Prenatal exposure to cannabinoids evokes long-lasting functional alterations by targeting CB1 receptors on developing cortical neurons

Proceedings of the National Academy of Sciences of the United States of America

Volumn 112, Issue 44, 2015, Pages 13693-13698

  De Salas Quiroga, Adán ^a,b,c   Díaz Alonso, Javier ^e   García Rincón, Daniel ^a,b,c   Remmers, Floortje ^d   Vega, David ^a,c   Gómez Cañas, María ^a,b,c   Lutz, Beat ^d   Guzmán, Manuel ^a,b,c   Galve Roperh, Ismael ^a,b,c  

^a Centro de Investigación Biomédica en Red de Cáncer CIBERONC University of Barcelona   (Spain)

^b INSTITUTO RAMÓN Y CAJAL DE INVESTIGACIÓN SANITARIA IRYCIS   (Spain)

^c UNIVERSIDAD COMPLUTENSE DE MADRID   (Spain)

^d UNIVERSITY MEDICAL CENTER MAINZ   (Germany)

^e UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Cannabis; CB1 cannabinoid receptor; Corticospinal; Neurodevelopment; Seizures

Indexed keywords

CANNABINOID; CANNABINOID 1 RECEPTOR; CRE RECOMBINASE; DRONABINOL;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BRAIN DEVELOPMENT; CANNABIS USE; CONNECTOME; CONTROLLED STUDY; EMBRYO; FEMALE; FOREBRAIN; GABAERGIC SYSTEM; GLUTAMATERGIC SYNAPSE; MOTONEURON; MOTOR PERFORMANCE; MOUSE; NERVE PROJECTION; NEUROBIOLOGY; NONHUMAN; PRENATAL EXPOSURE; PRIORITY JOURNAL; PROGENY; PROTEIN EXPRESSION; REGULATORY MECHANISM; SEIZURE SUSCEPTIBILITY; SIGNAL TRANSDUCTION; TELENCEPHALON; ANIMAL; BRAIN CORTEX; GROWTH, DEVELOPMENT AND AGING; MATERNAL EXPOSURE; METABOLISM; NERVE CELL; PREGNANCY;

ANIMALS; CEREBRAL CORTEX; DRONABINOL; FEMALE; MATERNAL EXPOSURE; MICE; NEURONS; PREGNANCY; RECEPTOR, CANNABINOID, CB1;

EID: 84946616222     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1514962112     Document Type: Article

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