Gabapentin therapy in psychiatric disorders: A systematic review

Primary Care Companion to the Journal of Clinical Psychiatry

Volumn 17, Issue 5, 2015, Pages 330-

  Berlin, Rachel K ^a   Butler, Paul M ^b   Perloff, Michael D ^c  

^a Cambridge Health Alliance ^*  (United States)

^b TUFTS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c BOSTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GABAPENTIN;

ALCOHOL WITHDRAWAL; ANXIETY DISORDER; ARTICLE; BIPOLAR DISORDER; CLINICAL TRIAL (TOPIC); DEPRESSION; DRUG EFFICACY; HUMAN; MANIA; MENTAL DISEASE; OBSESSIVE COMPULSIVE DISORDER; OPIATE ADDICTION; POSTTRAUMATIC STRESS DISORDER; RANDOMIZED CONTROLLED TRIAL (TOPIC); SYSTEMATIC REVIEW;

EID: 84946570334     PISSN: 15235998     EISSN: 1555211X     Source Type: Journal    
DOI: 10.4088/PCC.15r01821     Document Type: Article

References (103)

1. McLean MJ. Gabapentin. Epilepsia. 1995;36(suppl 2):S73-S86. PubMed doi:10.1111/j.1528-1157.1995.tb06001.x Show Abstract
2. Maneuf YP, Luo ZD, Lee K. alpha2delta and the mechanism of action of gabapentin in the treatment of pain. Semin Cell Dev Biol. 2006;17(5):565-570. PubMed doi:10.1016/j.semcdb.2006.09.003 Show Abstract
3. Singh D, Kennedy DH. The use of gabapentin for the treatment of postherpetic neuralgia. Clin Ther. 2003;25(3):852-889. PubMed doi:10.1016/S0149-2918(03)80111-X Show Abstract
4. Rice AS, Maton S; Postherpetic Neuralgia Study Group. Gabapentin in postherpetic neuralgia: a randomised, double blind, placebo controlled study. Pain. 2001;94(2):215-224. PubMed doi:10.1016/S0304-3959(01)00407-9 Show Abstract
5. Rowbotham M, Harden N, Stacey B, et al. Gabapentin for the treatment of postherpetic neuralgia: a randomized controlled trial. JAMA. 1998;280(21):1837-1842. PubMed doi:10.1001/jama.280.21.1837 Show Abstract
6. Steinman MA, Bero LA, Chren MM, et al. Narrative review: the promotion of gabapentin: an analysis of internal industry documents. Ann Intern Med. 2006;145(4):284-293. PubMed doi:10.7326/0003-4819-145-4-200608150-00008 Show Abstract
7. Petersen M. Court papers suggest scale of drug’s use: lawsuit says doctors were paid endorsers. N Y Times Web. 2003:C1, C2. PubMed
8. Larkin M. Warner-Lambert found guilty of promoting neurontin off label. Lancet Neurol. 2004;3(7):387. PubMed doi:10.1016/S1474-4422(04)00792-6 Show Abstract
9. Vedula SS, Bero L, Scherer RW, et al. Outcome reporting in industry-sponsored trials of gabapentin for off-label use. N Engl J Med. 2009;361(20):1963-1971. PubMed doi:10.1056/NEJMsa0906126 Show Abstract
10. Taylor CP, Gee NS, Su TZ, et al. A summary of mechanistic hypotheses of gabapentin pharmacology. Epilepsy Res. 1998;29(3):233-249. PubMed doi:10.1016/S0920-1211(97)00084-3 Show Abstract
11. Su TZ, Lunney E, Campbell G, et al. Transport of gabapentin, a gamma-amino acid drug, by system l alpha-amino acid transporters: a comparative study in astrocytes, synaptosomes, and CHO cells. J Neurochem. 1995;64(5):2125-2131. PubMed doi:10.1046/j.1471-4159.1995.64052125.x Show Abstract
12. Lanneau C, Green A, Hirst WD, et al. Gabapentin is not a GABAB receptor agonist. Neuropharmacology. 2001;41(8):965-975. PubMed doi:10.1016/S0028-3908(01)00140-X Show Abstract
13. Cheng JK, Lee SZ, Yang JR, et al. Does gabapentin act as an agonist at native GABA(B) receptors? J Biomed Sci. 2004;11(3):346-355. PubMed doi:10.1007/BF02254439 Show Abstract
