The potential role of Brachyury in inducing epithelial-to-mesenchymal transition (EMT) and HIF-1α expression in breast cancer cells

Biochemical and Biophysical Research Communications

Volumn 467, Issue 4, 2015, Pages 1083-1089

  Shao, Chao ^a   Zhang, Jingjing ^a   Fu, Jianhua ^a   Ling, Feihai ^a  

^a SUN YAT SEN UNIVERSITY   (China)

Author keywords

Brachyury; Breast cancer; Epithelial to mesenchymal transition; Hypoxia inducible factor 1 ; Tumor xenograft

Indexed keywords

HYPOXIA INDUCIBLE FACTOR 1ALPHA; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; PROTEIN KINASE B; SMALL INTERFERING RNA; T BOX TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR BRACHYURY; UNCLASSIFIED DRUG; UVOMORULIN; VIMENTIN; BRACHYURY PROTEIN; FETOPROTEIN; HIF1A PROTEIN, HUMAN;

ADULT; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BREAST CANCER; BREAST CARCINOGENESIS; CANCER STAGING; CANCER TISSUE; CELL MIGRATION; CELL PROLIFERATION; CLINICAL FEATURE; CONTROLLED STUDY; CORRELATIONAL STUDY; EPITHELIAL MESENCHYMAL TRANSITION; FEMALE; GENE SILENCING; HUMAN; HUMAN CELL; HUMAN TISSUE; HYPOXIA; IN VITRO STUDY; IN VIVO STUDY; LUNG METASTASIS; LYMPH NODE METASTASIS; MAJOR CLINICAL STUDY; MCF 7 CELL LINE; METASTASIS POTENTIAL; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; REAL TIME POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; TUMOR GROWTH; TUMOR XENOGRAFT; WESTERN BLOTTING; ANIMAL; BREAST TUMOR; METABOLISM; MIDDLE AGED; PATHOLOGY; PHYSIOLOGY;

ADULT; ANIMALS; BREAST NEOPLASMS; EPITHELIAL-MESENCHYMAL TRANSITION; FEMALE; FETAL PROTEINS; HUMANS; HYPOXIA-INDUCIBLE FACTOR 1, ALPHA SUBUNIT; MICE; MIDDLE AGED; T-BOX DOMAIN PROTEINS;

EID: 84946574127     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2015.09.076     Document Type: Article

References (35)

