메뉴 건너뛰기




Volumn 34, Issue 3, 2016, Pages 711-719

Transforming growth factor-β-induced KDM4B promotes chondrogenic differentiation of human mesenchymal stem cells

Author keywords

Chondrogenesis; Differentiation; KDM4B; Mesenchymal stem cells; SOX9; Transforming growth factor

Indexed keywords

KDM4B PROTEIN; PROTEIN; SHORT HAIRPIN RNA; SMAD3 PROTEIN; TRANSCRIPTION FACTOR SOX9; TRANSFORMING GROWTH FACTOR BETA; UNCLASSIFIED DRUG; HISTONE DEMETHYLASE; KDM4B PROTEIN, HUMAN; SMAD3 PROTEIN, HUMAN; SOX9 PROTEIN, HUMAN;

EID: 84947251698     PISSN: 10665099     EISSN: 15494918     Source Type: Journal    
DOI: 10.1002/stem.2231     Document Type: Article
Times cited : (57)

References (54)
  • 1
    • 77950551326 scopus 로고    scopus 로고
    • Mesenchymal stromal cells: Current understanding and clinical status
    • Salem HK, Thiemermann C,. Mesenchymal stromal cells: Current understanding and clinical status. Stem Cells 2010; 28: 585-596.
    • (2010) Stem Cells , vol.28 , pp. 585-596
    • Salem, H.K.1    Thiemermann, C.2
  • 2
    • 70349413284 scopus 로고    scopus 로고
    • Phenotypic characterization, osteoblastic differentiation, and bone regeneration capacity of human embryonic stem cell-derived mesenchymal stem cells
    • Arpornmaeklong P, Brown SE, Wang Z, et al., Phenotypic characterization, osteoblastic differentiation, and bone regeneration capacity of human embryonic stem cell-derived mesenchymal stem cells. Stem Cells Dev 2009; 18: 955-968.
    • (2009) Stem Cells Dev , vol.18 , pp. 955-968
    • Arpornmaeklong, P.1    Brown, S.E.2    Wang, Z.3
  • 3
    • 34247587041 scopus 로고    scopus 로고
    • Mesenchymal stromal cells. Biology of adult mesenchymal stem cells: Regulation of niche, self-renewal and differentiation
    • Kolf CM, Cho E, Tuan RS,. Mesenchymal stromal cells. Biology of adult mesenchymal stem cells: regulation of niche, self-renewal and differentiation. Arthritis Res Ther 2007; 9: 204.
    • (2007) Arthritis Res Ther , vol.9 , pp. 204
    • Kolf, C.M.1    Cho, E.2    Tuan, R.S.3
  • 4
    • 0035253558 scopus 로고    scopus 로고
    • Repair of large bone defects with the use of autologous bone marrow stromal cells
    • Quarto R, Mastrogiacomo M, Cancedda R, et al., Repair of large bone defects with the use of autologous bone marrow stromal cells. N Engl J Med 2001; 344: 385-386.
    • (2001) N Engl J Med , vol.344 , pp. 385-386
    • Quarto, R.1    Mastrogiacomo, M.2    Cancedda, R.3
  • 5
    • 0031661022 scopus 로고    scopus 로고
    • Articular cartilage: Injuries and potential for healing
    • Buckwalter JA,. Articular cartilage: Injuries and potential for healing. J Orthop Sports Phys Ther 1998; 28: 192-202.
    • (1998) J Orthop Sports Phys Ther , vol.28 , pp. 192-202
    • Buckwalter, J.A.1
  • 6
    • 0036680533 scopus 로고    scopus 로고
    • Tissue engineering: Advances in in vitro cartilage generation
    • Risbud MV, Sittinger M,. Tissue engineering: Advances in in vitro cartilage generation. Trends Biotechnol 2002; 20: 351-356.
    • (2002) Trends Biotechnol , vol.20 , pp. 351-356
    • Risbud, M.V.1    Sittinger, M.2
  • 7
    • 0036184589 scopus 로고    scopus 로고
    • Human autologous culture expanded bone marrow mesenchymal cell transplantation for repair of cartilage defects in osteoarthritic knees
    • Wakitani S, Imoto K, Yamamoto T, et al., Human autologous culture expanded bone marrow mesenchymal cell transplantation for repair of cartilage defects in osteoarthritic knees. Osteoarthritis Cartilage 2002; 10: 199-206.