14. Takasusuki T, Yaksh TL. The effects of intrathecal and systemic gabapentin on spinal substance P release. Anesth Analg. 2011;112(4):971-976. PubMed doi:10.1213/ANE.0b013e31820f2a16 Show Abstract
15. Hendrich J, Van Minh AT, Heblich F, et al. Pharmacological disruption of calcium channel trafficking by the a2d ligand gabapentin. Proc Natl Acad Sci U S A. 2008;105(9):3628-3633. PubMed doi:10.1073/pnas.0708930105 Show Abstract
16. Field MJ, Cox PJ, Stott E, et al. Identification of the a2-d-1 subunit of voltage-dependent calcium channels as a molecular target for pain mediating the analgesic actions of pregabalin. Proc Natl Acad Sci U S A. 2006;103(46):17537-17542. PubMed doi:10.1073/pnas.0409066103 Show Abstract
17. Procedure manual. US Preventive Services Task Force Web site. http://www.uspreventiveservicestaskforce.org/Page/Name/procedure-manual-section-4. Updated August 2011. Accessed April 4, 2015.
18. Jadad AR, Moore RA, Carroll D, et al. Assessing the quality of reports of randomized clinical trials: is blinding necessary? Control Clin Trials. 1996;17(1):1-12. PubMed doi:10.1016/0197-2456(95)00134-4 Show Abstract
19. Pande AC, Crockatt JG, Janney CA, et al; Gabapentin Bipolar Disorder Study Group. Gabapentin in bipolar disorder: a placebo-controlled trial of adjunctive therapy. Bipolar Disord. 2000;2(3 pt 2):249-255. PubMed doi:10.1034/j.1399-5618.2000.20305.x Show Abstract
20. Frye MA, Ketter TA, Kimbrell TA, et al. A placebo-controlled study of lamotrigine and gabapentin monotherapy in refractory mood disorders. J Clin Psychopharmacol. 2000;20(6):607-614. PubMed doi:10.1097/00004714-200012000-00004 Show Abstract
21. Obrocea GV, Dunn RM, Frye MA, et al. Clinical predictors of response to lamotrigine and gabapentin monotherapy in refractory affective disorders. Biol Psychiatry. 2002;51(3):253-260. PubMed doi:10.1016/S0006-3223(01)01206-9 Show Abstract
22. Astaneh AN, Rezaei O. Adjunctive treatment with gabapentin in bipolar patients during acute mania. Int J Psychiatry Med. 2012;43(3):261-271. PubMed doi:10.2190/PM.43.3.e Show Abstract
23. Perugi G, Toni C, Ruffolo G, et al. Clinical experience using adjunctive gabapentin in treatment-resistant bipolar mixed states. Pharmacopsychiatry. 1999;32(4):136-141. PubMed doi:10.1055/s-2007-979219 Show Abstract
24. Erfurth A, Kammerer C, Grunze H, et al. An open label study of gabapentin in the treatment of acute mania. J Psychiatr Res. 1998;32(5):261-264. PubMed doi:10.1016/S0022-3956(98)00010-7 Show Abstract
25. Sethi MA, Mehta R, Devanand DP. Gabapentin in geriatric mania. J Geriatr Psychiatry Neurol. 2003;16(2):117-120. PubMed doi:10.1177/0891988703016002010 Show Abstract
26. Cipriani A, Barbui C, Salanti G, et al. Comparative efficacy and acceptability of antimanic drugs in acute mania: a multiple-treatments meta-analysis. Lancet. 2011;378(9799):1306-1315. PubMed doi:10.1016/S0140-6736(11)60873-8 Show Abstract
27. Knoll J, Stegman K, Suppes T. Clinical experience using gabapentin adjunctively in patients with a history of mania or hypomania. J Affect Disord. 1998;49(3):229-233. PubMed doi:10.1016/S0165-0327(98)00027-5 Show Abstract
