Disruption of histone methylation in developing sperm impairs offspring health transgenerationally

Science

Volumn 350, Issue 6261, 2015, Pages

  Siklenka, Keith ^a   Erkek, Serap ^b,c,i,j   Godmann, Maren ^d,k   Lambrot, Romain ^d   McGraw, Serge ^e,l   Lafleur, Christine ^d   Cohen, Tamara ^d   Xia, Jianguo ^d   Suderman, Matthew ^f   Hallett, Michael ^g   Trasler, Jacquetta ^e,h   Peters, Antoine H F M ^b,c   Kimmins, Sarah ^a,d  

^a MCGILL UNIVERSITY   (Canada)

^b FRIEDRICH MIESCHER INSTITUTE FOR BIOMEDICAL RESEARCH   (Switzerland)

^c UNIVERSITY OF BASEL   (Switzerland)

^d MCGILL UNIVERSITY   (Canada)

^e MCGILL UNIVERSITY   (Canada)

^f UNIVERSITY OF BRISTOL   (United Kingdom)

^g MCGILL UNIVERSITY   (Canada)

^h RESEARCH INSTITUTE OF THE MCGILL UNIVERSITY HEALTH CENTRE   (Canada)

ⁱ EUROPEAN MOLECULAR BIOLOGY LABORATORY   (Germany)

^j GERMAN CANCER RESEARCH CENTER DKFZ   (Germany)

^k FRIEDRICH SCHILLER UNIVERSITY JENA   (Germany)

^l UNIVERSITÉ DE MONTRÉAL   (Canada)

more..

Author keywords

[No Author keywords available]

Indexed keywords

DNA; RNA; UNTRANSLATED RNA; AOF2 PROTEIN, MOUSE; HISTONE; HISTONE DEMETHYLASE; MESSENGER RNA;

DNA; GENE EXPRESSION; HERITABILITY; METHYLATION; PROTEIN; REPRODUCTIVE HEALTH; RNA; SPERM;

ANIMAL EXPERIMENT; ARTICLE; CHROMATIN; DNA METHYLATION; EPIGENETICS; FEMALE; HISTONE METHYLATION; INHERITANCE; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROGENY; REGULATOR GENE; RNA ANALYSIS; SPERM; SPERMATOGENESIS; ANIMAL; CONGENITAL DISORDER; CPG ISLAND; ENZYMOLOGY; GENE EXPRESSION REGULATION; GENETIC EPIGENESIS; GENETICS; GROWTH, DEVELOPMENT AND AGING; METABOLISM; METHYLATION; SPERMATOZOON; TRANSGENIC MOUSE;

MUS MUSCULUS;

ANIMALS; CONGENITAL ABNORMALITIES; CPG ISLANDS; DNA METHYLATION; EPIGENESIS, GENETIC; FEMALE; GENE EXPRESSION REGULATION, DEVELOPMENTAL; HISTONE DEMETHYLASES; HISTONES; MALE; METHYLATION; MICE; MICE, TRANSGENIC; RNA, MESSENGER; SPERMATOGENESIS; SPERMATOZOA;

EID: 84947439531     PISSN: 00368075     EISSN: 10959203     Source Type: Journal    
DOI: 10.1126/science.aab2006     Document Type: Article

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