The microglial/macrophagic response at the tumour-brain border of invasive meningiomas

Neuropathology and Applied Neurobiology

Volumn 35, Issue 1, 2009, Pages 82-88

  Grund, S ^a   Schittenhelm, J ^a   Roser, F ^a   Tatagiba, M ^a   Mawrin, C ^b   Kim, Y J ^c   Bornemann, A ^a  

^a UNIVERSITY OF TÜBINGEN   (Germany)

^b FRIEDRICH SCHILLER UNIVERSITY JENA   (Germany)

^c SAARLAND UNIVERSITY   (Germany)

Author keywords

Basement membrane; Brain invasion; CD14 CD163; Major histocompatibility complex class II; Microglial reaction

Indexed keywords

CD14 ANTIGEN; CD163 ANTIGEN; CD68 ANTIGEN; COLLAGEN TYPE 4; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2;

ADULT; AGED; ANTIBODY LABELING; ARTICLE; CELL MEMBRANE; CLINICAL ARTICLE; CONTROLLED STUDY; GLIA CELL; HISTOPATHOLOGY; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNE RESPONSE; MENINGIOMA; MICROGLIA; MONOCYTE; MONONUCLEAR CELL; PIA ARTERY; PRIORITY JOURNAL; WORLD HEALTH ORGANIZATION;

EID: 58849130186     PISSN: 03051846     EISSN: 13652990     Source Type: Journal    
DOI: 10.1111/j.1365-2990.2008.00960.x     Document Type: Article

References (18)

1. Kepes JJ. Presidential address: the histopathology of meningiomas. A reflection of origins and expected behaviour? J Neuropathol Exp Neurol 1986 45 : 95 107
2. Perry A, Stafford SL, Scheithauer BW, Suman VJ, Lohse CM. Meningioma grading: an analysis of histologic parameters. Am J Surg Pathol 1997 21 : 1455 65
3. Perry A, Scheithauer BW, Stafford SL, Lohse CM, Wollan PC. Malignancy' in meningiomas: a clinicopathologic study of 116 patients, with grading implications. Cancer 1999 85 : 2046 56
4. Perry A, Louis DN, Scheithauer BW, Budka H, von Deimling A. Meningiomas. In WHO Classification of Tumours of the Central Nervous System 4th edn. Eds D Louis, O Hiroko, OD Wiestler, WK Cavenee. Lyon : IARC, 2007 164 72
5. Fritz J, Roser F, Tatagiba M, Bornemann A. The basement membrane at the tumour-brain interface of brain-invasive grade I meningiomas. Neuropathol Appl Neurobiol 2005 31 : 339 42
6. Schittenhelm J, Mittelbronn M, Roser F, Tatagiba M, Mawrin C, Bornemann A. Patterns of SPARC expression and basement membrane intactness at the tumour-brain border of invasive meningiomas. Neuropathol Appl Neurobiol 2006 32 : 525 31
7. Esiri MM, McGee JO. Monoclonal antibody to macrophages (EMB/11) labels macrophages and microglial cells in human brain. J Clin Pathol 1986 39 : 615 21
8. Hulette CM, Downey BT, Burger PC. Macrophage markers in diagnostic neuropathology. Am J Surg Pathol 1992 16 : 493 9
9. Hayes GM, Woodroofe MN, Cuzner ML. Microglia are the major cell type expressing MHC Class II in human white matter. J Neurol Sci 1987 80 : 25 37
10. Esiri MM, al Izzi MS, Reading MC. Macrophages, microglial cells, and HLA-DR antigens in fetal and infant brain. J Clin Pathol 1991 44 : 102 6
11. Sasaki A, Nakazato Y. The identity of cells expressing MHC class II antigens in normal and pathological human brain. Neuropathol Appl Neurobiol 1992 18 : 13 26
12. Ulvestad E, Williams K, Mørk S, Antel J, Nyland H. Phenotypic differences between human macrophages/monocytes and microglial cells studied in situ and in vitro. J Neuropathol Exp Neurol 1994 53 : 492 501
13. Fabriek BO, Van Haastert ES, Galea I, Polfliet MM, Döpp ED, Van Den Heuvel MM, Van Den Berg TK, De Groot CJ, Van Der Valk P, Dijkstra CD. CD163-positive perivascular macrophages in the human CNS express molecules for antigen recognition and presentation. Glia 2005 51 : 297 305
14. Sandberg Nordqvist AC, Smurawa H, Mathiesen T. Expression of matrix metalloproteinases 2 and 9 in meningiomas associated with different degrees of brain invasiveness and edema. J Neurosurg 2001 95 : 839 44
15. Sixt M, Engelhardt B, Pausch F, Hallmann R, Wendler O, Sorokin LM. Endothelial cell laminin isoforms, laminins 8 and 10, play decisive roles in T cell recruitment across the blood-brain barrier in experimental autoimmune encephalomyelitis. J Cell Biol 2001 153 : 933 46
16. Comtesse N, Heckel D, Rácz A, Brass N, Glass B, Meese E. Five novel immunogenic antigens in meningioma: cloning, expression analysis, and chromosomal mapping. Clin Cancer Res 1999 5 : 3560 8
17. Comtesse N, Zippel A, Walle S, Monz D, Backes C, Fischer U, Mayer J, Ludwig N, Hildebrandt A, Keller A, Steudel WI, Lenhof HP, Meese E. Complex humoral immune response against a benign tumour: frequent antibody response against specific antigens as diagnostic targets. Proc Natl Acad Sci USA 2005 102 : 9601 6
18. Baia GS, Dinca EB, Ozawa T, Kimura ET, McDermott MW, James CD, Vandenberg SR, Lal A. An orthotopic skull base model of malignant meningioma. Brain Pathol 2008 18 : 172 9.