28. Altshuler LL, Keck PE Jr, McElroy SL, et al. Gabapentin in the acute treatment of refractory bipolar disorder. Bipolar Disord. 1999;1(1):61-65. PubMed doi:10.1034/j.1399-5618.1999.10113.x Show Abstract
29. Cabras PL, Hardoy MJ, Hardoy MC, et al. Clinical experience with gabapentin in patients with bipolar or schizoaffective disorder: results of an open-label study. J Clin Psychiatry. 1999;60(4):245-248. PubMed doi:10.4088/JCP.v60n0408 Show Abstract
30. McElroy SL, Soutullo CA, Keck PE Jr, et al. A pilot trial of adjunctive gabapentin in the treatment of bipolar disorder. Ann Clin Psychiatry. 1997;9(2):99-103. PubMed doi:10.3109/10401239709147781 Show Abstract
31. Schaffer CB, Schaffer LC. Open maintenance treatment of bipolar disorder spectrum patients who responded to gabapentin augmentation in the acute phase of treatment. J Affect Disord. 1999;55(2-3):237-240. PubMed doi:10.1016/S0165-0327(98)00198-0 Show Abstract
32. Vieta E, Manuel Goikolea J, Martínez-Arán A, et al. A double-blind, randomized, placebo-controlled, prophylaxis study of adjunctive gabapentin for bipolar disorder. J Clin Psychiatry. 2006;67(3):473-477. PubMed doi:10.4088/JCP.v67n0320 Show Abstract
33. Wang PW, Santosa C, Schumacher M, et al. Gabapentin augmentation therapy in bipolar depression. Bipolar Disord. 2002;4(5):296-301. PubMed doi:10.1034/j.1399-5618.2002.01211.x Show Abstract
34. Vieta E, Martinez-Arán A, Nieto E, et al. Adjunctive gabapentin treatment of bipolar disorder. Eur Psychiatry. 2000;15(7):433-437. PubMed doi:10.1016/S0924-9338(00)00514-9 Show Abstract
35. Sokolski KN, Green C, Maris DE, et al. Gabapentin as an adjunct to standard mood stabilizers in outpatients with mixed bipolar symptomatology. Ann Clin Psychiatry. 1999;11(4):217-222. PubMed doi:10.3109/10401239909147073 Show Abstract
36. Ghaemi SN, Katzow JJ, Desai SP, et al. Gabapentin treatment of mood disorders: a preliminary study. J Clin Psychiatry. 1998;59(8):426-429. PubMed doi:10.4088/JCP.v59n0805 Show Abstract
37. Ghaemi SN, Goodwin FK. Gabapentin treatment of the non-refractory bipolar spectrum: an open case series. J Affect Disord. 2001;65(2):167-171. PubMed doi:10.1016/S0165-0327(00)00218-4 Show Abstract
38. Fullerton CA, Busch AB, Frank RG. The rise and fall of gabapentin for bipolar disorder: a case study on off-label pharmaceutical diffusion. Med Care. 2010;48(4):372-379. PubMed doi:10.1097/MLR.0b013e3181ca404e Show Abstract
39. Carta MG, Hardoy MC, Dessì I, et al. Adjunctive gabapentin in patients with intellectual disability and bipolar spectrum disorders. J Intellect Disabil Res. 2001;45(pt 2):139-145. PubMed doi:10.1046/j.1365-2788.2001.00330.x Show Abstract
40. Perugi G, Toni C, Frare F, et al. Effectiveness of adjunctive gabapentin in resistant bipolar disorder: is it due to anxious-alcohol abuse comorbidity? J Clin Psychopharmacol. 2002;22(6):584-591. PubMed doi:10.1097/00004714-200212000-00008 Show Abstract
41. Aziz R, Lorberg B, Tampi RR. Treatments for late-life bipolar disorder. Am J Geriatr Pharmacother. 2006;4(4):347-364. PubMed doi:10.1016/j.amjopharm.2006.12.007 Show Abstract
42. Barrios C, Chaudhry TA, Goodnick PJ. Rapid cycling bipolar disorder. Expert Opin Pharmacother. 2001;2(12):1963-1973. PubMed doi:10.1517/14656566.2.12.1963 Show Abstract
43. Bhangoo RK, Lowe CH, Myers FS, et al. Medication use in children and adolescents treated in the community for bipolar disorder. J Child Adolesc Psychopharmacol. 2003;13(4):515-522. PubMed doi:10.1089/104454603322724904 Show Abstract
