Dexmedetomidine reduces postoperative delirium after joint replacement in elderly patients with mild cognitive impairment

Aging Clinical and Experimental Research

Volumn 28, Issue 4, 2016, Pages 729-736

  Liu, Yongzhe ^a   Ma, Li ^a   Gao, Minglong ^a   Guo, Wenzhi ^a   Ma, Yaqun ^a  

^a CHINESE PLA GENERAL HOSPITAL   (China)

Author keywords

Amnestic mild cognitive impairment; Delirium; Dexmedetomidine; Surgery

Indexed keywords

DEXMEDETOMIDINE; ETOMIDATE; FENTANYL; MIDAZOLAM; ONDANSETRON; PARECOXIB; PLACEBO; PROPOFOL; REMIFENTANIL; ROCURONIUM; SODIUM CHLORIDE;

AGED; ARTICLE; COGNITION; CONTINUOUS INFUSION; CONTROLLED STUDY; DRUG DOSE TITRATION; DRUG WITHDRAWAL; FEMALE; GENERAL ANESTHESIA; GERIATRIC DISORDER; HIP REPLACEMENT; HUMAN; INCIDENCE; KNEE REPLACEMENT; LARYNGEAL MASK; MAJOR CLINICAL STUDY; MALE; MILD COGNITIVE IMPAIRMENT; MINI MENTAL STATE EXAMINATION; POSTOPERATIVE DELIRIUM; PROSPECTIVE STUDY; RANDOMIZED CONTROLLED TRIAL; REPLACEMENT ARTHROPLASTY; SHOULDER REPLACEMENT; COGNITIVE DEFECT; COMPLICATION; DELIRIUM; POSTOPERATIVE COMPLICATION; VERY ELDERLY;

AGED; AGED, 80 AND OVER; ARTHROPLASTY, REPLACEMENT; COGNITIVE DYSFUNCTION; DELIRIUM; DEXMEDETOMIDINE; FEMALE; HUMANS; MALE; POSTOPERATIVE COMPLICATIONS; PROSPECTIVE STUDIES;

EID: 84946762117     PISSN: 15940667     EISSN: 17208319     Source Type: Journal    
DOI: 10.1007/s40520-015-0492-3     Document Type: Article

References (42)