    • (2002) Osteoarthritis Cartilage , vol.10 , pp. 199-206
    • Wakitani, S.1    Imoto, K.2    Yamamoto, T.3
  • 8
    • 77957845081 scopus 로고    scopus 로고
    • Bone marrow mesenchymal stem cells: Historical overview and concepts
    • Charbord P,. Bone marrow mesenchymal stem cells: Historical overview and concepts. Hum Gene Ther 2010; 21: 1045-1056.
    • (2010) Hum Gene Ther , vol.21 , pp. 1045-1056
    • Charbord, P.1
  • 9
    • 84890384748 scopus 로고    scopus 로고
    • Immunophenotypic comparison of heterogenous non-sorted versus sorted mononuclear cells from human umbilical cord blood: A novel cell enrichment approach
    • Indumathi S, Harikrishnan R, Rajkumar JS, et al., Immunophenotypic comparison of heterogenous non-sorted versus sorted mononuclear cells from human umbilical cord blood: A novel cell enrichment approach. Cytotechnology 2015; 67: 107-114.
    • (2015) Cytotechnology , vol.67 , pp. 107-114
    • Indumathi, S.1    Harikrishnan, R.2    Rajkumar, J.S.3
  • 10
    • 84873828780 scopus 로고    scopus 로고
    • Human embryonic stem cell-derived mesenchymal stroma cells (hES-MSCs) engraft in vivo and support hematopoiesis without suppressing immune function: Implications for off-the shelf ES-MSC therapies
    • Li O, Tormin A, Sundberg B, et al., Human embryonic stem cell-derived mesenchymal stroma cells (hES-MSCs) engraft in vivo and support hematopoiesis without suppressing immune function: implications for off-the shelf ES-MSC therapies. PLoS One 2013; 8: e55319.
    • (2013) PLoS One , vol.8 , pp. e55319
    • Li, O.1    Tormin, A.2    Sundberg, B.3
  • 11
    • 33646365065 scopus 로고    scopus 로고
    • Chondrogenic differentiation of mesenchymal stem cells isolated from patients in late adulthood: The optimal conditions of growth factors
    • Im GI, Jung NH, Tae SK,. Chondrogenic differentiation of mesenchymal stem cells isolated from patients in late adulthood: the optimal conditions of growth factors. Tissue Eng 2006; 12: 527-536.
    • (2006) Tissue Eng , vol.12 , pp. 527-536
    • Im, G.I.1    Jung, N.H.2    Tae, S.K.3
  • 12
    • 70350351398 scopus 로고    scopus 로고
    • Transforming growth factors beta coordinate cartilage and tendon differentiation in the developing limb mesenchyme
    • Lorda-Diez CI, Montero JA, Martinez-Cue C, et al., Transforming growth factors beta coordinate cartilage and tendon differentiation in the developing limb mesenchyme. J Biol Chem 2009; 284: 29988-29996.
    • (2009) J Biol Chem , vol.284 , pp. 29988-29996
    • Lorda-Diez, C.I.1    Montero, J.A.2    Martinez-Cue, C.3
  • 13
    • 70249124606 scopus 로고    scopus 로고
    • Controlled growth factor delivery for tissue engineering
    • Tayalia P, Mooney DJ,. Controlled growth factor delivery for tissue engineering. Adv Mater 2009; 21: 3269-3285.
    • (2009) Adv Mater , vol.21 , pp. 3269-3285
    • Tayalia, P.1    Mooney, D.J.2
  • 14
    • 0031438047 scopus 로고    scopus 로고
    • TGF-beta signalling from cell membrane to nucleus through SMAD proteins
    • Heldin CH, Miyazono K, ten Dijke P,. TGF-beta signalling from cell membrane to nucleus through SMAD proteins. Nature 1997; 390: 465-471.
