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Volumn 9, Issue 6, 2012, Pages 283-294

Inhibition of JNK and ERK pathways by SP600125-and U0126-enhanced osteogenic differentiation of bone marrow stromal cells

Author keywords

Inhibitors; Mitogen activated protein kinase; Osteogenic differentiation; SP600125; U0126

Indexed keywords

ALKALINE PHOSPHATASE ACTIVITY; BONE MARROW STROMAL CELLS; BONE MARROW STROMAL CELLS (BMSCS); BONE TISSUE ENGINEERING; MITOGEN ACTIVATED PROTEIN KINASE; OSTEOGENIC DIFFERENTIATION; SP600125; U0126;

EID: 84881465095     PISSN: 17382696     EISSN: None     Source Type: Journal    
DOI: 10.1007/s13770-012-0352-6     Document Type: Article
Times cited : (20)

References (43)
  • 1
    • 0034988303 scopus 로고    scopus 로고
    • Bone marrow stromal stem cells: Nature, biology, and potential applications
    • RPM Bianco, S Gronthos, PG Robey, Bone marrow stromal stem cells: nature, biology, and potential applications, Stem Cells, 19, 180, (2001).
    • (2001) Stem Cells , vol.19 , pp. 180
    • Rpm, B.1    Gronthos, S.2    Robey, P.G.3
  • 2
    • 1342306251 scopus 로고    scopus 로고
    • Stem cells as vehicles for orthopedic gene therapy
    • YTG Gafni, M Liebergal, G Pelled, et al., Stem cells as vehicles for orthopedic gene therapy, Gene Ther, 11, 417, (2004).
    • (2004) Gene Ther , vol.11 , pp. 417
    • Ytg, G.1    Liebergal, M.2    Pelled, G.3
  • 3
    • 0026537256 scopus 로고
    • Concepts of osteoblast growth and differentiation: Basis for modulation of bone cell development and tissue formation
    • JB Lian, GS Stein, Concepts of osteoblast growth and differentiation: basis for modulation of bone cell development and tissue formation, Critical Reviews In Oral Biol Med, 3, 269, (1992).
    • (1992) Critical Reviews In Oral Biol Med , vol.3 , pp. 269
    • Lian, J.B.1    Stein, G.S.2
  • 5
    • 0028926263 scopus 로고
    • Parallel signal processing among mammalian mapks
    • EML Cano, Parallel signal processing among mammalian MAPKs, Trends Biochem Sci, 20, 117, (1995).
    • (1995) Trends Biochem Sci , vol.20 , pp. 117
    • Eml, C.1
  • 6
    • 0028872649 scopus 로고
    • Specificity of receptor tyrosine kinase signaling: Transient versus sustained extracellular signal-regulated kinase activation
    • C Marshall, Specificity of receptor tyrosine kinase signaling: transient versus sustained extracellular signal-regulated kinase activation, Cell, 80, 179, (1995).
    • (1995) Cell , vol.80 , pp. 179
    • Marshall, C.1
  • 7
    • 0028880006 scopus 로고
    • Opposing effects of erk and jnk-p38 map kinases on apoptosis
    • ZG Xia, M Dikens, J Raingesud, et al., Opposing effects of ERK and JNK-p38 MAP kinases on apoptosis, Science, 270, 1336, (1995).
    • (1995) Science , vol.270 , pp. 1336
    • Xia, Z.G.1    Dikens, M.2    Raingesud, J.3
  • 8
    • 0033555529 scopus 로고    scopus 로고
    • Mitogenactivatedproteinkinase phosphatase: Anegativeregulator of the mitogen-activatedproteinkinasecascade
    • M Haneda, T Sugimoto, R Kikkawa, Mitogenactivatedproteinkinase phosphatase: anegativeregulator of the mitogen-activatedproteinkinasecascade, Eur J Pharm, 365, 1, (1999).