44. Botts SR, Raskind J. Gabapentin and lamotrigine in bipolar disorder. Am J Health Syst Pharm. 1999;56(19):1939-1944. PubMed Show Abstract
45. Brambilla P, Barale F, Soares JC. Perspectives on the use of anticonvulsants in the treatment of bipolar disorder. Int J Neuropsychopharmacol. 2001;4(4):421-446. PubMed doi:10.1017/S1461145701002668 Show Abstract
46. Carta MG, Hardoy MC, Hardoy MJ, et al. The clinical use of gabapentin in bipolar spectrum disorders. J Affect Disord. 2003;75(1):83-91. PubMed doi:10.1016/S0165-0327(02)00046-0 Show Abstract
47. Evins AE. Efficacy of newer anticonvulsant medications in bipolar spectrum mood disorders. J Clin Psychiatry. 2003;64 (suppl 8):9-14. PubMed Show Abstract
48. Williams JW Jr, Ranney L, Morgan LC, et al. How reviews covered the unfolding scientific story of gabapentin for bipolar disorder. Gen Hosp Psychiatry. 2009;31(3):279-287. PubMed doi:10.1016/j.genhosppsych.2009.02.006 Show Abstract
49. Yasmin S, Carpenter LL, Leon Z, et al. Adjunctive gabapentin in treatment-resistant depression: a retrospective chart review. J Affect Disord. 2001;63(1-3):243-247. PubMed doi:10.1016/S0165-0327(00)00187-7 Show Abstract
50. Maurer I, Volz HP, Sauer H. Gabapentin leads to remission of somatoform pain disorder with major depression. Pharmacopsychiatry. 1999;32(6):255-257. PubMed doi:10.1055/s-1999-7958 Show Abstract
51. Vigo DV, Baldessarini RJ. Anticonvulsants in the treatment of major depressive disorder: an overview. Harv Rev Psychiatry. 2009;17(4):231-241. PubMed doi:10.1080/10673220903129814 Show Abstract
52. Harden CL, Goldstein MA. Mood disorders in patients with epilepsy: epidemiology and management. CNS Drugs. 2002;16(5):291-302. PubMed doi:10.2165/00023210-200216050-00002 Show Abstract
53. Harden CL, Lazar LM, Pick LH, et al. A beneficial effect on mood in partial epilepsy patients treated with gabapentin. Epilepsia. 1999;40(8):1129-1134. PubMed doi:10.1111/j.1528-1157.1999.tb00830.x Show Abstract
54. Pande AC, Davidson JR, Jefferson JW, et al. Treatment of social phobia with gabapentin: a placebo-controlled study. J Clin Psychopharmacol. 1999;19(4):341-348. PubMed doi:10.1097/00004714-199908000-00010 Show Abstract
55. Pande AC, Pollack MH, Crockatt J, et al. Placebo-controlled study of gabapentin treatment of panic disorder. J Clin Psychopharmacol. 2000;20(4):467-471. PubMed doi:10.1097/00004714-200008000-00011 Show Abstract
56. Lavigne JE, Heckler C, Mathews JL, et al. A randomized, controlled, double-blinded clinical trial of gabapentin 300 versus 900 mg versus placebo for anxiety symptoms in breast cancer survivors. Breast Cancer Res Treat. 2012;136(2):479-486. PubMed doi:10.1007/s10549-012-2251-x Show Abstract
57. Tirault M, Foucan L, Debaene B, et al. Gabapentin premedication: assessment of preoperative anxiolysis and postoperative patient satisfaction. Acta Anaesthesiol Belg. 2010;61(4):203-209. PubMed Show Abstract
58. Khezri MB, Oladi MR, Atlasbaf A. Effect of melatonin and gabapentin on anxiety and pain associated with retrobulbar eye block for cataract surgery: a randomized double-blind study. Indian J Pharmacol. 2013;45(6):581-586. PubMed doi:10.4103/0253-7613.121368 Show Abstract
