The effects of gabapentin on methadone based addiction treatment: A randomized controlled trial

Pakistan Journal of Pharmaceutical Sciences

Volumn 26, Issue 5, 2013, Pages 985-989

  Moghadam, Mohsen Saber ^a   Alavinia, Mohammad ^a  

^a NORTH KHORASAN UNIVERSITY OF MEDICAL SCIENCES   (Iran)

Author keywords

Addiction; Gabapentin; Methadone

Indexed keywords

DIAMORPHINE; GABAPENTIN; METHADONE; OPIATE; PLACEBO; 4 AMINOBUTYRIC ACID; AMINE; CYCLOHEXANECARBOXYLIC ACID DERIVATIVE; NARCOTIC ANALGESIC AGENT;

ADD ON THERAPY; ADULT; ARTICLE; CLINICAL EFFECTIVENESS; CONSCIOUSNESS DISORDER; CONTROLLED STUDY; DOUBLE BLIND PROCEDURE; DRUG DOSE INCREASE; DRUG EFFICACY; DSM-IV; DYSPHORIA; FEMALE; FOLLOW UP; HUMAN; MAJOR CLINICAL STUDY; MALE; METHADONE TREATMENT; MOOD DISORDER; MUSCLE SPASM; OPIATE ADDICTION; OUTPATIENT; RANDOMIZED CONTROLLED TRIAL; TREATMENT DURATION; UNSPECIFIED SIDE EFFECT; WITHDRAWAL SYNDROME; DRUG COMBINATION; IRAN; MIDDLE AGED; OPIATE SUBSTITUTION TREATMENT; OPIOID-RELATED DISORDERS; SUBSTANCE WITHDRAWAL SYNDROME; TIME; TREATMENT OUTCOME; YOUNG ADULT;

ADULT; AMINES; ANALGESICS, OPIOID; CYCLOHEXANECARBOXYLIC ACIDS; DOUBLE-BLIND METHOD; DRUG THERAPY, COMBINATION; FEMALE; GAMMA-AMINOBUTYRIC ACID; HUMANS; IRAN; MALE; METHADONE; MIDDLE AGED; OPIATE SUBSTITUTION TREATMENT; OPIOID-RELATED DISORDERS; SUBSTANCE WITHDRAWAL SYNDROME; TIME FACTORS; TREATMENT OUTCOME; YOUNG ADULT;

EID: 84889570368     PISSN: 1011601X     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (19)

1. Bisaga A, Aharonovich E, Garawi F, Levin FR, Rubin E, Raby WN and Nunes EV (2006). A randomized placebo-controlled trial of gabapentin for cocaine dependence. Drug. Alcohol. Depend., 81: 267-274. (Pubitemid 43152453)
2. Bonnet U, Banger M, Leweke FM, Maschke M, Kowalski T and Gastpar M (1999). Treatment of alcohol withdrawal syndrome with gabapentin. Pharmacopsychiatry., 32: 107-109. (Pubitemid 29364444)
3. Brown JP, Boden P, Singh L and Gee NS (1996). Mechanism of action of gabapentin. Rev. Contemp. Pharmacother., 7: 203-214.
4. Compton P, Kehoe P, Sinha K, Torrington MA and Ling W (2010). Gabapentin improves cold-pressor pain responses in methadone-maintained patients. Drug Alcohol Depend., 109: 213-219.
5. Field MJ, Oles RJ, Lewis AS, McCleary S, Hughes J and Singh L (1997). Gabapentin (neurontin) and S-(+)-3-isobutylgaba represent a novel class of selective antihyperalgesic agents. Br. J. Pharmacol., 121: 1513-1522. (Pubitemid 27343376)
6. Freye E, Levy JV and Partecke L (2004). Use of gabapentin for attenuation of symptoms following rapid opiate detoxification (ROD)-correlation with neurophysiological parameters. Neurophysiol. Clin., 34: 81-89. (Pubitemid 38586795)
7. Goldstein DB (1961). Possible role of enzyme inhibition and repression in drug tolerance and addiction. Biochem. Pharmacol., 8: 48-53.
8. Gonzalez G, Desai R, Sofuoglu M, Poling J, Oliveto A, Gonsai K and Kosten TR (2007). Clinical efficacy of gabapentin versus tiagabine for reducing cocaine use among cocaine dependent methadone-treated patients. Drug Alcohol Depend., 87: 1-9. (Pubitemid 46074378)
9. Guo S, Winslow M, Manning V and Thane KK (2010). Monthly take-home methadone maintenance regime for elderly opium-dependent users in Singapore. Ann. Acad. Med. Singapore, 39: 429-434.
10. Kelly SM, O'Grady KE, Mitchell SG, Brown BS and Schwartz RP (2011). Predictors of methadone treatment retention from a multi-site study: A survival analysis. Drug Alcohol Depend., 117: 170-175.
11. Kheirabadi GR, Ranjkesh M, Maracy MR and Salehi M (2008). Effect of add-on gabapentin on opioid withdrawal symptoms in opium-dependent patients. Addiction,103: 1495-1499.
12. Kumar P and Jain MK (2003). Gabapentin in the management of pentazocine dependence: A potent analgesic - anti-craving agent. J. Assoc. Physicians India, 51: 673-676. (Pubitemid 41279892)
13. Marson AG, Kadir ZA, Hutton JL and Chadwick DW (2000). Gabapentin add-on for drug-resistant partial epilepsy. Cochrane. Database Syst. Rev., CD001415.
14. Martinez-Raga J, Sabater A, Perez-Galvez B, Castellano M and Cervera G (2004). Add-on gabapentin in the treatment of opiate withdrawal. Prog. Neuropsychopharmacol. Biol. Psychiatry, 28: 599-601. (Pubitemid 38490773)
15. Mellick GA and Mellick LB (1997). Reflex sympathetic dystrophy treated with gabapentin. Arch. Phys. Med. Rehabil.,78: 98-105. (Pubitemid 27034255)
16. Myrick H, Henderson S, Brady KT and Malcolm R (2001). Gabapentin in the treatment of cocaine dependence: a case series. J. Clin. Psychiatry, 62: 19-23. (Pubitemid 32154313)
17. Rice AS and Maton S (2001). Gabapentin in postherpetic neuralgia: a randomised, double blind, placebo controlled study. Pain, 94: 215-224. (Pubitemid 33016615)
18. Rosner H, Rubin L and Kestenbaum A (1996). Gabapentin adjunctive therapy in neuropathic pain states. Clin. J. Pain., 12: 56-58. (Pubitemid 26128587)
19. Stotts AL, Dodrill CL and Kosten TR (2009). Opioid dependence treatment: Options in pharmacotherapy. Expert Opin. Pharmacother., 10: 1727-1740.