Targeting rapamycin to podocytes using a vascular cell adhesion molecule-1 (VCAM-1)-harnessed SAINT-based lipid carrier system

PLoS ONE

Volumn 10, Issue 9, 2015, Pages

  Visweswaran, Ganesh Ram R ^a   Gholizadeh, Shima ^b   Ruiters, Marcel H J ^a   Molema, Grietje ^a   Kok, Robbert J ^b   Kamps, Jan A A M ^a  

^a UNIVERSITY MEDICAL CENTER GRONINGEN   (Netherlands)

^b UTRECHT UNIVERSITY   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

NANOCARRIER; RAPAMYCIN; TUMOR NECROSIS FACTOR ALPHA; VASCULAR CELL ADHESION MOLECULE 1; IMMUNOSUPPRESSIVE AGENT; LIPID; MONOCLONAL ANTIBODY; NANOCONJUGATE; TUMOR NECROSIS FACTOR;

AB13 CELL LINE; AB8 CELL LINE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ANTIGEN BINDING; ARTICLE; CELL MIGRATION; CONTROLLED STUDY; DRUG DELIVERY SYSTEM; ENDOCYTOSIS; GENE EXPRESSION; HUMAN; HUMAN CELL; IMMORTALIZED CELL LINE; INFLAMMATION; INTERNALIZATION; LIPID CARRIER SYSTEM; MALE; MOUSE; MPC 5 CELL LINE; NONHUMAN; PODOCYTE; PROTEIN EXPRESSION; ANIMAL; CELL DIFFERENTIATION; CELL LINE; CYTOLOGY; DRUG EFFECTS; GENETICS; METABOLISM;

ANIMALS; ANTIBODIES, MONOCLONAL; CELL DIFFERENTIATION; CELL LINE; GENE EXPRESSION; HUMANS; IMMUNOSUPPRESSIVE AGENTS; INFLAMMATION; LIPIDS; MALE; MICE; NANOCONJUGATES; PODOCYTES; SIROLIMUS; TUMOR NECROSIS FACTOR-ALPHA; VASCULAR CELL ADHESION MOLECULE-1;

EID: 84947256703     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0138870     Document Type: Article

References (24)