59. Ménigaux C, Adam F, Guignard B, et al. Preoperative gabapentin decreases anxiety and improves early functional recovery from knee surgery. Anesth Analg. 2005;100(5):1394-1399. PubMed doi:10.1213/01.ANE.0000152010.74739.B8 Show Abstract
60. Adam F, Bordenave L, Sessler DI, et al. Effects of a single 1200-mg preoperative dose of gabapentin on anxiety and memory. Ann Fr Anesth Reanim. 2012;31(10):e223-e227. PubMed doi:10.1016/j.annfar.2012.05.006 Show Abstract
61. Clarke H, Kay J, Orser BA, et al. Gabapentin does not reduce preoperative anxiety when given prior to total hip arthroplasty. Pain Med. 2010;11(6):966-971. PubMed doi:10.1111/j.1526-4637.2010.00826.x Show Abstract
62. Hamner MB, Brodrick PS, Labbate LA. Gabapentin in PTSD: a retrospective, clinical series of adjunctive therapy. Ann Clin Psychiatry. 2001;13(3):141-146. PubMed doi:10.3109/10401230109148960 Show Abstract
63. Berigan TR. Gabapentin in the treatment of posttraumatic stress disorder. Prim Care Companion J Clin Psychiatry. 2000;2(3):105. PubMed doi:10.4088/PCC.v02n0307 Show Abstract
64. Brannon N, Labbate L, Huber M. Gabapentin treatment for posttraumatic stress disorder. Can J Psychiatry. 2000;45(1):84. PubMed Show Abstract
65. Malek-Ahmadi P. Gabapentin and posttraumatic stress disorder. Ann Pharmacother. 2003;37(5):664-666. PubMed doi:10.1345/aph.1C082 Show Abstract
66. Stein MB, Kerridge C, Dimsdale JE, et al. Pharmacotherapy to prevent PTSD: results from a randomized controlled proof-of-concept trial in physically injured patients. J Trauma Stress. 2007;20(6):923-932. PubMed doi:10.1002/jts.20270 Show Abstract
67. Fowler M, Garza TH, Slater TM, et al. The relationship between gabapentin and pregabalin and posttraumatic stress disorder in burned servicemembers. J Burn Care Res. 2012;33(5):612-618. PubMed doi:10.1097/BCR.0b013e31823dc710 Show Abstract
68. Onder E, Tural U, Gökbakan M. Does gabapentin lead to early symptom improvement in obsessive-compulsive disorder? Eur Arch Psychiatry Clin Neurosci. 2008;258(6):319-323. PubMed doi:10.1007/s00406-007-0798-z Show Abstract
69. Anton RF, Myrick H, Baros AM, et al. Efficacy of a combination of flumazenil and gabapentin in the treatment of alcohol dependence: relationship to alcohol withdrawal symptoms. J Clin Psychopharmacol. 2009;29(4):334-342. PubMed doi:10.1097/JCP.0b013e3181aba6a4 Show Abstract
70. Anton RF, Myrick H, Wright TM, et al. Gabapentin combined with naltrexone for the treatment of alcohol dependence. Am J Psychiatry. 2011;168(7):709-717. PubMed doi:10.1176/appi.ajp.2011.10101436 Show Abstract
71. Bonnet U, Hamzavi-Abedi R, Specka M, et al. An open trial of gabapentin in acute alcohol withdrawal using an oral loading protocol. Alcohol Alcohol. 2010;45(2):143-145. PubMed doi:10.1093/alcalc/agp085 Show Abstract
72. Mariani JJ, Rosenthal RN, Tross S, et al. A randomized, open-label, controlled trial of gabapentin and phenobarbital in the treatment of alcohol withdrawal. Am J Addict. 2006;15(1):76-84. PubMed doi:10.1080/10550490500419110 Show Abstract
73. Myrick H, Malcolm R, Randall PK, et al. A double-blind trial of gabapentin versus lorazepam in the treatment of alcohol withdrawal. Alcohol Clin Exp Res. 2009;33(9):1582-1588. PubMed doi:10.1111/j.1530-0277.2009.00986.x Show Abstract
