Overexpression of Brachyury contributes to tumor metastasis by inducing epithelial-mesenchymal transition in hepatocellular carcinoma

Journal of Experimental and Clinical Cancer Research

Volumn 33, Issue 1, 2014, Pages

  Du, Rui ^a   Wu, Shanshan ^a   Lv, Xiaoning ^a   Fang, Henghu ^a   Wu, Sudong ^a   Kang, Jingbo ^a  

^a NAVY GENERAL HOSPITAL   (China)

Author keywords

Brachyury; Cancer metastasis; Epithelial mesenchymal transition; Hepatocellular carcinoma; PTEN Akt Snail dependent pathway

Indexed keywords

MATRIGEL; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; PLAKOGLOBIN; PROTEIN KINASE B; PROTEIN KINASE B INHIBITOR; SMALL INTERFERING RNA; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR BRACHYURY; TRANSCRIPTION FACTOR SNAIL; UNCLASSIFIED DRUG; UVOMORULIN; VIMENTIN; BRACHYURY PROTEIN; FETOPROTEIN; PTEN PROTEIN, HUMAN; SNAIL FAMILY TRANSCRIPTION FACTORS; T BOX TRANSCRIPTION FACTOR;

ADULT; AGED; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BIOASSAY; CANCER PROGNOSIS; CANCER SIZE; CANCER SURGERY; CANCER SURVIVAL; CELL MOTILITY; CELL NUCLEUS; CONTROLLED STUDY; DISTANT METASTASIS; ENZYME ACTIVATION; EPITHELIAL MESENCHYMAL TRANSITION; GENE OVEREXPRESSION; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOFLUORESCENCE; IMMUNOHISTOCHEMISTRY; LIVER CELL; LIVER CELL CARCINOMA; LIVER RESECTION; MAJOR CLINICAL STUDY; MALE; MATRIGEL INVASION ASSAY; METASTASIS POTENTIAL; MICROARRAY ANALYSIS; MOUSE; NONHUMAN; OVERALL SURVIVAL; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; UPREGULATION; WESTERN BLOTTING; WOUND HEALING ASSAY; ANIMAL; BAGG ALBINO MOUSE; CASE CONTROL STUDY; CELL MOTION; FEMALE; GENE EXPRESSION REGULATION; GENETIC TRANSFECTION; GENETICS; HEPG2 CELL LINE; KAPLAN MEIER METHOD; LIVER TUMOR; METABOLISM; MIDDLE AGED; MORTALITY; NUDE MOUSE; PATHOLOGY; SECONDARY; TIME; TUMOR INVASION;

ADULT; AGED; ANIMALS; CARCINOMA, HEPATOCELLULAR; CASE-CONTROL STUDIES; CELL MOVEMENT; ENZYME ACTIVATION; EPITHELIAL-MESENCHYMAL TRANSITION; FEMALE; FETAL PROTEINS; GENE EXPRESSION REGULATION, NEOPLASTIC; HEP G2 CELLS; HUMANS; KAPLAN-MEIER ESTIMATE; LIVER NEOPLASMS; MALE; MICE, INBRED BALB C; MICE, NUDE; MIDDLE AGED; NEOPLASM INVASIVENESS; PROTO-ONCOGENE PROTEINS C-AKT; PTEN PHOSPHOHYDROLASE; SIGNAL TRANSDUCTION; T-BOX DOMAIN PROTEINS; TIME FACTORS; TRANSCRIPTION FACTORS; TRANSFECTION; UP-REGULATION;

EID: 84924175796     PISSN: None     EISSN: 17569966     Source Type: Journal    
DOI: 10.1186/s13046-014-0105-6     Document Type: Article

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