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Volumn 75, Issue 21, 2015, Pages 4617-4628

PI3K-mTORC2 but not PI3K-mTORC1 regulates transcription of HIF2A/EPAS1and vascularization in neuroblastoma

Author keywords

[No Author keywords available]

Indexed keywords

HYPOXIA INDUCIBLE FACTOR 2ALPHA; MAMMALIAN TARGET OF RAPAMYCIN COMPLEX 1; MAMMALIAN TARGET OF RAPAMYCIN COMPLEX 2; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; SOMATOMEDIN C RECEPTOR; AKT1 PROTEIN, HUMAN; BASIC HELIX LOOP HELIX TRANSCRIPTION FACTOR; ENDOTHELIAL PAS DOMAIN-CONTAINING PROTEIN 1; HIF1A PROTEIN, HUMAN; HYPOXIA INDUCIBLE FACTOR 1ALPHA; IGF1R PROTEIN, HUMAN; INSR PROTEIN, HUMAN; INSULIN RECEPTOR; LEUKOCYTE ANTIGEN; MECHANISTIC TARGET OF RAPAMYCIN COMPLEX 1; MESSENGER RNA; MULTIPROTEIN COMPLEX; RPTOR PROTEIN, HUMAN; SIGNAL TRANSDUCING ADAPTOR PROTEIN; SMALL INTERFERING RNA; SOMATOMEDIN B RECEPTOR; SOMATOMEDIN RECEPTOR; TARGET OF RAPAMYCIN KINASE; TOR COMPLEX 2;

EID: 84946593823     PISSN: 00085472     EISSN: 15387445     Source Type: Journal    
DOI: 10.1158/0008-5472.CAN-15-0708     Document Type: Article
Times cited : (76)

References (50)
  • 1
    • 0032493368 scopus 로고    scopus 로고
    • Regulation of hypoxia-inducible factor 1a is mediated by an O2-dependent degradation domain via the ubiquitinproteasome pathway
    • Huang LE, Gu J, Schau M, Bunn HF. Regulation of hypoxia-inducible factor 1a is mediated by an O2-dependent degradation domain via the ubiquitinproteasome pathway. Proc Natl Acad Sci U S A 1998;95:7987-92.
    • (1998) Proc Natl Acad Sci U S A , vol.95 , pp. 7987-7992
    • Huang, L.E.1    Gu, J.2    Schau, M.3    Bunn, H.F.4
  • 2
    • 0033525830 scopus 로고    scopus 로고
    • Regulation of the hypoxia-inducible transcription factor 1a by the ubiquitin-proteasome pathway
    • Kallio PJ, Wilson WJ, O'Brien S, Makino Y, Poellinger L. Regulation of the hypoxia-inducible transcription factor 1a by the ubiquitin-proteasome pathway. J Biol Chem 1999;274:6519-25.
    • (1999) J Biol Chem , vol.274 , pp. 6519-6525
    • Kallio, P.J.1    Wilson, W.J.2    O'Brien, S.3    Makino, Y.4    Poellinger, L.5
  • 3
    • 0035860147 scopus 로고    scopus 로고
    • Relation of hypoxia inducible factor 1 a and 2 a in operable non-small cell lung cancer to angiogenic/molecular profile of tumours and survival
    • Giatromanolaki A, Koukourakis MI, Sivridis E, Turley H, Talks K, Pezzella F, et al. Relation of hypoxia inducible factor 1 a and 2 a in operable non-small cell lung cancer to angiogenic/molecular profile of tumours and survival. Br J Cancer 2001;85:881-90.
    • (2001) Br J Cancer , vol.85 , pp. 881-890
    • Giatromanolaki, A.1    Koukourakis, M.I.2    Sivridis, E.3    Turley, H.4    Talks, K.5    Pezzella, F.6
  • 4
    • 33750630119 scopus 로고    scopus 로고
    • Recruitment ofHIF-1a andHIF-2a tocommontarget genes is differentially regulated in neuroblastoma: HIF-2a promotes an aggressive phenotype
    • Holmquist-Mengelbier L, Fredlund E, Löfstedt T, Noguera R, Navarro S, Nilsson H, et al. Recruitment ofHIF-1a andHIF-2a tocommontarget genes is differentially regulated in neuroblastoma: HIF-2a promotes an aggressive phenotype. Cancer Cell 2006;10:413-23.