74. Stock CJ, Carpenter L, Ying J, et al. Gabapentin versus chlordiazepoxide for outpatient alcohol detoxification treatment. Ann Pharmacother. 2013;47(7-8):961-969. PubMed doi:10.1345/aph.1R751 Show Abstract
75. Bonnet U, Specka M, Leweke FM, et al. Gabapentin’s acute effect on mood profile-a controlled study on patients with alcohol withdrawal. Prog Neuropsychopharmacol Biol Psychiatry. 2007;31(2):434-438. PubMed doi:10.1016/j.pnpbp.2006.11.006 Show Abstract
76. Bonnet U, Banger M, Leweke FM, et al. Treatment of acute alcohol withdrawal with gabapentin: results from a controlled two-center trial. J Clin Psychopharmacol. 2003;23(5):514-519. PubMed doi:10.1097/01.jcp.0000088905.24613.ad Show Abstract
77. Reeves RR, Burke RS. Abuse of combinations of gabapentin and quetiapine. Prim Care Companion CNS Disord. 2014;16(5):doi:10.4088/PCC.14l01660. doi:10.4088/pcc.14l01660 PubMed Show Abstract
78. Bonnet U, Banger M, Leweke FM, et al. Treatment of alcohol withdrawal syndrome with gabapentin. Pharmacopsychiatry. 1999;32(3):107-109. PubMed doi:10.1055/s-2007-979203 Show Abstract
79. Bozikas V, Petrikis P, Gamvrula K, et al. Treatment of alcohol withdrawal with gabapentin. Prog Neuropsychopharmacol Biol Psychiatry. 2002;26(1):197-199. PubMed doi:10.1016/S0278-5846(01)00234-2 Show Abstract
80. Johnson BA, Swift RM, Addolorato G, et al. Safety and efficacy of GABAergic medications for treating alcoholism. Alcohol Clin Exp Res. 2005;29(2):248-254. PubMed doi:10.1097/01.ALC.0000153542.10188.B0 Show Abstract
81. Myrick H, Anton R, Voronin K, et al. A double-blind evaluation of gabapentin on alcohol effects and drinking in a clinical laboratory paradigm. Alcohol Clin Exp Res. 2007;31(2):221-227. PubMed doi:10.1111/j.1530-0277.2006.00299.x Show Abstract
82. Rustembegovic A, Sofic E, Tahirovic I, et al. A study of gabapentin in the treatment of tonic-clonic seizures of alcohol withdrawal syndrome. Med Arh. 2004;58(1):5-6. PubMed Show Abstract
83. Voris J, Smith NL, Rao SM, et al. Gabapentin for the treatment of ethanol withdrawal. Subst Abus. 2003;24(2):129-132. PubMed doi:10.1080/08897070309511541 Show Abstract
84. Furieri FA, Nakamura-Palacios EM. Gabapentin reduces alcohol consumption and craving: a randomized, double-blind, placebo-controlled trial. J Clin Psychiatry. 2007;68(11):1691-1700. PubMed doi:10.4088/JCP.v68n1108 Show Abstract
85. Mason BJ, Light JM, Williams LD, et al. Proof-of-concept human laboratory study for protracted abstinence in alcohol dependence: effects of gabapentin. Addict Biol. 2009;14(1):73-83. PubMed doi:10.1111/j.1369-1600.2008.00133.x Show Abstract
86. Mason BJ, Quello S, Goodell V, et al. Gabapentin treatment for alcohol dependence: a randomized clinical trial. JAMA Intern Med. 2014;174(1):70-77. PubMed doi:10.1001/jamainternmed.2013.11950 Show Abstract
87. Bisaga A, Aharonovich E, Garawi F, et al. A randomized placebo-controlled trial of gabapentin for cocaine dependence. Drug Alcohol Depend. 2006;81(3):267-274. PubMed doi:10.1016/j.drugalcdep.2005.07.009 Show Abstract
88. González G, Desai R, Sofuoglu M, et al. Clinical efficacy of gabapentin versus tiagabine for reducing cocaine use among cocaine dependent methadone-treated patients. Drug Alcohol Depend. 2007;87(1):1-9. PubMed doi:10.1016/j.drugalcdep.2006.07.003 Show Abstract
