Modification of marine natural product ningalin B and SAR study lead to potent P-glycoprotein inhibitors

Marine Drugs

Volumn 12, Issue 10, 2014, Pages 5209-5221

  Yang, Chao ^a   Wong, Iris L K ^b   Jin, Wen Bin ^a   Jiang, Tao ^a   Chow, Larry M C ^b   Wan, Sheng Biao ^a  

^a Laboratory for Marine Science and Technology   (China)

^b HONG KONG POLYTECHNIC UNIVERSITY   (Hong Kong)

Author keywords

Multidrug resistance (MDR); Ningalin B analogues; P glycoprotein; P gp modulators; Pyrrole

Indexed keywords

ANTINEOPLASTIC AGENT; BIOLOGICAL PRODUCT; FUSED HETEROCYCLIC RINGS; MULTIDRUG RESISTANCE PROTEIN; NINGALIN B; PIPERAZINE; PIPERAZINE DERIVATIVE;

ANTAGONISTS AND INHIBITORS; BREAST NEOPLASMS; CHEMISTRY; DRUG EFFECTS; DRUG RESISTANCE; FEMALE; HUMAN; K562 CELL LINE; LEUKEMIA; MULTIDRUG RESISTANCE; STRUCTURE ACTIVITY RELATION; TUMOR CELL LINE;

ANTINEOPLASTIC AGENTS; BIOLOGICAL PRODUCTS; BREAST NEOPLASMS; CELL LINE, TUMOR; DRUG RESISTANCE, MULTIPLE; DRUG RESISTANCE, NEOPLASM; FEMALE; HETEROCYCLIC COMPOUNDS, 3-RING; HUMANS; K562 CELLS; LEUKEMIA; P-GLYCOPROTEIN; PIPERAZINES; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84908199216     PISSN: None     EISSN: 16603397     Source Type: Journal    
DOI: 10.3390/md12105209     Document Type: Article

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