    • (1997) Nature , vol.390 , pp. 465-471
    • Heldin, C.H.1    Miyazono, K.2    Ten Dijke, P.3
  • 15
    • 0142104985 scopus 로고    scopus 로고
    • Smad-dependent and Smad-independent pathways in TGF-beta family signalling
    • Derynck R, Zhang YE,. Smad-dependent and Smad-independent pathways in TGF-beta family signalling. Nature 2003; 425: 577-584.
    • (2003) Nature , vol.425 , pp. 577-584
    • Derynck, R.1    Zhang, Y.E.2
  • 16
    • 0024994768 scopus 로고
    • The transforming growth factor-betas: Past, present, and future
    • Sporn MB, Roberts AB,. The transforming growth factor-betas: Past, present, and future. Ann N Y Acad Sci 1990; 593: 1-6.
    • (1990) Ann N y Acad Sci , vol.593 , pp. 1-6
    • Sporn, M.B.1    Roberts, A.B.2
  • 17
    • 0031104994 scopus 로고    scopus 로고
    • SOX9 binds DNA, activates transcription, and coexpresses with type II collagen during chondrogenesis in the mouse
    • Ng LJ, Wheatley S, Muscat GE, et al., SOX9 binds DNA, activates transcription, and coexpresses with type II collagen during chondrogenesis in the mouse. Dev Biol 1997; 183: 108-121.
    • (1997) Dev Biol , vol.183 , pp. 108-121
    • Ng, L.J.1    Wheatley, S.2    Muscat, G.E.3
  • 18
    • 0345711458 scopus 로고    scopus 로고
    • Sox9 is required for cartilage formation
    • Bi W, Deng JM, Zhang Z, et al., Sox9 is required for cartilage formation. Nat Genet 1999; 22: 85-89.
    • (1999) Nat Genet , vol.22 , pp. 85-89
    • Bi, W.1    Deng, J.M.2    Zhang, Z.3
  • 19
    • 0034846904 scopus 로고    scopus 로고
    • L-Sox5, Sox6 and Sox9 control essential steps of the chondrocyte differentiation pathway
    • Lefebvre V, Behringer RR, de Crombrugghe B,. L-Sox5, Sox6 and Sox9 control essential steps of the chondrocyte differentiation pathway. Osteoarthritis Cartilage 2001; 9 (Suppl A): S69-S75.
    • (2001) Osteoarthritis Cartilage , vol.9 , pp. S69-S75
    • Lefebvre, V.1    Behringer, R.R.2    De Crombrugghe, B.3
  • 20
    • 8444233948 scopus 로고    scopus 로고
    • The combination of SOX5, SOX6, and SOX9 (the SOX trio) provides signals sufficient for induction of permanent cartilage
    • Ikeda T, Kamekura S, Mabuchi A, et al., The combination of SOX5, SOX6, and SOX9 (the SOX trio) provides signals sufficient for induction of permanent cartilage. Arthritis Rheum 2004; 50: 3561-3573.
    • (2004) Arthritis Rheum , vol.50 , pp. 3561-3573
    • Ikeda, T.1    Kamekura, S.2    Mabuchi, A.3
  • 21
    • 49449100695 scopus 로고    scopus 로고
    • L-Sox5 and Sox6 drive expression of the aggrecan gene in cartilage by securing binding of Sox9 to a far-upstream enhancer
    • Han Y, Lefebvre V,. L-Sox5 and Sox6 drive expression of the aggrecan gene in cartilage by securing binding of Sox9 to a far-upstream enhancer. Mol Cell Biol 2008; 28: 4999-5013.
    • (2008) Mol Cell Biol , vol.28 , pp. 4999-5013
    • Han, Y.1    Lefebvre, V.2
  • 22
    • 78650270964 scopus 로고    scopus 로고
    • Beyond genetics: Epigenetic code in chronic kidney disease
    • Dwivedi RS, Herman JG, McCaffrey TA, et al., Beyond genetics: Epigenetic code in chronic kidney disease. Kidney Int 2011; 79: 23-32.
