The anti-fibrotic effects of CCN1/CYR61 in primary portal myofibroblasts are mediated through induction of reactive oxygen species resulting in cellular senescence, apoptosis and attenuated TGF-β signaling

Biochimica et Biophysica Acta - Molecular Cell Research

Volumn 1843, Issue 5, 2014, Pages 902-914

  Borkham Kamphorst, Erawan ^a   Schaffrath, Christian ^a   Van de Leur, Eddy ^a   Haas, Ute ^a   Tihaa, Lidia ^a   Meurer, Steffen K ^a   Nevzorova, Yulia A ^a   Liedtke, Christian ^a   Weiskirchen, Ralf ^a  

^a UNIVERSITY HOSPITAL RWTH AACHEN   (Germany)

Author keywords

Apoptosis; CCN protein; Hepatic stellate cell; Myofibroblast; Portal myofibroblast; Senescence

Indexed keywords

APOPTOSIS; CCN PROTEIN; HEPATIC STELLATE CELL; MYOFIBROBLAST; PORTAL MYOFIBROBLAST; SENESCENCE;

ANIMALS; APOPTOSIS; CELL AGING; CYSTEINE-RICH PROTEIN 61; MALE; MYOFIBROBLASTS; RATS; RATS, SPRAGUE-DAWLEY; REACTIVE OXYGEN SPECIES; SIGNAL TRANSDUCTION; TRANSFORMING GROWTH FACTOR BETA;

EID: 84894333735     PISSN: 01674889     EISSN: 18792596     Source Type: Journal    
DOI: 10.1016/j.bbamcr.2014.01.023     Document Type: Article

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