Shear-induced interaction of platelets with von Willebrand factor results in glycoprotein Ibα shedding

American Journal of Physiology - Heart and Circulatory Physiology

Volumn 297, Issue 6, 2009, Pages

  Cheng, Hong ^a   Yan, Rong ^a   Li, Suping ^a   Yuan, Yanhong ^a   Liu, Jun ^a   Ruan, Changgeng ^b   Dai, Kesheng ^a  

^a BEIHANG UNIVERSITY   (China)

^b SUZHOU UNIVERSITY   (China)

Author keywords

Calpain; Integrin IIb 3; Metalloproteinase; Shear stress; Thrombosis

Indexed keywords

CALPASTATIN; ETHYLENE GLYCOL 1,2 BIS(2 AMINOPHENYL) ETHER N,N,N',N' TETRAACETIC ACID; GLYCOCALICIN; GLYCOPROTEIN IB ALPHA; METALLOPROTEINASE INHIBITOR; MONOCLONAL ANTIBODY; VON WILLEBRAND FACTOR; WORTMANNIN;

ARTICLE; CARBOXY TERMINAL SEQUENCE; CONTROLLED STUDY; FLOW CYTOMETRY; HUMAN; PATHOPHYSIOLOGY; PRIORITY JOURNAL; PROTEIN DOMAIN; SHEAR RATE; SHEAR STRESS; THROMBOCYTE ACTIVATION; THROMBOCYTE ADHESION; THROMBOCYTE FUNCTION; VISCOMETER;

1-PHOSPHATIDYLINOSITOL 3-KINASE; ANTIBODIES, MONOCLONAL; BLOOD PLATELETS; CALPAIN; ENZYME INHIBITORS; HUMANS; MEMBRANE GLYCOPROTEINS; METALLOPROTEASES; PLATELET ADHESIVENESS; PLATELET GLYCOPROTEIN GPIIB-IIIA COMPLEX; PROTEIN STRUCTURE, TERTIARY; STRESS, MECHANICAL; TIME FACTORS; VON WILLEBRAND FACTOR;

EID: 72249088796     PISSN: 03636135     EISSN: 15221539     Source Type: Journal    
DOI: 10.1152/ajpheart.00107.2009     Document Type: Article

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