    • (1999) Eur J Pharm , vol.365 , pp. 1
    • Haneda, M.1    Sugimoto, T.2    Kikkawa, R.3
  • 9
    • 0028935270 scopus 로고
    • Pro-inflammatory cytokines and environmental stress cause p38 mitogen-activated protein kinase activation by dual phosphorylation on tyrosine and threonine
    • J Raingeaud, S Gupta, JS Rogers, et al., Pro-inflammatory cytokines and environmental stress cause p38 mitogen-activated protein kinase activation by dual phosphorylation on tyrosine and threonine, J Biol Chem, 270, 7420, (1995).
    • (1995) J Biol Chem , vol.270 , pp. 7420
    • Raingeaud, J.1    Gupta, S.2    Rogers, J.S.3
  • 10
    • 0028229012 scopus 로고
    • The stressactivated protein kinase subfamily of c-jun kinases
    • JM Kyriakis, P Banerjee, E Nikolakaki, et al., The stressactivated protein kinase subfamily of c-Jun kinases, Nature, 369, 156, (1994).
    • (1994) Nature , vol.369 , pp. 156
    • Kyriakis, J.M.1    Banerjee, P.2    Nikolakaki, E.3
  • 11
    • 78650049943 scopus 로고    scopus 로고
    • Effect of phosphatidyl inositol 3-kinase, extracellular signal-regulated kinases 1/2, and p38 mitogen-activated protein kinase inhibition on osteogenic differentiation of muscle-derived stem cells
    • KA Payne, LB Meszaros, JA Phillippi, et al., Effect of phosphatidyl inositol 3-kinase, extracellular signal-regulated kinases 1/2, and p38 mitogen-activated protein kinase inhibition on osteogenic differentiation of muscle-derived stem cells, Tissue Eng Part A, 16, 3647, (2010).
    • (2010) Tissue Eng Part A , vol.16 , pp. 3647
    • Payne, K.A.1    Meszaros, L.B.2    Phillippi, J.A.3
  • 12
    • 0033543653 scopus 로고    scopus 로고
    • Specific activation of the p38 mitogen-activated protein kinase signaling pathway and induction of neurite outgrowth in pc12 cells by bone morphogenetic protein-2
    • S Iwasaki, M Iguchi, K Watanabe, et al., Specific activation of the p38 mitogen-activated protein kinase signaling pathway and induction of neurite outgrowth in PC12 cells by bone morphogenetic protein-2, J Biol Chem, 274, 26503, (1999).
    • (1999) J Biol Chem , vol.274 , pp. 26503
    • Iwasaki, S.1    Iguchi, M.2    Watanabe, K.3
  • 13
    • 0033610788 scopus 로고    scopus 로고
    • Specific inhibitors of p38 mitogen-activated protein kinase block 3t3-l1 adipogenesis
    • JA Engelman, MP Lisanti, PE Scherer, Specific inhibitors of p38 mitogen-activated protein kinase block 3T3-L1 adipogenesis, J Biol Chem, 273, 32111, (1998).
    • (1998) J Biol Chem , vol.273 , pp. 32111
    • Engelman, J.A.1    Lisanti, M.P.2    Scherer, P.E.3
  • 14
    • 0035207024 scopus 로고    scopus 로고
    • Ctgf/hcs24 induces chondrocyte differentiation through a p38 mitogenactivated protein kinase (p38mapk), and proliferation through a p44/42 mapk/extracellular- signal regulated kinase (erk)
    • G Yoshimichi, T Nakanishi, T Nishida, et al., CTGF/Hcs24 induces chondrocyte differentiation through a p38 mitogenactivated protein kinase (p38MAPK), and proliferation through a p44/42 MAPK/extracellular- signal regulated kinase (ERK), Eur J Biochem, 268, 6058, (2001).
    • (2001) Eur J Biochem , vol.268 , pp. 6058
    • Yoshimichi, G.1    Nakanishi, T.2    Nishida, T.3
  • 15
    • 17644402750 scopus 로고    scopus 로고
    • Retinoid signaling regulates ctgf expression in hypertrophic chondrocytes with differential involvement of map kinases
    • T Shimo, E Koyama, H Sugito, et al., Retinoid signaling regulates CTGF expression in hypertrophic chondrocytes with differential involvement of MAP kinases, J Bone Miner Res, 20, 867, (2005).
