Protective HSP70 induction by Z-ligustilide against oxygen-glucose deprivation injury via activation of the MAPK pathway but not of HSF1

Biological and Pharmaceutical Bulletin

Volumn 38, Issue 10, 2015, Pages 1564-1572

  Yu, Jie ^a   Jiang, Zhuyun ^a   Ning, Ling ^a   Zhao, Zhilong ^b   Yang, Na ^b   Chen, Lu ^a   Ma, Hui ^a   Li, Li ^c   Fu, Ya ^c   Zhu, Huifeng ^a   Qi, Hongyi ^a  

^a SOUTHWEST UNIVERSITY   (China)

^b SICHUAN PROVINCIAL PEOPLE'S HOSPITAL   (China)

^c CHONGQING UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

Author keywords

Heat shock factor 1; Heat shock protein 70; Mitogen activated protein kinase; Oxygen glucose deprivation reoxygenation; Z ligustilide

Indexed keywords

GLUCOSE; HEAT SHOCK PROTEIN 70; HEAT SHOCK TRANSCRIPTION FACTOR 1; KNK 437; LIGUSTILIDE; LUCIFERASE; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE INHIBITOR; OLIGONUCLEOTIDE; OXYGEN; PROTEIN SYNTHESIS INHIBITOR; SHORT HAIRPIN RNA; UBIQUITINATED PROTEIN; UNCLASSIFIED DRUG; 2 PYRROLIDONE DERIVATIVE; BENZHYDRYL DERIVATIVE; GAMMA BUTYROLACTONE; NEUROPROTECTIVE AGENT; SMALL INTERFERING RNA;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; BRAIN INFARCTION SIZE; BRAIN INJURY; CELL DEATH; CELL VIABILITY; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME PHOSPHORYLATION; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; MALE; NEUROPROTECTION; NONHUMAN; PC12 CELL LINE; PROTEIN EXPRESSION; PROTEIN INDUCTION; RAT; RAT MODEL; REPERFUSION INJURY; ANALOGS AND DERIVATIVES; ANIMAL; CELL SURVIVAL; CEREBRAL ARTERY DISEASE; DRUG EFFECTS; GENETICS; HEK293 CELL LINE; METABOLISM; PATHOLOGY; SIGNAL TRANSDUCTION; SPRAGUE DAWLEY RAT;

4-BUTYROLACTONE; ANIMALS; BENZHYDRYL COMPOUNDS; CELL SURVIVAL; GLUCOSE; HEK293 CELLS; HSP70 HEAT-SHOCK PROTEINS; HUMANS; INFARCTION, MIDDLE CEREBRAL ARTERY; MALE; MAP KINASE SIGNALING SYSTEM; NEUROPROTECTIVE AGENTS; OXYGEN; PC12 CELLS; PYRROLIDINONES; RATS; RATS, SPRAGUE-DAWLEY; REPERFUSION INJURY; RNA, SMALL INTERFERING;

EID: 84946950117     PISSN: 09186158     EISSN: 13475215     Source Type: Journal    
DOI: 10.1248/bpb.b15-00352     Document Type: Article

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