Dexmedetomidine as a sedative agent in critically Ill patients: A meta-analysis of randomized controlled trials

PLoS ONE

Volumn 8, Issue 12, 2013, Pages

  Pasin, Laura ^a   Greco, Teresa ^a   Feltracco, Paolo ^b   Vittorio, Annalisa ^a   Neto, Caetano Nigro ^a   Cabrini, Luca ^a   Landoni, Giovanni ^a,c   Finco, Gabriele ^d   Zangrillo, Alberto ^a  

^a SAN RAFFAELE HOSPITAL   (Italy)

^b UNIVERSITY HOSPITAL OF PADOVA   (Italy)

^c OUTCOMES RESEARCH CONSORTIUM   (United States)

^d UNIVERSITY OF CAGLIARI   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

AIRWAY EXTUBATION; BRADYCARDIA; CRITICAL ILLNESS; DEXMEDETOMIDINE; HUMANS; HYPNOTICS AND SEDATIVES; HYPOTENSION; INTENSIVE CARE; LENGTH OF STAY; RANDOMIZED CONTROLLED TRIALS AS TOPIC; TIME FACTORS;

EID: 84894242870     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0082913     Document Type: Article

References (43)

1. Paris A, Tonner PH (2005) Dexmedetomidine in anaesthesia. CurrOpinAnaesthesiol 18: 412-8. (Pubitemid 41073138)
2. Huupponen E, Maksimow A, Lapinlampi P, Särkelä M, Saastamoinen A, et al. (2008) Electroencephalogram spindle activity during dexmedetomidine sedation and physiological sleep. Acta Anaesthesiol Scand 52: 289-94.
3. Guo TZ, Jiang JY, Buttermann AE, Maze M (1996) Dexmedetomidine injection into the locus ceruleus produces antinociception. Anesthesiology 84: 873-81. (Pubitemid 26106212)
4. Iirola T, Aantaa R, Laitio R, Kentala E, Lahtinen M, et al. (2011) Pharmacokinetics of prolonged infusion of high-dose dexmedetomidine in critically ill patients. Crit Care 15: R257.
5. Morsch RD, Ferri MB, Vasconcelos CP, Capone Neto A, Akamine N, et al. (2005) Dexmedetomidine as a sedative agent for more than 24 hours in acutely ill patients. Critical Care 9: P111.
6. Tan JA, Ho KM (2010) Use of dexmedetomidine as a sedative and analgesic agent in critically ill adult patients: a meta-analysis. Intensive Care Med 36: 926-39.
7. Abd Aziz N, Chue MC, Yong CY, Hassan Y, Awaisu A, et al. (2011) Efficacy and safety of dexmedetomidine versus morphine in post-operative cardiac surgery patients. Int J Clin Pharm 33: 150-4.
8. Jakob SM, Ruokonen E, Grounds RM, Sarapohja T, Garratt C, et al. (2012) Dexmedetomidinevs midazolam or propofol for sedation during prolonged mechanical ventilation: two randomized controlled trials. JAMA 307: 1151-60.
9. Leino K, Hynynen M, Jalonen J, Salmenperä M, Scheinin H, et al. (2011) Renal effects of dexmedetomidine during coronary artery bypass surgery: a randomized placebo-controlled study. BMC Anesthesiol 11: 9.
10. Menda F, Köner O, Sayin M, Türe H, Imer P, et al. (2010) Dexmedetomidine as an adjunct to anesthetic induction to attenuate hemodynamic response to endotracheal intubation in patients undergoing fast-track CABG. Ann Card Anaesth 13: 16-21.
11. Terao Y, Ichinomiya T, Higashijima U, Tanise T, Miura K, et al. (2012) Comparison between propofol and dexmedetomidine in postoperative sedation after extensive cervical spine surgery. J Anesth 26: 179-86.
12. Wan LJ, Huang QQ, Yue JX, Lin L, Li SH (2011) Comparison of sedative effect of dexmedetomidine and midazolam for post-operative patients undergoing mechanical ventilation in surgical intensive care unit. Zhongguo Wei Zhong Bing Ji Jiu Yi Xue 23: 543-6.
