Fucoidan promotes osteoblast differentiation via JNK- and ERK-dependent BMP2-Smad 1/5/8 signaling in human mesenchymal stem cells

Experimental and Molecular Medicine

Volumn 47, Issue 1, 2015, Pages

  Kim, Beom Su ^a,b   Kang, Hyo Jin ^a   Park, Ji Yun ^b   Lee, Jun ^a,b  

^a Wonkwang University   (South Korea)

^b Bonecell Biotech Inc   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; 4 (4 FLUOROPHENYL) 2 (4 METHYLSULFINYLPHENYL) 5 (4 PYRIDYL)IMIDAZOLE; ALKALINE PHOSPHATASE; ANTHRA[1,9 CD]PYRAZOL 6(2H) ONE; BONE MORPHOGENETIC PROTEIN 2; CALCIUM; COLLAGEN TYPE 1; FUCOIDIN; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE P38; OSTEOCALCIN; SHORT HAIRPIN RNA; SMAD1 PROTEIN; SMAD5 PROTEIN; SMAD8 PROTEIN; STRESS ACTIVATED PROTEIN KINASE; TRANSCRIPTION FACTOR RUNX2; POLYSACCHARIDE; PROTEIN KINASE INHIBITOR; SMAD PROTEIN;

ARTICLE; CELL DIFFERENTIATION; CELL PROLIFERATION; CONTROLLED STUDY; DRUG MECHANISM; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME PHOSPHORYLATION; GENE EXPRESSION; HUMAN; HUMAN CELL; MESENCHYMAL STEM CELL; OSTEOBLAST; REAL TIME POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; WESTERN BLOTTING; BONE DEVELOPMENT; CELL CULTURE; CYTOLOGY; DOSE RESPONSE; DRUG EFFECTS; GENE EXPRESSION REGULATION; GENE SILENCING; GENETICS; MESENCHYMAL STROMA CELL; METABOLISM; PHOSPHORYLATION;

BONE MORPHOGENETIC PROTEIN 2; CALCIUM; CELL DIFFERENTIATION; CELL PROLIFERATION; CELLS, CULTURED; DOSE-RESPONSE RELATIONSHIP, DRUG; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; GENE EXPRESSION REGULATION; GENE KNOCKDOWN TECHNIQUES; HUMANS; JNK MITOGEN-ACTIVATED PROTEIN KINASES; MESENCHYMAL STROMAL CELLS; OSTEOBLASTS; OSTEOGENESIS; PHOSPHORYLATION; POLYSACCHARIDES; PROTEIN KINASE INHIBITORS; RNA, MESSENGER; SIGNAL TRANSDUCTION; SMAD PROTEINS;

EID: 84928011509     PISSN: 12263613     EISSN: 20926413     Source Type: Journal    
DOI: 10.1038/emm.2014.95     Document Type: Article

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