    • (2005) J Bone Miner Res , vol.20 , pp. 867
    • Shimo, T.1    Koyama, E.2    Sugito, H.3
  • 16
    • 0034737742 scopus 로고    scopus 로고
    • Adult human mesenchymal stem cell differentiation to the osteogenic or adipogenic lineage is regulated by mitogen-activated protein kinase
    • RK Jaiswal, N Jaiswal, SP Bruder, et al., Adult human mesenchymal stem cell differentiation to the osteogenic or adipogenic lineage is regulated by mitogen-activated protein kinase, J Biol Chem, 275, 9645, (2000).
    • (2000) J Biol Chem , vol.275 , pp. 9645
    • Jaiswal, R.K.1    Jaiswal, N.2    Bruder, S.P.3
  • 17
    • 0032054919 scopus 로고    scopus 로고
    • Activation of c-jun nh2-terminal kinases by interleukin-1β in normal human osteoblastic and rat umr-106 cells
    • LR Chaudhary, LV Avioli, Activation of c-Jun NH2-terminal kinases by interleukin-1β in normal human osteoblastic and rat UMR-106 cells, J Cell Biochem, 69, 87, (1998).
    • (1998) J Cell Biochem , vol.69 , pp. 87
    • Chaudhary, L.R.1    Avioli, L.V.2
  • 18
    • 0031559807 scopus 로고    scopus 로고
    • Activation of extracellular signalregulated kinases 1 and 2 (erk1 and erk2) by fgf-2 and pdgf-bb in normal human osteoblastic and bone marrow stromal cells: Differences in mobility and in-gel renaturation of erk1 in human rat and mouse osteoblastic cells
    • LR Chaudhary, LV Avioli, Activation of extracellular signalregulated kinases 1 and 2 (ERK1 and ERK2) by FGF-2 and PDGF-BB in normal human osteoblastic and bone marrow stromal cells: differences in mobility and in-gel renaturation of ERK1 in human, rat, and mouse osteoblastic cells, Biochem Biophys Res Commun, 238, 134, (1997).
    • (1997) Biochem Biophys Res Commun , vol.238 , pp. 134
    • Chaudhary, L.R.1    Avioli, L.V.2
  • 19
    • 65349165237 scopus 로고    scopus 로고
    • Extracellular matrix remodeling integrin expression and downstream signaling pathways influence the osteogenic differentiation of mesenchymal stem cells on poly(lactide-co-glycolide) substrates
    • AK Kundu, CB Khatiwala, AJ Putnam, Extracellular matrix remodeling, integrin expression, and downstream signaling pathways influence the osteogenic differentiation of mesenchymal stem cells on poly(Lactide-Co-Glycolide) substrates, Tissue Eng Part , 15, 273, (2009).
    • (2009) Tissue Eng Part , vol.15 , pp. 273
    • Kundu, A.K.1    Khatiwala, C.B.2    Putnam, A.J.3
  • 20
    • 72649087101 scopus 로고    scopus 로고
    • The role of the extracellular signal-related kinase signaling pathway in osteogenic differentiation of human adipose-derived stem cells and in adipogenic transition initiated by dexamethasone
    • Q Liu, L Cen, H Zhou, et al., The role of the extracellular signal-related kinase signaling pathway in osteogenic differentiation of human adipose-derived stem cells and in adipogenic transition initiated by dexamethasone, Tissue Eng Part A, 15, 3487, (2009).
    • (2009) Tissue Eng Part A , vol.15 , pp. 3487
    • Liu, Q.1    Cen, L.2    Zhou, H.3
  • 21
    • 60549085756 scopus 로고    scopus 로고
    • Strontium promotes osteogenic differentiation of mesenchymal stem cells through the ras/ mapk signaling pathway
    • S Peng, G Zhou, KDK Luk, et al., Strontium promotes osteogenic differentiation of mesenchymal stem cells through the Ras/ MAPK signaling pathway, Cell Physiol Biochem, 23, 165, (2009).
