Complementation of yeast genes with human genes as an experimental platform for functional testing of human genetic variants

Genetics

Volumn 201, Issue 3, 2015, Pages 1263-1274

  Hamza, Akil ^a   Tammpere, Erik ^a   Kofoed, Megan ^a   Keong, Christelle ^a   Chiang, Jennifer ^b   Giaever, Guri ^b   Nislow, Corey ^b   Hieter, Philip ^a  

^a UNIVERSITY OF BRITISH COLUMBIA   (Canada)

^b UNIVERSITY OF BRITISH COLUMBIA   (Canada)

Author keywords

Chromosome instability; Human genetic variants; Human yeast cross species complementation; Model organisms and human disease; Tumor specific missense mutations

Indexed keywords

COMPLEMENTARY DNA;

ARTICLE; CHROMOSOMAL INSTABILITY; CONTROLLED STUDY; DNA DAMAGE; FUNGAL GENE; FUNGUS GROWTH; GENETIC COMPLEMENTATION; GENETIC IDENTIFICATION; GENETIC VARIABILITY; HUMAN; HUMAN CELL; HUMAN GENETICS; MISSENSE MUTATION; NONHUMAN; NULL ALLELE; PRIORITY JOURNAL; SOMATIC MUTATION; YEAST; ESSENTIAL GENE; FEASIBILITY STUDY; GENETIC VARIATION; GENETICS; MEDICAL GENETICS; MUTATION; NEOPLASM; SACCHAROMYCES CEREVISIAE;

DNA, COMPLEMENTARY; FEASIBILITY STUDIES; GENES, ESSENTIAL; GENES, FUNGAL; GENETIC COMPLEMENTATION TEST; GENETIC VARIATION; GENETICS, MEDICAL; HUMANS; MUTATION; NEOPLASMS; SACCHAROMYCES CEREVISIAE;

EID: 84946924969     PISSN: 00166731     EISSN: 19432631     Source Type: Journal    
DOI: 10.1534/genetics.115.181099     Document Type: Article

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