    • (2011) Kidney Int , vol.79 , pp. 23-32
    • Dwivedi, R.S.1    Herman, J.G.2    McCaffrey, T.A.3
  • 23
    • 4444285764 scopus 로고    scopus 로고
    • Beyond genetics - The emerging role of epigenetic changes in hematopoietic malignancies
    • Galm O, Esteller M,. Beyond genetics-The emerging role of epigenetic changes in hematopoietic malignancies. Int J Hematol 2004; 80: 120-127.
    • (2004) Int J Hematol , vol.80 , pp. 120-127
    • Galm, O.1    Esteller, M.2
  • 24
    • 84873909398 scopus 로고    scopus 로고
    • Genetic and epigenetic variants influencing the development of nonalcoholic fatty liver disease
    • Li YY,. Genetic and epigenetic variants influencing the development of nonalcoholic fatty liver disease. World J Gastroenterol 2012; 18: 6546-6551.
    • (2012) World J Gastroenterol , vol.18 , pp. 6546-6551
    • Li, Y.Y.1
  • 25
    • 70649099225 scopus 로고    scopus 로고
    • Epigenetic signatures associated with different levels of differentiation potential in human stem cells
    • Aranda P, Agirre X, Ballestar E, et al., Epigenetic signatures associated with different levels of differentiation potential in human stem cells. PLoS One 2009; 4: e7809.
    • (2009) PLoS One , vol.4 , pp. e7809
    • Aranda, P.1    Agirre, X.2    Ballestar, E.3
  • 26
    • 33746055381 scopus 로고    scopus 로고
    • Epigenetic conversion of human adult bone mesodermal stromal cells into neuroectodermal cell types for replacement therapy of neurodegenerative disorders
    • Hermann A, Maisel M, Storch A,. Epigenetic conversion of human adult bone mesodermal stromal cells into neuroectodermal cell types for replacement therapy of neurodegenerative disorders. Expert Opin Biol Ther 2006; 6: 653-670.
    • (2006) Expert Opin Biol Ther , vol.6 , pp. 653-670
    • Hermann, A.1    Maisel, M.2    Storch, A.3
  • 27
    • 80052719188 scopus 로고    scopus 로고
    • Epigenetic regulation of mesenchymal stem cells: A focus on osteogenic and adipogenic differentiation
    • Teven CM, Liu X, Hu N, et al., Epigenetic regulation of mesenchymal stem cells: A focus on osteogenic and adipogenic differentiation. Stem Cells Int 2011; 2011: 201371.
    • (2011) Stem Cells Int , vol.2011 , pp. 201371
    • Teven, C.M.1    Liu, X.2    Hu, N.3
  • 28
    • 44149105533 scopus 로고    scopus 로고
    • The emerging functions of histone demethylases
    • Agger K, Christensen J, Cloos PA, et al., The emerging functions of histone demethylases. Curr Opin Genet Dev 2008; 18: 159-168.
    • (2008) Curr Opin Genet Dev , vol.18 , pp. 159-168
    • Agger, K.1    Christensen, J.2    Cloos, P.A.3
  • 29
    • 33747455678 scopus 로고    scopus 로고
    • JmjC-domain-containing proteins and histone demethylation
    • Klose RJ, Kallin EM, Zhang Y,. JmjC-domain-containing proteins and histone demethylation. Nat Rev Genet 2006; 7: 715-727.
    • (2006) Nat Rev Genet , vol.7 , pp. 715-727
    • Klose, R.J.1    Kallin, E.M.2    Zhang, Y.3
  • 30
    • 35349006314 scopus 로고    scopus 로고
    • Histone lysine demethylases: Emerging roles in development, physiology and disease
    • Shi Y,. Histone lysine demethylases: Emerging roles in development, physiology and disease. Nat Rev Genet 2007; 8: 829-833.
    • (2007) Nat Rev Genet , vol.8 , pp. 829-833
    • Shi, Y.1
  • 31
    • 84863633423 scopus 로고    scopus 로고
    • Histone demethylases KDM4B and KDM6B promotes osteogenic differentiation of human MSCs
    • Ye L, Fan Z, Yu B, et al., Histone demethylases KDM4B and KDM6B promotes osteogenic differentiation of human MSCs. Cell Stem Cell 2012; 11: 50-61.