13. Yao L, Zhou XM, Zhao JJ (2010) The role of dexmedetomidine in treatment of serious patients in intensive care unit. Zhongguo Wei Zhong Bing Ji Jiu Yi Xue 22: 632-4.
14. Khalil MA, Abdel Azeem MS (2013) The impact of dexmedetomidine infusion in sparing morphine consumption in off-pump coronary artery bypass grafting. Semin CardiothoracVasc Anesth 17: 66-71.
15. Sahin N, Kabukcu H, Ozkan N, Titiz T (2005) The effects of postoperative dexmedetomidine and midazolam infusion on haemodynamics and sedation in patients after coronary artery bypass grafting. Eur J Anaesthesiol 22: 40.
16. Higgins JPT, Green S (2011) Cochrane handbook for systematic reviews of interventions. Version 5.1.0. Available: http://handbook.cochrane.org/ Accessed October 2013.
17. Begg CB, Mazumdar M (1994) Operating characteristics of a rank correlation test for publication bias. Biometrics 50:1088-101.
18. Peters JL, Sutton AJ, Jones DR, Abrams KR, Rushton L (2006) Comparison of two methods to detect publication bias in meta-analysis. JAMA 295: 676-80. (Pubitemid 43209069)
19. Biondi-Zoccai G, Lotrionte M, Landoni G, Modena MG (2011) The rough guide to systematic reviews and meta-analyses. HSR Proceedings in Intensive Care and Cardiovascular Anesthesia 3: 161-173.
20. Liberati A, Altman DG, Tetzlaff J, Mulrow C, Gøtzsche PC, et al. (2009) The PRISMA statement for reporting systematic reviews and meta-analyses of studies that evaluate healthcare interventions: explanation and elaboration. BMJ 339: b2700.
21. Corbett SM, Rebuck JA, Greene CM, Callas PW, Neale BW, et al. (2005) Dexmedetomidine does not improve patient satisfaction when compared with propofol during mechanical ventilation. Crit Care Med 33: 940-5. (Pubitemid 40638161)
22. Elbaradie S, El Mahalawy FH, Solyman AH (2004) Dexmedetomidine vs. propofol for short-term sedation of postoperative mechanically ventilated patients. J Egypt Natl CancInst 16: 153-8.
23. Esmaoglu A, Ulgey A, Akin A, Boyaci A (2009) Comparison between dexmedetomidine and midazolam for sedation of eclampsia patients in the intensive care unit. J Crit Care 24: 551-5.
24. Herr DL, Sum-Ping ST, England M (2003) ICU sedation after coronary artery bypass graft surgery: dexmedetomidine-based versus propofol-based sedation regimens. J Cardiothorac Vasc Anesth 17: 576-84. (Pubitemid 37296621)
25. Maldonado JR, Wysong A, van der Starre PJ, Block T, Miller C, et al. (2009) Dexmedetomidine and the reduction of postoperative delirium after cardiac surgery. Psychosomatics 50: 206-17.
26. Martin E, Ramsay G, Mantz J, Sum-Ping ST (2003) The role of the alpha2- adrenoceptor agonist dexmedetomidine in postsurgical sedation in the intensive care unit. J Intensive Care Med 18: 29-41. (Pubitemid 44526587)
27. Memis D, Dökmeci D, Karamanlioglu B, Turan A, Türe M (2006) A comparison of the effect on gastric emptying of propofol or dexmedetomidine in critically ill patients: preliminary study. Eur J Anaesthesiol 23: 700-04.
28. Memiş D, Hekimoǧlu S, Vatan I, Yandim T, Yüksel M, et al. (2007) Effects of midazolam and dexmedetomidine on inflammatory responses and gastric intramucosal pH to sepsis, in critically ill patients. Br J Anaesth 98: 550-2. (Pubitemid 47072665)
