Paradoxical Effect of Nonphysiological Shear Stress on Platelets and von Willebrand Factor

Artificial Organs

Volumn 40, Issue 7, 2016, Pages 659-668

  Chen, Zengsheng ^a,c   Mondal, Nandan K ^a   Ding, Jun ^a,b   Koenig, Steven C ^a   Slaughter, Mark S ^a   Wu, Zhongjun J ^a  

^a University of Louisville School of Medicine   (United States)

^b Baltimore County   (United States)

^c TSINGHUA UNIVERSITY   (China)

Author keywords

Bleeding; Blood contacting medical devices; Nonphysiological high shear stress; Receptor shedding; Thrombosis

Indexed keywords

BIOMEDICAL EQUIPMENT; BLOOD VESSELS; CHEMICAL ACTIVATION; COLLAGEN; PLATELETS; SHEAR FLOW; SHEAR STRESS;

BLEEDINGS; BLOOD CONTACTING MEDICAL DEVICE; HIGH SHEAR; MEDICAL DEVICES; MICRO PARTICLES; NONPHYSIOLOGICAL HIGH SHEAR STRESS; PLATELET ACTIVATION; RECEPTOR SHEDDING; SHEAR-INDUCED; VON WILLEBRAND FACTOR;

DISEASES;

CD36 ANTIGEN; COLLAGEN; FIBRINOGEN RECEPTOR; GLYCOPROTEIN IB ALPHA; PADGEM PROTEIN; RISTOCETIN; VON WILLEBRAND FACTOR;

ADULT; ARTICLE; BLEEDING; CONTROLLED STUDY; FEMALE; HUMAN; MALE; PLATELET MICROPARTICLE; PRIORITY JOURNAL; PROTEIN EXPRESSION; RISK FACTOR; SHEAR STRESS; THROMBOCYTE; THROMBOCYTE ACTIVATION; THROMBOCYTE AGGREGATION; THROMBOSIS; BLOOD; CYTOLOGY; HEMORRHAGE; MECHANICAL STRESS; METABOLISM; MIDDLE AGED; YOUNG ADULT;

ADULT; BLOOD PLATELETS; FEMALE; HEMORRHAGE; HUMANS; MALE; MIDDLE AGED; PLATELET ACTIVATION; PLATELET AGGREGATION; PLATELET MEMBRANE GLYCOPROTEINS; STRESS, MECHANICAL; THROMBOSIS; VON WILLEBRAND FACTOR; YOUNG ADULT;

EID: 84947447781     PISSN: 0160564X     EISSN: 15251594     Source Type: Journal    
DOI: 10.1111/aor.12606     Document Type: Article

References (27)