    • (2012) Cell Stem Cell , vol.11 , pp. 50-61
    • Ye, L.1    Fan, Z.2    Yu, B.3
  • 32
    • 33745146571 scopus 로고    scopus 로고
    • Jmjd2b antagonizes H3K9 trimethylation at pericentric heterochromatin in mammalian cells
    • Fodor BD, Kubicek S, Yonezawa M, et al., Jmjd2b antagonizes H3K9 trimethylation at pericentric heterochromatin in mammalian cells. Genes Dev 2006; 20: 1557-1562.
    • (2006) Genes Dev , vol.20 , pp. 1557-1562
    • Fodor, B.D.1    Kubicek, S.2    Yonezawa, M.3
  • 33
    • 33746332412 scopus 로고    scopus 로고
    • The putative oncogene GASC1 demethylates tri- and dimethylated lysine 9 on histone H3
    • Cloos PA, Christensen J, Agger K, et al., The putative oncogene GASC1 demethylates tri- and dimethylated lysine 9 on histone H3. Nature 2006; 442: 307-311.
    • (2006) Nature , vol.442 , pp. 307-311
    • Cloos, P.A.1    Christensen, J.2    Agger, K.3
  • 34
    • 33646124469 scopus 로고    scopus 로고
    • Reversal of histone lysine trimethylation by the JMJD2 family of histone demethylases
    • Whetstine JR, Nottke A, Lan F, et al., Reversal of histone lysine trimethylation by the JMJD2 family of histone demethylases. Cell 2006; 125: 467-481.
    • (2006) Cell , vol.125 , pp. 467-481
    • Whetstine, J.R.1    Nottke, A.2    Lan, F.3
  • 35
    • 79952200535 scopus 로고    scopus 로고
    • Derivation of mesenchymal stem cells from human embryonic stem cells
    • Choo A, Lim SK,. Derivation of mesenchymal stem cells from human embryonic stem cells. Methods Mol Biol 2011; 690: 175-182.
    • (2011) Methods Mol Biol , vol.690 , pp. 175-182
    • Choo, A.1    Lim, S.K.2
  • 36
    • 77950991204 scopus 로고    scopus 로고
    • In vitro high-capacity assay to quantify the clonal heterogeneity in trilineage potential of mesenchymal stem cells reveals a complex hierarchy of lineage commitment
    • Russell KC, Phinney DG, Lacey MR, et al., In vitro high-capacity assay to quantify the clonal heterogeneity in trilineage potential of mesenchymal stem cells reveals a complex hierarchy of lineage commitment. Stem Cells 2010; 28: 788-798.
    • (2010) Stem Cells , vol.28 , pp. 788-798
    • Russell, K.C.1    Phinney, D.G.2    Lacey, M.R.3
  • 37
    • 68249129007 scopus 로고    scopus 로고
    • BCOR regulates mesenchymal stem cell function by epigenetic mechanisms
    • Fan Z, Yamaza T, Lee JS, et al., BCOR regulates mesenchymal stem cell function by epigenetic mechanisms. Nat Cell Biol 2009; 11: 1002-1009.
    • (2009) Nat Cell Biol , vol.11 , pp. 1002-1009
    • Fan, Z.1    Yamaza, T.2    Lee, J.S.3
  • 38
    • 33846049299 scopus 로고    scopus 로고
    • NF-kappaB in breast cancer cells promotes osteolytic bone metastasis by inducing osteoclastogenesis via GM-CSF
    • Park BK, Zhang H, Zeng Q, et al., NF-kappaB in breast cancer cells promotes osteolytic bone metastasis by inducing osteoclastogenesis via GM-CSF. Nat Med 2007; 13: 62-69.
    • (2007) Nat Med , vol.13 , pp. 62-69
    • Park, B.K.1    Zhang, H.2    Zeng, Q.3
  • 39
    • 32344450824 scopus 로고    scopus 로고
    • Genomic DNA methylation: The mark and its mediators
    • Klose RJ, Bird AP,. Genomic DNA methylation: The mark and its mediators. Trends Biochem Sci 2006; 31: 89-97.
