Gabapentin combined with naltrexone for the treatment of alcohol dependence

American Journal of Psychiatry

Volumn 168, Issue 7, 2011, Pages 709-717

  Anton, Raymond F ^a   Myrick, Hugh ^a   Wright, Tara M ^a   Latham, Patricia K ^a   Baros, Alicia M ^a   Waid, L Randolph ^a   Randall, Patrick K ^a  

^a MEDICAL UNIVERSITY OF SOUTH CAROLINA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GABAPENTIN; GAMMA GLUTAMYLTRANSFERASE; NALTREXONE; PLACEBO; RIBOFLAVIN;

ADULT; ALCOHOL CONSUMPTION; ALCOHOL WITHDRAWAL; ALCOHOLISM; ARTICLE; BECK DEPRESSION INVENTORY; BLURRED VISION; CONTROLLED STUDY; DAYTIME SOMNOLENCE; DIAGNOSTIC AND STATISTICAL MANUAL OF MENTAL DISORDERS; DIZZINESS; DRINKING BEHAVIOR; DRUG EFFICACY; DRUG TOLERABILITY; EPWORTH SLEEPINESS SCALE; EVENING DOSAGE; FEMALE; HUMAN; MAJOR CLINICAL STUDY; MALE; MORNING DOSAGE; OBSESSIVE COMPULSIVE DISORDER; PREMATURE EJACULATION; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; SLEEP QUALITY; TREATMENT OUTCOME; TREATMENT RESPONSE;

ADULT; ALCOHOL DRINKING; ALCOHOLISM; AMINES; CYCLOHEXANECARBOXYLIC ACIDS; DRUG ADMINISTRATION SCHEDULE; DRUG THERAPY, COMBINATION; FEMALE; GAMMA-AMINOBUTYRIC ACID; HUMANS; MALE; MIDDLE AGED; NALTREXONE; NARCOTIC ANTAGONISTS; RECURRENCE; SUBSTANCE WITHDRAWAL SYNDROME; TREATMENT OUTCOME;

EID: 79960363489     PISSN: 0002953X     EISSN: 15357228     Source Type: Journal    
DOI: 10.1176/appi.ajp.2011.10101436     Document Type: Article

References (38)

