A New Glycan-Dependent CD4-Binding Site Neutralizing Antibody Exerts Pressure on HIV-1 In Vivo

PLoS Pathogens

Volumn 11, Issue 10, 2015, Pages

  Freund, Natalia T ^a   Horwitz, Joshua A ^a   Nogueira, Lilian ^a   Sievers, Stuart A ^b   Scharf, Louise ^b   Scheid, Johannes F ^a   Gazumyan, Anna ^a   Liu, Cassie ^a   Velinzon, Klara ^a   Goldenthal, Ariel ^c   Sanders, Rogier W ^d   Moore, John P ^e   Bjorkman, Pamela J ^b   Seaman, Michael S ^f   Walker, Bruce D ^c,g   Klein, Florian ^h,i   Nussenzweig, Michel C ^a,g  

^a ROCKEFELLER UNIVERSITY   (United States)

^b California Institute of Technology   (United States)

^c MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

^d UNIVERSITY OF AMSTERDAM   (Netherlands)

^e WEILL CORNELL MEDICAL COLLEGE   (United States)

^f HARVARD MEDICAL SCHOOL   (United States)

^g HOWARD HUGHES MEDICAL INSTITUTE   (United States)

^h UNIVERSITY HOSPITAL OF COLOGNE   (Germany)

ⁱ UNIVERSITY OF COLOGNE   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

CD4 ANTIGEN; IMMUNOGLOBULIN G; NEUTRALIZING ANTIBODY; HUMAN IMMUNODEFICIENCY VIRUS ANTIBODY; POLYSACCHARIDE;

ADULT; ANIMAL EXPERIMENT; ANTIBODY PRODUCTION; ANTIGEN PRESENTATION; ARTICLE; ENZYME LINKED IMMUNOSORBENT ASSAY; EPITOPE MAPPING; FLOW CYTOMETRY; HLA TYPING; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS 1; MAJOR CLINICAL STUDY; MOUSE; NONHUMAN; POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SEQUENCE ANALYSIS; SEROLOGY; TRANSIENT TRANSFECTION; VIRUS ISOLATION; VIRUS LOAD; ANIMAL; BINDING SITE; CHEMISTRY; HEK293 CELL LINE; IMMUNOLOGY;

ANIMALS; ANTIBODIES, NEUTRALIZING; ANTIGENS, CD4; BINDING SITES; HEK293 CELLS; HIV ANTIBODIES; HIV-1; HUMANS; MICE; POLYSACCHARIDES;

EID: 84946045414     PISSN: 15537366     EISSN: 15537374     Source Type: Journal    
DOI: 10.1371/journal.ppat.1005238     Document Type: Article

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