1. Mathers CD, Loncar D. Projections of global mortality and burden of disease from 2002 to 2030. PLoS Med 2006;3:e442.
2. Go AS, Mozaffarian D, Roger VL, et al. Heart disease and stroke statistics—2014 update: a report from the American Heart Association. Circulation 2014;129:e28–292.
3. Butchart EG, Ionescu A, Payne N, Giddings J, Grunkemeier GL, Fraser AG. A new scoring system to determine thromboembolic risk after heart valve replacement. Circulation 2003;108:II68–74.
4. Eckman PM, John R. Bleeding and thrombosis in patients with continuous-flow ventricular assist devices. Circulation 2012;125:3038–3047.
5. Bluestein D. Research approaches for studying flow-induced thromboembolic complications in blood recirculating devices. Expert Rev Med Devices 2004;1:65–80.
6. Steinlechner B, Dworschak M, Birkenberg B, et al. Platelet dysfunction in outpatients with left ventricular assist devices. Ann Thorac Surg 2009;87:131–137.
7. Kroll MH, Hellums JD, McIntire LV, Schafer AI, Moake JL. Platelets and shear stress. Blood 1996;88:1525–1541.
8. Zhang JN, Bergeron AL, Yu Q, et al. Platelet aggregation and activation under complex patterns of shear stress. Thromb Haemost 2002;88:817–821.
9. Yin W, Gallocher S, Pinchuk L, Schoephoerster RT, Jesty J, Bluestein D. Flow-induced platelet activation in a St. Jude mechanical heart valve, a trileaflet polymeric heart valve, and a St. Jude tissue valve. Artif Organs 2005;29:826–831.
10. Bluestein D, Yin W, Affeld K, Jesty J. Flow-induced platelet activation in mechanical heart valves. J Heart Valve Dis 2004;13:501–508.
11. Furie B, Furie BC. Mechanisms of thrombus formation. N Engl J Med 2008;359:938–949.
12. Canobbio I, Balduini C, Torti M. Signalling through the platelet glycoprotein Ib-V-IX complex. Cell Signal 2004;16:1329–1344.
13. Al-Tamimi M, Tan CW, Qiao J, et al. Pathologic shear triggers shedding of vascular receptors: a novel mechanism for down-regulation of platelet glycoprotein VI in stenosed coronary vessels. Blood 2012;119:4311–4320.
14. Tsai HM, Sussman II, Nagel RL. Shear stress enhances the proteolysis of von Willebrand factor in normal plasma. Blood 1994;83:2171–2179.
15. Cheng H, Yan R, Li S, et al. Shear-induced interaction of platelets with von Willebrand factor results in glycoprotein Ibα shedding. Am J Physiol Heart Circ Physiol 2009;297:H2128–2135.
16. Arthur JF, Dunkley S, Andrews RK. Platelet glycoprotein VI-related clinical defects. Br J Haematol 2007;139:363–372.
17. Hu J, Mondal NK, Sorensen EN, et al. Platelet glycoprotein Ibα ectodomain shedding and non-surgical bleeding in heart failure patients supported by continuous-flow left ventricular assist devices. J Heart Lung Transplant 2014;33:71–79.
18. Fraser KH, Zhang T, Taskin ME, Griffith BP, Wu ZJ. A quantitative comparison of mechanical blood damage parameters in rotary ventricular assist devices: shear stress, exposure time and hemolysis index. J Biomech Eng 2012;134:081002.
19. Taskin ME, Fraser KH, Zhang T, Wu C, Griffith BP, Wu ZJ. Evaluation of Eulerian and Lagrangian models for hemolysis estimation. ASAIO J 2012;58:363–372.
20. Heilmann C, Geisen U, Beyersdorf F, et al. Acquired von Willebrand syndrome in patients with extracorporeal life support (ECLS). Intensive Care Med 2012;38:62–68.
21. Kalbhenn J, Schmidt R, Nakamura L, Schelling J, Rosenfelder S, Zieger B. Early diagnosis of Acquired von Willebrand Syndrome (AVWS) is elementary for clinical practice in patients treated with ECMO therapy. J Atheroscler Thromb 2015;22:265–271.
22. Zhang T, Taskin ME, Fang HB, et al. Study of flow-induced hemolysis using novel Couette-type blood-shearing devices. Artif Organs 2011;35:1180–1186.
23. Paul R, Apel J, Klaus S, Schügner F, Schwindke P, Reul H. Shear stress related blood damage in laminar Couette flow. Artif Organs 2003;27:517–529.
24. Ding J, Chen Z, Niu S, et al. Quantification of shear-induced platelet activation: high shear stresses for short exposure time. Artif Organs 2015;39:576–583.
25. Hagberg IA, Lyberg T. Blood platelet activation evaluated by flow cytometry: optimised methods for clinical studies. Platelets 2000;11:137–150.
26. Krizek DR, Rick ME. A rapid method to visualize von Willebrand factor multimers by using agarose gel electrophoresis, immunolocalization and luminographic detection. Thromb Res 2000;97:457–462.
27. Heilmann C, Geisen U, Beyersdorf F, et al. Acquired von Willebrand syndrome in patients with ventricular assist device or total artificial heart. Thromb Haemost 2010;103:962–967.