    • (2006) Cancer Cell , vol.10 , pp. 413-423
    • Holmquist-Mengelbier, L.1    Fredlund, E.2    Löfstedt, T.3    Noguera, R.4    Navarro, S.5    Nilsson, H.6
  • 5
    • 56449095636 scopus 로고    scopus 로고
    • Hypoxia-inducible factor-2a correlates to distant recurrence and poor outcome in invasive breast cancer
    • Helczynska K, Larsson AM, Holmquist Mengelbier L, Bridges E, Fredlund E, Borgquist S, et al. Hypoxia-inducible factor-2a correlates to distant recurrence and poor outcome in invasive breast cancer. Cancer Res 2008;68: 9212-20.
    • (2008) Cancer Res , vol.68 , pp. 9212-9220
    • Helczynska, K.1    Larsson, A.M.2    Holmquist, M.L.3    Bridges, E.4    Fredlund, E.5    Borgquist, S.6
  • 6
    • 33646423829 scopus 로고    scopus 로고
    • Hypoxia inducible factor-1a is a prognosticmarker in premenopausal patients with intermediate to highly differentiated breast cancer but not a predictive marker for tamoxifen response
    • Kronblad A, Jirstrom K, Ryden L, Nordenskjold B, Landberg G. Hypoxia inducible factor-1a is a prognosticmarker in premenopausal patients with intermediate to highly differentiated breast cancer but not a predictive marker for tamoxifen response. Int J Cancer 2006;118:2609-16.
    • (2006) Int J Cancer , vol.118 , pp. 2609-2616
    • Kronblad, A.1    Jirstrom, K.2    Ryden, L.3    Nordenskjold, B.4    Landberg, G.5
  • 7
    • 65749106405 scopus 로고    scopus 로고
    • Hypoxiainducible factors regulate tumorigenic capacity of glioma stem cells
    • Li Z, Bao S, Wu Q, Wang H, Eyler C, Sathornsumetee S, et al. Hypoxiainducible factors regulate tumorigenic capacity of glioma stem cells. Cancer Cell 2009;15:501-13.
    • (2009) Cancer Cell , vol.15 , pp. 501-513
    • Li, Z.1    Bao, S.2    Wu, Q.3    Wang, H.4    Eyler, C.5    Sathornsumetee, S.6
  • 8
    • 73149112785 scopus 로고    scopus 로고
    • HIF-1a and HIF-2a are differentially regulated in vivo in neuroblastoma: High HIF-1a correlates negatively to advanced clinical stage and tumor vascularization
    • Noguera R, Fredlund E, Piqueras M, Pietras A, Beckman S, Navarro S, et al. HIF-1a and HIF-2a are differentially regulated in vivo in neuroblastoma: high HIF-1a correlates negatively to advanced clinical stage and tumor vascularization. Clin Cancer Res 2009;15:7130-6.
    • (2009) Clin Cancer Res , vol.15 , pp. 7130-7136
    • Noguera, R.1    Fredlund, E.2    Piqueras, M.3    Pietras, A.4    Beckman, S.5    Navarro, S.6
  • 9
    • 0036278899 scopus 로고    scopus 로고
    • Overexpression of hypoxia-inducible factor 1a is associated with an unfavorable prognosis in lymph node-positive breast cancer
    • Schindl M, Schoppmann SF, Samonigg H, Hausmaninger H, Kwasny W, Gnant M, et al. Overexpression of hypoxia-inducible factor 1a is associated with an unfavorable prognosis in lymph node-positive breast cancer. Clin Cancer Res 2002;8:1831-7.
    • (2002) Clin Cancer Res , vol.8 , pp. 1831-1837
    • Schindl, M.1    Schoppmann, S.F.2    Samonigg, H.3    Hausmaninger, H.4    Kwasny, W.5    Gnant, M.6
  • 10
    • 70350225829 scopus 로고    scopus 로고
    • The hypoxic microenvironment maintains glioblastoma stem cells and promotes reprogramming towards a cancer stem cell phenotype
    • Heddleston JM, Li Z, McLendon RE, Hjelmeland AB, Rich JN. The hypoxic microenvironment maintains glioblastoma stem cells and promotes reprogramming towards a cancer stem cell phenotype. Cell Cycle 2009;8: 3274-84.
