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Volumn 20, Issue 18, 2014, Pages 4949-4961

T-box transcription factor brachyury is associated with prostate cancer progression and aggressiveness

Author keywords

[No Author keywords available]

Indexed keywords

BRACHYURY PROTEIN; FETOPROTEIN; T BOX TRANSCRIPTION FACTOR; TUMOR MARKER;

EID: 84907916641     PISSN: 10780432     EISSN: 15573265     Source Type: Journal    
DOI: 10.1158/1078-0432.CCR-14-0421     Document Type: Article
Times cited : (67)

References (44)
  • 1
    • 78049470983 scopus 로고    scopus 로고
    • Prostate cancer incidence and mortality trends in 37 European countries: An overview
    • Bray F, Lortet-Tieulent J, Ferlay J, Forman D, Auvinen A. Prostate cancer incidence and mortality trends in 37 European countries: an overview. Eur J Cancer 2010;46:3040-52.
    • (2010) Eur J Cancer , vol.46 , pp. 3040-3052
    • Bray, F.1    Lortet-Tieulent, J.2    Ferlay, J.3    Forman, D.4    Auvinen, A.5
  • 2
    • 67650999875 scopus 로고    scopus 로고
    • The basics of epithelial-mesenchymal transition
    • Kalluri R, Weinberg RA. The basics of epithelial-mesenchymal transition. J Clin Invest 2009;119:1420-8.
    • (2009) J Clin Invest , vol.119 , pp. 1420-1428
    • Kalluri, R.1    Weinberg, R.A.2
  • 3
    • 44449144396 scopus 로고    scopus 로고
    • Epithelial-mesenchymal transition: At the crossroads of development and tumor metastasis
    • Yang J, Weinberg RA. Epithelial-mesenchymal transition: at the crossroads of development and tumor metastasis. Dev Cell 2008;14: 818-29.
    • (2008) Dev Cell , vol.14 , pp. 818-829
    • Yang, J.1    Weinberg, R.A.2
  • 4
    • 1642430626 scopus 로고    scopus 로고
    • Origin and evolution of endoderm and mesoderm
    • Technau U, Scholz CB. Origin and evolution of endoderm and mesoderm. Int J Dev Biol 2003;47:531-9.
    • (2003) Int J Dev Biol , vol.47 , pp. 531-539
    • Technau, U.1    Scholz, C.B.2
  • 5
    • 33744503681 scopus 로고    scopus 로고
    • Brachyury, a crucial regulator of notochordal development, is a novel biomarker for chordomas
    • Vujovic S, Henderson S, Presneau N, Odell E, Jacques TS, Tirabosco R, et al. Brachyury, a crucial regulator of notochordal development, is a novel biomarker for chordomas. J Pathol 2006;209:157-65.
    • (2006) J Pathol , vol.209 , pp. 157-165
    • Vujovic, S.1    Henderson, S.2    Presneau, N.3    Odell, E.4    Jacques, T.S.5    Tirabosco, R.6
  • 6
    • 84892818249 scopus 로고    scopus 로고
    • Expression of brachyury gene is a significant prognostic factor for primary lung carcinoma
    • Haro A, Yano T, Kohno M, Yoshida T, Koga T, Okamoto T, et al. Expression of brachyury gene is a significant prognostic factor for primary lung carcinoma. Ann Surg Oncol 2013;20 Suppl 3: S509-16.
    • (2013) Ann Surg Oncol , vol.20 , pp. S509-S516
    • Haro, A.1    Yano, T.2    Kohno, M.3    Yoshida, T.4    Koga, T.5    Okamoto, T.6
  • 7
    • 84869838257 scopus 로고    scopus 로고
    • T-box transcription factor Brachyury expression is correlated with epithelial-mesenchymal transition and lymph node metastasis in oral squamous cell carcinoma
    • Imajyo I, Sugiura T, Kobayashi Y, Shimoda M, Ishii K, Akimoto N, et al. T-box transcription factor Brachyury expression is correlated with epithelial-mesenchymal transition and lymph node metastasis in oral squamous cell carcinoma. Int J Oncol 2012;41:1985-95.
    • (2012) Int J Oncol , vol.41 , pp. 1985-1995
    • Imajyo, I.1    Sugiura, T.2    Kobayashi, Y.3    Shimoda, M.4    Ishii, K.5    Akimoto, N.6
  • 8
    • 79953690193 scopus 로고    scopus 로고
    • Brachyury expression predicts poor prognosis at early stages of colorectal cancer
    • Kilic N, Feldhaus S, Kilic E, Tennstedt P, Wicklein D, Wasielewski Rv, et al. Brachyury expression predicts poor prognosis at early stages of colorectal cancer. Eur J Cancer 2011;47:1080-5.
