Monitored anesthesia care with dexmedetomidine: A prospective, randomized, double-blind, multicenter trial

Anesthesia and Analgesia

Volumn 110, Issue 1, 2010, Pages 47-56

  Candiotti, Keith A ^a   Bergese, Sergio D ^b   Bokesch, Paula M ^c   Feldman, Marc A ^d   Wisemandle, Wayne ^c   Bekker, Alex Y ^e  

^a UNIVERSITY OF MIAMI MILLER SCHOOL OF MEDICINE   (United States)

^b OHIO STATE UNIVERSITY   (United States)

^c Hospira Inc   (United States)

^d LERNER RESEARCH INSTITUTE   (United States)

^e NEW YORK UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DEXMEDETOMIDINE; FENTANYL; MIDAZOLAM; SODIUM CHLORIDE; HYPNOTIC SEDATIVE AGENT; INTRAVENOUS ANESTHETIC AGENT;

ADULT; AGED; ANESTHESIA; ARTERIAL PRESSURE; ARTICLE; BRADYCARDIA; BREATHING RATE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DISEASE SEVERITY; DOUBLE BLIND PROCEDURE; DRUG DOSE TITRATION; DRUG EFFICACY; DRUG SAFETY; FEMALE; FOOD AND DRUG ADMINISTRATION; HEART RATE; HUMAN; HYPOTENSION; LOCAL ANESTHESIA; MAJOR CLINICAL STUDY; MALE; MULTICENTER STUDY; OXYGEN SATURATION; PATIENT MONITORING; PHASE 3 CLINICAL TRIAL; POSTOPERATIVE NAUSEA; POSTOPERATIVE PAIN; POSTOPERATIVE VOMITING; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; REGIONAL ANESTHESIA; RESPIRATION DEPRESSION; SEDATION; SIDE EFFECT; ADOLESCENT; DRUG EFFECT; HEMODYNAMICS; INTRAVENOUS ANESTHESIA; MIDDLE AGED; PATIENT SATISFACTION; PROSPECTIVE STUDY;

ADOLESCENT; ADULT; AGED; AGED, 80 AND OVER; ANESTHESIA; ANESTHESIA, INTRAVENOUS; ANESTHETICS, INTRAVENOUS; DEXMEDETOMIDINE; DOUBLE-BLIND METHOD; FEMALE; FENTANYL; HEMODYNAMICS; HUMANS; HYPNOTICS AND SEDATIVES; MALE; MIDDLE AGED; MONITORING, INTRAOPERATIVE; PATIENT SATISFACTION; PROSPECTIVE STUDIES; YOUNG ADULT;

EID: 74049113764     PISSN: 00032999     EISSN: None     Source Type: Journal    
DOI: 10.1213/ane.0b013e3181ae0856     Document Type: Article

References (26)

