Optimization of permethyl ningalin B analogs as P-glycoprotein inhibitors

Bioorganic and Medicinal Chemistry

Volumn 23, Issue 17, 2015, Pages 5566-5573

  Wang, Zhen ^a,b   Wong, Iris L K ^c   Li, Fu Xing ^a,b   Yang, Chao ^a,b   Liu, Zhen ^a,b   Jiang, Tao ^a   Jiang, Ting Fu ^a   Chow, Larry M C ^c   Wan, Sheng Biao ^a,b  

^a Laboratory for Marine Science and Technology   (China)

^b INSTITUTE OF MATERIA MEDICA   (China)

^c HONG KONG POLYTECHNIC UNIVERSITY   (Hong Kong)

Author keywords

ATP binding cassette (ABC) transporter; Multidrug resistance (MDR); P glycoprotein (P gp); P gp chemosensitizer; Permethyl ningalin B

Indexed keywords

1 [2 (5 BROMO 2,4 DIMETHOXYPHENYL) 2 OXOETHYL] 3,4 BIS(3,4 DIMETHOXYPHENYL) 1H PYRROLE 2,5 DIONE; 1 [2 [4 (BENZYLOXY) 3 NITROPHENYL] 2 OXOETHYL] 3,4 BIS(3,4 DIMETHOXYPHENYL) 1H PYRROLE 2,5 DIONE; 1 [2 [4 (BENZYLOXY) 5 BROMO 2 (2 MORPHOLINOETHOXY)PHENYL] 2 OXOETHYL] 3,4 BIS(3,4 DIMETHOXYPHENYL) 1H PYRROLE 2,5 DIONE; 1 [2 [4 (BENZYLOXY) 5 BROMO 2 (HYDROXYMETHOXY)PHENYL] 2 OXOETHYL] 3,4 BIS(3,4 DIMETHOXYPHENYL) 1H PYRROLE 2,5 DIONE; 1 [2 [4 (BENZYLOXY) 5 BROMO 2 METHOXYPHENYL] 2 OXOETHYL] 3,4 BIS(3,4 DIMETHOXYPHENYL) 1H PYRROLE 2,5 DIONE; 1 [2 [4 [2 [4 (BENZYLOXY) 3 METHOXYPHENYL] 2 OXOETHYL]PIPERAZIN 1 YL] 2 OXOETHYL] 3,4 BIS(3,4 DIMETHOXYPHENYL) 1H PYRROLE 2,5 DIONE; 2 [3,4 BIS(3,4 DIMETHOXYPHENYL) 2,5 DIOXO 2,5 DIHYDRO 1H PYRROL 1 YL] N (1 BUTYL 3 OXO 1,3 DIHYDROISOBENZOFURAN 5YL)ACETAMIDE; 2 [3,4 BIS(3,4 DIMETHOXYPHENYL) 2,5 DIOXO 2,5 DIHYDRO 1H PYRROL 1 YL] N (3 OXO 1,3 DIHYDROISOBENZOFURAN 4 YL)ACETAMIDE; 3,4 BIS(3,4 DIMETHOXYPHENYL) 1 [2 [4 [2 [4 (METHYLSULFONYL)PHENYL] 2 OXOETHYL]PIPERAZIN 1 YL] 2 OXOETHYL] 1H PYRROLE 2,5 DIONE; GLYCOPROTEIN P INHIBITOR; PERMETHYL NINGALIN B DERIVATIVE; UNCLASSIFIED DRUG; VERAPAMIL; ABC TRANSPORTER; FUSED HETEROCYCLIC RINGS; MULTIDRUG RESISTANCE PROTEIN; NINGALIN B;

ANTINEOPLASTIC ACTIVITY; ARTICLE; BREAST CANCER CELL LINE; CANCER RESISTANCE; CHEMOSENSITIZATION; CONTROLLED STUDY; DRUG CYTOTOXICITY; DRUG IDENTIFICATION; DRUG MECHANISM; DRUG POTENTIATION; DRUG SCREENING; DRUG SOLUBILITY; DRUG STRUCTURE; DRUG SYNTHESIS; EC50; IC50; REACTION OPTIMIZATION; SUBSTITUTION REACTION; ANTAGONISTS AND INHIBITORS; CHEMICAL STRUCTURE; HUMAN; METABOLISM; MULTIDRUG RESISTANCE; STRUCTURE ACTIVITY RELATION; TUMOR CELL LINE;

ATP-BINDING CASSETTE TRANSPORTERS; CELL LINE, TUMOR; DRUG RESISTANCE, MULTIPLE; HETEROCYCLIC COMPOUNDS, 3-RING; HUMANS; MOLECULAR STRUCTURE; P-GLYCOPROTEINS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84946494754     PISSN: 09680896     EISSN: 14643391     Source Type: Journal    
DOI: 10.1016/j.bmc.2015.07.027     Document Type: Article

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