    • (2009) Cell Cycle , vol.8 , pp. 3274-3284
    • Heddleston, J.M.1    Li, Z.2    McLendon, R.E.3    Hjelmeland, A.B.4    Rich, J.N.5
  • 12
    • 84874587449 scopus 로고    scopus 로고
    • HIF2A and IGF2 expression correlates in human neuroblastoma cells and normal immature sympathetic neuroblasts
    • Mohlin S, Hamidian A, Pa hlman S. HIF2A and IGF2 expression correlates in human neuroblastoma cells and normal immature sympathetic neuroblasts. Neoplasia 2013;15:328-34.
    • (2013) Neoplasia , vol.15 , pp. 328-334
    • Mohlin, S.1    Hamidian, A.2    Pahlman, S.3
  • 13
    • 40349088993 scopus 로고    scopus 로고
    • High levels of HIF-2a highlight an immature neural crest-like neuroblastoma cell cohort located in a perivascular niche
    • Pietras A, Gisselsson D, Øra I, Noguera R, Beckman S, Navarro S, et al. High levels of HIF-2a highlight an immature neural crest-like neuroblastoma cell cohort located in a perivascular niche. J Pathol 2008;214: 482-8.
    • (2008) J Pathol , vol.214 , pp. 482-488
    • Pietras, A.1    Gisselsson, D.2    Øra, I.3    Noguera, R.4    Beckman, S.5    Navarro, S.6
  • 14
    • 0027423419 scopus 로고
    • Role of insulin-like growth factors in embryonic and postnatal growth
    • Baker J, Liu JP, Robertson EJ, Efstratiadis A. Role of insulin-like growth factors in embryonic and postnatal growth. Cell 1993;75:73-82.
    • (1993) Cell , vol.75 , pp. 73-82
    • Baker, J.1    Liu, J.P.2    Robertson, E.J.3    Efstratiadis, A.4
  • 15
    • 0025320906 scopus 로고
    • A growth-deficiency phenotype in heterozygous mice carrying an insulin-like growth factor II gene disrupted by targeting
    • De Chiara TM, Efstratiadis A, Robertson EJ. A growth-deficiency phenotype in heterozygous mice carrying an insulin-like growth factor II gene disrupted by targeting. Nature 1990;345:78-80.
    • (1990) Nature , vol.345 , pp. 78-80
    • De Chiara, T.M.1    Efstratiadis, A.2    Robertson, E.J.3
  • 16
    • 56749184290 scopus 로고    scopus 로고
    • Insulin and insulin-like growth factor signalling in neoplasia
    • Pollak M. Insulin and insulin-like growth factor signalling in neoplasia. Nat Rev Cancer 2008;8:915-28.
    • (2008) Nat Rev Cancer , vol.8 , pp. 915-928
    • Pollak, M.1
  • 17
  • 18
    • 19644376976 scopus 로고    scopus 로고
    • Topotecan blocks hypoxia-inducible factor-1a and vascular endothelial growth factor expression induced by insulin-like growth factor-I in neuroblastoma cells
    • Beppu K, Nakamura K, Linehan WM, Rapisarda A, Thiele CJ. Topotecan blocks hypoxia-inducible factor-1a and vascular endothelial growth factor expression induced by insulin-like growth factor-I in neuroblastoma cells. Cancer Res 2005;65:4775-81.
    • (2005) Cancer Res , vol.65 , pp. 4775-4781
    • Beppu, K.1    Nakamura, K.2    Linehan, W.M.3    Rapisarda, A.4    Thiele, C.J.5
  • 19
    • 67649814136 scopus 로고    scopus 로고
    • PI3K/PTEN signaling in angiogenesis and tumorigenesis
    • Jiang BH, Liu LZ. PI3K/PTEN signaling in angiogenesis and tumorigenesis. Adv Cancer Res 2009;102:19-65.