1. Olofsson B, Lundström M, Borssén B et al (2005) Delirium is associated with poor rehabilitation outcome in elderly patients treated for femoral neck fractures. Scand J Caring Sci 19:119–127
2. Rooney S, Qadir M, Adamis D et al (2014) Diagnostic and treatment practices of delirium in a general hospital. Aging Clin Exp Res 26:625–633
3. Inouye SK (2006) Delirium in older persons. N Engl J Med 354:1157–1165
4. Demeure MJ, Fain MJ (2006) The elderly surgical patient and postoperative delirium. J Am Coll Surg 203:752–757
5. Mazzola P, Bellelli G, Broggini V et al (2015) Postoperative delirium and pre-fracture disability predict 6-month mortality among the oldest old hip fracture patients. Aging Clin Exp Res 27:53–60
6. American Psychiatric Association (1994) Diagnostic and statistical manual of mental disorders (DSM-IV). APA, Washington
7. Van der Mast RC, van den Broek WW, Fekkes D et al (1999) Incidence of and preoperative predictors for delirium after cardiac surgery. J Psychosom Res 46:479–483
8. Breteler MM, Claus JJ, Grobbee DE et al (1994) Cardiovascular disease and distribution of cognitive function in elderly people: the Rotterdam Study. BMJ 308:1604–1608
9. Gustafson Y, Berggren D, Brännström B et al (1988) Acute confusional states in elderly patients treated for femoral neck fracture. J Am Geriatr Soc 36:525–530
10. Brannstrom B, Gustafson Y, Norberg A et al (1989) Problems of basic nursing care in acutely confused and non-confused hip-fracture patients. Scand J Caring Sci 3:27–34
11. Marcantonio ER, Flacker JM, Michaels M et al (2000) Delirium is independently associated with poor functional recovery after hip fracture. J Am Geriatr Soc 48:618–624
12. Berggren D, Gustafson Y, Eriksson B et al (1987) Postoperative confusion after an-esthesia in elderly patients with femoral neck fractures. Anesth Analg 66:497–504
13. Rahkonen T, Luukkainen-Markkula R, Paanila S et al (2000) Delirium episode as a sign of undetected dementia among community dwelling elderly subjects: a 2 year follow up study. J Neurol Neurosurg Psychiatry 69:519–521
14. Evered LA, Silbert BS, Scott DA et al (2011) Preexisting cognitive impairment and mild cognitive impairment in subjects presenting for total hip joint replacement. Anesthesiology 114:1297–1304
15. Veliz-Reissmüller G, Agüero Torres H, Van der Linden J et al (2007) Pre-operative mild cognitive dysfunction predicts risk for post-operative delirium after elective cardiac surgery. Aging Clin Exp Res 19:172–177
16. Panza F, D’Introno A, Colacicco AM et al (2005) Current epidemiology of mild cognitive impairment and other predementia syndromes. Am J Geriatr Psychiatry 13:633–644
17. Forlenza OV, Diniz BS, Gattaz WF (2010) Diagnosis and biomarkers of predementia in Alzheimer’s disease. BMC Med 8:89
18. Welge-Lüssen A (2009) Ageing, neurodegeneration, and olfactory and gustatory loss. B-ENT 5(suppl 13):129–132
19. Markesbery WR, Schmitt FA, Kryscio RJ et al (2000) Neuropathologic substrate of mild cognitive impairment. Arch Neurol 63:38–46
20. Bhana N, Goa KL, McClellan KJ (2000) Dexmedetomidine. Drugs 59:263–268
21. Candiotti KA, Bergese SD, Bokesch PM et al (2000) Monitored anesthesia care with dexmedetomidine: a prospective, randomized, double-blind, multicenter trial. Anesth Analg 110:47–56
22. Cooper L, Candiotti K, Gallagher C et al (2011) A randomized, controlled trial on dexmedetomidine for providing adequate sedation and hemodynamic control for awake, diagnostic transesophageal echocardiography. J Cardiothorac Vasc Anesth 25:233–237
23. Yang S, Lee H (2014) A dose-finding study of preoperative intravenous dexmedetomidine in children’s emergence delirium after epiblepharon surgery. Eur J Ophthalmol 24:417–423
24. Bekker A, Haile M, Kline R et al (2013) The effect of intraoperative infusion of dexmedetomidine on the quality of recovery after major spinal surgery. J Neurosurg Anesthesiol 25:16–24
25. Zhang X, Wang J, Qian W et al (2014) Dexmedetomidine inhibits tumor necrosis factor-alpha and interleukin 6 in lipopolysaccharide-stimulated astrocytes by suppression of c-Jun N-terminal kinases. Inflammation 37:942–949
26. Zhang Y, Xing Z, Xu Y et al (2014) Effects of different doses of dexmedetomidine on cognitive dysfunction in elderly patients early after laparoscopic surgery for colorectal cancer. Nan Fang Yi Ke Da Xue Xue Bao 34:743–746
27. Shehabi Y, Grant P, Wolfenden H et al (2009) Prevalence of delirium with dexmedetomidine compared with morphine based therapy after cardiac surgery: a randomized controlled trial (dexmedetomidine compared to morphine-DEXCOM study). Anesthesiology 111:1075–1084
28. Chen J, Yan J, Han X (2013) Dexmedetomidine may benefit cognitive function after laparoscopic cholecystectomy in elderly patients. Exp Ther Med 5:489–494
29. Liu Y, Pan N, Ma Y et al (2013) Inhaled sevoflurane may promote progression of amnestic mild cognitive impairment: a prospective, randomized parallel-group study. Am J Med Sci 345:355–360
30. Inouye SK, van Dyck CH, Alessi CA et al (1990) Clarifying confusion: the confusion assessment method. A new method for detection of delirium. Ann Intern Med 113:941–948
31. Bickel H, Gradinger R, Kochs E et al (2008) High risk of cognitive and functional decline after postoperative delirium: a three-year prospective study. Dement Geriatr Cogn Disord 26:26–31
32. Lundstrom M, Edlund A, Bucht G et al (2003) Dementia after delirium in patients with femoral neck fractures. J Am Geriatr Soc 51:1002–1006
33. Koppel J (2005) Memory impairment, but not cerebrovascular disease, predicts progression of MCI to dementia. Neurology 64:766
34. Xie Z, Tanzi RE (2006) Alzheimer’s disease and post-operative cognitive dysfunction. Exp Gerontol 41:346–359
35. Levkoff SE, Evans DA, Liptzin B et al (1992) Delirium: the occurrence and persistence of symptoms among elderly hospitalized patients. Arch Intern Med 152:334–340
36. Murray AM, Levkoff SE, Wetle TT et al (1993) Acute delirium and functional decline in the hospitalized elderly patient. J Gerontol 48:M181–M186
37. Morrison RS, Magaziner J, Gilbert M et al (2003) Relationship between pain and opioid analgesics on the development of delirium following hip fracture. J Gerontol A Biol Sci Med Sci 58:76–81
38. Pasin L, Landoni G, Nardelli P et al (2014) Dexmedetomidine reduces the risk of delirium, agitation and confusion in critically ill patients: a meta-analysis of randomized controlled trials. J Cardiothorac Vasc Anesth 28:1459–1466
39. Haan MN, Shemanski L, Jagust WJ et al (1999) The role of APOE epsilon 4 in modulating effects of other risk factors for cognitive decline in elderly persons. JAMA 282:40–46
40. Qian XL, Zhang W, Liu MZ et al (2015) Dexmedetomidine improves early postoperative cognitive dysfunction in aged mice. Eur J Pharmacol 746:206–212
41. Pasin L, Greco T, Feltracco P (2013) Dexmedetomidine as a sedative agent in critically ill patients: a meta-analysis of randomized controlled trials. PLoS One 8:e82913
42. Mo Y, Zimmermann AE (2013) Role of dexmedetomidine for the prevention and treatment of delirium in intensive care unit patients. Ann Pharmacother 47:869–876