Differential reactions of microglia to brain metastasis of lung cancer

Molecular Medicine

Volumn 12, Issue 7-8, 2006, Pages 161-170

  He, Bei Ping ^a   Wang, Jian Jun ^b   Zhang, Xian ^a   Wu, Yan ^a   Wang, Miao ^c   Bay, Boon Huat ^a   Chang, Alex Yuang Chi ^c  

^a NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

^b SECOND MILITARY MEDICAL UNIVERSITY   (China)

^c Johns Hopkins Singapore   (Singapore)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBODY; CALCIUM BINDING PROTEIN; CELL MARKER; INDUCIBLE NITRIC OXIDE SYNTHASE; IONIZED CALCIUM BINDING ADAPTOR ANTIBODY; LIPOPOLYSACCHARIDE; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

APOPTOSIS; ARTICLE; BRAIN METASTASIS; CANCER CHEMOTHERAPY; CANCER RADIOTHERAPY; CANCER REGRESSION; CANCER RELAPSE; CELL ACTIVATION; CELL FUNCTION; CELL INTERACTION; CELL LABELING; CELL STIMULATION; CELLULAR DISTRIBUTION; CONTROLLED STUDY; CYTOTOXICITY; CYTOTOXICITY TEST; DISEASE COURSE; DOSE TIME EFFECT RELATION; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNE SYSTEM; IMMUNOCOMPETENT CELL; IMMUNOHISTOCHEMISTRY; IN VITRO STUDY; LUNG CANCER; LUNG METASTASIS; MICROGLIA; PRIORITY JOURNAL; PROGNOSIS; PROTEIN EXPRESSION; SUPERNATANT; TUMOR GROWTH; TUMOR VOLUME;

ANIMALS; ANNEXINS; BRAIN NEOPLASMS; CELL DEATH; CELL LINE, TUMOR; CELL SURVIVAL; DOSE-RESPONSE RELATIONSHIP, DRUG; HUMANS; IMMUNOHISTOCHEMISTRY; LIPOPOLYSACCHARIDES; LUNG NEOPLASMS; MICE; MICROGLIA; NITRIC OXIDE; NITRIC OXIDE SYNTHASE TYPE II; PROPIDIUM; TIME FACTORS; TUMOR NECROSIS FACTOR-ALPHA; UP-REGULATION;

EID: 33750480232     PISSN: 10761551     EISSN: None     Source Type: Journal    
DOI: 10.2119/2006-00033.He     Document Type: Article

References (41)