    • (2009) Adv Cancer Res , vol.102 , pp. 19-65
    • Jiang, B.H.1    Liu, L.Z.2
  • 20
    • 58049216350 scopus 로고    scopus 로고
    • Differential dependence of hypoxia-inducible factors 1 a and 2 a on mTORC1 and mTORC2
    • Toschi A, Lee E, Gadir N, Ohh M, Foster DA. Differential dependence of hypoxia-inducible factors 1 a and 2 a on mTORC1 and mTORC2. J Biol Chem 2008;283:34495-9.
    • (2008) J Biol Chem , vol.283 , pp. 34495-34499
    • Toschi, A.1    Lee, E.2    Gadir, N.3    Ohh, M.4    Foster, D.A.5
  • 21
    • 0034654174 scopus 로고    scopus 로고
    • Modulation of hypoxia-inducible factor 1a expression by the epidermal growth factor/phosphatidylinositol 3-kinase/PTEN/AKT/FRAP pathway in human prostate cancer cells: Implications for tumor angiogenesis and therapeutics
    • Zhong H, Chiles K, Feldser D, Laughner E, Hanrahan C, Georgescu MM, et al. Modulation of hypoxia-inducible factor 1a expression by the epidermal growth factor/phosphatidylinositol 3-kinase/PTEN/AKT/FRAP pathway in human prostate cancer cells: implications for tumor angiogenesis and therapeutics. Cancer Res 2000;60:1541-5.
    • (2000) Cancer Res , vol.60 , pp. 1541-1545
    • Zhong, H.1    Chiles, K.2    Feldser, D.3    Laughner, E.4    Hanrahan, C.5    Georgescu, M.M.6
  • 23
    • 84907272714 scopus 로고    scopus 로고
    • Fructose-1, 6- bisphosphatase opposes renal carcinoma progression
    • Li B, Qiu B, Lee DS, Walton ZE, Ochocki JD, Mathew LK, et al. Fructose-1, 6- bisphosphatase opposes renal carcinoma progression. Nature 2014;513: 251-5.
    • (2014) Nature , vol.513 , pp. 251-255
    • Li, B.1    Qiu, B.2    Lee, D.S.3    Walton, Z.E.4    Ochocki, J.D.5    Mathew, L.K.6
  • 25
    • 84946612144 scopus 로고    scopus 로고
    • Broad Institute [Internet]. [cited 2015 Aug 20]
    • Broad Institute [Internet]. [cited 2015 Aug 20]. Available from: www.broad.mit.edu/gsea/msigdb.
  • 26
    • 84870490179 scopus 로고    scopus 로고
    • [Internet]. [cited 2015 Aug 20]
    • National Center for Biotechnology Information [Internet]. [cited 2015 Aug 20]. Available from: http://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc1/4GSE69833.
    • National Center for Biotechnology Information
  • 27
    • 84918532694 scopus 로고    scopus 로고
    • Neuroblastoma patient-derived orthotopic xenografts retain metastatic patterns and geno- And phenotypes of patient tumours
    • Braekeveldt N, Wigerup C, Gisselsson D, Mohlin S, Merselius M, Beckman S, et al. Neuroblastoma patient-derived orthotopic xenografts retain metastatic patterns and geno- And phenotypes of patient tumours. Int J Cancer 2015;136:E252-61.
    • (2015) Int J Cancer , vol.136 , pp. E252-E261
    • Braekeveldt, N.1    Wigerup, C.2    Gisselsson, D.3    Mohlin, S.4    Merselius, M.5    Beckman, S.6
  • 28
    • 84946612145 scopus 로고    scopus 로고
    • [Internet]. [cited 2015 Aug 20]
    • AMC Oncogenomics [Internet]. [cited 2015 Aug 20]. Available from: http://r2.amc.nl.
    • AMC Oncogenomics
  • 31
    • 84875804031 scopus 로고    scopus 로고
    • Targeting activated Akt with GDC-0068, a novel selective Akt inhibitor that is efficacious in multiple tumor models
    • Lin J, Sampath D, Nannini MA, Lee BB, Degtyarev M, Oeh J, et al. Targeting activated Akt with GDC-0068, a novel selective Akt inhibitor that is efficacious in multiple tumor models. Clin Cancer Res 2013;19:1760-72.
