Inhibition of autophagy exerts anti-colon cancer effects via apoptosis induced by p53 activation and ER stress

BMC Cancer

Volumn 15, Issue 1, 2015, Pages

  Sakitani, Kosuke ^a,b,c   Hirata, Yoshihiro ^b   Hikiba, Yohko ^a   Hayakawa, Yoku ^b   Ihara, Sozaburo ^b   Suzuki, Hirobumi ^b   Suzuki, Nobumi ^b   Serizawa, Takako ^b   Kinoshita, Hiroto ^b   Sakamoto, Kei ^a   Nakagawa, Hayato ^b   Tateishi, Keisuke ^b   Maeda, Shin ^c   Ikenoue, Tsuneo ^d   Kawazu, Shoji ^a   Koike, Kazuhiko ^b  

^a INSTITUTE FOR ADULT DISEASES   (Japan)

^b UNIVERSITY OF TOKYO   (Japan)

^c YOKOHAMA CITY UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^d UNIVERSITY OF TOKYO   (Japan)

Author keywords

Apoptosis; Autophagy; Colon cancer

Indexed keywords

AUTOPHAGY PROTEIN 5; CASPASE 3; CCAAT ENHANCER BINDING PROTEIN; CYTOKERATIN 19; GLUCOSE REGULATED PROTEIN 78; PROTEIN P53; SMALL INTERFERING RNA;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; AUTOPHAGY; CANCER CELL LINE; CELL MUTANT; COLON CANCER; CONTROLLED STUDY; ENDOPLASMIC RETICULUM STRESS; GENE ACTIVATION; GENE EXPRESSION; GENE SILENCING; GENETIC TRANSFECTION; IN VITRO STUDY; IN VIVO STUDY; MALE; MOUSE; NONHUMAN; P53 GENE; TUMOR VOLUME; UNFOLDED PROTEIN RESPONSE; UPREGULATION; WILD TYPE; ANIMAL; BIOSYNTHESIS; C57BL MOUSE; COLONIC NEOPLASMS; HCT 116 CELL LINE; HUMAN; METABOLISM; PHYSIOLOGY; TRANSGENIC MOUSE; TUMOR CELL LINE; TUMOR SUPPRESSOR GENE;

ANIMALS; APOPTOSIS; AUTOPHAGY; CELL LINE, TUMOR; COLONIC NEOPLASMS; ENDOPLASMIC RETICULUM STRESS; GENES, P53; HCT116 CELLS; HUMANS; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; TUMOR SUPPRESSOR PROTEIN P53;

EID: 84946486735     PISSN: None     EISSN: 14712407     Source Type: Journal    
DOI: 10.1186/s12885-015-1789-5     Document Type: Article

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