The relationship between gabapentin and pregabalin and posttraumatic stress disorder in burned servicemembers

Journal of Burn Care and Research

Volumn 33, Issue 5, 2012, Pages 612-618

  Fowler, Marice ^a   Garza, Thomas H ^a   Slater, Terry M ^a   Maani, Christopher V ^a   McGhee, Laura L ^a  

^a US ARMY INSTITUTE OF SURGICAL RESEARCH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GABAPENTIN; PREGABALIN;

ADULT; ARTICLE; BODY SURFACE; BURN; CHECKLIST; HUMAN; INJURY SCALE; INTENSIVE CARE; LENGTH OF STAY; MAJOR CLINICAL STUDY; POSTTRAUMATIC STRESS DISORDER; RETROSPECTIVE STUDY;

ADULT; AMINES; ANALGESICS; ANTI-ANXIETY AGENTS; BURNS; CYCLOHEXANECARBOXYLIC ACIDS; FEMALE; GAMMA-AMINOBUTYRIC ACID; HEALTH STATUS INDICATORS; HUMANS; MALE; MILITARY PERSONNEL; PROPENSITY SCORE; PSYCHOLOGY, MILITARY; PSYCHOMETRICS; RETROSPECTIVE STUDIES; STATISTICS AS TOPIC; STRESS DISORDERS, POST-TRAUMATIC; UNITED STATES;

EID: 84866370431     PISSN: 1559047X     EISSN: 15590488     Source Type: Journal    
DOI: 10.1097/BCR.0b013e31823dc710     Document Type: Article

References (55)

