Use of physiologically based kinetic (PBK) modeling to study interindividual human variation and species differences in plasma concentrations of quercetin and its metabolites

Biochemical Pharmacology

Volumn 98, Issue 4, 2015, Pages 690-702

  Boonpawa, Rungnapa ^a   Moradi, Nooshin ^a   Spenkelink, Albertus ^a   Rietjens, Ivonne M C M ^a   Punt, Ans ^a  

^a WAGENINGEN UNIVERSITY   (Netherlands)

Author keywords

Absorption distribution metabolism excretion (ADME); Human variation; Physiologically based kinetic (PBK) modeling; Quercetin; Species differences

Indexed keywords

4' O METHYLQUERCETIN; DRUG METABOLITE; GLUCURONIC ACID; ISORHAMNETIN; QUERCETIN; QUERCETIN 3 O GLUCURONIDE; QUERCETIN 3' O GLUCURONIDE; QUERCETIN 3' O SULFATE; QUERCETIN 4' O GLUCURONIDE; QUERCETIN 7 O GLUCURONIDE; QUERCETIN 7 O SULFATE; QUERCETIN DIGLUCURONIDE; SULFATE; UNCLASSIFIED DRUG; QUERCETIN 3-O-GLUCURONIDE;

ADOLESCENT; ADULT; AGED; ANIMAL EXPERIMENT; ARTICLE; BILIARY EXCRETION; BODY WEIGHT; CHILD; CONTROLLED STUDY; DRUG BLOOD LEVEL; EXPERIMENTAL DESIGN; FEMALE; GLUCURONIDATION; HEART OUTPUT; HUMAN; HUMAN TISSUE; IN VITRO STUDY; INTESTINE BLOOD FLOW; KIDNEY BLOOD FLOW; KIDNEY SIZE; LIVER BLOOD FLOW; LIVER WEIGHT; MALE; METABOLIC PARAMETERS; METHYLATION; MICHAELIS MENTEN KINETICS; NONHUMAN; PHARMACOKINETIC ASSAY; PHARMACOKINETIC PARAMETERS; PHYSIOLOGICALLY BASED KINETIC MODEL; PREDICTION; PRIORITY JOURNAL; PROTEIN CONTENT; RAT; SENSITIVITY ANALYSIS; SMALL INTESTINE; SPECIES DIFFERENCE; SUBSTRATE CONCENTRATION; SULFATION; TISSUE BLOOD FLOW; URINARY EXCRETION; ANALOGS AND DERIVATIVES; ANIMAL; BIOLOGICAL MODEL; BLOOD; DRUG EFFECTS; INSECT; KINETICS; LIVER; METABOLISM; MIDDLE AGED; YOUNG ADULT;

ADOLESCENT; ADULT; AGED; ANIMALS; FEMALE; HUMANS; INSECTS; INTESTINE, SMALL; KINETICS; LIVER; MALE; MIDDLE AGED; MODELS, BIOLOGICAL; QUERCETIN; RATS; SPECIES SPECIFICITY; YOUNG ADULT;

EID: 84947258414     PISSN: 00062952     EISSN: 18732968     Source Type: Journal    
DOI: 10.1016/j.bcp.2015.09.022     Document Type: Article

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