    • (2011) Eur J Cancer , vol.47 , pp. 1080-1085
    • Kilic, N.1    Feldhaus, S.2    Kilic, E.3    Tennstedt, P.4    Wicklein, D.5    Rv, W.6
  • 9
    • 84863955851 scopus 로고    scopus 로고
    • Brachyury, a driver of the epithelial-mesenchymal transition, is overexpressed in human lung tumors: An opportunity for novel interventions against lung cancer
    • Roselli M, Fernando RI, Guadagni F, Spila A, Alessandroni J, Palmirotta R, et al. Brachyury, a driver of the epithelial-mesenchymal transition, is overexpressed in human lung tumors: an opportunity for novel interventions against lung cancer. Clin Cancer Res 2012;18:3868-79.
    • (2012) Clin Cancer Res , vol.18 , pp. 3868-3879
    • Roselli, M.1    Fernando, R.I.2    Guadagni, F.3    Spila, A.4    Alessandroni, J.5    Palmirotta, R.6
  • 10
    • 83655201491 scopus 로고    scopus 로고
    • BRACHYURY confers cancer stem cell characteristics on colorectal cancer cells
    • Sarkar D, Shields B, Davies ML, Müller J, Wakeman JA. BRACHYURY confers cancer stem cell characteristics on colorectal cancer cells. Int J Cancer 2012;130:328-37.
    • (2012) Int J Cancer , vol.130 , pp. 328-337
    • Sarkar, D.1    Shields, B.2    Davies, M.L.3    Müller, J.4    Wakeman, J.A.5
  • 11
    • 84865418683 scopus 로고    scopus 로고
    • The Tbox transcription factor Brachyury regulates epithelial-mesenchymal transition in association with cancer stem-like cells in adenoid cystic carcinoma cells
    • Shimoda M, Sugiura T, Imajyo I, Ishii K, Chigita S, Seki K, et al. The Tbox transcription factor Brachyury regulates epithelial-mesenchymal transition in association with cancer stem-like cells in adenoid cystic carcinoma cells. BMC Cancer 2012;12:377.
    • (2012) BMC Cancer , vol.12 , pp. 377
    • Shimoda, M.1    Sugiura, T.2    Imajyo, I.3    Ishii, K.4    Chigita, S.5    Seki, K.6
  • 12
    • 76649138588 scopus 로고    scopus 로고
    • The T-box transcription factor Brachyury promotes epithelialmesenchymal transition in human tumor cells
    • Fernando RI, Litzinger M, Trono P, Hamilton DH, Schlom J, Palena C. The T-box transcription factor Brachyury promotes epithelialmesenchymal transition in human tumor cells. J Clin Invest 2010; 120:533-44.
    • (2010) J Clin Invest , vol.120 , pp. 533-544
    • Fernando, R.I.1    Litzinger, M.2    Trono, P.3    Hamilton, D.H.4    Schlom, J.5    Palena, C.6
  • 13
    • 84884524473 scopus 로고    scopus 로고
    • An autocrine loop between TGF-beta1 and the transcription factor brachyury controls the transition of human carcinoma cells into a mesenchymal phenotype
    • Larocca C, Cohen JR, Fernando RI, Huang B, Hamilton DH, Palena C. An autocrine loop between TGF-beta1 and the transcription factor brachyury controls the transition of human carcinoma cells into a mesenchymal phenotype. Mol Cancer Ther 2013;12:1805-15.
    • (2013) Mol Cancer Ther , vol.12 , pp. 1805-1815
    • Larocca, C.1    Cohen, J.R.2    Fernando, R.I.3    Huang, B.4    Hamilton, D.H.5    Palena, C.6
  • 14
    • 79960952144 scopus 로고    scopus 로고
    • IL-8 signaling plays a critical role in the epithelial-mesenchymal transition of human carcinoma cells
    • Fernando RI, Castillo MD, Litzinger M, Hamilton DH, Palena C. IL-8 signaling plays a critical role in the epithelial-mesenchymal transition of human carcinoma cells. Cancer Res 2011;71:5296-306.
    • (2011) Cancer Res , vol.71 , pp. 5296-5306
    • Fernando, R.I.1    Castillo, M.D.2    Litzinger, M.3    Hamilton, D.H.4    Palena, C.5
  • 15
    • 84879680963 scopus 로고    scopus 로고
    • The embryonic transcription factor Brachyury blocks cell cycle progression and mediates tumor resistance to conventional antitumor therapies
    • Huang B, Cohen JR, Fernando RI, Hamilton DH, Litzinger MT, Hodge JW, et al. The embryonic transcription factor Brachyury blocks cell cycle progression and mediates tumor resistance to conventional antitumor therapies. Cell Death Dis 2013;4:e682.