1. Bailey PL, Pace NL, Ashburn MA, Moll JWB, East KA, Stanley TH. Frequent hypoxemia and apnea after sedation with midazolam and fentanyl. Anesthesiology 1990;73:826-830
2. ASA Task Force on Sedation and Analgesia by Non- Anesthesiologists. Practice guidelines for sedation and analgesia by non-anesthesiologists. Anesthesiology 2002;96:1004-1017
3. Herr DL, Sum-Ping STJ, England M. ICU sedation after coronary artery bypass graft surgery: dexmedetomidine-based versus propofol-based sedation regimens. J Cardiothorac Vasc Anesth 2003;17:576-584
4. Bhananker SM, Posner KL, Cheney FW, Caplan RA, Lee LA, Domino KB. Injury and liability associated with monitored anesthesia care: a closed claims analysis. Anesthesiology 2006;104:228-234
5. Hall JE, Uhrich TD, Barney JA, Arain SA, Ebert TJ. Sedative, amnestic, and analgesic properties of small-dose dexmedetomidine infusions. Anesth Analg 2000;90:699-705
6. Ebert TJ, Hall JE, Barney JA, Uhrich TD, Colinco MD. The effects of increasing plasma concentrations of dexmedetomidine in humans. Anesthesiology 2000;93:382-394
7. Venn RM, Hell J, Grounds RM. Respiratory effects of dexmedetomidine in the surgical patient requiring intensive care. Crit Care 2000;4:302-308
8. Arain SR, Ebert TJ. The efficacy, side effects, and recovery characteristics of dexmedetomidine versus propofol when used for intraoperative sedation. Anesth Analg 2002;95:461-466
9. Venn RM, Grounds RM. Comparison between dexmedetomidine and propofol for sedation in the intensive care unit: patient and clinical perceptions. Br J Anaesth 2001;87:684-690
10. Elbaradie S, El Mahalawy FH, Solyman AH. Dexmedetomidine vs. propofol for short-term sedation of postoperative mechanically ventilated patients. J Egypt Natl Canc Inst 2004;16:153-158
11. Abdalla MIM, Mansouri FA, Bener A. Dexmedetomidine during local anesthesia. J Anesth 2006;20:54-56
12. Taghinia AH, Shapiro FE, Slavin SA. Dexmedetomidine in aesthetic facial surgery: improving anesthetic safety and efficacy. Plast Reconstr Surg 2008;121:269-276
13. Demiraran Y, Korkut E, Tamer A, Yorulmaz I, Kocaman B, Sezen G, Akcan Y. The comparison of dexmedetomidine and midazolam used for sedation of patients during upper endoscopy: a prospective, randomized study. Can J Gastroenterol 2007;21:25-29
14. Alhashemi JA. Dexmedetomidine vs midazolam for monitored anesthesia care during cataract surgery. Br J Anaesth 2006;96:722-726
15. Ustün Y, Gündü z M, Erdog?an O, Benlidayi ME. Dexmedetomidine versus midazolam in outpatient third molar surgery. J Oral Maxillofac Surg 2006;64:1353-1358
16. Cooper L, Candiotti K, Gallagher C. Dexmedetomidine provides adequate sedation and hemodynamic control for awake, diagnostic transesophageal echocardiography. Anesth Analg 2007;104:S41 (abstract)
17. Chernik DA, Gillings D, Laine H, Hendler J, Silver JM, Davidson AB, Schwam EM, Siegel JL. Validity and reliability of the Observer's Assessment of Alertness/Sedation Scale: study with intravenous midazolam. J Clin Psychopharmacol 1990;10:244-251
18. Aldrete JA. The post-anesthesia recovery score revisited. J Clin Anesth 1995;7:89-91
19. Dexter F, Aker J, Wright W. Development of a measure of patient satisfaction with monitored anesthesia care: the Iowa Satisfaction with Anesthesia Scale. Anesthesiology 1997;87:865-873
20. McCutcheon C, Orme R, Scott D, Davies MJ, McGlade DP. A comparison of dexmedetomidine versus conventional therapy for sedation and hemodynamic control during carotid endarterectomy performed under regional anesthesia. Anesth Analg 2006;102:668-675
21. Smith H, Elliot J. Alpha-2 receptors and agonists in pain management. Cur Opin Anesthesiol 2001;14:513-518
22. Zeyneloglu P, Pirat A, Candan S, Kuyumcu S, Tekin I, Arslan G. Dexmedetomidine causes prolonged recovery when compared with midazolam/fentanyl combination in outpatient shock wave lithotripsy. Eur J Anaesthesiol 2008;25:961-967
23. Reich DL, Bennett-Guerrero E, Bodian CA, Hossain S, Winfree W, Krol M. Intraoperative tachycardia and hypertension are independently associated with adverse outcome in noncardiac surgery of long duration. Anesth Analg 2002;95:273-277
24. Wijeysundera DN, Naik JS, Beattie WS. Alpha-2 adrenergic agonists to prevent perioperative cardiovascular complications: a meta analysis. Am J Med 2003;114:742-752
25. Jalowiecki P, Rudner R, Gonciarz M, Kawecki P, Petelenz M, Dziurdzik P. Sole use of dexmedetomidine has limited utility for conscious sedation during outpatient colonoscopy. Anesthesiology 2005;103:269-273
26. Muttu S, Liu E, Ang S, Chew PT, Lee TL, Ti LK. Comparison of dexmedetomidine and midazolam sedation for cataract surgery under topical anesthesia. J Cataract Refract Surg 2005;31:1845-1846