    • (2009) Cell Physiol Biochem , vol.23 , pp. 165
    • Peng, S.1    Zhou, G.2    Kdk, L.3
  • 22
    • 0036786236 scopus 로고    scopus 로고
    • Continuous inhibition of mapk signaling promotes the early osteoblastic differentiation and mineralization of the extracellular matrix
    • C Higuchi, A Myoui, N Hashimoto, et al., Continuous inhibition of MAPK signaling promotes the early osteoblastic differentiation and mineralization of the extracellular matrix, J Bone Miner Res, 17, 1785, (2002).
    • (2002) J Bone Miner Res , vol.17 , pp. 1785
    • Higuchi, C.1    Myoui, A.2    Hashimoto, N.3
  • 23
    • 33750514356 scopus 로고    scopus 로고
    • Long-term loading inhibits erk1/2 phosphorylation and increases fgfr3 expression in mc3t3-e1 osteoblast cells
    • RA Jackson, A Kumarasuriyar, V Nurcombe, et al., Long-term loading inhibits ERK1/2 phosphorylation and increases FGFR3 expression in MC3T3-E1 osteoblast cells, J Cell Physiol, 209, 894, (2006).
    • (2006) J Cell Physiol , vol.209 , pp. 894
    • Jackson, R.A.1    Kumarasuriyar, A.2    Nurcombe, V.3
  • 24
    • 0026577727 scopus 로고
    • Expression of collagen, osteocalcin, and bone alkaline phosphatase in a mineralizing rat osteoblastic cell culture
    • P Collin, JR Nefussi, A Wetterwald, et al., Expression of collagen, osteocalcin, and bone alkaline phosphatase in a mineralizing rat osteoblastic cell culture, Calcif Tissue Int, 50, 175, (1992).
    • (1992) Calcif Tissue Int , vol.50 , pp. 175
    • Collin, P.1    Nefussi, J.R.2    Wetterwald, A.3
  • 25
    • 77952634909 scopus 로고    scopus 로고
    • Transient hypoxia induces erk-dependent anti-apoptotic cell survival in endothelial cells
    • FV Hartel, M Holl, M Arshad, et al., Transient hypoxia induces ERK-dependent anti-apoptotic cell survival in endothelial cells, Am J Physiol Cell Physiol, 298, 1501, (2010).
    • (2010) Am J Physiol Cell Physiol , vol.298 , pp. 1501
    • Hartel, F.V.1    Holl, M.2    Arshad, M.3
  • 26
    • 0034757779 scopus 로고    scopus 로고
    • Cell cycle regulation by p38 map kinases
    • C Ambrosino, AR Nebreda, Cell cycle regulation by p38 MAP kinases, Biol Cell, 93, 47, (2001).
    • (2001) Biol Cell , vol.93 , pp. 47
    • Ambrosino, C.1    Nebreda, A.R.2
  • 27
    • 0034067079 scopus 로고    scopus 로고
    • P38 and extracellular signal-regulated kinases regulate the myogenic program at multiple steps
    • Z Wu, PJ Woodring, KS Bhakta, et al., p38 and extracellular signal-regulated kinases regulate the myogenic program at multiple steps, Mol Cell Biol, 20, 3951, (2000).
    • (2000) Mol Cell Biol , vol.20 , pp. 3951
    • Wu, Z.1    Woodring, P.J.2    Bhakta, K.S.3
  • 28
    • 0032737614 scopus 로고    scopus 로고
    • The developmental control of osteoblastspecific gene expression: Role of specific transcription factors and the extracellular matrix environment
    • RT Franceschi, The developmental control of osteoblastspecific gene expression: role of specific transcription factors and the extracellular matrix environment, Crit Rev Oral Biol Med, 10, 40, (1999).