    • (2013) Cell Death Dis , vol.4 , pp. e682
    • Huang, B.1    Cohen, J.R.2    Fernando, R.I.3    Hamilton, D.H.4    Litzinger, M.T.5    Hodge, J.W.6
  • 16
    • 36248939277 scopus 로고    scopus 로고
    • Epigenetic silencing of human T (brachyury homologue) gene in non-small-cell lung cancer
    • Park JC, Chae YK, Son CH, KimMS, Lee J, Ostrow K, et al. Epigenetic silencing of human T (brachyury homologue) gene in non-small-cell lung cancer. Biochem Biophys Res Commun 2008;365:221-6.
    • (2008) Biochem Biophys Res Commun , vol.365 , pp. 221-226
    • Park, J.C.1    Chae, Y.K.2    Son, C.H.3    Kimms Lee, J.4    Ostrow, K.5
  • 18
    • 24144493035 scopus 로고    scopus 로고
    • Egevad LLISUP grading committee. The 2005 international society of urological pathology (isup) consensus conference on gleason grading of prostatic carcinoma
    • Epstein JI, Allsbrook WC Jr, Amin MB, Egevad LLISUP Grading Committee. The 2005 International Society of Urological Pathology (ISUP) Consensus Conference on Gleason Grading of Prostatic Carcinoma. Am J Surg Pathol 2005;29:1228-42.
    • (2005) Am J Surg Pathol , vol.29 , pp. 1228-1242
    • Epstein, J.I.1    Allsbrook, W.C.2    Amin, M.B.3
  • 20
    • 84875122880 scopus 로고    scopus 로고
    • RKIP inhibition in cervical cancer is associated with higher tumor aggressive behavior and resistance to cisplatin therapy
    • Martinho O, Pinto F, Granja S, Miranda-Goncalves V, Moreira MA, Ribeiro LF, et al. RKIP inhibition in cervical cancer is associated with higher tumor aggressive behavior and resistance to cisplatin therapy. PLoS One 2013;8:e59104.
    • (2013) PLoS One , vol.8 , pp. e59104
    • Martinho, O.1    Pinto, F.2    Granja, S.3    Miranda-Goncalves, V.4    Moreira, M.A.5    Ribeiro, L.F.6
  • 21
    • 84871200220 scopus 로고    scopus 로고
    • Loss of WNK2 expression by promoter gene methylation occurs in adult gliomas and triggers Rac1-mediated tumour cell invasiveness
    • Moniz S, Martinho O, Pinto F, Sousa B, Loureiro C, Oliveira MJ, et al. Loss of WNK2 expression by promoter gene methylation occurs in adult gliomas and triggers Rac1-mediated tumour cell invasiveness. Hum Mol Genet 2013;22:84-95.
    • (2013) Hum Mol Genet , vol.22 , pp. 84-95
    • Moniz, S.1    Martinho, O.2    Pinto, F.3    Sousa, B.4    Loureiro, C.5    Oliveira, M.J.6
  • 22
    • 0036682002 scopus 로고    scopus 로고
    • Comprehensive gene expression analysis of prostate cancer reveals distinct transcriptional programs associated with metastatic disease
    • LaTulippe E, Satagopan J, Smith A, Scher H, Scardino P, Reuter V, et al. Comprehensive gene expression analysis of prostate cancer reveals distinct transcriptional programs associated with metastatic disease. Cancer Res 2002;62:4499-506.
    • (2002) Cancer Res , vol.62 , pp. 4499-4506
    • La Tulippe, E.1    Satagopan, J.2    Smith, A.3    Scher, H.4    Scardino, P.5    Reuter, V.6
  • 23
    • 27644506613 scopus 로고    scopus 로고
    • Integrative genomic and proteomic analysis of prostate cancer reveals signatures of metastatic progression
    • Varambally S, Yu J, Laxman B, Rhodes DR, Mehra R, Tomlins SA, et al. Integrative genomic and proteomic analysis of prostate cancer reveals signatures of metastatic progression. Cancer Cell 2005;8:393-406.
