Baicalein inhibits prostate cancer cell growth and metastasis via the caveolin-1/AKT/mTOR pathway

Molecular and Cellular Biochemistry

Volumn 406, Issue 1-2, 2015, Pages 111-119

  Guo, Zhaoxin ^a   Hu, Xiaolin ^b   Xing, Zhaoquan ^a   Xing, Rui ^c   Lv, Renguang ^d   Cheng, Xiangyu ^a   Su, Jing ^b   Zhou, Zunlin ^a   Xu, Zhonghua ^a   Nilsson, Sten ^e   Liu, Zhaoxu ^a,b,e  

^a SHANDONG UNIVERSITY   (China)

^b SHANDONG UNIVERSITY   (China)

^c Linyi County Deping Hospital   (China)

^d Design Institute of Jinan Iron and Steel Company   (China)

^e KAROLINSKA INSTITUTE   (Sweden)

Author keywords

Androgen independent prostate cancer; Anti cancer activity; Baicalein; Caveolin 1; Metastasis

Indexed keywords

2 MORPHOLINO 8 PHENYLCHROMONE; BAICALEIN; CAVEOLIN 1; MAMMALIAN TARGET OF RAPAMYCIN; PROTEIN KINASE B; ANTINEOPLASTIC AGENT; CAV1 PROTEIN, HUMAN; FLAVANONE DERIVATIVE; MTOR PROTEIN, HUMAN; TARGET OF RAPAMYCIN KINASE;

APOPTOSIS ASSAY; ARTICLE; CANCER CELL LINE; CANCER INHIBITION; CELL VIABILITY; DRUG MECHANISM; DRUG POTENTIATION; ENZYME PHOSPHORYLATION; FLOW CYTOMETRY; HUMAN; HUMAN CELL; IN VITRO STUDY; METASTASIS; METASTASIS INHIBITION; PROSTATE CANCER; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; TUMOR INVASION; APOPTOSIS; CELL MOTION; CELL PROLIFERATION; DRUG EFFECTS; DRUG SCREENING; MALE; METABOLISM; PATHOLOGY; PROSTATIC NEOPLASMS; SIGNAL TRANSDUCTION;

ANTINEOPLASTIC AGENTS; APOPTOSIS; CAVEOLIN 1; CELL MOVEMENT; CELL PROLIFERATION; DRUG SCREENING ASSAYS, ANTITUMOR; FLAVANONES; HUMANS; MALE; NEOPLASM METASTASIS; PROSTATIC NEOPLASMS; PROTO-ONCOGENE PROTEINS C-AKT; SIGNAL TRANSDUCTION; TOR SERINE-THREONINE KINASES;

EID: 84945980654     PISSN: 03008177     EISSN: 15734919     Source Type: Journal    
DOI: 10.1007/s11010-015-2429-8     Document Type: Article

References (43)