    • (1999) Crit Rev Oral Biol Med , vol.10 , pp. 40
    • Franceschi, R.T.1
  • 29
    • 0032879350 scopus 로고    scopus 로고
    • Differentiation of human marrow stromal precursor cells: Bone morphogenetic protein-1 increases osf2/cbfa1, enhances osteoblast commitment, and inhibits late adipocyte maturation
    • F Gori, T Thomas, KC Hicok, et al., Differentiation of human marrow stromal precursor cells: bone morphogenetic protein-1 increases OSF2/CBFA1, enhances osteoblast commitment, and inhibits late adipocyte maturation, J Bone Miner Res, 14, 1522, (1999).
    • (1999) J Bone Miner Res , vol.14 , pp. 1522
    • Gori, F.1    Thomas, T.2    Hicok, K.C.3
  • 30
    • 1242316272 scopus 로고    scopus 로고
    • Impaired calcification around matrix vesicles of growth plate and bone in alkaline phosphatase-deficient mice
    • HC Anderson, JB Sipe, L Hessle, et al., Impaired calcification around matrix vesicles of growth plate and bone in alkaline phosphatase-deficient mice, Am J Pathol, 164, 841, (2004).
    • (2004) Am J Pathol , vol.164 , pp. 841
    • Anderson, H.C.1    Sipe, J.B.2    Hessle, L.3
  • 32
    • 78649296143 scopus 로고    scopus 로고
    • Formation of bonelike tissue by dental follicle cells co-cultured with dental papilla cells
    • Y Bai, K Matsuzaka, S Hashimoto, et al., Formation of bonelike tissue by dental follicle cells co-cultured with dental papilla cells, Cell Tissue Res, 342, 221, (2010).
    • (2010) Cell Tissue Res , vol.342 , pp. 221
    • Bai, Y.1    Matsuzaka, K.2    Hashimoto, S.3
  • 33
    • 0027954438 scopus 로고
    • The mouse osteocalcin gene cluster contains three genes with two separate spatial and temporal patterns of expression
    • C Desbois, DA Hogue, G Karsenty, The mouse osteocalcin Gene cluster contains three genes with two separate spatial and temporal patterns of expression, J Biol Chem, 269, 1183, (1994).
    • (1994) J Biol Chem , vol.269 , pp. 1183
    • Desbois, C.1    Hogue, D.A.2    Karsenty, G.3
  • 34
    • 34248355601 scopus 로고    scopus 로고
    • Distinct roles of bone morphogenetic proteins in osteogenic differentiation of mesenchymal stem cells
    • HH Luu, WX Song, X Luo, et al., Distinct roles of bone morphogenetic proteins in osteogenic differentiation of mesenchymal stem cells, J Orthop Res, 25, 665, (2007).
    • (2007) J Orthop Res , vol.25 , pp. 665
    • Luu, H.H.1    Song, W.X.2    Luo, X.3
  • 35
    • 20144389396 scopus 로고    scopus 로고
    • Gene therapy for bone regeneration
    • J Luo, MH Sun, Q Kang, et al., Gene therapy for bone regeneration, Curr Gene Ther, 5, 167, (2005).
    • (2005) Curr Gene Ther , vol.5 , pp. 167
    • Luo, J.1    Sun, M.H.2    Kang, Q.3
  • 36
    • 0042134565 scopus 로고    scopus 로고
    • Osteogenic activity of the fourteen types of human bone morphogenetic proteins (bmps)
    • H Cheng, W Jiang, FM Phillips, et al., Osteogenic activity of the fourteen types of human bone morphogenetic proteins (BMPs), J Bone Joint Surg Am, 85, 1544, (2003).
    • (2003) J Bone Joint Surg Am , vol.85 , pp. 1544
    • Cheng, H.1    Jiang, W.2    Phillips, F.M.3
  • 37
    • 0035700994 scopus 로고    scopus 로고
    • Divergent regulation by p44/p42 map kinase and p38 map kinase of bone morphogenetic protein-4-stimulated osteocalcin synthesis in osteoblasts
    • O Kozawa, D Hatakeyama, T Uematsu, Divergent regulation by p44/p42 MAP kinase and p38 MAP kinase of bone morphogenetic protein-4-stimulated osteocalcin synthesis in osteoblasts, J Cell Biochem, 84, 583, (2002).
