Caveolin-1 mediates testosterone-stimulated survival/clonal growth and promotes metastatic activities in prostate cancer cells

Cancer Research

Volumn 61, Issue 11, 2001, Pages 4386-4392

  Li, L ^a   Yang, G ^a   Ebara, S ^a   Satoh, T ^a   Nasu, Y ^a   Timme, T L ^a   Ren, C ^a   Wang, J ^a   Tahir, S A ^a   Thompson, T C ^a  

^a BAYLOR COLLEGE OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANDROGEN; CAVEOLIN 1; TESTOSTERONE;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CANCER CELL CULTURE; CELL SURVIVAL; CLONOGENIC ASSAY; CONTROLLED STUDY; MALE; METASTASIS; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROSTATE CANCER; PROTEIN INDUCTION; TRANSCRIPTION INITIATION; TRANSCRIPTION REGULATION;

ANIMALS; CAVEOLIN 1; CAVEOLINS; CELL DIVISION; CELL SURVIVAL; DNA, ANTISENSE; DOSE-RESPONSE RELATIONSHIP, DRUG; HUMANS; LUNG NEOPLASMS; LYMPHATIC METASTASIS; MALE; MICE; NEOPLASM METASTASIS; NEOPLASMS, HORMONE-DEPENDENT; PROMOTER REGIONS (GENETICS); PROSTATIC NEOPLASMS; TESTOSTERONE; TRANS-ACTIVATION (GENETICS); TUMOR CELLS, CULTURED; UP-REGULATION;

EID: 0035361376     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (30)

1. Cancer statistics, 2000
2. Studies on prostate cancer: Effect of castration, of estrogen, and androgen injection on serum phosphatase in metastatic carcinoma of the prostate
3. Elevated expression of caveolin is associated with prostate and breast cancer
4. Caveolin-1 expression in clinically confined human prostate cancer: A novel prognostic marker
5. Suppression of caveolin expression induces androgen sensitivity in metastatic androgen-insensitive mouse prostate cancer cells
6. Up-regulation of caveolae and caveolar constituents in multidrug-resistant cancer cells
7. Upregulation of caveolin-1 and caveolae organelles in Taxol-resistant A549 cells
8. Caveolin-1 levels are down-regulated in human colon tumors, and ectopic expression of caveolin-1 in colon carcinoma cell lines reduces cell tumorigenicity
9. Caveolin-1 is regulated by c-myc and suppresses c-myc-induced apoptosis
10. Caveolae, digs, and the dynamics of sphingolipid-cholesterol microdomains
11. Functional rafts in cell membranes
12. Role of plasmalemmal caveolae in signal transduction
13. Caveolins, liquid-ordered domains, and signal transduction
14. Reduction of caveolin and caveolae in oncogenically transformed cells
15. Reduction of caveolin-1 expression in tumorigenic human cell hybrids
16. Recombinant expression of caveolin-1 in oncogenically transformed cells abrogates anchorage-dependent growth
17. Tumor cell growth inhibition by caveolin re-expression in human breast cancer cells
18. Chromosomal localization, genomic organization, and developmental expression of murine caveolin gene family (Cav-1, -2, and -3): Cav-1 and Cav-2 genes map to a known tumor suppressor locus (6-A2/7q31)
19. Analysis of the caveolin-1 gene at human chromosome 7q31.1 in primary tumors and tumor-derived cell lines
20. Expression level of Bcl-2 determines anti- or proapoptotic function
21. Bcl-2 has a cell cycle inhibitory function separable from its enhancement of cell survival
22. The anti-apoptosis function of Bcl-2 can be genetically separated from its inhibitory effect on cell cycle entry
23. Tumorigenic transformation of immortalized ECV endothelial cells by cyclooxygenase-1 overexpression
24. Overexpression of cyclooxygenase-2 induces cell cycle arrest. Evidence for a prostaglandin-independent mechanism
25. Loss of p53 function leads to metastasis in ras+myc-initiated mouse prostate cancer
26. Spontaneous but not experimental metastatic activities differentiate primary tumor-derived versus metastasis-derived mouse prostate cancer cell lines
27. Caveolin expression is decreased following androgen deprivation in human prostate cancer cell lines
28. Regulation of androgen receptor mRNA and protein in the rat testis by testosterone
29. Targeted downregulation of caveolin-1 is sufficient to drive cell transformation and hyperactivate the p42/44 MAP kinase cascade
30. Constitutive and growth factor-regulated phosphorylation of caveolin-1 occurs at the same site (Tyr-14) in vivo: Identification of c-Src/Cav-1/Grb7 signaling cassette