  • 108
    • 84872686569 scopus 로고    scopus 로고
    • Characterization of the inflammatory response to solid cancer metastases in the human brain
    • Berghoff AS, Lassmann H, Preusser M, Höftberger R. Characterization of the inflammatory response to solid cancer metastases in the human brain. Clin Exp Metastasis 2013; 30:69-81.
    • (2013) Clin Exp Metastasis , vol.30 , pp. 69-81
    • Berghoff, A.S.1    Lassmann, H.2    Preusser, M.3    Höftberger, R.4
  • 109
    • 84901460759 scopus 로고    scopus 로고
    • Characterization of the melanoma brain metastatic niche in mice and humans
    • Amit M, Laider-Trejo L, Shalom V, et al. Characterization of the melanoma brain metastatic niche in mice and humans. Cancer Med 2013; 2:155-163.
    • (2013) Cancer Med , vol.2 , pp. 155-163
    • Amit, M.1    Laider-Trejo, L.2    Shalom, V.3
  • 110
    • 84925266488 scopus 로고    scopus 로고
    • Tumour-infiltrating lymphocytes and expression of programmed death ligand 1 (PD-L1) in melanoma brain metastases
    • Berghoff AS, Ricken G, Widhalm G, et al. Tumour-infiltrating lymphocytes and expression of programmed death ligand 1 (PD-L1) in melanoma brain metastases. Histopathology 2015; 66:289-299.
    • (2015) Histopathology , vol.66 , pp. 289-299
    • Berghoff, A.S.1    Ricken, G.2    Widhalm, G.3
  • 111
    • 84941022331 scopus 로고    scopus 로고
    • Density of tumor-infiltrating lymphocytes correlates with extent of brain edema and overall survival time in patients with brain metastases
    • (In press)
    • Berghoff A, Fuchs E, Ricken G, et al. Density of tumor-infiltrating lymphocytes correlates with extent of brain edema and overall survival time in patients with brain metastases. Oncoimmunology 2015. (In press).
    • (2015) Oncoimmunology
    • Berghoff, A.1    Fuchs, E.2    Ricken, G.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.