Effect of add-on gabapentin on opioid withdrawal symptoms in opium-dependent patients

Addiction

Volumn 103, Issue 9, 2008, Pages 1495-1499

  Kheirabadi, Gholam R ^a,b   Ranjkesh, Mansour ^a   Maracy, Mohamad R ^a   Salehi, Mehrdad ^a  

^a ISFAHAN UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^b ISFAHAN UNIVERSITY OF MEDICAL SCIENCES   (Iran)

Author keywords

Gabapentin; Opioid; Opioid withdrawal; Opium dependence; Withdrawal; Withdrawal symptoms

Indexed keywords

CLONIDINE; GABAPENTIN; METHADONE; OPIATE; OXAZEPAM; PLACEBO; TRAZODONE;

ADD ON THERAPY; ADULT; ARTICLE; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DIAGNOSTIC AND STATISTICAL MANUAL OF MENTAL DISORDERS; DISEASE SEVERITY; DOUBLE BLIND PROCEDURE; DRUG DETOXIFICATION; DRUG DOSE INCREASE; DRUG DOSE REDUCTION; DRUG EFFICACY; FEMALE; HUMAN; IRAN; MALE; OPIATE ADDICTION; OUTPATIENT CARE; OUTPATIENT DEPARTMENT; RANDOMIZED CONTROLLED TRIAL; RATING SCALE; SUBJECTIVE OPIATE WITHDRAWAL SCALE; TREATMENT OUTCOME; WITHDRAWAL SYNDROME;

ADULT; AMINES; ANALGESICS; CYCLOHEXANECARBOXYLIC ACIDS; DOUBLE-BLIND METHOD; FEMALE; GAMMA-AMINOBUTYRIC ACID; HUMANS; MALE; MIDDLE AGED; OPIOID-RELATED DISORDERS; STATISTICS, NONPARAMETRIC; SUBSTANCE WITHDRAWAL SYNDROME; TREATMENT OUTCOME;

EID: 49249127433     PISSN: 09652140     EISSN: 13600443     Source Type: Journal    
DOI: 10.1111/j.1360-0443.2008.02248.x     Document Type: Article

References (25)

1. Goldstein D. B. Possible role of enzyme inhibition and repression in drug tolerance and addiction. Biochem Pharmacol 1961 8:48 53.
2. Gowing L. R., Farrell M., Ali R. L., White J. M. Alpha2-adrenergic agonists in opioid withdrawal. Addiction 2002 97:49 58.
3. American Psychiatric Association. Practice guideline for the treatment of patients with substance use disorders: alcohol, cocaine, opioids. Am J Psychiatry 1995 152:1 59.
4. Zullino D. F., Khazaal Y., Hattenschwiler J., Borgeat F., Besson J. Anticonvulsant drugs in the treatment of substance withdrawal. Drugs Today (Barc) 2004 40:603 19.
5. Marson A. G., Kadir Z. A., Hutton J. L., Chadwick D. W. Gabapentin add-on for drug- resistant partial epilepsy. Cochrane Database Syst Rev 2000 3:CD001415.
6. Rice A. S., Maton S. Gabapentin in postherpetic neuralgia: a randomised, double blind, placebo controlled study. Pain 2001 94:215 24.
7. Bonnet U., Banger M., Leweke F. M., Maschke M., Kowalski T., Gastpar M. Treatment of alcohol withdrawal syndrome with gabapentin. Pharmacopsychiatry 1999 32:107 9.
8. Myrick H., Henderson S., Brady K. T., Malcolm R. Gabapentin in the treatment of cocaine dependence: a case series. J Clin Psychiatry 2001 62:19 23.
9. Kumar P., Jain M. K. Gabapentin in the management of pentazocine dependence: a potent analgesic-anticraving agent. J Assoc Physicians India 2003 51:673 6.
10. Dirks J., Fredensborg B. B., Christensen D., Fomsgaard J. S., Flyger H., Dahl J. B. A randomized study of the effects of single-dose gabapentin versus placebo on postoperative pain and morphine consumption after mastectomy. Anesthesiology 2002 97:560 4.
11. Martínez-Raga J., Sabater A., Perez-Galvez B., Castellano M., Cervera G. Add-on gabapentin in the treatment of opiate withdrawal. Prog Neuropsychopharmacol Biol Psychiatry 2004 28:599 601.
12. Field M. J., Oles R. J., Lewis A. S., McVlerary S., Hughes J., Singh L. Gabapentin (neurontin) and S (+)-3-isobutylgaba represent a novel class of selective antihyperalgesic agents. Br J Pharmacol 1997 121:1513 22.
13. Brown J. P., Boden P., Singh L., Gee N. S. Mechanism of action of gabapentin. Rev Contemp Pharmacother 1996 7:203 14.
14. Mellik G. A., Larry D. O., Mellik B. Reflex sympathetic dystrophy treated with gabapentin. Arch Phys Med Rehabil 1997 78:98 105.
15. Rosner H., Rubin L., Kestenbaum A. Gabapentin adjunctive therapy in neuropathic pain states. Clin J Pain 1996 12:56 8.
16. Handelsman L., Cochrane K. J., Aronson M. J., Ness R., Rubinstein K. J., Kanof P. D. et al. Two new rating scales for opiate withdrawal. Am J Drug Alcohol Abuse 1987 13:293 308.
17. Freye E., Levy J. V., Partecke L. Use of gabapentin for attenuation of symptoms following rapid opiate detoxification (ROD)correlation with neurophysiological parameters. Neurophysiol Clin 2004 34:81 9.
18. Gotz T. J., Feuerstein A., Lais A., Meyer D. K. Effects of gabapentin on release of gamma-aminobutyric acid from slices of rat neostriatum. Arzneimittelforschung 1993 43:636 8.
19. Goldlust A., Su T. Z., Welty D. F., Taylor C. P., Oxender D. L. Effects of anticonvulsant drug gabapentin on the enzymes in metabolic pathways of glutamate and GABA. Epilepsy Res 1995 22:1 11.
20. Gee J. P., Brown V. U., Dissanayake J., Offord R., Thurlow R., Woodruff G. N. The novel anticonvulsant drug, gabapentin (Neurontin), binds to the alpha2delta subunit of a calcium channel. J Biol Chem 1996 271:5768 76.
21. Sills G. J. The mechanisms of action of gabapentin and pregabalin. Curr Opin Pharmacol 2006 6:108 13.
22. Happe S., Klosch G., Saletu B., Zeitlhofer J. Treatment of idiopathic restless legs syndrome (RLS) with gabapentin. Neurology 2001 57:1717 19.
23. Garcia-Borreguero D., Larrosa O., Llave Y. Treatment of restless legs syndrome with gabapentin: a double-blind, cross-over study. Neurology 2002 59:1573 9.
24. Silber M. H., Ehrenberg B. L., Allen R. P., Buchfuhrer M. J., Earley C. J. et al. An algorithm for the management of restless legs syndrome. Mayo Clin Proc 2004 79:916 22.
25. Peng P. W., Wijeysundera D. N., Li C. C. Use of gabapentin for perioperative pain control - a meta-analysis. Pain Res Manage 2007 12:85 92.