1. Bonnet U, Banger M, Leweke FM, Maschke M, Kowalski T, Gastpar M: Treatment of alcohol withdrawal syndrome with gabapentin. Pharmacopsychiatry 1999; 32:107-109 (Pubitemid 29364444)
2. Volpicelli JR, Watson NT, King AC , Sherman CE, O'Brien CP: Effect of naltrexone on alcohol "high" in alcoholics. Am J Psychiatry 1995; 152:613-615
3. O'Malley SS, Krishnan-Sarin S, Farren C , Sinha R, Kreek MJ: Naltrexone decreases craving and alcohol self-administration in alcohol-dependent subjects and activates the hypothalamopituitary-adrenocortical axis. Psychopharmacology (Berl) 2002; 160:19-29 (Pubitemid 34169822)
4. Anton RF, O'Malley SS, Ciraulo DA, Cisler RA, Couper D, Donovan DM, Gastfriend DR, Hosking JD, Johnson BA, LoCastro JS, Longabaugh R, Mason BJ, Mattson ME, Miller WR, Pettinati HM, Randall CL, Swift R, Weiss RD, Williams LD, Zweben A; COMBINE Study Research Group: Combined Pharmacotherapies and Behavioral Interventions for Alcohol Dependence: the COMBINE study: a randomized controlled trial. JAMA 2006; 295:2003-2017 (Pubitemid 44794003)
5. Malcolm R, Myrick H, Brady KT, Ballenger JC: Update on anticonvulsants for the treatment of alcohol withdrawal. Am J Addict 2001; 10:16-23 (Pubitemid 32199528)
6. Leggio L, Kenna G, Swift R: New developments for the pharmacological treatment of alcohol withdrawal syndrome: a focus on non-benzodiazepine GABAergic medications. Prog Neuropsychopharmacol Biol Psychiatry 2008; 32:1106-1117
7. Book SW, Myrick H: Novel anticonvulsants in the treatment of alcoholism. Expert Opin Investig Drugs 2005; 14:371-376 (Pubitemid 40711848)
8. Mariani JJ, Rosenthal RN, Tross S, Singh P, Anand OP: A randomized, open-label, controlled trial of gabapentin and phenobarbital in the treatment of alcohol withdrawal. Am J Addict 2006; 15:76-84 (Pubitemid 43207192)
9. Myrick H, Malcolm R, Randall PK, Boyle E, Anton RF, Becker HC , Randall CL: A double-blind trial of gabapentin versus lorazepam in the treatment of alcohol withdrawal. Alcohol Clin Exp Res 2009; 33:1582-1588
10. Furieri FA, Nakamura-Palacios EM: Gabapentin reduces alcohol consumption and craving: a randomized, double-blind, placebo-controlled trial. J Clin Psychiatry 2007; 68:1691-1700 (Pubitemid 350247498)
11. Anton RF, Myrick H, Baros AM, Latham PK, Randall PK, Wright TM, Stewart SH, Waid R, Malcolm R: Efficacy of a combination of flumazenil and gabapentin in the treatment of alcohol dependence: relationship to alcohol withdrawal symptoms. J Clin Psychopharmacol 2009; 29:334-342
12. Littleton J: Neurochemical mechanisms underlying alcohol withdrawal. Alcohol Health Res World 1998; 22:13-24
13. Gass JT, Olive MF: Glutamatergic substrates of drug addiction and alcoholism. Biochem Pharmacol 2008; 75:218-265 (Pubitemid 350235390)
14. Bisaga A, Evans SM: The acute effects of gabapentin in combination with alcohol in heavy drinkers. Drug Alcohol Depend 2006; 83:25-32
15. Brower KJ, Myra Kim H, Strobbe S, Karam-Hage MA, Consens F, Zucker RA: A randomized double-blind pilot trial of gabapentin versus placebo to treat alcohol dependence and comorbid insomnia. Alcohol Clin Exp Res 2008; 32:1429-1438
16. Skinner HA, Allen BA: Alcohol dependence syndrome: measurement and validation. J Abnorm Psychol 1982; 91:199-209
17. Roberts JS, Anton RF, Latham PK, Moak DH: Factor structure and predictive validity of the Obsessive Compulsive Drinking Scale. Alcohol Clin Exp Res 1999; 23:1484-1491 (Pubitemid 29468445)
18. Miller WR: Form 90: A Structured Assessment Interview for Drinking and Related Behaviors: Test Manual (pub no NIH 96- 4004). Bethesda, Md, US Department of Health and Human Services, National Institutes of Health, 1996
19. McNair DM, Lorr M, Droppleman LF: Manual for the Profi le of Mood States. San Diego, Educational and Industrial Testing Service, 1971
20. Beck AT, Ward CH, Mendelson M, Mock J, Erbaugh J: An inventory for measuring depression. Arch Gen Psychiatry 1961; 4:561-571
21. Johns MW: A new method for measuring daytime sleepiness: the Epworth Sleepiness Scale. Sleep 1991; 14:540-545
22. Bastien CH, Vallieres A, Morin CM: Validation of the Insomnia Severity Index as an outcome measure for insomnia research. Sleep Med 2001; 2:297-307 (Pubitemid 32677404)
23. Sullivan JT, Sykora K, Schneiderman J, Naranjo CA, Sellers EM: Assessment of alcohol withdrawal: the revised Clinical Institute Withdrawal Assessment for Alcohol Scale (CIWA-Ar). Br J Addict 1989; 84:1353-1357 (Pubitemid 19281139)
24. Anton RF, Dominick C , Bigelow M, Westby C; CDTect Research Group: Comparison of Bio-Rad %CDT TIA and CDTect as laboratory markers of heavy alcohol use and their relationship with γ-glutamyltransferase. Clin Chem 2001; 47:1769-1775 (Pubitemid 32881188)
25. Miller WR: Combined Behavioral Intervention Manual: A Clinical Research Guide for Therapists Treating People With Alcohol Abuse and Dependence (pub no NIH 04-5288). Edited by Mattson ME. Bethesda, Md, US Department of Health and Human Services, 2004
26. Roberto M, Gilpin NW, O'Dell LE, Cruz MT, Morse AC , Siggins GR, Koob GF: Cellular and behavioral interactions of gabapentin with alcohol dependence. J Neurosci 2008; 28:5762-5771
27. Bazil CW, Battista J, Basner RC: Gabapentin improves sleep in the presence of alcohol. J Clin Sleep Med 2005; 1:284-287
28. Mason BJ, Light JM, Williams LD, Drobes DJ: Proof-of-concept human laboratory study for protracted abstinence in alcohol dependence: effects of gabapentin. Addict Biol 2009; 14:73-83
29. Malcolm R, Myrick LH, Veatch LM, Boyle E, Randall PK: Self-reported sleep, sleepiness, and repeated alcohol withdrawals: a randomized, double blind, controlled comparison of lorazepam vs gabapentin. J Clin Sleep Med 2007; 3:24-32 (Pubitemid 46761005)
30. Karam-Hage M, Brower KJ: Open pilot study of gabapentin versus trazodone to treat insomnia in alcoholic outpatients. Psychiatry Clin Neurosci 2003; 57:542-544 (Pubitemid 37247752)
31. Myrick H, Anton R, Voronin K, Wang W, Henderson S: A double-blind evaluation of gabapentin on alcohol effects and drinking in a clinical laboratory paradigm. Alcohol Clin Exp Res 2007; 31:221-227 (Pubitemid 46155221)
32. Drobes DJ, Anton RF, Thomas SE, Voronin K: A clinical laboratory paradigm for evaluating medication effects on alcohol consumption: naltrexone and nalmefene. Neuropsychopharmacology 2003; 28:755-764
33. O'Malley SS, Jaffe AJ, Rode S, Rounsaville BJ: Experience of a "slip" among alcoholics treated with naltrexone or placebo. Am J Psychiatry 1996; 153:281-283
34. Kalivas PW, Volkow ND: The neural basis of addiction: a pathology of motivation and choice. Am J Psychiatry 2005; 162:1403-1413 (Pubitemid 41105554)
35. Johnson BA, Rosenthal N, Capece JA, Wiegand F, Mao L, Beyers K, McKay A, Ait-Daoud N, Anton RF, Ciraulo DA, Kranzler HR, Mann K, O'Malley SS, Swift RM, for the Topiramate for Alcoholism Advisory Board and the Topiramate for Alcoholism Study Group: Topiramate for treating alcohol dependence: a randomized controlled trial. JAMA 2007; 298:1641-1651
36. Myrick H, Anton R, Voronin K, Wang W, Henderson S: A doubleblind evaluation of gabapentin on alcohol effects and drinking in a clinical laboratory paradigm. Alcohol Clin Exp Res 2007; 31:221-227 (Pubitemid 46155221)
37. Anton RF, Drobes DJ, Voronin K, Durazo-Avizu R, Moak D: Naltrexone effects on alcohol consumption in a clinical laboratory paradigm: temporal effects of drinking. Psychopharmacology (Berl) 2004; 173:32-40 (Pubitemid 38591144)
38. Anton RF: Genetic basis for predicting response to naltrexone in the treatment of alcohol dependence. Pharmacogenomics 2008; 9:655-658