1. Jafri NF, Ma PC, Maulik G, Salgia R. (2003) Mechanisms of metastasis as related to receptor tyrosine kinases in small-cell lung cancer. J. Environ. Pathol. Toxicol. Oncol. 22:147-65.
2. Schuette W. (2004) Treatment of brain metastases from lung cancer: chemotherapy. Lung Cancer 45:S253-7.
3. Zabel A, Debus J. (2004) Treatment of brain metastases from non-small-cell lung cancer (NSCLC): radiotherapy. Lung Cancer 45:S247-52.
4. Pottgen C, Stuschke M. (2001) The role of prophylactic cranial irradiation in the treatment of lung cancer. Lung Cancer 33:S153-8.
5. Nakamura Y. (2002) Regulating factors for microglial activation. Biol. Pharm. Bul. 25:945-53.
6. Kas HS. (2004) Drug delivery to brain by microparticulate systems. Adv. Exp. Med. Biol. 553:221-30.
7. Longley DB, Johnston PG. (2005) Molecular mechanisms of drug resistance. J. Pathol. 205:275-92.
8. Kreutzberg GW. (1996) Microglia: a sensor for pathological events in the CNS. Trends Neurosci. 19:312-8.
9. Chen JW et al. (2005) Tumor-associated macrophages: the double-edged sword in cancer progression. J. Clin. Oncol. 23:953-64.
10. Morimura T, Neuchrist C, Kitz K, Budka H, Scheiner O, Kraft D, Lassmann H. (1990) Monocyte subpopulations in human gliomas: expression of Fc and complement receptors and correlation with tumor proliferation. Acta Neuropathol. (Berl) 80:287-94.
11. Roggendorf W, Strupp S, Paulus W. (1996) Distribution and characterization of microglia/macrophages in human brain tumours. Acta Neuropathol. (Berl) 92:288-93.
12. Badie B, Schartner J. (2001) Role of microglia in glioma biology. Microsc. Res. Tech. 54:106-13.
13. Huettner C, Czub S, Kerkau S, Roggendorf W, Tonn JC. (1997) Interleukin 10 is expressed in human gliomas in vivo and increases glioma cell proliferation and motility in vitro. Anticancer Res. 17:3217-24.
14. Platten M et al. (2003) Monocyte chemoattractant protein-1 increases microglial infiltration and aggressiveness of gliomas. Ann. Neurol. 54:388-92.
15. Taniguchi Y, Ono K, Yoshida S, Tanaka R. (2000) Antigen-presenting capability of glial cells under glioma-harboring conditions and the effect of glioma-derived factors on antigen presentation. J Neuroimmunol. 111:177-85.
16. Wagner S, Czub S, Greif M, Vince GH, Suss N, Kerkau S, Rieckmann P, Roggendorf W, Roosen K, Tonn JC. (1999) Microglial/macrophage expression of interleukin 10 in human glioblastomas. Int. J. Cancer 82:12-6.
17. Bettinger I, Thanos S, Paulus W. (2002) Microglia promote glioma migration. Acta Neuropathol. (Berl) 103:351-5.
18. Hao C et al. (2002) Cytokine and cytokine receptor mRNA expression in human glioblastomas: evidence of Th1, Th2 and Th3 cytokine dysregulation. Acta Neuropathol. (Berl). 103:171-8.
19. Choucair AK et al. (1986) Development of multiple lesions during radiation therapy and chemotherapy in patients with gliomas. J. Neurosurg. 65:654-58.
20. Ito D, Imai Y, Ohsawa K, Nakajima K, Fukuuchi Y, Kohsaka S. (1998) Microglia-specific localisation of a novel calcium binding protein, Ibal. Mol. Brain Res. 57:1-9.
21. Blasi E, Barluzzi R, Bocchini V, Mazzolla R, Bistoni F. (1990) Immortalization of murine microglial cells by a v-raf/v-myc carrying retrovirus. J. Neuroimmunol. 27:229-37.
22. He BP, Wen W, Strong MJ. (2002) Activated microglia (BV-2) facilitation of TNF-alpha-mediated motor neuron death in vitro. J. Neuroimmunol. 128:31-8.
23. Kojima H, Nakatsubo N, Kikuchi K, Urano Y, Higuchi T, Tanaka J, Kudo Y, Nagano T. (1998) Direct evidence of NO production in rat hippocampus and cortex using a new fluorescent indicator: DAF-2 DA. Neuroreport 9:3345-8.
24. Gebicke-Haerter PJ. (2001) Microglia in neurodegeneration: molecular aspects. Microsc. Res. Tech. 54:47-8.
25. Jana M, Anderson JA, Saha RN, Liu X, Pahan K. (2005) Regulation of inducible nitric oxide synthase in proinflammatory cytokine-stimulated human primary astrocytes. Free Radic. Biol. Med. 38:655-64.
26. Kozuka N, Itofusa R, Kudo Y, Morita M. (2005) Lipopolysaccharide and proinflammatory cytokines require different astrocyte states to induce nitric oxide production. J. Neurosci. Res. 82:717-28.
27. Lechner M, Lirk P, Rieder J. (2005) Inducible nitric oxide synthase (iNOS) in tumor biology: the two sides of the same coin. Semin. Cancer Biol. 15:277-89.
28. Bossy-Wetzel E, Talantova MV, Lee WD, et al. (2004) Crosstalk between nitric oxide and zinc pathways to neuronal cell death involving mitochondrial dysfunction and p38-activated K+ channels. Neuron 41:351-365.
29. Liberatore GT, Jackson-Lewis V, Vukosavic S, et al. (1999) Inducible nitric oxide synthase stimulates dopaminergic neurodegeneration in the MPTP model of Parkinson disease. Nat. Med. 5:1403-1409.
30. Land SC, Rae C. (2005) iNOS initiates and sustains metabolic arrest in hypoxic lung adenocarcinoma cells: mechanism of cell survival in solid tumor core. Am. J. Physiol. Cell Physiol. 289:C918-933.
31. Roy A, Fung YK, Liu X, Pahan K. (2006) Upregulation of microglial cd11b expression by nitric oxide. J. B. C. (In press)
32. Gonzalez-Scaranol F, Baltuch G (1999) Microglia as mediators of inflammatory and degenerative diseases. Annu. Rev. Neurosci. 22:219-240.
33. Le W, Rowe D, Xie W, Ortiz I, He Y, Appel SH. (2001) Microglial activation and dopaminergic cell injury: an in vitro model relevant to Parkinson's disease. J. Neurosci. 21:8447-8455.
34. Elkabes S, DiCicco-Bloom EM, Black IB. (1996) Brain microglia/macrophages express neurotrophins that selectively regulate microglial proliferation and function. J. Neurosci. 16:2508-2521.
35. Vadlamani L, Iyengar S (2004) Tumor Necrosis Factor α Polymorphism in Heart Failure/Cardiomyopathy. Congest Heart Fail. 10:289-292.
36. Schubert P, Ogata T, Miyazaki H, Marchini C, Ferroni S, Rudolphi K. (1998) Pathological immuno-reactions of glial cells in Alzheimer's disease and possible sites of interference. J. Neural Transm. Suppl. 54:167-174.
37. Wu YP, Mizukami H, Matsuda J, Saito Y, Proia RL, Suzuki K. (2005) Apoptosis accompanied by upregulation of TNF-alpha death pathway genes in the brain of Niemann-Pick type C disease. Mol. Genet. Metab. 84:9-17.
38. Roessler K, Suchanek G, Breitschopf H, Kitz K, Matula C, Lassmann H, Koos WT. (1995) Detection of tumor necrosis factor-alpha protein and messenger RNA in human glial brain tumours: comparison of immunohistochemistry with in situ hybridization using molecular probes. J. Neurosurg. 83:291-297.
39. Mantovani A, Sozzani S, Locati M, Allavena P, Sica A. (2002) Macrophage polarization: tumor-associated macrophages as a paradigm for polarized M2 mononuclear phagocytes. Trends Immunol. 23:549-555.
40. Dinapoli MR, Calderon CL, Lopez DM. (1996) The altered tumoricidal capacity of macrophages isolated from tumor-bearing mice is related to reduce expression of the inducible nitric oxide synthase gene. J. Exp. Med. 183:1323-1329.
41. Strik HM, Stoll M, Meyermann R. (2004) Immune cell infiltration of intrinsic and metastatic intracranial tumours. Anticancer Res. 24:37-42.