1. Leeuwis JW, Nguyen TQ, Dendooven A, Kok RJ, Goldschmeding R (2010) Targeting podocyte-associated diseases. Adv Drug Deliv Rev 62: 1325-1336. doi: 10.1016/j.addr.2010.08.012 PMID: 20828590
2. Siddiqi FS, Advani A (2013) Endothelial-podocyte crosstalk: the missing link between endothelial dysfunction and albuminuria in diabetes. Diabetes 62: 3647-3655. doi: 10.2337/db13-0795 PMID: 24158990
3. Haraldsson B, Jeansson M (2009) Glomerular filtration barrier. Curr Opin Nephrol Hypertens 18: 331-335. doi: 10.1097/MNH.0b013e32832c9dba PMID: 19458528
4. Chiang WC, Geel TM, Altintas MM, Sever S, Ruiters MH, Reiser J (2010) Establishment of protein delivery systems targeting podocytes. PLoS ONE 5: e11837. doi: 10.1371/journal.pone.0011837 PMID: 20686602
5. Hauser PV, Pippin JW, Kaiser C, Krofft RD, Brinkkoetter PT, Hudkins KL, et al. (2010) Novel siRNA delivery system to target podocytes in vivo. PLoS ONE 5: e9463. doi: 10.1371/journal.pone.0009463 PMID: 20209128
6. Canaud G, Bienaimé F, Viau A, Treins C, Baron W, Nguyen C, et al. (2013) AKT2 is essential to maintain podocyte viability and function during chronic kidney disease. Nat Med 19: 1288-1296. doi: 10.1038/nm.3313 PMID: 24056770
7. Fogo AB (2011) The targeted podocyte. J Clin Invest 121: 2142-2145. doi: 10.1172/JCI57935 PMID: 21606599
8. Kowalski PS, Lintermans LL, Morselt HW, Leus NG, Ruiters MH, Molema G, et al. (2013) Anti-VCAM-1 and anti-E-selectin SAINT-O-Somes for selective delivery of siRNA into inflammation-activated primary endothelial cells. Mol Pharm 10: 3033-3044. doi: 10.1021/mp4001124 PMID: 23819446
9. Adrian JE, Morselt HWM, Süss R, Barnert S, Kok JW, Asgeirsdóttir SA, et al. (2010) Targeted SAINTO-Somes for improved intracellular delivery of siRNA and cytotoxic drugs into endothelial cells. J Control Release 144: 341-349. doi: 10.1016/j.jconrel.2010.03.003 PMID: 20226822
10. Saleem MA, O'Hare MJ, Reiser J, Coward RJ, Inward CD, Farren T, et al. (2002) A conditionally immortalized human podocyte cell line demonstrating nephrin and podocin expression. J Am Soc Nephrol 13: 630-638. PMID: 11856766
11. Mundel P, Reiser J, Zúñiga Mejía Borja A, Pavenstädt H, Davidson GR, Kriz W, et al. (1997) Rearrangements of the cytoskeleton and cell contacts induce process formation during differentiation of conditionally immortalized mouse podocyte cell lines. Exp Cell Res 236: 248-258. PMID: 9344605
12. Jin E, Liu J, Suehiro J, Yuan L, Okada Y, Nikolova-Krstevski V, et al. (2009) Differential roles for ETS, CREB, and EGR binding sites in mediating VEGF receptor 1 expression in vivo. Blood 114: 5557-5566. doi: 10.1182/blood-2009-05-220434 PMID: 19822898
13. Böttcher CJF, Van gent CM (1961) A rapid and sensitive sub-micro phosphorus determination. Analytica Chimica Acta 24: 203-204.
14. Rouser G, Fkeischer S, Yamamoto A (1970) Two dimensional then layer chromatographic separation of polar lipids and determination of phospholipids by phosphorus analysis of spots. Lipids 5: 494-496. PMID: 5483450
15. Khattree N, Ritter LM, Goldberg AFX (2013) Membrane curvature generation by a C-terminal amphipathic helix in peripherin-2/rds, a tetraspanin required for photoreceptor sensory cilium morphogenesis. J Cell Sci 126: 4659-4670. doi: 10.1242/jcs.126888 PMID: 23886945
16. Vichai V, Kirtikara K (2006) Sulforhodamine B colorimetric assay for cytotoxicity screening. Nat Protocols 1: 1112-1116. PMID: 17406391
17. Ricard I, Payet MD, Dupuis G (1998) VCAM-1 is internalized by a clathrin-related pathway in human endothelial cells but its alpha 4 beta 1 integrin counter-receptor remains associated with the plasma membrane in human T lymphocytes. Eur J Immunol 28: 1708-1718. PMID: 9603478
18. Sapra P, Allen TM (2002) Internalizing antibodies are necessary for improved therapeutic efficacy of antibody-targeted liposomal drugs. Cancer Res 62: 7190-7194. PMID: 12499256
19. Vollenbröker B, George B, Wolfgart M, Saleem MA, Pavenstädt H, Weide T (2009) mTOR regulates expression of slit diaphragm proteins and cytoskeleton structure in podocytes. Am J Physiol Renal Physiol 296: F418-F426. doi: 10.1152/ajprenal.90319.2008 PMID: 19019920
20. Kułdo JM, Ásgeirsdóttir SA, Zwiers PJ, Bellu AR, Rots MG, Schalk JA, et al. (2013) Targeted adenovirus mediated inhibition of NF-κB-dependent inflammatory gene expression in endothelial cells in vitro and in vivo. J Control Release 166: 57-65. doi: 10.1016/j.jconrel.2012.12.016 PMID: 23266453
21. Gao H-X, Campbell SR, Burkly LC, Jakubowski A, Jarchum I, Banas B, et al. (2009) TNF-like weak inducer of apoptosis (TWEAK) induces inflammatory and proliferative effects in human kidney cells. Cytokine 46: 24-35. doi: 10.1016/j.cyto.2008.12.001 PMID: 19233685
22. Kowalski PS, Zwiers PJ, Morselt HW, Kuldo JM, Leus NG, Ruiters MH, et al. (2014) Anti-VCAM-1 SAINT-O-Somes enable endothelial-specific delivery of siRNA and downregulation of inflammatory genes in activated endothelium in vivo. J. Control. Rel. 176: 64-75.
23. Asgeirsdóttir SA, van Solingen C, Kurniati NF, Zwiers PJ, Heeringa P, van Meurs M, et al. (2012) Micro-RNA-126 contributes to renal microvascular heterogeneity of VCAM-1 protein expression in acute inflammation. Am J Physiol Renal Physiol 302: F1630-F1639. doi: 10.1152/ajprenal.00400.2011 PMID: 22419694
24. Ásgeirsdóttir SA, Zwiers PJ, Morselt HWM, Moorlag HE, Bakker HI, Heeringa P, et al. (2008) Inhibition of proinflammatory genes in anti-GBM glomerulonephritis by targeted dexamethasone-loaded AbEsel liposomes. Am. J. Physiol.: Renal Physiol 294: F554-F561.