CCN1/CYR61 overexpression in hepatic stellate cells induces ER stress-related apoptosis

Cellular Signalling

Volumn 28, Issue 1, 2016, Pages 34-42

  Borkham Kamphorst, Erawan ^a   Steffen, Bettina T ^a   Van de Leur, Eddy ^a   Haas, Ute ^a   Tihaa, Lidia ^a   Friedman, Scott L ^b   Weiskirchen, Ralf ^a  

^a UNIVERSITY HOSPITAL RWTH AACHEN   (Germany)

^b MOUNT SINAI SCHOOL OF MEDICINE   (United States)

Author keywords

CCN1 CYR61; ER stress; Hepatic stellate cells; Matricellular protein; Myofibroblasts; Unfolded protein response

Indexed keywords

ADENOVIRUS VECTOR; ALPHA SMOOTH MUSCLE ACTIN; CASPASE 12; CASPASE 3; CASPASE 9; CELL PROTEIN; COLLAGEN TYPE 1; COLLAGEN TYPE 1 ALPHA 1; CYSTEINE RICH PROTEIN 61; CYTOCHROME C; DNAJC3 PROTEIN; EDEM1 PROTEIN; EROA1 PROTEIN; GLUCOSE REGULATED PROTEIN 78; GLUCOSE REGULATED PROTEIN 94; GROWTH ARREST AND DNA DAMAGE INDUCIBLE PROTEIN 153; INITIATION FACTOR 2ALPHA; PDIA4 PROTEIN; PROTEIN IRE1; PROTEIN IRE1 ALPHA; SMAD2 PROTEIN; STRESS ACTIVATED PROTEIN KINASE; UNCLASSIFIED DRUG; X BOX BINDING PROTEIN 1; CASP3 PROTEIN, RAT; CYR61 PROTEIN, RAT;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIFIBROTIC ACTIVITY; APOPTOSIS; ARTICLE; CCN1 GENE; CELL AGING; CONTROLLED STUDY; CYTOMEGALOVIRUS; DOWN REGULATION; DRUG ACTIVITY; ENDOPLASMIC RETICULUM STRESS; ENZYME PHOSPHORYLATION; GENE EXPRESSION REGULATION; HUMAN; HUMAN ADENOVIRUS 5; HUMAN CELL; LIVER FIBROSIS; MALE; NONHUMAN; PRIORITY JOURNAL; PROTEIN CLEAVAGE; PROTEIN EXPRESSION; PROTEIN UNFOLDING; RAT; RNA SPLICING; STELLATE CELL; UPREGULATION; VIRAL GENE DELIVERY SYSTEM; ANIMAL; ENDOPLASMIC RETICULUM; LIVER CIRRHOSIS; METABOLISM; MYOFIBROBLAST; PHYSIOLOGY; SPRAGUE DAWLEY RAT; UNFOLDED PROTEIN RESPONSE;

ANIMALS; APOPTOSIS; CASPASE 3; CYSTEINE-RICH PROTEIN 61; ENDOPLASMIC RETICULUM; ENDOPLASMIC RETICULUM STRESS; HEPATIC STELLATE CELLS; LIVER CIRRHOSIS; MYOFIBROBLASTS; RATS, SPRAGUE-DAWLEY; UNFOLDED PROTEIN RESPONSE;

EID: 84946430177     PISSN: 08986568     EISSN: 18733913     Source Type: Journal    
DOI: 10.1016/j.cellsig.2015.10.013     Document Type: Article

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