1. L. Fan, K. Strasser-Weippl, J.J. Li, J. St Louis, D.M. Finkelstein, K.D. Yu, W.Q. Chen, Z.M. Shao, and P.E. Goss Breast cancer in China Lancet Oncol. 15 2014 e279 289
2. R. Kalluri, and R.A. Weinberg The basics of epithelial-mesenchymal transition J. Clin. Invest. 119 2009 1420 1428
3. V.E. Papaioannou The T-box gene family: emerging roles in development, stem cells and cancer Development 141 2014 3819 3833
4. F. Pinto, N. Pertega-Gomes, M.S. Pereira, J.R. Vizcaino, P. Monteiro, R.M. Henrique, F. Baltazar, R.P. Andrade, and R.M. Reis T-box transcription factor brachyury is associated with prostate cancer progression and aggressiveness Clin. Cancer Res. 20 2014 4949 4961
5. N. Presneau, A. Shalaby, H. Ye, N. Pillay, D. Halai, B. Idowu, R. Tirabosco, D. Whitwell, T.S. Jacques, L.G. Kindblom, S. Bruderlein, P. Moller, A. Leithner, B. Liegl, F.M. Amary, N.N. Athanasou, P.C. Hogendoorn, F. Mertens, K. Szuhai, and A.M. Flanagan Role of the transcription factor T (brachyury) in the pathogenesis of sporadic chordoma: a genetic and functional-based study J. Pathol. 223 2011 327 335
6. A.C. Nelson, N. Pillay, S. Henderson, N. Presneau, R. Tirabosco, D. Halai, F. Berisha, P. Flicek, D.L. Stemple, C.D. Stern, F.C. Wardle, and A.M. Flanagan An integrated functional genomics approach identifies the regulatory network directed by brachyury (T) in chordoma J. Pathol. 228 2012 274 285
7. R.I. Fernando, M. Litzinger, P. Trono, D.H. Hamilton, J. Schlom, and C. Palena The T-box transcription factor Brachyury promotes epithelial-mesenchymal transition in human tumor cells J. Clin. Invest. 120 2010 533 544
8. U. Martinez-Outschoorn, F. Sotgia, and M.P. Lisanti Tumor microenvironment and metabolic synergy in breast cancers: critical importance of mitochondrial fuels and function Semin. Oncol. 41 2014 195 216
9. P. Vaupel, S. Briest, and M. Hockel Hypoxia in breast cancer: pathogenesis, characterization and biological/therapeutic implications Wien Med. Wochenschr. 152 2002 334 342
10. N.R. Prabhakar, and G.L. Semenza Adaptive and maladaptive cardiorespiratory responses to continuous and intermittent hypoxia mediated by hypoxia-inducible factors 1 and 2 Physiol. Rev. 92 2012 967 1003
11. G.L. Semenza HIF-1 mediates metabolic responses to intratumoral hypoxia and oncogenic mutations J. Clin. Invest. 123 2013 3664 3671
12. H. Zhong, A.M. De Marzo, E. Laughner, M. Lim, D.A. Hilton, D. Zagzag, P. Buechler, W.B. Isaacs, G.L. Semenza, and J.W. Simons Overexpression of hypoxia-inducible factor 1alpha in common human cancers and their metastases Cancer Res. 59 1999 5830 5835
13. D. Liao, C. Corle, T.N. Seagroves, and R.S. Johnson Hypoxia-inducible factor-1alpha is a key regulator of metastasis in a transgenic model of cancer initiation and progression Cancer Res. 67 2007 563 572
14. 2 availability on human cancer Nat. Rev. Cancer 8 2008 967 975
15. D. Samanta, D.M. Gilkes, P. Chaturvedi, L. Xiang, and G.L. Semenza Hypoxia-inducible factors are required for chemotherapy resistance of breast cancer stem cells Proc. Natl. Acad. Sci. U. S. A. 111 2014 E5429 E5438
16. L. Zhang, G. Huang, X. Li, Y. Zhang, Y. Jiang, J. Shen, J. Liu, Q. Wang, J. Zhu, X. Feng, J. Dong, and C. Qian Hypoxia induces epithelial-mesenchymal transition via activation of SNAI1 by hypoxia-inducible factor -1alpha in hepatocellular carcinoma BMC Cancer 13 2013 108
17. C.C. Chou, H.C. Chuang, S.B. Salunke, S.K. Kulp, and C.S. Chen A novel HIF-1alpha-integrin-linked kinase regulatory loop that facilitates hypoxia-induced HIF-1alpha expression and epithelial-mesenchymal transition in cancer cells Oncotarget 6 2015 8271 8285
18. F. Nigim, J. Cavanaugh, A.P. Patel, W.T. Curry Jr., S. Esaki, E.M. Kasper, A.S. Chi, D.N. Louis, R.L. Martuza, S.D. Rabkin, and H. Wakimoto Targeting hypoxia-inducible factor 1alpha in a new orthotopic model of glioblastoma recapitulating the hypoxic tumor microenvironment J. Neuropathol. Exp. Neurol. 74 2015 710 722