    • (2013) Clin Cancer Res , vol.19 , pp. 1760-1772
    • Lin, J.1    Sampath, D.2    Nannini, M.A.3    Lee, B.B.4    Degtyarev, M.5    Oeh, J.6
  • 32
    • 0030826662 scopus 로고    scopus 로고
    • Src-induced activation of inducible T cell kinase (ITK) requires phosphatidylinositol 3-kinase activity and the Pleckstrin homology domain of inducible T cell kinase
    • August A, Sadra A, Dupont B, Hanafusa H. Src-induced activation of inducible T cell kinase (ITK) requires phosphatidylinositol 3-kinase activity and the Pleckstrin homology domain of inducible T cell kinase. Proc Natl Acad Sci U S A 1997;94:11227-32.
    • (1997) Proc Natl Acad Sci U S A , vol.94 , pp. 11227-11232
    • August, A.1    Sadra, A.2    Dupont, B.3    Hanafusa, H.4
  • 33
    • 33644513730 scopus 로고    scopus 로고
    • Beyond PTEN mutations: The PI3K pathway as an integrator of multiple inputs during tumorigenesis
    • Cully M, You H, Levine AJ, Mak TW. Beyond PTEN mutations: The PI3K pathway as an integrator of multiple inputs during tumorigenesis. Nat Rev Cancer 2006;6:184-92.
    • (2006) Nat Rev Cancer , vol.6 , pp. 184-192
    • Cully, M.1    You, H.2    Levine, A.J.3    Mak, T.W.4
  • 35
    • 84879694703 scopus 로고    scopus 로고
    • Stabilization of HIF-2a through redox regulation of mTORC2 activation and initiation of mRNA translation
    • Nayak BK, Feliers D, Sudarshan S, Friedrichs WE, Day RT, New DD, et al. Stabilization of HIF-2a through redox regulation of mTORC2 activation and initiation of mRNA translation. Oncogene 2013;32:3147-55.
    • (2013) Oncogene , vol.32 , pp. 3147-3155
    • Nayak, B.K.1    Feliers, D.2    Sudarshan, S.3    Friedrichs, W.E.4    Day, R.T.5    New, D.D.6
  • 36
    • 12344331744 scopus 로고    scopus 로고
    • HIF-2a expression in human fetal paraganglia and neuroblastoma: Relation to sympathetic differentiation, glucose deficiency, and hypoxia
    • Nilsson H, Jögi A, Beckman S, Harris AL, Poellinger L, Pa hlman S. HIF-2a expression in human fetal paraganglia and neuroblastoma: relation to sympathetic differentiation, glucose deficiency, and hypoxia. Exper Cell Res 2005;303:447-56.
    • (2005) Exper Cell Res , vol.303 , pp. 447-456
    • Nilsson, H.1    Jögi, A.2    Beckman, S.3    Harris, A.L.4    Poellinger, L.5    Pa Hlman, S.6
  • 38
    • 33748068792 scopus 로고    scopus 로고
    • Inhibition of phosphatidylinositol 3-kinase destabilizes Mycn protein and blocks malignant progression in neuroblastoma
    • Chesler L, Schlieve C, Goldenberg DD, Kenney A, Kim G, McMillan A, et al. Inhibition of phosphatidylinositol 3-kinase destabilizes Mycn protein and blocks malignant progression in neuroblastoma. Cancer Res 2006;66: 8139-46.
    • (2006) Cancer Res , vol.66 , pp. 8139-8146
    • Chesler, L.1    Schlieve, C.2    Goldenberg, D.D.3    Kenney, A.4    Kim, G.5    McMillan, A.6
  • 39
    • 42949133285 scopus 로고    scopus 로고
    • Inhibitors of mammalian target of rapamycin downregulate MYCN protein expression and inhibit neuroblastoma growth in vitro and in vivo
    • Johnsen JI, Segerstrom L, Orrego A, Elfman L, Henriksson M, Kagedal B, et al. Inhibitors of mammalian target of rapamycin downregulate MYCN protein expression and inhibit neuroblastoma growth in vitro and in vivo. Oncogene 2008;27:2910-22.