29. Memiş D, Kargi M, Sut N (2009) Effects of propofol and dexmedetomidine on indocyanine green elimination assessed with LIMON to patients with early septic shock: a pilot study. J Crit Care 24: 603-8.
30. Ozkan N, Sahin N, Karakaya Kabukcu H, Celikbilek G, Aydogdu Titiz T (2007) Comparison of the effects of dexmedetomidine with midasolam on haemodynamics and oxygen profile in patients undergoing coronary artery bypass grafting. Gogus-Kalp-Damar Anestezive Yogun Bakim Dernegi Dergisi 13:161-168. (Pubitemid 351676181)
31. Pandharipande PP, Pun BT, Herr DL, Maze M, Girard TD, et al. (2007) Effect of sedation with dexmedetomidinevslorazepam on acute brain dysfunction in mechanically ventilated patients: the MENDS randomized controlled trial. JAMA 298: 2644-2653. (Pubitemid 350254956)
32. Reade MC, O'Sullivan K, Bates S, Goldsmith D, Ainslie WR, et al. (2009) Dexmedetomidine vs. haloperidol in delirious, agitated, intubated patients: a randomised open-label trial. Crit Care 13: R75.
33. Riker RR, Shehabi Y, Bokesch PM, Ceraso D, Wisemandle W, et al. (2009) Dexmedetomidinevs midazolam for sedation of critically ill patients: a randomized trial. JAMA 301: 489-99.
34. Ruokonen E, Parviainen I, Jakob SM, Nunes S, Kaukonen M, et al. (2009) Dexmedetomidine versus propofol/midazolam for long-term sedation during mechanical ventilation. J Intensive Care Med 35: 282-90.
35. Shehabi Y, Grant P, Wolfenden H, Hammond N, Bass F, et al. (2009) Prevalence of delirium with dexmedetomidine compared with morphine based therapy after cardiac surgery: a randomized controlled trial (DEXmedetomidineCOmpared to Morphine-DEXCOM Study). Anesthesiology 111: 1075-84.
36. Tasdogan M, Memis D, Sut N, Yuksel M (2009) Results of a pilot study on the effects of propofol and dexmedetomidine on inflammatory responses and intraabdominal pressure in severe sepsis. J Clin Anesth 21: 394-400.
37. Triltsch AE, Welte M, von Homeyer P, Grosse J, Genähr A, et al. (2002) Bispectral index-guided sedation with dexmedetomidine in intensive care: a prospective, randomized, double blind, placebo-controlled phase II study. Crit Care Med 30: 1007-14. (Pubitemid 34508021)
38. Venn RM, Grounds RM (2001) Comparison between dexmedetomidine and propofol for sedation in the intensive care unit: patient and clinician perceptions. Br J Anaesth 87: 684-90. (Pubitemid 33069556)
39. Aho M, Erkola O, Kallio A, Scheinin H, Korttila K (1993) Comparison of dexmedetomidine and midazolam sedation and antagonism of dexmedetomidine with atipamezole. J Clin Anesth 5: 194-203. (Pubitemid 23171952)
40. Gertler R, Brown HC, Mitchell DH, Silvius EN, Mitchell DH (2001) Dexmedetomidine: a novel secative-analgesic agent. Proc (Bayl Univ Med Cent) 14: 13-21.
41. Talke P, Li J, Jain U, Leung J, Drasner K, et al. (1995) Effects of perioperative dexmedetomidine infusion in patients undergoing vascular surgery. The Study of Perioperative Ischemia Research Group. Anesthesiology 82: 620-633.
42. Chorney SR, Gooch ME, Oberdier MT, Keating D, Stahl RF (2013) The safety and efficacy of dexmedetomidinefor postoperative sedation in the cardiac surgery intensive care unit. HSR Proc Intensive Care Cardiovasc Anesth 5(1): 17-24.
43. Yazbek-Karam VG, Aouad MM (2006) Perioperative uses of dexmedetomidine. Middle East J Anesthesiol 18: 1043-58.