    • (2002) J Cell Biochem , vol.84 , pp. 583
    • Kozawa, O.1    Hatakeyama, D.2    Uematsu, T.3
  • 38
    • 62549163858 scopus 로고    scopus 로고
    • Inhibition of erk promotes collagen gel compaction and fibrillogenesis to amplify the osteogenesis of human mesenchymal stem cells in three dimensional, collagen i culture
    • AW Lund, JP Stegemann, GE Plopper, Inhibition of ERK promotes collagen gel compaction and fibrillogenesis to amplify the osteogenesis of human mesenchymal stem cells in three dimensional, collagen I culture, Stem Cells Dev, 18, 331, (2008).
    • (2008) Stem Cells Dev , vol.18 , pp. 331
    • Lund, A.W.1    Stegemann, J.P.2    Plopper, G.E.3
  • 39
    • 0038185348 scopus 로고    scopus 로고
    • Activation of p38 mitogenactivated protein kinase is required for osteoblast differentiation
    • Y Hu, E Chan, SX Wang, et al., Activation of p38 mitogenactivated protein kinase is required for osteoblast differentiation, Endocrinology, 144, 2068, (2003).
    • (2003) Endocrinology , vol.144 , pp. 2068
    • Hu, Y.1    Chan, E.2    Wang, S.X.3
  • 40
    • 0242664611 scopus 로고    scopus 로고
    • Activation of p38 mitogen-activated protein kinase and c-jun-nh2-terminal kinase by bmp-2 and their implication in the stimulation of osteoblastic cell differentiation
    • J Guicheux, J Lemonnier, C Ghayor, et al., Activation of p38 mitogen-activated protein kinase and c-Jun-NH2-terminal kinase by BMP-2 and their implication in the stimulation of osteoblastic cell differentiation, J Bone Miner Res, 18, 2060, (2003).
    • (2003) J Bone Miner Res , vol.18 , pp. 2060
    • Guicheux, J.1    Lemonnier, J.2    Ghayor, C.3
  • 41
    • 0036138735 scopus 로고    scopus 로고
    • Evidence for a role of p38 map kinase in expression of alkaline phosphatase during osteoblastic cell differentiation
    • A Suzuki, J Guicheux, G Palmer, et al., Evidence for a role of p38 MAP kinase in expression of alkaline phosphatase during osteoblastic cell differentiation, Bone, 30, 91, (2002).
    • (2002) Bone , vol.30 , pp. 91
    • Suzuki, A.1    Guicheux, J.2    Palmer, G.3
  • 42
    • 0142103359 scopus 로고    scopus 로고
    • Transforming growth factor-β- mediated chondrogenesis of human mesenchymal progenitor cells involves n-cadherin and mitogen-activated protein kinase and wnt signaling cross-talk
    • R Tuli, S Tuli, S Nandi, et al., Transforming growth factor-β- mediated chondrogenesis of human mesenchymal progenitor cells involves N-cadherin and mitogen-activated protein kinase and wnt signaling cross-talk, J Biol Chem, 278, 41227, (2003).
    • (2003) J Biol Chem , vol.278 , pp. 41227
    • Tuli, R.1    Tuli, S.2    Nandi, S.3
  • 43
    • 17544395678 scopus 로고    scopus 로고
    • Activation of p38 and smads mediates bmp-2 effects on human trabecular bonederived osteoblasts
    • U Noth, R Tuli, R Seghatoleslami, et al., Activation of p38 and smads mediates BMP-2 effects on human trabecular bonederived osteoblasts, Exp Cell Res, 291, 201, (2003).
    • (2003) Exp Cell Res , vol.291 , pp. 201
    • Noth, U.1    Tuli, R.2    Seghatoleslami, R.3


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