Development of a diverse human T-cell repertoire despite stringent restriction of hematopoietic clonality in the thymus

Proceedings of the National Academy of Sciences of the United States of America

Volumn 112, Issue 44, 2015, Pages E6020-E6027

  Brugman, Martijn H ^a   Wiekmeijer, Anna Sophia ^a   Van Eggermond, Marja ^a   Wolvers Tettero, Ingrid ^b   Langerak, Anton W ^b   De Haas, Edwin F E ^a   Bystrykh, Leonid V ^c   Van Rood, Jon J ^a   De Haan, Gerald ^c   Fibbe, Willem E ^a   Staal, Frank J T ^a  

^a LEIDEN UNIVERSITY MEDICAL CENTER   (Netherlands)

^b ERASMUS MEDICAL CENTER   (Netherlands)

^c UNIVERSITY MEDICAL CENTER GRONINGEN   (Netherlands)

Author keywords

Hematopoietic stem cell; T lymphocyte; T cell development; T cell receptor; Thymus

Indexed keywords

DNA; LENTIVIRUS VECTOR; T LYMPHOCYTE RECEPTOR; VIRUS DNA;

ANIMAL CELL; ARTICLE; BONE MARROW CELL; CHIMERA; CLONAL VARIATION; CONTROLLED STUDY; DNA BARCODING; DNA SEQUENCE; GENE REARRANGEMENT; HEMATOPOIETIC STEM CELL TRANSPLANTATION; HUMAN; HUMAN CELL; LYMPHOID CELL; MOUSE; NONHUMAN; POLYCLONAL ACTIVATION; PRIORITY JOURNAL; T LYMPHOCYTE; TARGET CELL; THYMOCYTE; THYMUS; UMBILICAL CORD BLOOD; XENOGRAFT; ANIMAL; CYTOLOGY; NONOBESE DIABETIC MOUSE; SCID MOUSE;

ANIMALS; BONE MARROW CELLS; HUMANS; MICE; MICE, INBRED NOD; MICE, SCID; T-LYMPHOCYTES; THYMUS GLAND;

EID: 84946616220     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1519118112     Document Type: Article

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