Enhanced osteoblastic differentiation and bone formation in co-culture of human bone marrow mesenchymal stromal cells and peripheral blood mononuclear cells with exogenous VEGF

Orthopaedics and Traumatology: Surgery and Research

Volumn 101, Issue 3, 2015, Pages 381-386

  Joensuu, K ^a   Uusitalo, L ^a   Alm, J J ^b   Aro, H T ^b   Hentunen, T A ^a   Heino, T J ^a,b  

^a Department of Cell Biology and Anatomy ^*  (Finland)

^b UNIVERSITY OF TURKU   (Finland)

Author keywords

Mesenchymal stromal cells; Mononuclear cells; Osteoblastic differentiation; Tissue engineering; Vascular endothelial growth factor

Indexed keywords

ALKALINE PHOSPHATASE; VASCULOTROPIN; VASCULOTROPIN A;

ADULT; ANGIOGENESIS; ARTICLE; BONE MARROW DERIVED MESENCHYMAL STEM CELL; BONE MINERAL; BONE MINERALIZATION; CELL CONTACT; CELL DIFFERENTIATION; CELL PROLIFERATION; COCULTURE; FILTERS AND MEMBRANES; HUMAN; HUMAN CELL; HUMAN EXPERIMENT; NORMAL HUMAN; OSSIFICATION; OSTEOBLAST; PERIPHERAL BLOOD MONONUCLEAR CELL; PRIORITY JOURNAL; BONE DEVELOPMENT; CYTOLOGY; MESENCHYMAL STROMA CELL; METABOLISM; MONONUCLEAR CELL; TISSUE ENGINEERING;

ALKALINE PHOSPHATASE; CELL DIFFERENTIATION; CELL PROLIFERATION; COCULTURE TECHNIQUES; HUMANS; LEUKOCYTES, MONONUCLEAR; MESENCHYMAL STROMAL CELLS; OSTEOBLASTS; OSTEOGENESIS; TISSUE ENGINEERING; VASCULAR ENDOTHELIAL GROWTH FACTOR A;

EID: 84947489573     PISSN: 18770568     EISSN: 18770568     Source Type: Journal    
DOI: 10.1016/j.otsr.2015.01.014     Document Type: Article

References (26)