    • (2006) Trends Biochem Sci , vol.31 , pp. 89-97
    • Klose, R.J.1    Bird, A.P.2
  • 40
    • 27444436736 scopus 로고    scopus 로고
    • Sox9 and p300 cooperatively regulate chromatin-mediated transcription
    • Furumatsu T, Tsuda M, Yoshida K, et al., Sox9 and p300 cooperatively regulate chromatin-mediated transcription. J Biol Chem 2005; 280: 35203-35208.
    • (2005) J Biol Chem , vol.280 , pp. 35203-35208
    • Furumatsu, T.1    Tsuda, M.2    Yoshida, K.3
  • 41
    • 44349118589 scopus 로고    scopus 로고
    • Transcriptional regulation of chondrogenesis by coactivator Tip60 via chromatin association with Sox9 and Sox5
    • Hattori T, Coustry F, Stephens S, et al., Transcriptional regulation of chondrogenesis by coactivator Tip60 via chromatin association with Sox9 and Sox5. Nucleic Acids Res 2008; 36: 3011-3024.
    • (2008) Nucleic Acids Res , vol.36 , pp. 3011-3024
    • Hattori, T.1    Coustry, F.2    Stephens, S.3
  • 42
    • 0037697096 scopus 로고    scopus 로고
    • Transcriptional co-activators CREB-binding protein and p300 regulate chondrocyte-specific gene expression via association with Sox9
    • Tsuda M, Takahashi S, Takahashi Y, et al., Transcriptional co-activators CREB-binding protein and p300 regulate chondrocyte-specific gene expression via association with Sox9. J Biol Chem 2003; 278: 27224-27229.
    • (2003) J Biol Chem , vol.278 , pp. 27224-27229
    • Tsuda, M.1    Takahashi, S.2    Takahashi, Y.3
  • 43
    • 34347273763 scopus 로고    scopus 로고
    • Transcriptional activation of cartilage oligomeric matrix protein by Sox9, Sox5, and Sox6 transcription factors and CBP/p300 coactivators
    • Liu CJ, Zhang Y, Xu K, et al., Transcriptional activation of cartilage oligomeric matrix protein by Sox9, Sox5, and Sox6 transcription factors and CBP/p300 coactivators. Front Biosci 2007; 12: 3899-3910.
    • (2007) Front Biosci , vol.12 , pp. 3899-3910
    • Liu, C.J.1    Zhang, Y.2    Xu, K.3
  • 44
    • 84901322964 scopus 로고    scopus 로고
    • Arid5b facilitates chondrogenesis by recruiting the histone demethylase Phf2 to Sox9-regulated genes
    • Hata K, Takashima R, Amano K, et al., Arid5b facilitates chondrogenesis by recruiting the histone demethylase Phf2 to Sox9-regulated genes. Nat Commun 2013; 4: 2850.
    • (2013) Nat Commun , vol.4 , pp. 2850
    • Hata, K.1    Takashima, R.2    Amano, K.3
  • 45
    • 84876738726 scopus 로고    scopus 로고
    • Changes in the epigenetic status of the SOX-9 promoter in human osteoarthritic cartilage
    • Kim K, K. I., Park YS, Im GI,. Changes in the epigenetic status of the SOX-9 promoter in human osteoarthritic cartilage. J Bone Miner Res 2013; 28: 1050-1060.
    • (2013) J Bone Miner Res , vol.28 , pp. 1050-1060
    • Kim, K.1    Park, Y.S.2    Im, G.I.3
  • 46
    • 84873732990 scopus 로고    scopus 로고
    • Genome-wide map of quantified epigenetic changes during in vitro chondrogenic differentiation of primary human mesenchymal stem cells
    • Herlofsen SR, Bryne JC, Hoiby T, et al., Genome-wide map of quantified epigenetic changes during in vitro chondrogenic differentiation of primary human mesenchymal stem cells. BMC Genomics 2013; 14: 105.
