Adolescent exposure to THC in female rats disrupts developmental changes in the prefrontal cortex

Neurobiology of Disease

Volumn 73, Issue , 2015, Pages 60-69

  Rubino, Tiziana ^a   Prini, Pamela ^a   Piscitelli, Fabiana ^b   Zamberletti, Erica ^a   Trusel, Massimo ^c   Melis, Miriam ^d   Sagheddu, Claudia ^d   Ligresti, Alessia ^b   Tonini, Raffaella ^c   Di Marzo, Vincenzo ^b   Parolaro, Daniela ^a,e  

^a UNIVERSITY OF INSUBRIA   (Italy)

^b CNR   (Italy)

^c ISTITUTO ITALIANO DI TECNOLOGIA   (Italy)

^d UNIVERSITY OF CAGLIARI   (Italy)

^e Zardi Gori Foundation   (Italy)

Author keywords

Adolescence; AMPA receptors; Endocannabinoid system; NMDA receptors; Prefrontal cortex; Spine density; THC

Indexed keywords

2 ARACHIDONOYLGLYCEROL; ACYLGLYCEROL LIPASE; AMPA RECEPTOR; AMPA RECEPTOR 1; AMPA RECEPTOR 2; ANANDAMIDE; CANNABINOID 1 RECEPTOR; ENDOCANNABINOID; ESTRADIOL; FATTY ACID AMIDASE; GLUTAMIC ACID; N METHYL DEXTRO ASPARTIC ACID; N METHYL DEXTRO ASPARTIC ACID RECEPTOR 2A; N METHYL DEXTRO ASPARTIC ACID RECEPTOR 2B; POSTSYNAPTIC DENSITY PROTEIN 95; TETRAHYDROCANNABINOL; UNCLASSIFIED DRUG; 1 (2,4 DICHLOROPHENYL) 5 (4 IODOPHENYL) 4 METHYL N (1 PIPERIDYL) 1H PYRAZOLE 3 CARBOXAMIDE; 3-(2-HYDROXY-4-(1,1-DIMETHYLHEPTYL)PHENYL)-4-(3-HYDROXYPROPYL)CYCLOHEXANOL; AMINO ACID RECEPTOR BLOCKING AGENT; CANNABINOID RECEPTOR AGONIST; CYCLOHEXANOL DERIVATIVE; DIZOCILPINE MALEATE; DRONABINOL; GLUTAMATE RECEPTOR; PIPERIDINE DERIVATIVE; PYRAZOLE DERIVATIVE; TRITIUM;

ADOLESCENT; ADULTHOOD; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BIOCHEMISTRY; BRAIN DEVELOPMENT; BRAIN ELECTROPHYSIOLOGY; COGNITIVE DEFECT; CONTROLLED STUDY; DENDRITIC SPINE; DRUG EXPOSURE; ENZYME ACTIVITY; FEMALE; LONG TERM DEPRESSION; MAZE TEST; MENTAL DISEASE; NONHUMAN; PREFRONTAL CORTEX; PYRAMIDAL NERVE CELL; RAT; RECEPTOR BLOCKING; RISK FACTOR; SIGNAL TRANSDUCTION; SPATIAL MEMORY; SYNAPSE; WORKING MEMORY; AGE; ANIMAL; BLOOD; CHEMICALLY INDUCED; DEVELOPMENTAL DISORDER; DRUG EFFECTS; ESTRUS CYCLE; IN VITRO STUDY; METABOLISM; NEURITE; PHYSIOLOGY; SCINTISCANNING; SPRAGUE DAWLEY RAT; SYNAPTIC POTENTIAL; ULTRASTRUCTURE;

AGE FACTORS; ANIMALS; CANNABINOID RECEPTOR AGONISTS; CYCLOHEXANOLS; DEVELOPMENTAL DISABILITIES; DIZOCILPINE MALEATE; DRONABINOL; ESTRADIOL; ESTROUS CYCLE; EXCITATORY AMINO ACID ANTAGONISTS; FEMALE; IN VITRO TECHNIQUES; NEURITES; PIPERIDINES; PREFRONTAL CORTEX; PYRAZOLES; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, GLUTAMATE; SYNAPTIC POTENTIALS; TRITIUM;

EID: 84908424384     PISSN: 09699961     EISSN: 1095953X     Source Type: Journal    
DOI: 10.1016/j.nbd.2014.09.015     Document Type: Article

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