Establishment of protein delivery systems targeting podocytes

PLoS ONE

Volumn 5, Issue 7, 2010, Pages

  Chiang, Wen Chih ^a,b   Geel, Tessa M ^c   Altintas, Mehmet M ^d   Sever, Sanja ^a   Ruiters, Marcel H J ^e   Reiser, Jochen ^a,d  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

^b NATIONAL TAIWAN UNIVERSITY HOSPITAL   (Taiwan)

^c UNIVERSITY OF GRONINGEN   (Netherlands)

^d UNIVERSITY OF MIAMI MILLER SCHOOL OF MEDICINE   (United States)

^e Synvolux Therapeutics Inc   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

BETA GALACTOSIDASE; DRUG CARRIER; DYNAMIN; IMMUNOGLOBULIN G; LIPID; PUROMYCIN; RESTRICTION ENDONUCLEASE; RESTRICTION ENDONUCLEASE MUNI; UNCLASSIFIED DRUG; ANTINEOPLASTIC ANTIMETABOLITE; IMMUNOGLOBULIN; PROTEIN; PUROMYCIN AMINONUCLEOSIDE;

ANIMAL CELL; ANTIBODY LABELING; ARTICLE; CELL DIFFERENTIATION; CELL STRAIN 3T3; COATED PARTICLE; CONTROLLED STUDY; DNA DEGRADATION; DNA FRAGMENTATION; DRUG DELIVERY SYSTEM; ENZYME SUBSTRATE; EXTRACELLULAR MATRIX; MOUSE; NONHUMAN; PODOCYTE; PROCESS OPTIMIZATION; PROFECTION; PROTEIN FOLDING; PROTEIN PURIFICATION; PROTEIN RESTRICTION; PROTEIN STRUCTURE; ANIMAL; DRUG EFFECT; FLOW CYTOMETRY; METABOLISM;

MAMMALIA;

ANIMALS; ANTIMETABOLITES, ANTINEOPLASTIC; BETA-GALACTOSIDASE; DYNAMINS; FLOW CYTOMETRY; IMMUNOGLOBULINS; MICE; NIH 3T3 CELLS; PODOCYTES; PROTEINS; PUROMYCIN AMINONUCLEOSIDE;

EID: 77955590203     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0011837     Document Type: Article

References (19)

1. Kestilä M, Lenkkeri U, Männikkö M, Lamerdin J, McCready P, et al. (1998) Positionally cloned gene for a novel glomerular protein-nephrin- is mutated in congenital nephritic syndrome. Mol Cell 1: 575-582.
2. Boute N, Gribouval O, Roselli S, Benessy F, Lee H, et al. (2000) NPHS2,encoding the glomerular protein podocin, is mutated in autosomal recessive steroid-resistant nephrotic syndrome. Nat Genet 24: 349-354.
3. Kaplan JM, Kim SH, North KN, Rennke H, Correia LA, et al. (2000) Mutations in ACTN4, encoding alpha-actinin-4, cause familial focal segmental glomerulosclerosis. Nat Genet 24(3): 251-256.
4. Winn MP, Conlon PJ, Lynn KL, Farrington MK, Creazzo T, et al. (2005) A mutation in the TRPC6 cation channel causes familial focal segmental glomerulosclerosis. Science 308: 1801-1804.
5. Reiser J, Polu KR, Moller CC, Kenlan P, Altintas MM, et al. (2005) TRPC6 is a glomerular slit diaphragm-associated channel required for normal renal function. Nat Genet 37: 739-744.
6. Sever S, Altintas MM, Nankoe SR, Möller CC, Ko D, et al. (2007) Proteolytic processing of dynamin by cytoplasmic cathepsin L is a mechanism for proteinuric kidney disease. J Clin Invest 117: 2095-2104.
7. Wei C, Mö ller CC, Altintas MM, Li J, Schwarz K, et al. (2008) Modification of kidney barrier function by the urokinase receptor. Nat Med 4: 55-63.
8. Banfi B, Maturana A, Jaconi S, Arnaudeau S, Laforge T, et al. (2000) A mammalian H+channel generated through alternative splicing of the NADPH oxidase homolog NOH-1. Science 287: 138-142.
9. van der Gun BT, Monami A, Laarmann S, Rasko T, Slaska-Kiss K, et al. (2007) Serum insensitive, intranuclear protein delivery by the multipurpose cationic lipid SAINT-2. J Control Release 123: 228-238.
10. Mundel P, Reiser J (2009) Proteinuria: an enzymatic disease of the podocyte? Kidney Int 77: 571-580.
11. Faul C, Donnelly M, Merscher-Gomez S, Chang YH, Franz S, et al. (2008) The actin cytoskeleton of kidney podocytes is a direct target of the antiproteinuric effect of cyclosporine A. Nat Med 14: 931-938.
12. Frankel AD, Pabo CO (1988) Cellular uptake of the Tat protein from human immunodeficiency virus. Cell 55: 1189-1193.
13. Joliot A, Pernelle C, Deagostini-Bazin H, Prochiantz A (1991) Antennapedia homeobox peptide regulates neural morphogenesis. Proc Natl Acad Sci USA 88: 1864-1868.
14. Elliott G, O'Hare H (1997) Intercellular trafficking and protein delivery by a herpesvirus structural protein. Cell 88: 223-233.
15. Hirakura T, Yasugi K, Nemoto T, Sato M, Shimoboji T, et al. (2010) Hybrid hyaluronan hydrogel encapsulating nanogel as a protein nanocarrier: New system for sustained delivery of protein with a chaperone-like function. J Control Release 142: 483-489.
16. Hasegawa U, Sawada S, Shimizu T, Kishida T, Otsuji E, et al. (2009) Raspberry-like assembly of cross-linked nanogels for protein delivery. J Control Release 140: 312-317.
17. Schwarze SR, Hruska KA, Dowdy SF (2000) Protein transduction: unrestricted delivery into all cells? Trends Cell Biol 10: 290-295.
18. Hartleben B, Gödel M, Meyer-Schwesinger C, Liu S, Ulrich T, et al. (2010) Autophagy influences glomerular disease susceptibility and maintains podocyte homeostasis in aging mice. J Clin Invest 120: 1084-1096.
19. Geel TM, Meiss G, van der Gun BT, Kroesen BJ, de Leij LF, et al. (2009) Endonucleases induced TRAIL-insensitive apoptosis in ovarian carcinoma cells. Exp Cell Res 315: 2487-2495.