    • (2008) Oncogene , vol.27 , pp. 2910-2922
    • Johnsen, J.I.1    Segerstrom, L.2    Orrego, A.3    Elfman, L.4    Henriksson, M.5    Kagedal, B.6
  • 40
    • 24944536147 scopus 로고    scopus 로고
    • Comparison of phosphatidylinositol-3-kinase signalling within a panel of human colorectal cancer cell lines withmutant or wild-type PIK3CA
    • Morrow CJ, Gray A, Dive C. Comparison of phosphatidylinositol-3-kinase signalling within a panel of human colorectal cancer cell lines withmutant or wild-type PIK3CA. FEBS Lett 2005;579:5123-8.
    • (2005) FEBS Lett , vol.579 , pp. 5123-5128
    • Morrow, C.J.1    Gray, A.2    Dive, C.3
  • 42
    • 79953216041 scopus 로고    scopus 로고
    • Evidence for direct activation of mTORC2 kinase activity by phosphatidylinositol 3, 4, 5-trisphosphate
    • Gan X, Wang J, Su B, Wu D. Evidence for direct activation of mTORC2 kinase activity by phosphatidylinositol 3, 4, 5-trisphosphate. J Biol Chem 2011;286:10998-1002.
    • (2011) J Biol Chem , vol.286 , pp. 10998-11002
    • Gan, X.1    Wang, J.2    Su, B.3    Wu, D.4
  • 45
    • 79953211540 scopus 로고    scopus 로고
    • Amino acids activate mammalian target of rapamycin complex 2 (mTORC2) via PI3K/Akt signaling
    • Tato I, Bartrons R, Ventura F, Rosa JL. Amino acids activate mammalian target of rapamycin complex 2 (mTORC2) via PI3K/Akt signaling. J Biol Chem 2011;286:6128-42.
    • (2011) J Biol Chem , vol.286 , pp. 6128-6142
    • Tato, I.1    Bartrons, R.2    Ventura, F.3    Rosa, J.L.4
  • 46
    • 84903985731 scopus 로고    scopus 로고
    • PI3K-p110-a-subtype signalling mediates survival, proliferation and neurogenesis of cortical progenitor cells via activation of mTORC2
    • Wahane SD, Hellbach N, Prentzell MT, Weise SC, Vezzali R, Kreutz C, et al. PI3K-p110-a-subtype signalling mediates survival, proliferation and neurogenesis of cortical progenitor cells via activation of mTORC2. J Neurochem 2014;130:255-67.
    • (2014) J Neurochem , vol.130 , pp. 255-267
    • Wahane, S.D.1    Hellbach, N.2    Prentzell, M.T.3    Weise, S.C.4    Vezzali, R.5    Kreutz, C.6
  • 47
    • 84906895091 scopus 로고    scopus 로고
    • Patient-derived xenograft models: An emerging platform for translational cancer research
    • Hidalgo M, Amant F, Biankin AV, Budinska E, Byrne AT, Caldas C, et al. Patient-derived xenograft models: An emerging platform for translational cancer research. Cancer Discov 2014;4:998-1013.
    • (2014) Cancer Discov , vol.4 , pp. 998-1013
    • Hidalgo, M.1    Amant, F.2    Biankin, A.V.3    Budinska, E.4    Byrne, A.T.5    Caldas, C.6
  • 48
    • 79959215471 scopus 로고    scopus 로고
    • Differential hypoxic regulation of hypoxia-inducible factors 1a and 2a
    • Lin Q, Cong X, Yun Z. Differential hypoxic regulation of hypoxia-inducible factors 1a and 2a. Mol Cancer Res 2011;9:757-65.
    • (2011) Mol Cancer Res , vol.9 , pp. 757-765
    • Lin, Q.1    Cong, X.2    Yun, Z.3
  • 50
    • 84896401739 scopus 로고    scopus 로고
    • Molecular targets for cancer therapy in the PI3K/AKT/mTOR pathway
    • Polivka J Jr., Janku F. Molecular targets for cancer therapy in the PI3K/AKT/mTOR pathway. Pharmacol Ther 2014;142:164-75.
    • (2014) Pharmacol Ther , vol.142 , pp. 164-175
    • Polivka, J.1    Janku, F.2


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