    • (2013) BMC Genomics , vol.14 , pp. 105
    • Herlofsen, S.R.1    Bryne, J.C.2    Hoiby, T.3
  • 47
    • 63449115501 scopus 로고    scopus 로고
    • Multiple recurrent genetic events converge on control of histone lysine methylation in medulloblastoma
    • Northcott PA, Nakahara Y, Wu X, et al., Multiple recurrent genetic events converge on control of histone lysine methylation in medulloblastoma. Nat Genet 2009; 41: 465-472.
    • (2009) Nat Genet , vol.41 , pp. 465-472
    • Northcott, P.A.1    Nakahara, Y.2    Wu, X.3
  • 48
    • 84855876194 scopus 로고    scopus 로고
    • Histone demethylase JMJD2B is required for tumor cell proliferation and survival and is overexpressed in gastric cancer
    • Li W, Zhao L, Zang W, et al., Histone demethylase JMJD2B is required for tumor cell proliferation and survival and is overexpressed in gastric cancer. Biochem Biophys Res Commun 2011; 416: 372-378.
    • (2011) Biochem Biophys Res Commun , vol.416 , pp. 372-378
    • Li, W.1    Zhao, L.2    Zang, W.3
  • 49
    • 83055162300 scopus 로고    scopus 로고
    • The histone demethylase JMJD2B plays an essential role in human carcinogenesis through positive regulation of cyclin-dependent kinase 6
    • Toyokawa G, Cho HS, Iwai Y, et al., The histone demethylase JMJD2B plays an essential role in human carcinogenesis through positive regulation of cyclin-dependent kinase 6. Cancer Prev Res 2011; 4: 2051-2061.
    • (2011) Cancer Prev Res , vol.4 , pp. 2051-2061
    • Toyokawa, G.1    Cho, H.S.2    Iwai, Y.3
  • 50
    • 84865536482 scopus 로고    scopus 로고
    • HIF-1alpha-induced histone demethylase JMJD2B contributes to the malignant phenotype of colorectal cancer cells via an epigenetic mechanism
    • Fu L, Chen L, Yang J, et al., HIF-1alpha-induced histone demethylase JMJD2B contributes to the malignant phenotype of colorectal cancer cells via an epigenetic mechanism. Carcinogenesis 2012; 33: 1664-1673.
    • (2012) Carcinogenesis , vol.33 , pp. 1664-1673
    • Fu, L.1    Chen, L.2    Yang, J.3
  • 51
    • 67650506105 scopus 로고    scopus 로고
    • TGF-beta1-induced migration of bone mesenchymal stem cells couples bone resorption with formation
    • Tang Y, Wu X, Lei W, et al., TGF-beta1-induced migration of bone mesenchymal stem cells couples bone resorption with formation. Nat Med 2009; 15: 757-765.
    • (2009) Nat Med , vol.15 , pp. 757-765
    • Tang, Y.1    Wu, X.2    Lei, W.3
  • 52
    • 78650018824 scopus 로고    scopus 로고
    • Conversion of vascular endothelial cells into multipotent stem-like cells
    • Medici D, Shore EM, Lounev VY, et al., Conversion of vascular endothelial cells into multipotent stem-like cells. Nat Med 2010; 16: 1400-1406.
    • (2010) Nat Med , vol.16 , pp. 1400-1406
    • Medici, D.1    Shore, E.M.2    Lounev, V.Y.3
  • 53
    • 77950685384 scopus 로고    scopus 로고
    • Gs signaling in osteoblasts and hematopoietic stem cells
    • Kronenberg HM,. Gs signaling in osteoblasts and hematopoietic stem cells. Ann N Y Acad Sci 2010; 1192: 327-329.
    • (2010) Ann N y Acad Sci , vol.1192 , pp. 327-329
    • Kronenberg, H.M.1
  • 54
    • 77954608305 scopus 로고    scopus 로고
    • Harnessing traction-mediated manipulation of the cell/matrix interface to control stem-cell fate
    • Huebsch N, Arany PR, Mao AS, et al., Harnessing traction-mediated manipulation of the cell/matrix interface to control stem-cell fate. Nat Mater 2010; 9: 518-526.
    • (2010) Nat Mater , vol.9 , pp. 518-526
    • Huebsch, N.1    Arany, P.R.2    Mao, A.S.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.