19. A. Subramani, S. Alsidawi, S. Jagannathan, K. Sumita, A.T. Sasaki, B. Aronow, R.E. Warnick, S. Lawler, and J.J. Driscoll The brain microenvironment negatively regulates miRNA-768-3p to promote K-ras expression and lung cancer metastasis Sci. Rep. 3 2013 2392
20. K. Xu, B. Liu, and Y. Liu Impact of Brachyury on epithelial-mesenchymal transitions and chemosensitivity in non-small cell lung cancer Mol. Med. Rep. 12 2015 995 1001
21. Y.P. Tsai, and K.J. Wu Hypoxia-regulated target genes implicated in tumor metastasis J. Biomed. Sci. 19 2012 102
22. Y. Liu, H. Nie, K. Zhang, D. Ma, G. Yang, Z. Zheng, K. Liu, B. Yu, C. Zhai, and S. Yang A feedback regulatory loop between HIF-1alpha and miR-21 in response to hypoxia in cardiomyocytes FEBS Lett. 588 2014 3137 3146
23. C. Palena, D.E. Polev, K.Y. Tsang, R.I. Fernando, M. Litzinger, L.L. Krukovskaya, A.V. Baranova, A.P. Kozlov, and J. Schlom The human T-box mesodermal transcription factor Brachyury is a candidate target for T-cell-mediated cancer immunotherapy Clin. Cancer Res. 13 2007 2471 2478
24. M. Roselli, R.I. Fernando, F. Guadagni, A. Spila, J. Alessandroni, R. Palmirotta, L. Costarelli, M. Litzinger, D. Hamilton, B. Huang, J. Tucker, K.Y. Tsang, J. Schlom, and C. Palena Brachyury, a driver of the epithelial-mesenchymal transition, is overexpressed in human lung tumors: an opportunity for novel interventions against lung cancer Clin. Cancer Res. 18 2012 3868 3879
25. R. Du, S. Wu, X. Lv, H. Fang, and J. Kang Overexpression of brachyury contributes to tumor metastasis by inducing epithelial-mesenchymal transition in hepatocellular carcinoma J. Exp. Clin. Cancer Res. 33 2014 105
26. C. Palena, M. Roselli, M.T. Litzinger, P. Ferroni, L. Costarelli, A. Spila, F. Cavaliere, B. Huang, R.I. Fernando, D.H. Hamilton, C. Jochems, K.Y. Tsang, Q. Cheng, H.K. Lyerly, J. Schlom, and F. Guadagni Overexpression of the EMT driver brachyury in breast carcinomas: association with poor prognosis J. Natl. Cancer Inst. 106 2014
27. T.L. Medley, M. Furtado, N.T. Lam, R. Idrizi, D. Williams, P.J. Verma, M. Costa, and D.M. Kaye Effect of oxygen on cardiac differentiation in mouse iPS cells: role of hypoxia inducible factor-1 and Wnt/beta-catenin signaling PLoS One 8 2013 e80280
28. D.L. Ramirez-Bergeron, A. Runge, K.D. Dahl, H.J. Fehling, G. Keller, and M.C. Simon Hypoxia affects mesoderm and enhances hemangioblast specification during early development Development 131 2004 4623 4634
29. R.I. Fernando, M.D. Castillo, M. Litzinger, D.H. Hamilton, and C. Palena IL-8 signaling plays a critical role in the epithelial-mesenchymal transition of human carcinoma cells Cancer Res. 71 2011 5296 5306
30. L.B. Liu, F. Xie, K.K. Chang, M.Q. Li, Y.H. Meng, X.H. Wang, H. Li, D.J. Li, and J.J. Yu Hypoxia promotes the proliferation of cervical carcinoma cells through stimulating the secretion of IL-8 Int. J. Clin. Exp. Pathol. 7 2014 575 583
31. G.L. Semenza Hypoxia-inducible factors: mediators of cancer progression and targets for cancer therapy Trends Pharmacol. Sci. 33 2012 207 214
32. G.L. Semenza Molecular mechanisms mediating metastasis of hypoxic breast cancer cells Trends Mol. Med. 18 2012 534 543
33. H. Huang, L.L. Benzonana, H. Zhao, H.R. Watts, N.J. Perry, C. Bevan, R. Brown, and D. Ma Prostate cancer cell malignancy via modulation of HIF-1alpha pathway with isoflurane and propofol alone and in combination Br. J. Cancer 111 2014 1338 1349
34. T.W. Miller, B.N. Rexer, J.T. Garrett, and C.L. Arteaga Mutations in the phosphatidylinositol 3-kinase pathway: role in tumor progression and therapeutic implications in breast cancer Breast Cancer Res. 13 2011 224
35. X. Li, W. Xie, C. Xie, C. Huang, J. Zhu, Z. Liang, F. Deng, M. Zhu, W. Zhu, R. Wu, J. Wu, S. Geng, and C. Zhong Curcumin modulates miR-19/PTEN/AKT/p53 axis to suppress bisphenol A-induced MCF-7 breast cancer cell proliferation Phytother. Res. 28 2014 1553 1560