    • (2005) Cancer Cell , vol.8 , pp. 393-406
    • Varambally, S.1    Yu, J.2    Laxman, B.3    Rhodes, D.R.4    Mehra, R.5    Tomlins, S.A.6
  • 27
    • 4344561557 scopus 로고    scopus 로고
    • Gene expression alterations in prostate cancer predicting tumor aggression and preceding development of malignancy
    • Yu YP, Landsittel D, Jing L, Nelson J, Ren B, Liu L, et al. Gene expression alterations in prostate cancer predicting tumor aggression and preceding development of malignancy. J Clin Oncol 2004;22: 2790-9.
    • (2004) J Clin Oncol , vol.22 , pp. 2790-2799
    • Yu, Y.P.1    Landsittel, D.2    Jing, L.3    Nelson, J.4    Ren, B.5    Liu, L.6
  • 28
    • 85081851679 scopus 로고    scopus 로고
    • The Cancer Genome Atlas (TCGA). [cited 2013 Nov 30] Available from
    • The Cancer Genome Atlas (TCGA). [cited 2013 Nov 30] Available from: https://tcga-data.nci.nih.gov/tcga/.
  • 29
    • 70349448674 scopus 로고    scopus 로고
    • Identification of the transcription factor single-minded homologue 2 as a potential biomarker and immunotherapy target in prostate cancer
    • Arredouani MS, Lu B, Bhasin M, Eljanne M, Yue W, Mosquera JM, et al. Identification of the transcription factor single-minded homologue 2 as a potential biomarker and immunotherapy target in prostate cancer. Clin Cancer Res 2009;15:5794-802.
    • (2009) Clin Cancer Res , vol.15 , pp. 5794-5802
    • Arredouani, M.S.1    Lu, B.2    Bhasin, M.3    Eljanne, M.4    Yue, W.5    Mosquera, J.M.6
  • 30
    • 85081848514 scopus 로고    scopus 로고
    • Oncomine. Ann Arbor MI:Compendia Bioscience.-2007-2010 [cited 2013 Nov 30]. Available from
    • Oncomine. Ann Arbor, MI:Compendia Bioscience.-2007-2010 [cited 2013 Nov 30]. Available from: https://www.oncomine.org.
  • 31
    • 33847246805 scopus 로고    scopus 로고
    • Oncomine 3.0: Genes, pathways, and networks in a collection of 18,000 cancer gene expression profiles
    • Rhodes DR, Kalyana-Sundaram S, Mahavisno V, Varambally R, Yu J, Briggs BB, et al. Oncomine 3.0: Genes, pathways, and networks in a collection of 18,000 cancer gene expression profiles. Neoplasia 2007; 9:166-80
    • (2007) Neoplasia , vol.9 , pp. 166-180
    • Rhodes, D.R.1    Kalyana-Sundaram, S.2    Mahavisno, V.3    Varambally, R.4    Yu, J.5    Briggs, B.B.6
  • 32
    • 61449172037 scopus 로고    scopus 로고
    • Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources
    • Huang da W, Sherman BT, Lempicki RA. Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources. Nat Protoc 2009;4:44-57.
    • (2009) Nat Protoc , vol.4 , pp. 44-57
    • Huang Da, W.1    Sherman, B.T.2    Lempicki, R.A.3
  • 33
    • 58549112996 scopus 로고    scopus 로고
    • Bioinformatics enrichment tools: Paths toward the comprehensive functional analysis of large gene lists
    • Huang da W, Sherman BT, Lempicki RA. Bioinformatics enrichment tools: paths toward the comprehensive functional analysis of large gene lists. Nucleic Acids Res 2009;37:1-13.
    • (2009) Nucleic Acids Res , vol.37 , pp. 1-13
    • Huang Da, W.1    Sherman, B.T.2    Lempicki, R.A.3
  • 34
    • 0025054992 scopus 로고
    • Expression pattern of the mouse T gene and its role in mesoderm formation
    • Wilkinson DG, Bhatt S, Herrmann BG. Expression pattern of the mouse T gene and its role in mesoderm formation. Nature 1990;343:657-9.
    • (1990) Nature , vol.343 , pp. 657-659
    • Wilkinson, D.G.1    Bhatt, S.2    Herrmann, B.G.3
  • 35
    • 84887495550 scopus 로고    scopus 로고
    • Acquisition of epithelial-mesenchymal transition and cancer stem cell phenotypes is associated with activation of the PI3K/Akt/mTOR pathway in prostate cancer radioresistance
    • Chang L, Graham PH, Hao J, Ni J, Bucci J, Cozzi PJ, et al. Acquisition of epithelial-mesenchymal transition and cancer stem cell phenotypes is associated with activation of the PI3K/Akt/mTOR pathway in prostate cancer radioresistance. Cell Death Dis 2013;4:e875.