1. Jemal A, Siegel R, Ward E, Hao Y, Xu J, Thun MJ (2009) Cancer statistics, 2009. CA 59:225–249
2. Mohler JL, Gregory CW, Ford OH 3rd et al (2004) The androgen axis in recurrent prostate cancer. Clin Cancer Res 10:440–448
3. Agoulnik IU, Weigel NL (2006) Androgen receptor action in hormone-dependent and recurrent prostate cancer. J Cell Biochem 99:362–372
4. Hui C, Qi X, Qianyong Z, Xiaoli P, Jundong Z, Mantian M (2013) Flavonoids, flavonoid subclasses and breast cancer risk: a meta-analysis of epidemiologic studies. PLoS One 8:e54318
5. Geybels MS, Verhage BA, Arts IC, van Schooten FJ, Goldbohm RA, van den Brandt PA (2013) Dietary flavonoid intake, black tea consumption, and risk of overall and advanced stage prostate cancer. Am J Epidemiol 177:1388–1398
6. Li-Weber M (2009) New therapeutic aspects of flavones: the anticancer properties of Scutellaria and its main active constituents wogonin, baicalein and baicalin. Cancer Treat Rev 35:57–68
7. Wang L, Ling Y, Chen Y et al (2010) Flavonoid baicalein suppresses adhesion, migration and invasion of MDA-MB-231 human breast cancer cells. Cancer Lett 297:42–48
8. Chiu YW, Lin TH, Huang WS et al (2011) Baicalein inhibits the migration and invasive properties of human hepatoma cells. Toxicol Appl Pharmacol 255:316–326
9. Wang AM, Ku HH, Liang YC, Chen YC, Hwu YM, Yeh TS (2009) The autonomous notch signal pathway is activated by baicalin and baicalein but is suppressed by niclosamide in K562 cells. J Cell Biochem 106:682–692
10. Huang WS, Kuo YH, Chin CC et al (2012) Proteomic analysis of the effects of baicalein on colorectal cancer cells. Proteomics 12:810–819
11. Bonham M, Posakony J, Coleman I, Montgomery B, Simon J, Nelson PS (2005) Characterization of chemical constituents in Scutellaria baicalensis with antiandrogenic and growth-inhibitory activities toward prostate carcinoma. Clin Cancer Res 11:3905–3914
12. Yan L, Xing Z, Guo Z et al (2013) Somatostatin derivative (smsDX) targets cellular metabolism in prostate cancer cells after androgen deprivation therapy. PLoS One 8:e55790
13. Gavathiotis E, Suzuki M, Davis ML et al (2008) BAX activation is initiated at a novel interaction site. Nature 455:1076–1081
14. Pollack A, Cowen D, Troncoso P et al (2003) Molecular markers of outcome after radiotherapy in patients with prostate carcinoma: Ki-67, bcl-2, bax, and bcl-x. Cancer 97:1630–1638
15. Li L, Yang G, Ebara S et al (2001) Caveolin-1 mediates testosterone-stimulated survival/clonal growth and promotes metastatic activities in prostate cancer cells. Cancer Res 61:4386–4392
16. Courtney KD, Corcoran RB, Engelman JA (2013) The PI3K pathway as drug target in human cancer. J Clin Oncol 28:1075–1083
17. Liu P, Cheng H, Roberts TM, Zhao JJ (2009) Targeting the phosphoinositide 3-kinase pathway in cancer. Nat Rev Drug Discov 8:627–644
18. Hsieh AC, Liu Y, Edlind MP et al (2010) The translational landscape of mTOR signalling steers cancer initiation and metastasis. Nature 485:55–61
19. Sallusto F, Poupot R, Clergue M, DePalma R, Fournie JJ (2000) A flavonoid sulfate antigen activates human alphabeta CD8+ Th2 lymphocytes in pollen allergy. Eur J Immunol 30:964–968
20. Wall C, Lim R, Poljak M, Lappas M (2013) Dietary flavonoids as therapeutics for preterm birth: luteolin and kaempferol suppress inflammation in human gestational tissues in vitro. Oxid Med Cell Longev 2013:485201
21. Mahboubi M, Kazempour N, Boland Nazar AR (2013) Total phenolic, total flavonoids, antioxidant and antimicrobial activities of scrophularia striata boiss extracts. Jundishapur J Nat Pharm Prod 8:15–19
22. Belguise K, Guo S, Sonenshein GE (2007) Activation of FOXO3a by the green tea polyphenol epigallocatechin-3-gallate induces estrogen receptor alpha expression reversing invasive phenotype of breast cancer cells. Cancer Res 67:5763–5770
23. Hazgui S, Bonnomet A, Nawrocki-Raby B et al (2008) Epigallocatechin-3-gallate (EGCG) inhibits the migratory behavior of tumor bronchial epithelial cells. Respir Res 9:33
24. Bello IA, Ndukwe GI, Audu OT, Habila JD (2011) A bioactive flavonoid from Pavetta crassipes K. Schum. Org Med Chem Lett 1:14
25. Kim KH, Park YD, Park H et al (2014) Synthesis and biological evaluation of a novel baicalein glycoside as an anti-inflammatory agent. Eur J Pharmacol 744:147–156
26. Mansuri ML, Parihar P, Solanki I, Parihar MS (2014) Flavonoids in modulation of cell survival signalling pathways. Genes Nutr 9:400
27. Chen S, Ruan Q, Bedner E et al (2001) Effects of the flavonoid baicalin and its metabolite baicalein on androgen receptor expression, cell cycle progression and apoptosis of prostate cancer cell lines. Cell Prolif 34:293–304
28. Sternberg PW, Schmid SL (1999) Caveolin, cholesterol and Ras signalling. Nat Cell Biol 1:E35–E37
29. Linge A, Weinhold K, Blasche R, Kasper M, Barth K (2007) Downregulation of caveolin-1 affects bleomycin-induced growth arrest and cellular senescence in A549 cells. Int J Biochem Cell Biol 39:1964–1974
30. Yu Q (2006) Restoring p53-mediated apoptosis in cancer cells: new opportunities for cancer therapy. Drug Resist Updat 9:19–25
31. Zou H, Volonte D, Galbiati F (2012) Interaction of caveolin-1 with Ku70 inhibits bax-mediated apoptosis. PLoS One 7:e39379
32. Nam KS, Shon YH (2009) Suppression of metastasis of human breast cancer cells by chitosan oligosaccharides. J Microbiol Biotechnol 19:629–633
33. Williams TM, Lisanti MP (2005) Caveolin-1 in oncogenic transformation, cancer, and metastasis. Am J Physiol Cell Physiol 288:C494–C506
34. Iguchi K, Matsunaga S, Nakano T, Usui S, Hirano K (2006) Inhibition of caveolin-1 expression by incadronate in PC-3 prostate cells. Anticancer Res 26:2977–2981
35. Sugie S, Mukai S, Tsukino H et al (2013) Increased plasma caveolin-1 levels are associated with progression of prostate cancer among Japanese men. Anticancer Res 33:1893–1897
36. Shack S, Wang XT, Kokkonen GC, Gorospe M, Longo DL, Holbrook NJ (2003) Caveolin-induced activation of the phosphatidylinositol 3-kinase/Akt pathway increases arsenite cytotoxicity. Mol Cell Biol 23:2407–2414
37. Morgensztern D, McLeod HL (2005) PI3K/Akt/mTOR pathway as a target for cancer therapy. Anticancer Drugs 16:797–803
38. Yap TA, Garrett MD, Walton MI, Raynaud F, de Bono JS, Workman P (2008) Targeting the PI3K-AKT-mTOR pathway: progress, pitfalls, and promises. Curr Opin Pharmacol 8:393–412
39. Anderson RG (1993) Caveolae: where incoming and outgoing messengers meet. Proc Natl Acad Sci USA 90:10909–10913
40. Kim HA, Kim KH, Lee RA (2006) Expression of caveolin-1 is correlated with Akt-1 in colorectal cancer tissues. Exp Mol Pathol 80:165–170
41. Kim JK, Jung Y, Wang J et al (2013) TBK1 regulates prostate cancer dormancy through mTOR inhibition. Neoplasia 15:1064–1074
42. Downward J (2004) PI 3-kinase, Akt and cell survival. Semin Cell Dev Biol 15:177–182
43. Maddika S, Ande SR, Panigrahi S et al (2007) Cell survival, cell death and cell cycle pathways are interconnected: implications for cancer therapy. Drug Resist Updates 10:13–29