1. Gaylord KM, Cooper DB, Mercado JM, Kennedy JE, Yoder LH, Holcomb JB. Incidence of posttraumatic stress disorder and mild traumatic brain injury in burned service members: preliminary report. J Trauma 2008;64(2 Suppl):S200-5; discussion S205-6.
2. Asmundson GJ, Coons MJ, Taylor S, et al. PTSD and the experience of pain: research and clinical implications of shared vulnerability and mutual maintenance models. Can J Psychiatry 2002;47:930-7.
3. Asmundson GJ, Wright KD, Stein MB. Pain and PTSD symptoms in female veterans. Eur J Pain 2004;8:345-50.
4. McGhee LL, Slater TM, Garza TH, Fowler M, DeSocio PA, Maani CV. The relationship of early pain scores and posttraumatic stress disorder in burned soldiers. J Burn Care Res 2011;32:46-51.
5. Holbrook TL, Hoyt DB, Stein MB, Sieber WJ. Perceived threat to life predicts posttraumatic stress disorder after major trauma: risk factors and functional outcome. J Trauma 2001;51:287-92; discussion 292-3.
6. Diagnostic and statistical manual of mental disorders. 4th ed. Washington, DC: American Psychiatric Association; 1994.
7. Labbate LA, Snow MP. Posttraumatic stress symptoms among soldiers exposed to combat in the Persian Gulf. Hosp Community Psychiatry 1992;43:831-3.
8. Freeman MP, Freeman SA, McElroy SL. The comorbidity of bipolar and anxiety disorders: prevalence, psychobiology, and treatment issues. J Affect Disord 2002;68:1-23.
9. Jakupcak M, Conybeare D, Phelps L, et al. Anger, hostility, and aggression among Iraq and Afghanistan War veterans reporting PTSD and subthreshold PTSD. J Trauma Stress 2007;20:945-54.
10. Maher MJ, Rego SA, Asnis GM. Sleep disturbances in patients with post-traumatic stress disorder: epidemiology, impact and approaches to management. CNS Drugs 2006;20:567-90.
11. Palmieri PA, Weathers FW, Difede J, King DW. Confirmatory factor analysis of the PTSD Checklist and the Clinician-Administered PTSD Scale in disaster workers exposed to the World Trade Center Ground Zero. J Abnorm Psychol 2007;116:329-41.
12. Grieger TA, Cozza SJ, Ursano RJ, et al. Posttraumatic stress disorder and depression in battle-injured soldiers. Am J Psychiatry 2006;163:1777-83; quiz 1860.
13. Hetrick SE, Purcell R, Garner B, Parslow R. Combined pharmacotherapy and psychological therapies for post traumatic stress disorder (PTSD). Cochrane Database Syst Rev 2010;7:CD007316.
14. Adamou M, Puchalska S, Plummer W, Hale AS. Valproate in the treatment of PTSD: systematic review and meta analysis. Curr Med Res Opin 2007;23:1285-91.
15. Alderman CP, McCarthy LC, Condon JT, Marwood AC, Fuller Jr. Topiramate in combat-related posttraumatic stress disorder. Ann Pharmacother 2009;43:635-41.
16. Asnis GM, Kohn SR, Henderson M, Brown NL. SSRIs versus non-SSRIs in post-traumatic stress disorder: an update with recommendations. Drugs 2004;64:383-404.
17. McAllister TW. Psychopharmacological issues in the treatment of TBI and PTSD. Clin Neuropsychol 2009;23:1338-67.
18. Stein MB, Kerridge C, Dimsdale JE, Hoyt DB. Pharmacotherapy to prevent PTSD: results from a randomized controlled proof-of-concept trial in physically injured patients. J Trauma Stress 2007;20:923-32.
19. Van Ameringen M, Mancini C, Pipe B, Bennett M. Antiepileptic drugs in the treatment of anxiety disorders: role in therapy. Drugs 2004;64:2199-220.
20. Zohar J, Amital D, Miodownik C, et al. Double-blind placebo-controlled pilot study of sertraline in military veterans with posttraumatic stress disorder. J Clin Psychopharmacol 2002;22:190-5.
21. Taylor CP, Vartanian MG, Andruszkiewicz R, Silverman RB. 3-Alkyl GABA and 3-alkylglutamic acid analogues: two new classes of anticonvulsant agents. Epilepsy Res 1992;11:103-10.
22. Belliotti TR, Capiris T, Ekhato IV, et al. Structure-activity relationships of pregabalin and analogues that target the alpha(2)-delta protein. J Med Chem 2005;48:2294-307.
23. Gee NS, Brown JP, Dissanayake VU, Offord J, Thurlow R, Woodruff GN. The novel anticonvulsant drug, gabapentin (Neurontin), binds to the alpha2delta subunit of a calcium channel. J Biol Chem 1996;271:5768-76.
24. Fink K, Dooley DJ, Meder WP, et al. Inhibition of neuronal Ca(2+) influx by gabapentin and pregabalin in the human neocortex. Neuropharmacology 2002;42:229-36.
25. McClelland D, Evans RM, Barkworth L, Martin DJ, Scott RH. A study comparing the actions of gabapentin and pregabalin on the electrophysiological properties of cultured DRG neurones from neonatal rats. BMC Pharmacol 2004;4:14.
26. Sills GJ. The mechanisms of action of gabapentin and pregabalin. Curr Opin Pharmacol 2006;6:108-13.