    • (2013) Cell Death Dis , vol.4 , pp. e875
    • Chang, L.1    Graham, P.H.2    Hao, J.3    Ni, J.4    Bucci, J.5    Cozzi, P.J.6
  • 36
    • 34247887629 scopus 로고    scopus 로고
    • The human T-box mesodermal transcription factor Brachyury is a candidate target for T-cell-mediated cancer immunotherapy
    • Palena C, Polev DE, Tsang KY, Fernando RI, Litzinger M, Krukovskaya LL, et al. The human T-box mesodermal transcription factor Brachyury is a candidate target for T-cell-mediated cancer immunotherapy. Clin Cancer Res 2007;13:2471-8.
    • (2007) Clin Cancer Res , vol.13 , pp. 2471-2478
    • Palena, C.1    De, P.2    Tsang, K.Y.3    Fernando, R.I.4    Litzinger, M.5    Krukovskaya, L.L.6
  • 37
    • 84886745437 scopus 로고    scopus 로고
    • Immunological targeting of tumor cells undergoing an epithelialmesenchymal transition via a recombinant brachyury-yeast vaccine
    • Hamilton DH, Litzinger MT, Jales A, Huang B, Fernando RI, Hodge JW, et al. Immunological targeting of tumor cells undergoing an epithelialmesenchymal transition via a recombinant brachyury-yeast vaccine. Oncotarget 2013;4:1777-90.
    • (2013) Oncotarget , vol.4 , pp. 1777-1790
    • Hamilton, D.H.1    Litzinger, M.T.2    Jales, A.3    Huang, B.4    Fernando, R.I.5    Hodge, J.W.6
  • 38
    • 84888639681 scopus 로고    scopus 로고
    • The roles of TGFbeta in the tumour microenvironment
    • Pickup M, Novitskiy S, Moses HL. The roles of TGFbeta in the tumour microenvironment. Nat Rev Cancer 2013;13:788-99.
    • (2013) Nat Rev Cancer , vol.13 , pp. 788-799
    • Pickup, M.1    Novitskiy, S.2    Moses, H.L.3
  • 40
    • 84879301158 scopus 로고    scopus 로고
    • Endothelial cells enhance prostate cancer metastasis via IL-6-androgen receptor-TGF-beta-MMP-9 signals
    • Wang X, Lee SO, Xia S, Jiang Q, Luo J, Li L, et al. Endothelial cells enhance prostate cancer metastasis via IL-6-androgen receptor-TGF-beta-MMP-9 signals. Mol Cancer Ther 2013;12: 1026-37.
    • (2013) Mol Cancer Ther , vol.12 , pp. 1026-1037
    • Wang, X.1    Lee, S.O.2    Xia, S.3    Jiang, Q.4    Luo, J.5    Li, L.6
  • 41
    • 78650597625 scopus 로고    scopus 로고
    • Role of the transcription factor T (brachyury) in the pathogenesis of sporadic chordoma: A genetic and functional-based study
    • Presneau N, Shalaby A, Ye H, Pillay N, Halai D, Idowu B, et al. Role of the transcription factor T (brachyury) in the pathogenesis of sporadic chordoma: a genetic and functional-based study. J Pathol 2011;223: 327-35.
    • (2011) J Pathol , vol.223 , pp. 327-335
    • Presneau, N.1    Shalaby, A.2    Ye, H.3    Pillay, N.4    Halai, D.5    Idowu, B.6
  • 42
    • 43049165453 scopus 로고    scopus 로고
    • The epithelial-mesenchymal transition generates cells with properties of stem cells
    • Mani SA, Guo W, Liao MJ, Eaton EN, Ayyanan A, Zhou AY, et al. The epithelial-mesenchymal transition generates cells with properties of stem cells. Cell 2008;133:704-15.
    • (2008) Cell , vol.133 , pp. 704-715
    • Mani, S.A.1    Guo, W.2    Liao, M.J.3    Eaton, E.N.4    Ayyanan, A.5    Zhou, A.Y.6
  • 43
    • 84864536251 scopus 로고    scopus 로고
    • In vitro and in vivo prostate cancer metastasis and chemoresistance can be modulated by expression of either CD44 or CD147
    • Hao J, Madigan MC, Khatri A, Power CA, Hung TT, Beretov J, et al. In vitro and in vivo prostate cancer metastasis and chemoresistance can be modulated by expression of either CD44 or CD147. PLoS One 2012;7:e40716.
    • (2012) PLoS One , vol.7 , pp. e40716
    • Hao, J.1    Madigan, M.C.2    Khatri, A.3    Power, C.A.4    Hung, T.T.5    Beretov, J.6


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