1. Muschler G.F., Nakamoto C., Griffith L.G. Engineering principles of clinical cell-based tissue engineering. J Bone Joint Surg Am 2004, 86:1541-1558.
2. Kuroda R., Matsumoto T., KawakamiY, Fukui T., Mifune Y., Kurosaka M., et al. Clinical impact of circulating CD34-positive cells on bone regeneration and healing. Tissue Eng Part B Rev 2014, 20:190-199.
3. Guillotin B., Bourget C., Remy-Zolgadri M., Bareille R., Fernandez P., Conrad V., et al. Human primary endothelial cells stimulate human osteoprogenitor cell differentiation. Cell Physiol Biochem 2004, 14:325-332.
4. James A.W., Zara J.N., Zhang X., Askarinam A., Goyal R., Chiang M., et al. Perivascular stem cells: a prospectively purified mesenchymal stem cell population for bone tissue engineering. Stem Cells Trans Med 2012, 1:510-519.
5. Pedersen T.O., Blois A.L., Xing Z., Xue Y., Sun Y., Finne-Wistrand A., et al. Endothelial microvascular networks affect gene expression profiles and osteogenic potential of tissue-engineered constructs. Stem Cell Res Ther 2013, 4:52.
6. Kasper G., Dankert N., Tuischer J., Hoeft M., Gaber T., Glaeser J.D., et al. Mesenchymal stem cells regulate angiogenesis according to their mechanical environment. Stem Cells 2007, 25:903-910.
7. Takahashi T., Kalka C., Masuda H., Chen D., Silver M., Kearney M., et al. Ishemia- and cytokine-induced mobilization of bone marrow-derived endothelial progenitor cells for neovascularization. Nat Med 1999, 5:434-438.
8. Petri M., Namazian A., Wilke F., Ettinger M., Stubig T., Brand S., et al. Repair of segmental long-bone defects by stem cell concentrate augmented scaffolds: a clinical and positron emission tomography-computed tomography analysis. Int Orthop 2013, 37:2231-2237.
9. Scaglione M., Fabbri L., Dell'omo D., Gambini F., Guido G. Long bone nonunions treated with autologous concentrated bone marrow-derived cells combined with dried bone allograft. Musculoskelet Surg 2014, 98:101-106.
10. Street J., Bao M., deGuzman L., Bunting S., Peale F.V., Ferrara N., et al. Vascular endothelial growth factor stimulates bone repair by promoting angiogenesis and bone turnover. Proc Natl Acad Sci U S A 2002, 99:9656-9661.
11. Keramaris N.C., Calori G.M., Nikolaou V.S., Schemitsch E.H., Giannoudis P.V. Fracture vascularity and bone healing: a systematic review of the role of VEGF. Injury 2008, 39(Suppl 2):S45-S57.
12. Kusumble A.P., Ramasamy S.K., Adams R.H. Coupling of angiogenesis and osteogenesis by a specific vessel subtype in bone. Nature 2014, 507:323-328.
13. Liu Y., Berendsen A., Jia D., Lotinun S., Baron R., Ferrara N., et al. regulates the balance between osteoblast and adipocyte differentiation. J Clin Invest 2012, 122:3101-3113.
14. Street J., Lenehan B. Vascular endothelial growth factor regulates osteoblastic survival-evidence for an autocrine feedback mechanism. J Orthop Surg Res 2009, 4:19-32.
15. Clarkin C.E., Emery R.J., Pitsillides A.A., Wheeler-Jones C.P. Evaluation of VEGF-mediated signalling in primary human cells reveals a paracrine action for VEGF in osteoblast-mediated crosstalk to endothelial cells. J Cell Phys 2008, 214:537-544.
16. Joensuu K., Paatero I., Alm J.J., Elenius K., Aro H.T., Heino T.J., et al. Interaction between marrow-derived human mesenchymal stem cells and peripheral blood mononuclear cells in endothelial cell differentiation. Scand J Surg 2011, 100:216-222.
17. Alm J.J., Koivu H.M., Heino T.J., Hentunen T.A., Laitinen S., Aro H.T. Circulating plastic adherent mesenchymal stem cells in aged hip fracture patients. J Orthop Res 2010, 28:1634-1642.
18. Alm J.J., Heino T.J., Hentunen T.A. Transient 100nM dexamethasone treatment reduces inter- and intraindividual variations in osteoblastic differentiation of bone marrow-derived human mesenchymal stem cells. Tissue Eng part C 2012, 18:660-666.
19. Heino T.J., Hentunen T.A., Väänänen H.K. Conditioned medium from osteocytes stimulates the proliferation of bone marrow mesenchymal stem cells and their differentiation into osteoblasts. Exp Cell Res 2004, 294:458-468.
20. Maccarrone G., Rewerts C., Lebar M., Turck C.W., Martins-de-Souza D. Proteome profiling of peripheral mononuclear cells from human blood. Proteomics 2013, 13:893-897.
21. Guihard P., Danger Y., Brounais B., David E., Brion R., Delecrin J., et al. Induction of osteogenesis in mesenchymal stem cells by activated monocytes/macrophages depends on oncostatin M signaling. Stem Cells 2012, 30:762-772.
22. Nicolaidou V., Wong M.M., Redpath A.N., Ersek A., Baban D.F., Williams L.M., et al. Monocytes induce STAT3 activation in human mesenchymal stem cells to promote osteoblast formation. PLoS One 2012, 7.
23. Behr B., Tang C., Germann G., Longaker M.T., Quarto N. Locally applied VEGFA increases the osteogenic healing capacity of human adipose derived stem cells by promoting osteogenic and endothelial differentiation. Stem Cells 2011, 29:286-296.
24. Pilz G.A., Braun J., Ulrich C., Felka T., Warstat K., Ruh M., et al. Human mesenchymal stromal cells express CD14 cross-reactive epitopes. Cytometry A 2011, 79:635-645.
25. Li Q., Wang Z. Influence of mesenchymal stem cells with endothelial progenitor cells in co-culture on osteogenesis and angiogenesis: an in vitro study. Arch Med Res 2013, 44:504-513.
26. Hoch A.I., Binder B.Y., Genetors D.C., Leach K.J. Differentiation-dependent secretion of proangiogenic factors by mesenchymal stem cells. PLoS One 2012, 7.