27. Willmore LJ. Clinical pharmacology of new antiepileptic drugs. Neurology 2000;55(11 Suppl 3):S17-24.
28. Spina E, Perugi G. Antiepileptic drugs: indications other than epilepsy. Epileptic Disord 2004;6:57-75.
29. Cuignet O, Pirson J, Soudon O, Zizi M. Effects of gabapentin on morphine consumption and pain in severely burned patients. Burns 2007;33:81-6.
30. O'Connor AB, Dworkin RH. Treatment of neuropathic pain: an overview of recent guidelines. Am J Med 2009;122(10 Suppl):S22-32.
31. Richardson P, Mustard L. The management of pain in the burns unit. Burns 2009;35:921-36.
32. Rosner H, Rubin L, Kestenbaum A. Gabapentin adjunctive therapy in neuropathic pain states. Clin J Pain 1996;12:56-8.
33. Wiffen PJ, McQuay HJ, Edwards JE, Moore RA. Gabapentin for acute and chronic pain. Cochrane Database Syst Rev 2005;3:CD005452.
34. Berigan TR. Gabapentin and PTSD. J Clin Psychiatry 2002;63:744.
35. Hamner MB, Brodrick PS, Labbate LA. Gabapentin in PTSD: a retrospective, clinical series of adjunctive therapy. Ann Clin Psychiatry 2001;13:141-6.
36. Malek-Ahmadi P. Gabapentin and posttraumatic stress disorder. Ann Pharmacother 2003;37:664-6.
37. Aurora RN, Zak RS, Auerbach SH, et al. Best practice guide for the treatment of nightmare disorder in adults. J Clin Sleep Med 2011;6:389-401.
38. Sabatowski R, Gálvez R, Cherry DA, et al. Pregabalin reduces pain and improves sleep and mood disturbances in patients with post-herpetic neuralgia: results of a randomised, placebo-controlled clinical trial. Pain 2004;109:26-35.
39. Hamilton RJ, editor. Tarascon pharmacopoeia. 12th ed. Subury, MA: Jones & Bartlett Learning; 2010.
40. Blanchard EB, Jones-Alexander J, Buckley TC, Forneris CA. Psychometric properties of the PTSD Checklist (PCL). Behav Res Ther 1996;34:669-73.
41. Keck PE Jr, McElroy SL, Friedman LM. Valproate and carbamazepine in the treatment of panic and posttraumatic stress disorders, withdrawal states, and behavioral dyscontrol syndromes. J Clin Psychopharmacol 1992;12 (1 Suppl):36S-41S.
42. Bliese PD, Wright KM, Adler AB, Cabrera O, Castro CA, Hoge CW. Validating the primary care posttraumatic stress disorder screen and the posttraumatic stress disorder checklist with soldiers returning from combat. J Consult Clin Psychol 2008;76:272-81.
43. Brewin CR. Systematic review of screening instruments for adults at risk of PTSD. J Trauma Stress 2005;18:53-62.
44. McGhee LL, Maani CV, Garza TH, DeSocio PA, Gaylord KM, Black IH. The relationship of intravenous midazolam and posttraumatic stress disorder development in burned soldiers. J Trauma 2009;66(4 Suppl):S186-90.
45. McGhee LL, Maani CV, Garza TH, Gaylord KM, Black IH. The correlation between ketamine and posttraumatic stress disorder in burned service members. J Trauma 2008;64 (2 Suppl):S195-8; discussion S197-8.
46. Patterson DR, Carrigan L, Questad KA, Robinson R. Post-traumatic stress disorder in hospitalized patients with burn injuries. J Burn Care Rehabil 1990;11:181-4.
47. Powers PS, Cruse CW, Daniels S, Stevens B. Posttraumatic stress disorder in patients with burns. J Burn Care Rehabil 1994;15:147-53.
48. Saxe G, Stoddard F, Courtney D, et al. Relationship between acute morphine and the course of PTSD in children with burns. J Am Acad Child Adolesc Psychiatry 2001;40:915-21.
49. Van Loey NE, Maas CJ, Faber AW, Taal LA. Predictors of chronic posttraumatic stress symptoms following burn injury: results of a longitudinal study. J Trauma Stress 2003;16:361-9.
50. Holbrook TL, Galarneau MR, Dye JL, Quinn K, Dougherty AL. Morphine use after combat injury in Iraq and post-traumatic stress disorder. N Engl J Med 362:110-7.
51. Strawn JR, Dowling BP, Geracioti TD Jr. Pregabalin treatment of posttraumatic stress disorder. J Clin Psychopharmacol 2008;28:596-7.
52. Zohar J, Matar MA, Ifergane G, Kaplan Z, Cohen H. Brief post-stressor treatment with pregabalin in an animal model for PTSD: short-term anxiolytic effects without long-term anxiogenic effect. Eur Neuropsychopharmacol 2008;18:653-66.
53. Baker DG, Nievergelt CM, Risbrough VB. Post-traumatic stress disorder: emerging concepts of pharmacotherapy. Expert Opin Emerg Drugs 2009;14:251-72.
54. Berlin HA. Antiepileptic drugs for the treatment of post-traumatic stress disorder. Curr Psychiatry Rep 2007;9:291-300.
55. Ramchand R, Schell TL, Karney BR, Osilla KC, Burns RM, Caldarone LB. Disparate prevalence estimates of PTSD among service members who served in Iraq and Afghanistan: possible explanations. J Trauma Stress 2010;23:59-68.