89. Mancino MJ, McGaugh J, Chopra MP, et al. Clinical efficacy of sertraline alone and augmented with gabapentin in recently abstinent cocaine-dependent patients with depressive symptoms. J Clin Psychopharmacol. 2014;34(2):234-239. PubMed doi:10.1097/JCP.0000000000000062 Show Abstract
90. Hart CL, Ward AS, Collins ED, et al. Gabapentin maintenance decreases smoked cocaine-related subjective effects, but not self-administration by humans. Drug Alcohol Depend. 2004;73(3):279-287
91. Berger SP, Winhusen TM, Somoza EC, et al. A medication screening trial evaluation of reserpine, gabapentin and lamotrigine pharmacotherapy of cocaine dependence. Addiction. 2005; 100(Suppl 1):58-67. doi:10.1111/j.1360-0443.2005.00983.x PubMed Show Abstract
92. Hart CL, Haney M, Collins ED, et al. Smoked cocaine self-administration by humans is not reduced by large gabapentin maintenance doses. Drug Alcohol Depend. 2007;86(2-3):274-277. PubMed doi:10.1016/j.drugalcdep.2006.05.028 Show Abstract
93. Haney M, Hart C, Collins ED, et al. Smoked cocaine discrimination in humans: effects of gabapentin. Drug Alcohol Depend. 2005;80(1):53-61. PubMed doi:10.1016/j.drugalcdep.2005.03.006 Show Abstract
94. Myrick H, Henderson S, Brady KT, et al. Gabapentin in the treatment of cocaine dependence: a case series. J Clin Psychiatry. 2001;62(1):19-23. PubMed doi:10.4088/JCP.v62n0105 Show Abstract
95. Heinzerling KG, Shoptaw S, Peck JA, et al. Randomized, placebo-controlled trial of baclofen and gabapentin for the treatment of methamphetamine dependence. Drug Alcohol Depend. 2006;85(3):177-184. PubMed doi:10.1016/j.drugalcdep.2006.03.019 Show Abstract
96. Urschel HC 3rd, Hanselka LL, Baron M. A controlled trial of flumazenil and gabapentin for initial treatment of methylamphetamine dependence. J Psychopharmacol. 2011;25(2):254-262. PubMed doi:10.1177/0269881109349837 Show Abstract
97. Ling W, Shoptaw S, Hillhouse M, et al. Double-blind placebo-controlled evaluation of the PROMETA protocol for methamphetamine dependence. Addiction. 2012;107(2):361-369. PubMed doi:10.1111/j.1360-0443.2011.03619.x Show Abstract
98. Martínez-Raga J, Sabater A, Perez-Galvez B, et al. Add-on gabapentin in the treatment of opiate withdrawal. Prog Neuropsychopharmacol Biol Psychiatry. 2004;28(3):599-601. PubMed doi:10.1016/j.pnpbp.2003.11.020 Show Abstract
99. Tay KH. Gabapentin and opioid craving. Pain Med. 2009;10(4):774. PubMed doi:10.1111/j.1526-4637.2009.00617.x Show Abstract
100. Kheirabadi GR, Ranjkesh M, Maracy MR, et al. Effect of add-on gabapentin on opioid withdrawal symptoms in opium-dependent patients. Addiction. 2008;103(9):1495-1499. PubMed doi:10.1111/j.1360-0443.2008.02248.x Show Abstract
101. Salehi M, Kheirabadi GR, Maracy MR, et al. Importance of gabapentin dose in treatment of opioid withdrawal. J Clin Psychopharmacol. 2011;31(5):593-596. PubMed doi:10.1097/JCP.0b013e31822bb378 Show Abstract
102. Moghadam MS, Alavinia M. The effects of gabapentin on methadone based addiction treatment: a randomized controlled trial. Pak J Pharm Sci. 2013;26(5):985-989. PubMed Show Abstract
103. Sanders NC, Mancino MJ, Gentry WB, et al. Randomized, placebo-controlled pilot trial of gabapentin during an outpatient, buprenorphine-assisted detoxification procedure. Exp Clin Psychopharmacol. 2013;21(4):294-302. PubMed doi:10.1037/a0033724 Show Abstract